60 results on '"Simon, Patrick"'
Search Results
2. Whole-genome sequencing of SARS-CoV-2 reveals diverse mutations in circulating Alpha and Delta variants during the first, second, and third waves of COVID-19 in South Kivu, east of the Democratic Republic of the Congo
- Author
-
Patrick Bisimwa Ntagereka, Samuel O. Oyola, Simon Patrick Baenyi, Gilbert Kibet Rono, Ahadi Bwihangane Birindwa, Dieudonné Wasso Shukuru, Tshass Chasinga Baharanyi, Théophile Mitima Kashosi, Jean-Paul Cikwanine Buhendwa, Parvine Basimane Bisimwa, Aline Byabene Kusinza, Rodrigue Ayagirwe Basengere, and Denis Mukwege
- Subjects
Microbiology (medical) ,Infectious Diseases ,SARS-CoV-2 ,Mutation ,Democratic Republic of the Congo ,Animals ,COVID-19 ,Humans ,Pangolins ,Genome, Viral ,General Medicine ,Phylogeny - Abstract
We used whole-genome sequencing of SARS-CoV-2 to identify variants circulating in the Democratic Republic of the Congo and obtain molecular information useful for diagnosis, improving treatment, and general pandemic control strategies.A total of 74 SARS-CoV-2 isolates were sequenced using Oxford Nanopore platforms. Generated reads were processed to obtain consensus genome sequences. Sequences with more than 80% genome coverage were used for variant calling, phylogenetic analysis, and classification using Pangolin lineage annotation nomenclature.Phylogenetic analysis based on Pangolin classification clustered South Kivu sequences into seven lineages (A.23.1, B.1.1.6, B.1.214, B.1.617.2, B.1.351, C.16, and P.1). The Delta (B.1.617.2) variant was the most dominant and responsible for outbreaks during the third wave. Based on the Wuhan reference genome, 289 distinct mutations were detected, including 141 missenses, 123 synonymous, and 25 insertions/deletions when our isolates were mapped to the Wuhan reference strain. Most of these point mutations were located within the coding sequences of the SARS-CoV-2 genome that includes spike, ORF1ab, ORF3, and nucleocapsid protein genes. The most common mutation was D614G (1841AG) observed in 61 sequences, followed by L4715L (14143 CT) found in 60 sequences.Our findings highlight multiple introductions of SARS-CoV-2 into South Kivu through different sources and subsequent circulation of variants in the province. These results emphasize the importance of timely monitoring of genetic variation and its effect on disease severity. This work set a foundation for the use of genomic surveillance as a tool for future global pandemic management and control.
- Published
- 2022
3. Enabling the green total factor productivity of the construction industry with the prospect of digital transformation
- Author
-
Hui Li, Xiaqing Peng, Jingxiao Zhang, Pablo Ballesteros-Perez, Simon Patrick Philbin, Zhaoling Li, Xiaoying Tang, and Jiawei Cheng
- Subjects
Economics and Econometrics ,Geography, Planning and Development ,Management, Monitoring, Policy and Law - Published
- 2023
4. Shareholder und Investor Activism – Rechtsfragen der aktuellen Praxis
- Author
-
Simon Patrick Link
- Published
- 2021
5. Liquid phase exfoliated WS2 nanosheet-based gas sensor for room temperature NO2 detection
- Author
-
D. Simon Patrick, M. Krishna Mohan, M. Navaneethan, S. Harish, P. Bharathi, and C. Muthamizchelvan
- Subjects
Materials science ,Sonication ,Liquid phase ,Thin sheet ,Condensed Matter Physics ,Exfoliation joint ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Chemical engineering ,Transition metal ,Molecule ,Electrical and Electronic Engineering ,Dispersion (chemistry) ,Nanosheet - Abstract
Layered transition metal dichalcogenide (TMD) materials possess novel and unique semiconducting properties when exfoliated into thin sheets or individual layers. The exfoliation leads to effective sensing towards gas molecule due to the increase in surface-active sites and edge zone disorders. In this work, we present exfoliation of bulk WS2 sheets with liquid-based dispersion technique using facile bath sonication method for NO2 molecule sensing. The exfoliated WS2 nanosheets show reversible and selective response towards NO2 gas molecules operating at room temperature. The sensitive film shows p-type characteristics providing sensor response rate around 27% for 10 ppm NO2 with rapid response and recovery time around 45 s and 60 s, respectively. The sensitive response was further studied at high temperature of 150 °C showing a drastic increase in response rate as 45% with effective response and recovery time. This improvement in NO2 gas sensing was attributed to the facile exfoliation of WS2 nanosheets.
- Published
- 2021
6. Effect of Sr doping in ZnO microspheres for solar light-driven photodegradation of organic pollutants
- Author
-
Chellamuthu Muthamizhchelvan, Baskaran Palanivel, S. Ponnusamy, M. Krishna Mohan, Simon Patrick, M. Navaneethan, and Saravanan Selvaraj
- Subjects
Materials science ,Band gap ,Doping ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Hydrothermal circulation ,Electronic, Optical and Magnetic Materials ,Metal ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,visual_art ,visual_art.visual_art_medium ,Rhodamine B ,Photocatalysis ,Degradation (geology) ,Electrical and Electronic Engineering ,Photodegradation - Abstract
In recent times, the nanostructured materials of foreign metal ion doped ZnO photocatalysts acts as a hotspot in the research area of photocatalysis because of its non-toxic, cost-effective and environmental friendly behaviour. Sr-doped ZnO microspheres were synthesized by the hydrothermal method. In foreign metal ion-doped ZnO photocatalysts, Sr ions are uniformly distributed into ZnO lattice, which reflects the enhancement in the light absorption behaviour. Especially, 5% Sr-doped ZnO shifts the bandgap to visible region up to 422 nm. Sunlight-driven photocatalytic activity revealed that Sr (5%)-doped ZnO shows maximum degradation efficiency of 99%, 90%, and 93% on methylene blue, Rhodamine B, and ciprofloxacin, respectively. Further, the possible degradation mechanism was well-discussed with the help of the elemental trapping test.
- Published
- 2021
7. Synthesis and Characterization of Bis[(R or S)-N-1-(X-C6H4)ethyl-2-oxo-1-naphthaldiminato-κ2N,O]-Λ/Δ-cobalt(II) (X = H, p-CH3O, p-Br) with Symmetry- and Distance-Dependent Vibrational Circular Dichroism Enhancement and Sign Inversion
- Author
-
Simon-Patrick Höfert, Gennaro Pescitelli, Mohammad Khairul Islam, Marcin Górecki, Mohammad Ariful Islam, Dennis Woschko, Mohammed Enamullah, and Christoph Janiak
- Subjects
Inorganic Chemistry ,Crystallography ,Circular dichroism ,Enantiopure drug ,chemistry ,Vibrational circular dichroism ,Center (category theory) ,chemistry.chemical_element ,Molecule ,Physical and Theoretical Chemistry ,Absorption (chemistry) ,Chirality (chemistry) ,Cobalt - Abstract
The enantiopure Schiff bases (R or S)-N-1-(X-C6H4)ethyl-2-hydroxy-1-naphthaldimine {X = H [(R or S)-HL1], p-CH3O [(R or S)-HL2], and p-Br [(R- or S)-HL3]} react with cobalt(II) acetate to give bis[(R or S)-N-1-(X-C6H4)ethyl-2-oxo-1-naphthaldiminato-κ2N,O]-Λ/Δ-cobalt(II) {X = H [Λ/Δ-Co-(R or S)-L1], p-CH3O [Λ/Δ-Co-(R or S)-L2], and p-Br [Λ/Δ-Co-(R or S)-L3]} (1-3), respectively. Induced Λ and Δ chirality originates at the metal center of the C2-symmetric molecule in pseudotetrahedral geometry. Differential scanning calorimetry analyses explored the thermal stability of the complexes, which undergo reversible phase transformation from crystalline solid to isotropic liquid phase for 1 and 3 but irreversible phase transformation for 2. Like other cobalt(II) complexes, compounds 1-3 exhibit a continuous ensemble of absorption and circular dichroism bands, which span from the UV to IR region and can be collected into a superspectrum. Infrared vibrational circular dichroism (IR-VCD) spectra witness the coupling between Co2+-centered low-lying electronic states and ligand-centered vibrations. The coupling produces enhanced and almost monosignate VCD spectra, with both effects being mode-dependent in terms of the A or B symmetry (in the C2 point group) and distance from the Co2+ core.
- Published
- 2021
8. A mixed‐valence copper(I/II) coordination polymer directed with a bifunctional soft‐hard pyrazolate−carboxylate ligand
- Author
-
Alexa Schmitz, Christoph Janiak, Saskia Menzel, Simon-Patrick Höfert, and Secil Öztürk
- Subjects
Inorganic Chemistry ,chemistry.chemical_compound ,Valence (chemistry) ,chemistry ,Coordination polymer ,Polymer chemistry ,chemistry.chemical_element ,Carboxylate ,Bifunctional ,Copper - Published
- 2021
9. Aufsichtsratsstudie 2020 – Verbesserungspotenzial in Krisensituationen insbesondere bei nicht börsennotierten Unternehmen
- Author
-
Simon Patrick Link, Daniela Favoccia, and Stefan Siepelt
- Published
- 2020
10. Production Systems, Genetic Diversity and Genes Associated with Prolificacy and Milk Production in Indigenous Goats of Sub-Saharan Africa: A Review
- Author
-
Ahadi Bwihangane Birindwa, Christian Keambou Tiambo, Getinet Mekuriaw Tarekegn, J.O. Jung'a, Joel W. Ochieng, Katcho Karume, and Simon Patrick Baenyi
- Subjects
Genetic diversity ,Animal breeding ,business.industry ,Grazing ,Livestock ,Adaptation ,Biology ,business ,Domestication ,Haplogroup A ,Haplogroup ,Biotechnology - Abstract
Goats are one of the oldest domesticated animal species widely distributed in the world playing an important role in the food production system in Sub-Saharan African Region (SSAR). Due to their multiple uses (milk production, meat, fiber and hides) and adaptation aptitudes to ecological conditions, goats produce and contribute positively to farmers’ socio-economy status in various production systems. This review aimed at giving a summary overview on the goat’s production systems characteristics, the genetic diversity and the candidate genes affecting reproductive and milk production performances in goat breeds in SSAR. It has been observed that traditional livestock production system with communal grazing system is the most used in goat keeping in SSAR. The geographical locations play an important role in the relationships between goat’s distributions in the region. At the same time, goats might have been differentiated and isolated one to others due to the wide geographic range, the diversify climate and the topography in the region. Among the six worldwide known haplogroups of goat (A, B, C, D, G and F), haplogroup A is the most representative in SSAR. However, haplogroup G and B can be found in some goat populations in some countries in east (Kenya and Ethiopia) and south parts of Africa. This review reveals that little is known on the candidate genes associated with prolificacy and milk production traits in indigenous goat breeds in the region. That observation suggests the importance of assessing candidate genes associated with economic traits in the populations of goat in SSAR.
- Published
- 2020
11. Increase of network hydrophilicity from sql to lvt supramolecular isomers of Cu-MOFs with the bifunctional 4-(3,5-dimethyl-1H-pyrazol-4-yl)benzoate linker
- Author
-
Simon Millan, Simon-Patrick Höfert, Alexa Schmitz, Saskia Menzel, Christoph Janiak, Serkan Gökpinar, and Alexander Nuhnen
- Subjects
Inorganic Chemistry ,Solvent ,chemistry.chemical_compound ,chemistry ,Polymer chemistry ,Supramolecular chemistry ,Dimethylformamide ,Molecule ,Acetonitrile ,Bifunctional ,Linker ,Benzoic acid - Abstract
The bifunctional linker 4-(3,5-dimethyl-1H-pyrazol-4-yl)benzoic acid (H2mpba) was used for the synthesis of new (square lattice) sql 2D metal–organic frameworks (MOFs) [Cu(Hmpba)2]·L (L = DMF or ACN) in a solvent-mixture of dimethylformamide/water and acetonitrile/water. These sql 2D MOFs are supramolecular isomers of the lvt 3D network [Cu(Hmpba)2]·4MeOH·1H2O (lvt-MeOH) that was synthesized previously by Richardson and co-workers. All these frameworks are potentially porous structures with solvent molecules included in the channels of the as synthesized materials. After activation all three materials showed good CO2 adsorption capacity, demonstrated here for lvt-MeOH for the first time, with a saturation uptake of 113 cm3 g−1 (lvt-MeOH-act.), 111 cm3 g−1 (sql-DMF-act.) and 90 cm3 g−1 (sql-ACN-act.) at 195 K. The flexibility of the lvt-MeOH-act. network is evidenced by a gate-opening effect seen in the CO2 measurement at 195 K and under gravimetric high-pressure CO2 adsorption. According to the water and ethanol sorption measurements the new sql frameworks can be categorized as hydrophobic materials in contrast to the hydrophilic lvt framework. In the lvt-MeOH structure the crystal solvent can be replaced with water to yield the structurally authenticated water-only network lvt-H2O containing 3D arrays of S4-symmetric (H2O)20 clusters.
- Published
- 2020
12. Effects of coat color pattern and sex on physiological traits and heat tolerance of indigenous goats exposed to solar radiation
- Author
-
Arthur Munga, Bienfait Mitima, Valence Bwana Mutwedu, Rodrigue Basengere Balthazar Ayagirwe, Ahadi Bwihangane Birindwa, Yannick Mugumaarhahama, Simon Patrick Baenyi, and Vanessa W. Kamgang
- Subjects
Heat tolerance ,Atmospheric Science ,Coat ,Animal science ,Ecology ,South kivu ,Animal Science and Zoology ,Biology ,Physiological reaction ,Heat stress - Published
- 2020
13. Annexe méthodologique - Populations et Sociétés, n° 565, 2019
- Author
-
Coulmont, Baptiste, Simon, Patrick, and Editions, Ined
- Subjects
Prénoms ,Méthodologie ,Immigrés ,Enquête TeO - Abstract
Annexe à l'article Baptiste Coulmont, Patrick Simon. Quels prénoms les immigrés donnent-ils à leurs enfants en France ? Population et Sociétés, n° 565, avril 2019. Disponible en ligne : https://www.ined.fr/fr/publications/editions/population-et-societes/prenoms-immigres-enfants-france/
- Published
- 2022
- Full Text
- View/download PDF
14. Hierarchical ZnO/g-C3N4 nanocomposites for enhanced NO2 gas sensing applications
- Author
-
D. Simon Patrick, A Govind, P Bharathi, M. Krishna Mohan, S Harish, J Archana, and M. Navaneethan
- Subjects
General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
15. Dividendenzahlung in (vom Geschäftsverlauf abhängigen) Raten
- Author
-
Gerd Krieger and Simon Patrick Link
- Published
- 2021
16. Techno-Economic Analysis of Solar Power Plants in Kuwait: Modelling the Performance of PV and CSP Systems
- Author
-
Yaqoub E.Y.Y.E Althuwaini and Simon Patrick Philbin
- Subjects
Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology - Published
- 2021
17. It takes more than the project manager: The importance of senior management support for successful social sector projects
- Author
-
Riaz Ahmed and Simon Patrick Philbin
- Subjects
Public Administration ,Sociology and Political Science ,Social Sciences (miscellaneous) - Published
- 2022
18. Influencing factors of urban innovation and development: a grounded theory analysis
- Author
-
Jing-Xiao Zhang, Jia-Wei Cheng, Simon Patrick Philbin, Pablo Ballesteros-Perez, Martin Skitmore, and Ge Wang
- Subjects
Economics and Econometrics ,Geography, Planning and Development ,Influencing factors ,Review ,Urban innovation and development ,Management, Monitoring, Policy and Law ,Social-economic-natural complex ecosystem theory ,Grounded theory - Abstract
Urban innovation and development are a core driver for promoting the industrial, economic, and social development of cities. However, the factors that affect the innovation and development of cities lack systematic analysis as well as interaction analysis. Based on a multidimensional perspective, this study suggests that natural, economic, and social factors are three major factors conditioning urban innovation and development. A grounded theoretical qualitative method is further adopted to code relevant research literatures, news reports and interview materials, resulting in an onion factors model. We find that natural factors–including environmental quality, geographic location, and city scale–are prerequisite for conditioning urban innovation and development. Economic factors are also key, including economic level, industrial structure, industrial agglomeration, and technological innovation. Social factors are guarantee factors, including administrative hierarchy, cultural environment, population structure, and government management and services, i.e., they are essential for cities to become adaptable in the current dynamic situation. The study provides theoretical support and practical directions for the formulation of policies for urban innovation development.
- Published
- 2021
19. Increase of network hydrophilicity from sql to lvt supramolecular isomers of Cu-MOFs with the bifunctional 4-(3,5-dimethyl-1
- Author
-
Saskia, Menzel, Simon, Millan, Simon-Patrick, Höfert, Alexander, Nuhnen, Serkan, Gökpinar, Alexa, Schmitz, and Christoph, Janiak
- Abstract
The bifunctional linker 4-(3,5-dimethyl-1H-pyrazol-4-yl)benzoic acid (H2mpba) was used for the synthesis of new (square lattice) sql 2D metal-organic frameworks (MOFs) [Cu(Hmpba)2]·L (L = DMF or ACN) in a solvent-mixture of dimethylformamide/water and acetonitrile/water. These sql 2D MOFs are supramolecular isomers of the lvt 3D network [Cu(Hmpba)2]·4MeOH·1H2O (lvt-MeOH) that was synthesized previously by Richardson and co-workers. All these frameworks are potentially porous structures with solvent molecules included in the channels of the as synthesized materials. After activation all three materials showed good CO2 adsorption capacity, demonstrated here for lvt-MeOH for the first time, with a saturation uptake of 113 cm3 g-1 (lvt-MeOH-act.), 111 cm3 g-1 (sql-DMF-act.) and 90 cm3 g-1 (sql-ACN-act.) at 195 K. The flexibility of the lvt-MeOH-act. network is evidenced by a gate-opening effect seen in the CO2 measurement at 195 K and under gravimetric high-pressure CO2 adsorption. According to the water and ethanol sorption measurements the new sql frameworks can be categorized as hydrophobic materials in contrast to the hydrophilic lvt framework. In the lvt-MeOH structure the crystal solvent can be replaced with water to yield the structurally authenticated water-only network lvt-H2O containing 3D arrays of S4-symmetric (H2O)20 clusters.
- Published
- 2020
20. Synthesis and Characterization of g-C3N4/ZnO Nanocomposites for Gas Sensing Application
- Author
-
C.S Yethukrishnan, Govind A. Vangari, D Simon Patrick, and M. Krishna Mohan
- Abstract
Air pollution is one of the prevailing issues in our atmosphere, which greatly affects humans and causes dangerous diseases. Toxic and green gases (NO2, CO2, NOx, H2S, CO, Sulphur dioxide, and CH4) are present in the ambient atmosphere arising from different industries, vehicles, and fossil fuel combustion. g-C3N4/ZnO nanocomposites were prepared via a facile hydrothermal method. The synthesized g-C3N4/ZnO samples were analyzed using FE-SEM for morphological analysis and structural parameters are confirmed by XRD. Further investigation is done on sensing films for toxic gases by varying temperature, resistance change, and gas type.
- Published
- 2022
21. Synthesis and Characterization of Graphene oxide for Gas Sensing Applications
- Author
-
G Mathankumar, D Simon Patrick, P Praveen., and M Krishna Mohan.
- Abstract
Organic 2D materials have gained extensive attraction in the field of the gas sensor. Because of their critical role in environmental monitoring, chemical manufacturing industries, and human health safety. In recent years most of the research groups have been interested, to fabricate the Graphene oxide-based chemi-resistive gas sensor, owing to its superior structural, mechanical, and electrical properties. Excellent mechanical strength (Young modulus ∼0.05 TPA), the potentiality of ultrafast electron transport (highest mobility ∼200,000 cm2/V s) along with the best surface to volume ratio. In this paper, we have prepared Graphene oxide nanosheets by the modified hummers method. Structural properties of the as-prepared sample were confirmed by XRD and RAMAN spectroscopy. morphological analyses were done by FE-SEM analysis.
- Published
- 2022
22. Two-dimensional Cobalt-Carboxylate Framework with Hourglass Trinuclear Co3 (COO)6 (DMA)3 Secondary Building Unit
- Author
-
Simon Millan, Simon-Patrick Höfert, Christoph Janiak, Anna Goldman, and Katharina Nardin
- Subjects
Secondary building unit ,Chemistry ,Coordination polymer ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,Inorganic Chemistry ,Crystallography ,chemistry.chemical_compound ,law ,Ionic liquid ,Carboxylate ,Hourglass ,0210 nano-technology ,Cobalt - Published
- 2018
23. Metabolites from the endophytic fungus Cylindrocarpon sp. isolated from tropical plant Sapium ellipticum
- Author
-
Rainer Kalscheuer, Lasse van Geelen, Ramsay S.T. Kamdem, Matthias U. Kassack, Wafo Pascal, Parichat Sureechatchaiyan, Zhen Liu, Nidja Rehberg, Christoph Janiak, Wenhan Lin, Tim-Oliver Knedel, Peter Proksch, and Simon-Patrick Höfert
- Subjects
Sapium ellipticum ,Staphylococcus aureus ,Stereochemistry ,Antineoplastic Agents ,Microbial Sensitivity Tests ,Sapium ,01 natural sciences ,chemistry.chemical_compound ,Alkaloids ,Cell Line, Tumor ,Drug Discovery ,Endophytes ,Humans ,Cytotoxicity ,Pharmacology ,Cylindrocarpon ,Molecular Structure ,biology ,010405 organic chemistry ,Absolute configuration ,General Medicine ,Endophytic fungus ,biology.organism_classification ,Pyrone ,Anti-Bacterial Agents ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Pyrones ,Polyketides ,Hypocreales ,Antibacterial activity ,Cylindrocarpon sp - Abstract
Three new polyketides, cylindrocarpones A−C (1–3), two new pyridone alkaloids, cylindrocarpyridones A−B (5–6), a new pyrone cylindropyrone (7), together with seven know compounds were isolated from the endophytic fungus, Cylindrocarpon sp., obtained from the tropical plant Sapium ellipticum. The structures of the new compounds were elucidated by extensive analysis of their spectroscopic data (1D and 2D NMR, HRESIMS). The absolute configuration of 19-O-methyl-pyrrocidine B (13) was confirmed by X-ray analysis. All isolated compounds were screened for their cytotoxic and antibacterial activities. Pyrrocidine A (12) exhibited potent cytotoxicity against the human ovarian cancer cell line A2780 with an IC50 value of 1.7 μM. 19-O-Methyl-pyrrocidine B (13) showed moderate antibacterial activity against S. aureus ATCC25923 and ATCC700699 with MIC values of 50 and 25 μM, respectively.
- Published
- 2018
24. Substituted<scp>l</scp>-tryptophan-<scp>l</scp>-phenyllactic acid conjugates produced by an endophytic fungusAspergillus aculeatususing an OSMAC approach
- Author
-
Peter Proksch, Hao-Fu Dai, Raha Orfali, Hao Wang, Peter M. Eze, Festus B. C. Okoye, Simon-Patrick Höfert, Zhen Liu, Charles O. Esimone, Rudolf Hartmann, and Christoph Janiak
- Subjects
0301 basic medicine ,Chromatography ,biology ,010405 organic chemistry ,General Chemical Engineering ,Metabolite ,Aspergillus aculeatus ,Tryptophan ,Absolute configuration ,General Chemistry ,Nuclear magnetic resonance spectroscopy ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,chemistry ,ddc:540 ,Fermentation ,Ammonium ,Carica - Abstract
The endophytic fungus Aspergillus aculeatus isolated from leaves of the papaya plant Carica papaya was fermented on solid rice medium, yielding a new L-tryptophan-L-phenyllactic acid conjugate (1) and thirteen known compounds (11, 14–25). In addition, an OSMAC approach was employed by adding eight different sodium or ammonium salts to the rice medium. Addition of 3.5% NaNO3 caused a significant change of the metabolite pattern of the fungus as indicated by HPLC analysis. Subsequent isolation yielded several new substituted L-tryptophan-L-phenyllactic acid conjugates (1–10) in addition to three known compounds (11–13), among which compounds 2–10, 12–13 were not detected in the rice control culture. All structures were unambiguously elucidated by one and two dimensional NMR spectroscopy and by mass spectrometry. The absolute configuration of the new compounds was determined by Marfey's reaction and X-ray single crystal diffraction. Compounds 19–22 showed cytotoxicity against the L5178Y mouse lymphoma cell line with IC50 values of 3.4, 1.4, 7.3 and 23.7 μM, respectively.
- Published
- 2018
25. Spontaneous resolution of a Δ/Λ-chiral-at-metal pseudo-tetrahedral Schiff-base zinc complex to a racemic conglomerate with C–H⋯O organized 41- and 43-helices
- Author
-
Christoph Janiak, Simon-Patrick Höfert, Mohammad Abdul Quddus, Mohammad Khairul Islam, Vera Vasylyeva, and Mohammed Enamullah
- Subjects
Schiff base ,010405 organic chemistry ,Chemistry ,Ligand ,Hydrogen bond ,Intermolecular force ,Supramolecular chemistry ,chemistry.chemical_element ,Space group ,General Chemistry ,Zinc ,010402 general chemistry ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Crystallography ,chemistry.chemical_compound ,Molecule ,General Materials Science - Abstract
The Schiff-base ligand N-2-(pyridyl)salicylaldimine (HL) reacts with zinc(II) acetate or nitrate to obtain the enantiomorphous chiral-at-metal compound Δ/Λ-bis[N-2-(pyridyl)salicylaldiminato-κ2N,O]zinc(II), [Zn(L)2] (1), which crystallizes as a racemic conglomerate via spontaneous resolution. Two deprotonated N,O-chelate ligands form a pseudo-tetrahedral N2O2-coordination sphere with a Δ/Λ-configured zinc atom. The Δ- and Λ-configured molecular complexes in 1 assemble in P (right)- and M (left)-handed 41- and 43-helical chains in the chiral space groups P41212 and P43212, respectively, through weak C–H⋯O hydrogen bonding between neighbouring molecules along the chain axis. Only molecules of the same Δ- or Λ-configuration combine into a helical chain and only chains of the same P- or M-handedness combine to form homochiral crystals. According to the analyses of intermolecular interactions with the Hirshfeld surface, the supramolecular packing features C–H⋯O bonding as the most apparent significant contribution. This is a rare example of solely weak C–H⋯O hydrogen bonding interaction leading to spontaneous resolution to a racemic conglomerate. This case also supports the notion of less repulsive packing interactions between homochiral molecules because of spin polarization. Optimized structures and excited state properties by DFT/TD-DFT calculations are comparable to experimental results.
- Published
- 2018
26. Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae
- Author
-
Zhen Liu, Hao-Fu Dai, Christoph Janiak, Sebastian Wesselborg, Fabian Stuhldreier, Peter Proksch, Haiqian Yu, Simon-Patrick Höfert, Julia Sperlich, Chenyin Wang, Matthias U. Kassack, and Nicole Teusch
- Subjects
Coniella fragariae ,Stereochemistry ,Pyrenophorin ,Fungus ,01 natural sciences ,Aldehyde ,Pigment ,Feces ,Ascomycota ,Cell Line, Tumor ,Germany ,Drug Discovery ,Geese ,Ic50 values ,Animals ,Humans ,Benzopyrans ,Alkyl ,Benzofurans ,Pharmacology ,chemistry.chemical_classification ,biology ,Molecular Structure ,010405 organic chemistry ,General Medicine ,Pigments, Biological ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,visual_art ,visual_art.visual_art_medium ,North Sea ,Cancer cell lines ,Drug Screening Assays, Antitumor - Abstract
Two azaphilone pigments (1 and 2), two dihydrobenzofurans (3 and 4), two macrodiolides (5 and 6), and a dimeric alkyl aromatic constituent (7) were isolated from the goose dung-derived fungus Coniella fragariae. Compounds 1–3 proved to be new natural products. Coniellins H and I (1 and 2) feature a tetracyclic core and an aldehyde group at C-5, which is unusual for azaphilone derivatives. The X-ray structure of pyrenophorin (5) is reported for the first time. Pyrenophorin (5) showed strong cytotoxicity against several cancer cell lines with IC50 values ranging from 0.07 to 7.8 μM.
- Published
- 2019
27. Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial
- Author
-
Kozhuharov, Nikola, Goudev, Assen, Flores, Dayana, Maeder, Micha T., Walter, Joan, Shrestha, Samyut, Gualandro, Danielle Menosi, de Oliveira Junior, Mucio Tavares, Sabti, Zaid, Müller, Beat, Noveanu, Markus, Socrates, Thenral, Ziller, Ronny, Bayés-Genís, Antoni, Sionis, Alessandro, Simon, Patrick, Michou, Eleni, Gujer, Samuel, Gori, Tommaso, Wenzel, Philip, Pfister, Otmar, Conen, David, Kapos, Ioannis, Kobza, Richard, Rickli, Hans, Breidthardt, Tobias, Münzel, Thomas, Erne, Paul, Mueller, Christian, Galactic Investigators, Dimov, Bojidar, Hartwiger, Sabine, Arenja, Nisha, Glatz, Bettina, Herr, Natascha, Isenrich, Rahel, Mosimann, Tamina, Twerenbold, Raphael, Boeddinghaus, Jasper, Nestelberger, Thomas, Puelacher, Christian, Freese, Michael, Vögele, Janine, Meissner, Kathrin, Martin, Jasmin, Strebel, Ivo, Wussler, Desiree, Schumacher, Carmela, Osswald, Stefan, Vogt, Fabian, Hilti, Jonas, Barata, Sara, Schneider, Deborah, Schwarz, Jonas, Fitze, Brigitte, Rentsch, Katharina, Bossa, Aline, Jallad, Sergio, Soeiro, Alexandre, Georgiev, Dimitar, Jansen, Thomas, Gebel, Gabriele, Bossard, Matthias, and Christ, Michael
- Published
- 2019
- Full Text
- View/download PDF
28. Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense
- Author
-
Christoph Janiak, Sebastian Wesselborg, Zhen Liu, Werner E. G. Müller, Simon-Patrick Höfert, Peter Proksch, Anna-Lene Kiffe-Delf, Ying Gao, Marian Frank, Fabian Stuhldreier, Rudolf Hartmann, Rainer Kalscheuer, and Ni Putu Ariantari
- Subjects
Fusarium ,biology ,010405 organic chemistry ,Stereochemistry ,Organic Chemistry ,Absolute configuration ,010402 general chemistry ,Bothriospermum chinense ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Endophyte ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Cytotoxicity ,Two-dimensional nuclear magnetic resonance spectroscopy ,Derivative (chemistry) ,Bacteria - Abstract
Three new lipodepsipeptides, fusaristatins D–F (1–3) and a new α-pyrone derivative, (7S,8R)-(−)-chlamydospordiol (5), together with eight known compounds (4, 6–12) were obtained from solid rice cultures of Fusarium sp. BZCB-CA, an endophyte of the Chinese medicinal plant, Bothriospermum chinense. The planar structures of the new metabolites (1–3, 5) were established by spectroscopic techniques (1D/2D NMR and HRESIMS). Marfey’s method was applied to determine the absolute configuration of 1, while the absolute configuration of 5 was determined by single-crystal X-ray crystallography analysis in addition to Mosher’s method. Crystallographic data of inflatin C (7) are also supplied here for the first time. In cytotoxicity assays, rubrofusarin (8) showed a moderate effect on the lymphoma cell lines L5178Y, Ramos and Jurkat, with IC50 values of 7.7, 6.2 and 6.3 μM, respectively, while the remaining compounds were inactive. When subjected to antibacterial assay, only lateropyrone (9) exhibited good to weak activity against a panel of Gram-positive bacteria including drug-resistant strains with MICs ranging from 3.1 to 25 μM.
- Published
- 2021
29. Shaping of MOFs via freeze-casting method with hydrophilic polymers and their effect on textural properties
- Author
-
Simon-Patrick Höfert, Carsten Schlüsener, Emrah Hastürk, Burhan Topalli, and Christoph Janiak
- Subjects
chemistry.chemical_classification ,Materials science ,Sodium polyacrylate ,Polyacrylic acid ,Sorption ,02 engineering and technology ,General Chemistry ,Polyethylene glycol ,Polymer ,Polyethylene ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Polyvinyl alcohol ,0104 chemical sciences ,Freezing point ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Mechanics of Materials ,General Materials Science ,0210 nano-technology - Abstract
Shaping of metal-organic frameworks (MOFs) and tuning of their sorption properties is a very important and challenging aspect for the usage of MOFs for many applications. Both shaping and tuning can be addressed by composite preparation as an effective method. Herein, we present the shaping of the hydrothermally stable MOFs aluminum fumarate, MIL-160(Al) and MIL-101(Cr) using the freeze-casting method with the hydrophilic polymer binders polyacrylic acid (PAA), sodium polyacrylate (PAANa), polyethylene glycol (PEG), polyethylene imine (PEI), polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP). Furthermore, the effect of in-situ cross-linking below the freezing point (cryopolymerization) on the textural properties of monoliths was also investigated using MIL-101(Cr) and aluminum fumarate with the polymer PVA. The selected MOFs were chosen due to their outstanding stability, sorption properties and differing hydrophilicities. In the obtained mechanically stable monoliths, each MOF showed a different compatibility with the used polymers. From 21 different MOF@polymer composites with 80 wt% loading of MOF, 12 of them exhibited negligible pore blocking effects and very high nitrogen sorption properties in correspondence with the MOF mass fraction. On the other hand, water uptake is especially in cases of MOF@PVA and MOF@PVP in good agreement with the MOF fraction and can be enhanced by the contribution of the hydrophilic polymer to the composite. In particular, most MIL-101(Cr) composites showed a hydrophilic shift to lower relative pressure p·p0−1 compared to the rather hydrophobic neat MIL-101(Cr). IR spectroscopy indicated a clear interaction of PEI with the Al-MOFs aluminum fumarate and MIL-160(Al) resulting in MOF pore blocking. The molecular weight of the polymer is not significant for the freeze-casting method but plays an important role in the cryopolymerization.
- Published
- 2020
30. Syntheses, spectroscopy, tautomerism, induced chirality and molecular structure of 3-(o/p-tolylimino)indolin-2-one and bis[3-(o/p-tolylimino)indole-2-olato-κ2N,O]-Δ/Λ-zinc(II)
- Author
-
Christoph Janiak, Simon-Patrick Höfert, Mohammad Khairul Islam, and Mohammed Enamullah
- Subjects
010405 organic chemistry ,Hydrogen bond ,Supramolecular chemistry ,010402 general chemistry ,01 natural sciences ,Tautomer ,Enol ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Crystallography ,chemistry ,Excited state ,Materials Chemistry ,Proton NMR ,Molecule ,Physical and Theoretical Chemistry ,Chirality (chemistry) - Abstract
The isatin-Schiff bases 3-(o/p-tolylimino)indolin-2-one (HL1 and HL2) undergo tautomerization from lactam (L)- to enol (E)-form in solution, which in turn reacts with zinc(II) nitrate to give bis[3-(o/p-tolylimino)indole-2-olato-κ2N,O]-Δ/Λ-zinc(II) (1 and 2). IR spectra for the Schiff bases suggest solely the lactam-form at solid state, while both the forms in solution. 1H NMR spectra show the peaks associated to both the lactam- and enol-forms in solution. Molecular structure for HL1 explores two symmetry independent molecules (A and B) in an asymmetric unit due to intermolecular O⋯H and N⋯H hydrogen bonding interactions. The molecule crystallises with monoclinic P21/n space group. Supramolecular analyses suggest that the packing in the crystals is organized, in addition to hydrogen bonds, by a few intra- and inter-molecular C–H…π contacts. Studies of Hirshfeld surfaces using CrystalExplorer strongly support the quantitative analyses by supramolecular packing in the crystals. 1H NMR spectra for 1 or 2 show two sets of peaks for each proton, correspond to the Δ-Zn and Λ-Zn configured isomers at a ratio of ca. 65:35, resulting from induced chirality at-metal centre. 1H NMR spectra taken at different time intervals rule out any possibility of interconversion between the isomers in solution, that is, the same ratio of the isomers exists at solid state. These results indicate preferential formation one isomer over another (i.e., Δ-Zn or Λ-Zn) both in solution and at solid state. Optimized structures and excited state properties by DFT/TDDFT correspond well to the experimental results.
- Published
- 2020
31. Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a
- Author
-
Werner E.G. Müller, Simon-Patrick Höfert, Zhen Liu, Christoph Janiak, Peter Proksch, Mariam Moussa, Haiqian Yu, BO Umeokoli, and Hao-Fu Dai
- Subjects
biology ,Tetrapeptide ,010405 organic chemistry ,Stereochemistry ,Organic Chemistry ,Endophytic fungus ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Amide ,Drug Discovery ,Phomopsis sp ,Alternanthera bettzickiana ,Two-dimensional nuclear magnetic resonance spectroscopy ,Derivative (chemistry) - Abstract
Three new polyketides, phomopones A−C (1–3), one new cyclic tetrapeptide, 18-hydroxydihydrotentoxin (4), and a new amide, 6-hydroxyenamidin (5) together with a known derivative, enamindin (6) were obtained from the endophytic fungus Phomopsis sp. D15a2a isolated from the plant Alternanthera bettzickiana. The structures of the new compounds were elucidated by 1D, 2D NMR and HRMS data. The absolute configurations of the isolated metabolites were determined either by X-ray crystallography, Marfey’s method or by converting the compounds to Mosher esters.
- Published
- 2019
32. Substituted l-tryptophan-l-phenyllactic acid conjugates produced by an endophytic fungus
- Author
-
Hao, Wang, Peter M, Eze, Simon-Patrick, Höfert, Christoph, Janiak, Rudolf, Hartmann, Festus B C, Okoye, Charles O, Esimone, Raha S, Orfali, Haofu, Dai, Zhen, Liu, and Peter, Proksch
- Abstract
The endophytic fungus
- Published
- 2018
33. Introduction
- Author
-
Simon, Patrick, Beauchemin, Cris, Hamel, Christelle, and Institut national d'études démographiques (INED)
- Subjects
[SHS]Humanities and Social Sciences - Abstract
Even before it was a project, the Trajectories and Origins (TeO) survey was a clear necessity. France, a country of immigration throughout the twentieth century, has become a multicultural society, and the diversity of origins represented in its population is unprecedented. And yet little was known about the situation of populations with an immigrant background. In public debate, they are portrayed through false representations and stereotypes. The list of anxieties and fears is long; living in segregated neighbourhoods, failing at school, and lacking national identity, the children of immigrants, it was argued, would be tempted by communautarisme. What should we think about this? Does the problem ultimately lie in the behaviours and strategies of individuals with an immigrant background, or in the way that French society responds to its growing population diversity? This book brings to the reader the main findings of an unprecedent survey on the diversity of population in France, and offers new insights on the processes of integration and discrimination.
- Published
- 2018
34. An efficient approach for treating composition-dependent diffusion within organic particles
- Author
-
Rahul Zaveri, Gordon McFiggans, David Topping, and Simon Patrick O'Meara
- Abstract
Mounting evidence demonstrates that under certain conditions the rate of component partitioning between the gas- and particle-phase in atmospheric organic aerosol is limited by particle-phase diffusion. To date, however, particle-phase diffusion has not been incorporated to regional atmospheric models. An analytical rather than numerical solution to diffusion through organic particulate matter is desirable because of its comparatively small computational expense in regional models. Current analytical models assume diffusion to be independent of composition, and therefore use a constant diffusion coefficient. To realistically model diffusion, however, it should be composition-dependent (e.g. due to the partitioning of components that plasticise, vitrify or solidify). This study assesses the modelling capability of an analytical solution to diffusion corrected to account for composition dependence against a numerical solution. Results show reasonable agreement when the gas-phase saturation ratio of a partitioning component is constant and particle-phase diffusion limits partitioning rate (
- Published
- 2017
35. New eremophilane-type sesquiterpenes and maleimide-bearing compounds from Carpesium abrotanoides L
- Author
-
Kun Zou, Simon-Patrick Höfert, Guan Jin, Zhen Liu, Peter Proksch, Weaam Ebrahim, Zhiyong Guo, Jianfeng Chen, Lei Wang, Li Tian, Fan Cheng, Till F. Schäberle, and Christoph Janiak
- Subjects
China ,Stereochemistry ,Phytochemicals ,Asteraceae ,Sesquiterpene ,01 natural sciences ,Maleimides ,chemistry.chemical_compound ,Cell Line, Tumor ,Drug Discovery ,Ic50 values ,Humans ,Cytotoxicity ,Maleimide ,Pharmacology ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Mtt method ,Absolute configuration ,General Medicine ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Carpesium abrotanoides ,Sesquiterpenes ,Human cancer - Abstract
Two new eremophilane-type sesquiterpenes, carperemophilanes A and B (1–2), three new maleimide-bearing compounds, carpesiumaleimides A–C (3–5), along with a known sesquiterpene, carabrol (6), were isolated from the ethanol extract of Carpesium abrotanoides L. Their structures were elucidated by analysis of their NMR and MS data as well as by comparison with the literature. The absolute configuration of carperemophilane A (1) was determined by single-crystal X-ray diffraction analysis. All isolated compounds (1–6) were evaluated in vitro for cytotoxicity against two human cancer cell lines MDA-MB-231 and HGC-27 using the MTT method. Compounds 1, 2 and 6 showed cytotoxic activities with IC50 values ranging from 7.45 to 37.35 μM.
- Published
- 2019
36. Reform and Revolution: The Arab Spring at One Year
- Author
-
Simon Patrick Brown
- Subjects
Geography ,geography.geographical_feature_category ,Spring (hydrology) ,Context (language use) ,Ancient history - Abstract
This paper concerns the differences in the development of the Algerian and Egyptian uprisings within the context of the Arab Spring revolts.
- Published
- 2011
37. Article 23: Formal Validity, Material Validity or Both?
- Author
-
Simon Patrick Camilleri
- Subjects
Engineering ,Conflict of laws ,Publishing ,business.industry ,Project commissioning ,Law ,Political Science and International Relations ,business - Abstract
(2011). Article 23: Formal Validity, Material Validity or Both? Journal of Private International Law: Vol. 7, No. 2, pp. 297-320.
- Published
- 2011
38. Improving the customer experience for heterogeneous wireless access
- Author
-
Yacine El Mghazli, Francois Taburet, Stephen Howard Johnson, Telemaco Melia, Frank Scahill, Erick Bizouarn, Barbara Orlandi, Richard Evenden, Simon Patrick Alexander Ringland, Jean-Luc Lafragette, and Tim Twell
- Subjects
Engineering ,Exploit ,business.industry ,End user ,Mobile broadband ,media_common.quotation_subject ,Session (web analytics) ,Handover ,Mobile phone ,Wireless ,Quality (business) ,Electrical and Electronic Engineering ,Telecommunications ,business ,media_common - Abstract
The landscape for wireless connectivity is changing rapidly, and with these changes come new challenges for delivering a high quality customer experience. Over the last few years there has been a massive growth in the volume of mobile data consumed by both laptops and smartphones. The latter, in particular, have seen a huge expansion in numbers with smartphones forecast to rise to 64 percent of all mobile phone sales in Western Europe by 2015. In parallel, public Wi-Fi networks have grown beyond expectations—in the UK, for example, BT (British Telecommunications plc) now has over 1.5 million public hotspots. This leaves the challenge of how best to exploit both cellular and Wi-Fi coverage while delivering a simple customer experience to the end users. In this paper, we describe a prototype connection management solution that makes use of network based session mobility, congestion detection, user movement modeling, and network-based handover control. We then present results of a small scale trial of the system and identify remaining issues. This work is the product of a collaborative research project between BT and Alcatel-Lucent.
- Published
- 2011
39. Can young people reliably rate side effects of low-dose antipsychotic medication using a self-report survey?
- Author
-
Glenn E. Hunt, Simon Patrick Byrne, Patrick E. Concannon, Garry Walter, Nerissa Li Soh, Michelle Cleary, Paul Duffy, Peter Krabman, Geoff Crawford, Gin S Malhi, and Oren Griffiths
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Low dose ,Mental health ,Psychiatry and Mental health ,Self-report study ,medicine ,Antipsychotic ,business ,Psychiatry ,Self report ,Biological Psychiatry ,Clinical psychology - Abstract
Walter G, Byrne S, Griffiths O, Hunt G, Soh N, Cleary M, Duffy P, Crawford G, Krabman P, Concannon P, Malhi G. Can young people reliably rate side effects of low-dose antipsychotic medication using a self-report survey?
- Published
- 2010
40. Flawless Startups in Iraq - Majnoon Oil Field Achieves First Commercial Production
- Author
-
Will Tierney, Simon Patrick Ames, Tom Hooft van Huysduynen, and Remo Verspoor
- Subjects
Engineering ,Petroleum engineering ,business.industry ,Production (economics) ,Oil field ,business - Abstract
The Majnoon Field was discovered in 1976 and brought online in 2002 by the Iraq South Oil Company (SOC). In December 2009, during the Ministry of Oil's 2nd Petroleum Licensing Round, Shell won the right to develop the field under a Development and Production Services Contract. Shell Iraq Petroleum Development BV (SIPD) became operator for the Majnoon Field (45%), with partners Petronas Carigali (30%) and Missan Oil Company (25%). In September 2013, first oil from the combination of newly built and the refurbished existing facilities & wells, was established. In accordance with the terms of the contract, a minimum average flow rate of 175k bpd over a period of 90 days was achieved in order to meet the First Commercial Production (FCP) target and thus allow Shell to begin cost recovery. This paper will be based on Shell's experience executing the Majnoon field development in South Iraq. The project scope was completed in challenging circumstances, with very little subsurface information available to confirm design assumptions. As a result, a number of execution risks were transferred to the commissioning & initial start-up operations. The team ultimately relied on experience, planned contingencies and intelligent workarounds to achieve the FCP production target. The key startup challenges will be discussed in this paper that are relevant to the audience, particularly those involved in field start-up & operations. Conclusions will relate to how the team overcame flow instabilities (slugging) from daisy chained pipelines (linking the multiple wellpads), crude foaming in the process facilities, welding debris in the flare system, dealing with export curtailment (process stops and re-starts) and establishing custody transfer measurement with SOC. In addition, this paper will present a selected number of Majnoon lessons learned during the commissioning & startup period and how Shell improves Project Delivery in subsequent projects to achieve Flawless Startups to meet the original project premises of safe, reliable production under specified costs and schedule constraints.
- Published
- 2014
41. A Novel Anti-Foam Chemical Application As Contributor To The Successful Start-Up Of The Majnoon Oilfield
- Author
-
Mark Grutters, Sunil Pandya, Simon Patrick Ames, Sayf Khalil, Elias Korosoglou, and Ian Turner
- Subjects
Engineering ,Petroleum engineering ,Waste management ,business.industry ,Start up ,business - Abstract
The Majnoon oilfield in Southern Iraq, one of the largest in the world, recommenced production in September 2013. The field was developed by the Iraqi South Oil Company in the 1980s and originally produced around 50,000 BOPD. As result of Iraq's second licensing round a consortium of Shell, Petronas and Missan Oil Company worked closely with SOC and redeveloped Majnoon to increase its daily production from 50,000 BOPD to more than 175,000 BOPD. Over a period of several days the production increased from 15,000 to 40,000 BOPD, when several plant trips occurred due to excessive liquid carry over from the separators into the flare system. At first this was attributed to unstable flow and tuning of the production facilities. However, more plant trips followed while ramping up to more than 100,000 BOPD as debris accumulated in the flare system which resulted in multiple blockages. A root-cause analysis was carried out by a team from production chemistry, operations and production support before piloting an anti-foam chemical solution which proved to be an immediate success and production stabilised within hours. After three days the pilot project was converted into a permanent solution and since the introduction of the anti-foam chemical Majnoon hasn't suffered any further plant trips due to liquid carry over. In fact, the chemical has allowed production to be increased by at least 15,000 BOPD through improved flow through the separators. This paper will explain the theory behind foaming and highlight the process of fluid testing. We will present the results of the plant trips root-cause analysis and describe in detail how the anti-foam trial developed. A novel monitoring program has been developed that allows for immediate correction in case of changes to production or chemical injection, which has greatly contributed to the safe and successful Majnoon start-up.
- Published
- 2014
42. Comparative effects of Bcl-2 over-expression and ZVAD.FMK treatment on dexamethasone and VP16-induced apoptosis in CEM cells
- Author
-
Alastair John Mackenzie Watson, Roderick Simon Patrick Benson, and Caroline Dive
- Subjects
Programmed cell death ,Cell Membrane Permeability ,Membrane permeability ,T-Lymphocytes ,Cell ,Apoptosis ,Mitochondrion ,Dexamethasone ,Amino Acid Chloromethyl Ketones ,Tumor Cells, Cultured ,medicine ,Humans ,Enzyme Inhibitors ,Fragmentation (cell biology) ,Molecular Biology ,Caspase ,Cell Size ,Etoposide ,biology ,Proteins ,Depolarization ,Cell Biology ,Flow Cytometry ,Caspase Inhibitors ,Chromatin ,Mitochondria ,Cell biology ,Gene Expression Regulation, Neoplastic ,medicine.anatomical_structure ,Proto-Oncogene Proteins c-bcl-2 ,biology.protein - Abstract
It is becoming apparent that caspases are essential mediators of the execution phase of apoptosis. A decrease in mitochondrial membrane potential (PsiM) is also thought to be an early event in apoptosis. In this study, we compare the effects of Bcl-2 over-expression against N-benzyloxycabonyl-Val-Ala-Asp-fluoromethylketone (ZVAD. FMK)-sensitive caspase blockade on dexamethasone (DEX) and etoposide (VP16)-induced apoptosis in CEM T lymphoid cells. We assessed changes in nuclear chromatin, cell size, fragmentation, cell membrane permeability and PsiM. We found Bcl-2 over-expression and ZVAD.FMK-sensitive caspase inhibition were able to prevent chromatin condensation and cellular fragmentation. However, ZVAD.FMK was neither able to prevent loss of plasma membrane integrity nor PsiM depolarization which occur in both VP16 and DEX-induced apoptosis. In VP16-induced apoptosis, the increase in cell membrane permeability was actually potentiated by caspase inhibition. Interestingly, ZVAD.FMK did prevent VP16-induced but not DEX-induced cell shrinkage. These results suggest that not all the actions of Bcl-2 can be explained by its ability to prevent caspase activation. Rather Bcl-2 must have other targets of action which include functions associated with mitochondria.
- Published
- 1998
43. L’ acculturation linguistique. Utilisation du français et transmission de la langue des immigrés à leurs enfants
- Author
-
Simon, Patrick
- Abstract
Dans le cadre familial, les immigrés pratiquent des formes relativement complexes de combinaisons linguistiques, qui varient selon les populations et les interlocuteurs (conjoint ou enfant). L’usage du français est cependant prépondérant. Contrairement aux enfants d’origine portugaise ou espagnole, les enfants d’Algériens abandonnent assez largement la pratique de la langue des parents et, en majorité, considèrent la langue française comme leur langue maternelle., Simon Patrick. L’ acculturation linguistique. Utilisation du français et transmission de la langue des immigrés à leurs enfants. In: Migrants formation, n°108, mars 1997. Questions de langue. pp. 53-66.
- Published
- 1997
44. L’agencement de la mosaïque ethnique à Belleville
- Author
-
Simon, Patrick
- Abstract
Loin des clichés contradictoires de l’échange pacifique ou de l’affrontement permanent, la cohabitation interethnique se déroule souvent dans l’indifférence. Devenu une donnée quotidienne pour des milliers d’habitants, le multiculturalisme n’est plus vécu comme un choix ou un enjeu, mais plutôt comme une réalité qui nécessite des aménagements. Ce sont précisément ces aménagements qu’on a observés dans le cadre d’un quartier populaire ancien de Paris., Simon Patrick. L’agencement de la mosaïque ethnique à Belleville. In: Migrants formation, n°109, juin 1997. Relations interethniques : complexité et ambiguïté. pp. 68-80.
- Published
- 1997
45. Überblick über die Pflichten zur Offenlegung der Vorstandsvergütung
- Author
-
Simon Patrick Link and Philip Goj
- Published
- 2013
46. Low dimensionality of the diamond surface conductivity
- Author
-
Hauf, Moritz V., Simon, Patrick, Seifert, Max, Holleitner, Alexander W., Stutzmann, Martin, and Garrido, Jose A.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Mesoscale and Nanoscale Physics (cond-mat.mes-hall) ,FOS: Physical sciences ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect - Abstract
Undoped diamond, a remarkable bulk electrical insulator, exhibits a high surface conductivity in air when the surface is hydrogen-terminated. Although theoretical models have claimed that a two-dimensional hole gas is established as a result of surface energy band bending, no definitive experimental demonstration has been reported so far. Here, we prove the two-dimensional character of the surface conductivity by low temperature characterization of diamond in-plane gated field-effect transistors that enable the lateral confinement of the transistor's drain-source channel to nanometer dimensions. In these devices, we observe Coulomb blockade effects of multiple quantum islands varying in size with the gate voltage. The charging energy and thus the size of these zero-dimensional islands exhibits a gate voltage dependence which is the direct result of the two-dimensional character of the conductive channel formed at hydrogen-terminated diamond surfaces.
- Published
- 2013
- Full Text
- View/download PDF
47. First lensing measurements of SZ-discovered clusters
- Author
-
McInnes, Rachel N., Menanteau, Felipe, Heavens, Alan F., Hughes, John P., Jimenez, Raul, Massey, Richard, Simon, Patrick, and Taylor, Andy N.
- Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics::Galaxy Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the first lensing mass measurements of Sunyaev-Zel'dovich (SZ) selected clusters. Using optical imaging from the Southern Cosmology Survey (SCS), we present weak lensing masses for three clusters selected by their SZ emission in the South Pole Telescope survey (SPT). We confirm that the SZ selection procedure is successful in detecting mass concentrations. We also study the weak lensing signals from 38 optically-selected clusters in ~8 square degrees of the SCS survey. We fit Navarro, Frenk and White (NFW) profiles and find that the SZ clusters have amongst the largest masses, as high as 5x10^14 Msun. Using the best fit masses for all the clusters, we analytically calculate the expected SZ integrated Y parameter, which we find to be consistent with the SPT observations., Comment: Minor changes to match accepted version, 5 pages, 3 figures
- Published
- 2009
- Full Text
- View/download PDF
48. Unfolding the matter distribution using 3-D weak gravitational lensing
- Author
-
Simon, Patrick, Taylor, Andy, and Hartlap, Jan
- Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,FOS: Physical sciences ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Combining redshift and galaxy shape information offers new exciting ways of exploiting the gravitational lensing effect for studying the large scales of the cosmos. One application is the three-dimensional reconstruction of the matter density distribution which is explored in this paper. We give a generalisation of an already known minimum-variance estimator of the 3-D matter density distribution that facilitates the combination of thin redshift slices of sources with samples of broad redshift distributions for an optimal reconstruction. We show how, in principle, intrinsic alignments of source ellipticities or shear/intrinsic alignment correlations can be accommodated, albeit these effects are not the focus of this paper. We describe an efficient and fast way to implement the estimator on a contemporary desktop computer. Analytic estimates for the noise and biases in the reconstruction are given. The bias -- a spread and shift of structures in radial direction -- can be expressed in terms of a radial PSF, comprising the limitations of the reconstruction due to source shot-noise and the unavoidably broad lensing kernel. We conclude that a 3-D mass-density reconstruction on galaxy cluster scales is feasible but, for foreseeable surveys, a map with a S/N>~3 threshold is limited to structures with M200>~10^14 Msol/h, or 7x10^14 Msol/h, at low to moderate redshifts (z=0.1 or 0.6). However, we find that a heavily smoothed full-sky map of the very large-scale density field may also be possible as the S/N of reconstructed modes increases towards larger scales. Future improvements of the method can be obtained by including higher-order lensing information (flexion) which could also be implemented into our algorithm. [ABRIDGED], 22 pages, 13 figures, accepted by MNRAS
- Published
- 2009
- Full Text
- View/download PDF
49. Unternehmensinformation und Wettbewerbsschutz – Problemeinschätzung deutscher börsennotierter Unternehmen
- Author
-
Simon Patrick Link
- Abstract
4.1. Unternehmensinformation und Wettbewerbsschutz – Problemeinschatzung deutscher borsennotierter Unternehmen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 529 4.1.1. Problemstellung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 529 4.1.2. Literatur zum Gegenstand der Untersuchung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 530 4.1.3. Untersuchungsdesign . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 533 4.1.4. Umfrageergebnisse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 534 4.1.4.1. Respondenten . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 534 4.1.4.1.1. Unternehmensangaben . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 535 4.1.4.1.1.1 Unternehmen und Marktposition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 535 4.1.4.1.1.2 Rechnungslegung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 539 4.1.4.1.2. Antwortende Person . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 540 4.1.4.2. Competitive Disadvantage durch Pflichtangaben in der Rechnungslegung . . . . . . . . . . . . . . . 541 4.1.4.2.1. Ausmas und Auspragungen des Problems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 541 4.1.4.2.2. Kritische Veroffentlichungen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 547 4.1.4.2.3. Schadenspotential . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 551 4.1.4.2.4. Vermeidung von Wettbewerbsnachteilen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 552 4.1.4.3. Nutzung von Pflichtveroffentlichungen zur Wettbewerbsanalyse . . . . . . . . . . . . . . . . . . . . . . . 554 4.1.4.3.1. Aktivitaten zur Wettbewerbsanalyse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 554 4.1.4.3.2. Wert der Angaben der Wettbewerber . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 554 4.1.4.3.3. Nutzungsmoglichkeiten der Informationen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 558 4.1.5. Zusammenfassung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 559 Literatur . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 560
- Published
- 2008
50. Neue Möglichkeiten für ASP-betriebene Applikationen
- Author
-
Simon, Patrick
- Published
- 2002
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.