1. Roles of androgen receptor and Wnt signaling pathway in prostate cancer
- Author
-
Liu Shan-rong, Xu Bin, Sheng HaiBo, and Liang JingJing
- Subjects
Oncology ,medicine.medical_specialty ,Signal Pathways ,business.industry ,Wnt signaling pathway ,LRP6 ,General Medicine ,medicine.disease ,Androgen receptor ,Prostate cancer ,Crosstalk (biology) ,Internal medicine ,medicine ,Cancer research ,Signal transduction ,business - Abstract
Abnormal activation of Wnt signaling pathway plays an important role in the development and progression of prostate cancer;androgen receptor(AR) is the key for the transformation of androgen-independent prostate cancer(AIPC),and AR signaling pathway is now the focus of prostate cancer research.Many signal pathways can affect AR signaling pathway;in this paper we review the Wnt signaling pathway,androgen receptor and their crosstalk in prostate cancer.
- Published
- 2010