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Wearable devices for continuous monitoring of electronic health increased attention due to their richness in information. Often, inference is drawn from features that quantify some summary of the data, leading to a loss of information that could be useful when one utilizes the functional nature of the response. When functional trajectories are observed repeated over time, it is termed longitudinal functional data. This work is motivated by the interest to assess the efficacy of a noninflammatory medication, meloxicam, on the daily activity levels of household cats with a pre-existing condition of osteoarthritis under a crossover design. These activity profiles are recorded at a minute level by accelerometer over the entire study period. To this aspect, we propose an orthogonal projection-based test pseudo generalized F test for significance of the functional treatment effect under a functional additive crossover model after adjusting for the carryover effect and other baseline covariates. Under mild conditions, we derive the asymptotic null distribution of the test statistic when the projection function for the underlying Hilbert space is estimated from the data. In finite sample numerical studies, the proposed test maintains the size, is powerful to detect the significance of the smooth effect of meloxicam, and is very efficient compared to bootstrap-based alternatives., Comment: made with biometrics template guide, to confine it within 5 pages

In many modern applications, a dependent functional response is observed for each subject over repeated time, leading to longitudinal functional data. In this paper, we propose a novel statistical procedure to test whether the mean function varies over time. Our approach relies on reducing the dimension of the response using data-driven orthogonal projections and it employs a likelihood-based hypothesis testing. We investigate the methodology theoretically and discuss a computationally efficient implementation. The proposed test maintains the type I error rate, and shows excellent power to detect departures from the null hypothesis in finite sample simulation studies. We apply our method to the longitudinal diffusion tensor imaging study of multiple sclerosis (MS) patients to formally assess whether the brain's health tissue, as summarized by fractional anisotropy (FA) profile, degrades over time during the study period.

Scalar-on-function linear models are commonly used to regress functional predictors on a scalar response. However, functional models are more difficult to estimate and interpret than traditional linear models, and may be unnecessarily complex for a data application. Hypothesis testing can be used to guide model selection by determining if a functional predictor is necessary. Using a mixed effects representation with penalized splines and variance component tests, we propose a framework for testing functional linear models with responses from exponential family distributions. The proposed method can accommodate dense and sparse functional data, and be used to test functional predictors for no effect and form of the effect. We show via simulation study that the proposed method achieves the nominal level and has high power, and we demonstrate its utility with two data applications., Comment: 30 pages, 4 figures

Wearable devices including accelerometers are increasingly being used to collect high-frequency human activity data in situ. There is tremendous potential to use such data to inform medical decision making and public health policies. However, modeling such data is challenging as they are high-dimensional, heterogeneous, and subject to informative missingness, e.g., zero readings when the device is removed by the participant. We propose a flexible and extensible continuous-time hidden Markov model to extract meaningful activity patterns from human accelerometer data. To facilitate estimation with massive data we derive an efficient learning algorithm that exploits the hierarchical structure of the parameters indexing the proposed model. We also propose a bootstrap procedure for interval estimation. The proposed methods are illustrated using data from the 2003 - 2004 and 2005 - 2006 National Health and Nutrition Examination Survey., Comment: 18 pages, 4 figures

We propose a Bayesian modeling framework for jointly analyzing multiple functional responses of different types (e.g. binary and continuous data). Our approach is based on a multivariate latent Gaussian process and models the dependence among the functional responses through the dependence of the latent process. Our framework easily accommodates additional covariates. We offer a way to estimate the multivariate latent covariance, allowing for implementation of multivariate functional principal components analysis (FPCA) to specify basis expansions and simplify computation. We demonstrate our method through both simulation studies and an application to real data from a periodontal study.

We consider analysis of dependent functional data that are correlated because of a longitudinal-based design: each subject is observed at repeated time visits and for each visit we record a functional variable. We propose a novel parsimonious modeling framework for the repeatedly observed functional variables that allows to extract low dimensional features. The proposed methodology accounts for the longitudinal design, is designed for the study of the dynamic behavior of the underlying process, and is computationally fast. Theoretical properties of this framework are studied and numerical investigation confirms excellent behavior in finite samples. The proposed method is motivated by and applied to a diffusion tensor imaging study of multiple sclerosis. Using Shiny (Chang et al., 2015) we implement interactive plots to help visualize longitudinal functional data as well as the various components and prediction obtained using the proposed method., Comment: 32 pages, 4 figures