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2 results on '"Soler MT"'

1. Allergen specificity and endothelial transmigration of T cells in allergic contact dermatitis and atopic dermatitis are associated with the cutaneous lymphocyte antigen

Author

Santamaria Lf, Hauser C, Perez Soler Mt, and Blaser K

Subjects
Adult, Antigens, Differentiation, T-Lymphocyte, T cell, Immunology, Receptors, Lymphocyte Homing, Lymphocyte Activation, Proinflammatory cytokine, Dermatitis, Atopic, Antigen, Antigens, Neoplasm, T-Lymphocyte Subsets, medicine, Immunology and Allergy, Skin immunity, Animals, Humans, Antigens, Dermatophagoides, Allergic contact dermatitis, Cells, Cultured, Glycoproteins, Mites, Membrane Glycoproteins, integumentary system, biology, business.industry, food and beverages, Antibodies, Monoclonal, General Medicine, T lymphocyte, Atopic dermatitis, Allergens, Patch Tests, medicine.disease, Asthma, Chemotaxis, Leukocyte, medicine.anatomical_structure, Dermatitis, Allergic Contact, biology.protein, lipids (amino acids, peptides, and proteins), Endothelium, Vascular, Antibody, business, Cell Adhesion Molecules, Immunologic Memory
Abstract

Recent investigations have indicated a role for antigen-specific T lymphocytes in the local skin immunity. The cutaneous lymphocyte antigen (CLA) is supposed to represent a skin-homing receptor for T cells. Inhibition experiments with specific monoclonal antibody demonstrate that CLA participates in selective transendothelial migration of memory/effector T cells in vitro by interaction with E-selectin on endothelial cell layers after activation with proinflammatory cytokines. In addition, the receptor-ligand pairs VLA-4/VCAM-1 and LFA-1/ICAM-1 are involved in this process. Moreover, only CLA+, CD45RO+ (memory/effector) T cells freshly isolated from peripheral blood of patients with allergic contact dermatitis or atopic dermatitis specifically proliferate in response to the respective allergen. CLA-, CD45RO- T cells from these patients do not respond to the allergens. In contrast, memory T cells from asthmatic individuals and patients with both asthma and atopic dermatitis express the allergen specificity in both T cell subsets. Tetanus toxoid, a systemically acting antigen, also induces a proliferative response in both CLA+ and CLA- memory/effector T cell subsets. These results strongly support the selective role of CLA in homing T cells to the cutaneous tissues and therefore playing a role in the local immunity and inflammatory reactions of the skin.

Published
1995

2. Skin-homing T cells in human cutaneous allergic inflammation

Author

Perez Soler Mt, Blaser K, Santamaria Babi Lf, and Hauser C

Subjects
Antigens, Differentiation, T-Lymphocyte, Chemokine, CD3 Complex, T-Lymphocytes, Immunology, Vascular Cell Adhesion Molecule-1, Biology, Dermatitis, Contact, Epitope, Allergic inflammation, Dermatitis, Atopic, Epitopes, Immune system, Antigen, Antigens, Neoplasm, Nickel, Cytotoxic T cell, Animals, Humans, Antigen-presenting cell, Mites, Membrane Glycoproteins, integumentary system, Interleukin-8, food and beverages, Intercellular Adhesion Molecule-1, Lymphocyte Function-Associated Antigen-1, biology.protein, Leukocyte Common Antigens, lipids (amino acids, peptides, and proteins), Human umbilical vein endothelial cell, E-Selectin, Immunologic Memory
Abstract

The cutaneous lymphocyte-associated antigen (CLA) is a carbohydrate epitope present on memory/effector T cells that infiltrate inflamed skin. E-selectin is the ligand for CLA and is induced under inflammation on endothelial cells. CLA was originally postulated as a phenotype marker for skin-associated T cells. We studied the specific in vitro response to skin-associated allergens of CLA+ and CLA-CD45RO+ T cells in atopic dermatitis (AD) and contact dermatitis (CD), which represent two well-characterized T cell-mediated cutaneous allergic inflammations. Whereas CLA+ T cells from AD patients preferentially responded to house dust mite (HDM) and CLA+ T cells from nickel CD patients showed an increased response to nickel, CLA-T cells showed very little response in both cases. In contrast, tetanus toxoid, a systemically acting antigen, induced a proliferative response in both CLA+ and CLA- cells. Interestingly the response to HDM in patients with asthma +/- AD was preferentially found in the CLA- subset indicating the involvement of different homing receptors for mucosal tissues. Moreover, CLA+ T cells showed enhanced migration through activated human umbilical vein endothelial cell monolayers compared to CLA- T cells. The CLA binding to E-selectin is initially responsible for the extravasation that also involves VLA-4/VCAM-1 and LFA-1/ICAM-1 interactions. We have recently identified IL-8 as an endothelial cell-derived chemokine and the IL-8 receptor type B which control CLA+ T cell migration. Such a CLA-mediated migration would localize memory/effector T cells that respond to antigens and reach the body through inflamed skin. Our data support the existence of a regionalization of the immune system and in particular of the skin immune system. It may allow an efficient distribution of the immune defense to different sites of the body.

Published
1995

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