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11 results on '"Small, T."'

2. Graft failure after T-cell-depleted human leukocyte antigen identical marrow transplants for leukemia: II. In vitro analyses of host effector mechanisms

Author

BORDIGNON , CLAUDIO, Keever C. A., Small T. N., Flomenberg N., Dupont B., O'Reilly R. J., N. A. Kernan, Bordignon, Claudio, Keever, C. A., Small, T. N., Flomenberg, N., Dupont, B., O'Reilly, R. J., and N. A., Kernan

Subjects
Colony-Forming Units Assay, Killer Cells, Natural, Graft vs Host Reaction, Leukemia, Neutrophils, T-Lymphocytes, Antigens, Surface, Graft Survival, Humans, In Vitro Techniques, T-Lymphocytes, Regulatory, Bone Marrow Transplantation, Hematopoiesis
Abstract

To identify mechanisms potentially contributing to graft failure, 19 leukemic recipients of T-cell-depleted marrow transplants who failed to engraft following a transplant of HLA identical sibling marrow depleted of T cells by soybean agglutinin (SBA) and sheep erythrocytes (E) were evaluated. Peripheral blood mononuclear cells isolated at the time of failure were consistently of host origin, bearing the phenotype of suppressor T cells (CD3+, CD8+, Leu 7+). A direct cytolytic effect on 51Cr-labeled donor-derived target cells was not detected, a finding that contrasts with the donor-specific cytotoxic host T lymphocytes that have been regularly observed in patients rejecting HLA nonidentical SBA -E- BMTs. However, these host T cells did exhibit a strong and specific suppressive activity against the donor marrow CFU-GM in vitro. Furthermore, in contrast to prior findings in durably engrafted recipients of SBA -E- BMTs, the lymphocytes isolated prior to or at the time of graft failure lacked natural killer surface antigen expression and effector function.

Published
1989

5. A phase II trial of peri-transplant palifermin with busulfan, melphalan and fludarabine followed by T-cell depleted hematopoietic stem cell transplants in patients with advanced myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) evolved from MDS

Author

Tamari, R., Sheetal, S. R., Deborah Kuk, Papadopoulos, E. B., Jakubowski, A. A., Boulad, F., Small, T. N., Kernan, N. A., Perales, M. A., Koehne, G., Ponce, D. M., Devlin, S., Goldberg, J. D., Young, J. W., Giralt, S. A., O Reilly, R. J., and Castro-Malaspina, H. R.

6. Classification and Characterization of Objects from GALEX and SDSS surveys

Author

Luciana Bianchi, Seibert, M., Zheng, W., Thilker, D., Friedman, P., Wyder, T., Donas, J., Barlow, T., Byun, Yong-Ik, Forster, K., Heckman, T., Jelinsky, P., Lee, Y. -W, Madore, B., Malina, R., Martin, C., Milliard, B., Morrissey, P., Neff, S., Rich, M., Schiminovich, D., Siegmund, O., Small, T., Szalay, A., and Welsh, B.

Subjects
Astrophysics (astro-ph), Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Astrophysics::Galaxy Astrophysics
Abstract

We use the GALEX (Galaxy Evolution Explorer) Medium Imaging Survey (MIS) and All-Sky Imaging Survey (AIS) data available in the first internal release, matched to the SDSS catalogs in the overlapping regions, to classify objects by comparing the multi-band photometry to model colors. We show an example of the advantage of such broad wavelength coverage (GALEX far-UV and near-UV, SDSS ugriz) in classifying objects and augmenting the existing samples and catalogs. From the MIS [AIS] sample over an area of 75 [92] square degrees, we select a total of 1736 [222] QSO candidates at redshift less than 2, significantly extending the number of fainter candidates, and moderately increasing the number of bright objects in the SDSS list of spectroscopically confirmed QSO. Numerous hot stellar objects are also revealed by the UV colors, as expected., This paper will be published as part of the Galaxy Evolution Explorer (GALEX) Astrophysical Journal Letters Special Issue. Full paper available from http://dolomiti.pha.jhu.edu . Links to the full set of papers available at http://www.galex.caltech.edu/PUBLICATIONS/ after Nov.22, 2004

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