1. Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases
- Author
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Susanna Lopez, Lutfu Hanoglu, Raffaele Ferri, Raffaella Franciotti, Lucia Fraioli, Heinrich Garn, Francesco Famà, Dag Aarsland, Fabrizia D'Antonio, Bahar Güntekin, Andrea Soricelli, Peter Fuhr, Maria Francesca De Pandis, Görsev Yener, Marco Onofrj, Maria Teresa Pascarelli, Laura Bonanni, Carla Buttinelli, Francesco Orzi, Valentina Catania, Claudio Babiloni, Franco Giubilei, Erol Başar, Giuseppe Noce, Gerhard Ransmayr, John-Paul Taylor, Michela Pievani, Giovanni B. Frisoni, Claudio Del Percio, Antonio Ivano Triggiani, Carlo de Lena, Flavio Nobili, Laura Vacca, Derya Durusu Emek-Savaş, Ute Gschwandtner, Roberta Lizio, Dario Arnaldi, Paola Stirpe, Fabrizio Stocchi, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy, Stocchi, Fabrizio, Vacca, Laura, Stirpe, Paola IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neuroscience DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS AOU S Martino IST, Genoa, Italy, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Onofrj, Marco, Franciotti, Raffaella, Bonanni, Laura Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Med Fac, Kepler Univ Hosp, Dept Neurol 2, Med Campus 3, Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia Hosp San Raffaele Cassino, Cassino, Italy, Pievani, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, Frisoni, Giovanni B. Univ Hosp Geneva, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Basar, Erol, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurol, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurosci, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, England, Guntekin, Bahar -- 0000-0002-0860-0524, Ferri, Raffaele -- 0000-0001-6937-3065, Pievani, Michela -- 0000-0002-1794-8987, triggiani, antonio ivano -- 0000-0003-3291-9452, Taylor, John-Paul -- 0000-0001-7958-6558, and Aarsland, Dag -- 0000-0001-6314-216X
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0301 basic medicine ,Male ,Audiology ,0302 clinical medicine ,mild cognitive impairment due to dementia with Lewy bodies ,media_common ,resting state electroencephalographic rhythms ,medicine.diagnostic_test ,Exact low resolution brain electromagnetic source tomography (eLORETA) ,General Neuroscience ,Brain ,Electroencephalography ,Signal Processing, Computer-Assisted ,General Medicine ,Psychiatry and Mental health ,Clinical Psychology ,mild cognitive impairment due to Alzheimer’s disease ,receiver operating characteristic curve ,Educational Status ,Female ,Alzheimer's disease ,Vigilance (psychology) ,Lewy Body Disease ,medicine.medical_specialty ,media_common.quotation_subject ,Rest ,03 medical and health sciences ,Exact low resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer's disease, mild cognitive impairment due to dementia with Lewy bodies, receiver operating characteristic curve, resting state electroencephalographic rhythms ,Alzheimer Disease ,medicine ,Humans ,Cognitive Dysfunction ,Aged ,Retrospective Studies ,Psychotropic Drugs ,Mini–Mental State Examination ,Resting state fMRI ,Lewy body ,Dementia with Lewy bodies ,business.industry ,medicine.disease ,Mild Cognitive Impairment Due to Alzheimer's Disease ,030104 developmental biology ,Delta Rhythm ,ddc:618.97 ,Geriatrics and Gerontology ,Occipital lobe ,business ,030217 neurology & neurosurgery - Abstract
WOS: 000424245200019 PubMed ID: 29439335 The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC > 0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers. H2020 Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Bodies. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.
- Published
- 2018