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1. Re: Cillekens B, Huysmans MA, Holtermann A, van Mechelen W, Straker L, Krause N, van der Beek AJ, Coenen P. Physical activity at work may not be health enhancing. A systematic review with meta-analysis on the association between occupational physical activity and cardiovascular disease mortality covering 23 studies with 655 892 participants. Scand J Work Environ Health. 2022;48(2):86–98. doi:10.5271/sjweh.3993

Author

Cillekens, Bart, Huysmans, Maaike A., Holtermann, Andreas, van Mechelen, Willem, Straker, Leon, Krause, Niklas, van der Beek, Allard J., Coenen, Pieter, Public and occupational health, APH - Societal Participation & Health, APH - Health Behaviors & Chronic Diseases, and AMS - Musculoskeletal Health

Subjects
Public Health, Environmental and Occupational Health
Published
2023

2. Adults’ perspectives on young children’s use of digital technology: A systematic review of questionnaires used and findings

Author

Harris, Courtenay, Calvezzi, Gemma, Straker, Leon, Beynon, Amber, Edwards, Suzy, Hendry, Danica, Kervin, Lisa, Stearne, Sarah, Rasmussen, Charlotte Lund, Zabatiero, Juliana, Thomas, George, Mannell, Kate, and Burley, Jade

Subjects
Medicine and Health Sciences, Public Health, Social and Behavioral Sciences
Abstract

This systematic review will explore questionnaires used to assess adult perspectives on young children’s use of technology related to health, wellbeing, and development.

Published
2023
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3. Methods used to explore adults’ perspectives on young children’s use of technology: A scoping review

Author

Thomas, George, Hendry, Danica, Straker, Leon, Zabatiero, Juliana, Burley, Jade, Edwards, Suzy, Harris, Courtenay, Mannell, Kate, and Kervin, Lisa

Subjects
Medicine and Health Sciences, Education
Abstract

This scoping review will explore methods used to assess adult perspectives on young children’s use of technology related to health, wellbeing, and development.

Published
2022
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5. Additional file 5 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 5 Supplementary Table S3. All triplets of conditions with prevalence > 1.5% and observed/expected (O/E) ratio > 1.5 (and p value

Published
2021
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6. Additional file 4 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 4. Supplementary Table S2. Relationship between number of conditions and participant characteristics.

Published
2021
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7. Additional file 4 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 4. Supplementary Table S2. Relationship between number of conditions and participant characteristics.

Published
2021
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8. Additional file 1 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 1. Supplementary File 1. BHAS Phase 1 Questionnaire 2010–2015.

Published
2021
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9. The association of mobile touch screen device use with parent-child attachment: a systematic review

Author

Hood, Rebecca, Zabatiero, Juliana, Zubrick, Stephen R., Silva, Desiree, and Straker, Leon

Abstract

Mobile touch screen devices (smartphones and tablet computers) have become an integral part of many parents��� and children���s lives, with this interaction linked to physical, mental and social outcomes. Despite the known importance of parent-child attachment, evidence on the association between device use and attachment was yet to be reviewed. Following protocol pre-registration, databases were searched, papers screened, and methodological quality assessed. Three papers met the inclusion criteria, and reported some negative associations between duration of parent/child smartphone use and attachment outcomes. A narrative synthesis on two groups of related papers found child time using any screen technology (including television viewing), and child ���problematic��� internet, mobile phone, gaming and social media use, was negatively associated with attachment outcomes. Currently there is limited direct evidence on any association between time parents or children spend using these devices and parent-child attachment to support time guidelines for families and professionals working with families. Practitioner summary: Many parents and children regularly spend time using smartphones and tablet computers. This systematic review found limited evidence evaluating associations between child/adolescent or parent time using devices and parent-child attachment. Until quality evidence exists, practitioners should be alert to potential impacts of device use on family relationships and child outcomes.

Published
2021
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10. Additional file 2 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 2. Supplementary File 2. Statistical Supplement. Latent Class Analysis method.

Published
2021
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11. Additional file 6 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Subjects
mental disorders
Abstract

Additional file 6. Supplementary Table S4. Morbidity patterns and number of conditions. Number of participants with each number of conditions and percentage within each morbidity pattern.

Published
2021
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12. Additional file 5 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 5 Supplementary Table S3. All triplets of conditions with prevalence > 1.5% and observed/expected (O/E) ratio > 1.5 (and p value

Published
2021
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13. Additional file 2 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 2. Supplementary File 2. Statistical Supplement. Latent Class Analysis method.

Published
2021
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15. Additional file 3 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Abstract

Additional file 3. Supplementary Table S1. Mean, median and maximum number of conditions by gender and demographic groups.

Published
2021
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16. Additional file 6 of Prevalence and patterns of multimorbidity in Australian baby boomers: the Busselton healthy ageing study

Author

Hunter, Michael L., Knuiman, Matthew W., Musk, Bill (A.W.), Hui, Jennie, Murray, Kevin, Beilby, John P., Hillman, David R., Hung, Joseph, Newton, Robert U., Bucks, Romola S., Straker, Leon, Walsh, John P., Zhu, Kun, Bruce, David G., Eikelboom, Robert H., Davis, Timothy M. E., Mackey, David A., and James, Alan L.

Subjects
mental disorders
Abstract

Additional file 6. Supplementary Table S4. Morbidity patterns and number of conditions. Number of participants with each number of conditions and percentage within each morbidity pattern.

Published
2021
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19. Additional file 1 of Process evaluation of a workplace-based health promotion and exercise cluster-randomised trial to increase productivity and reduce neck pain in office workers: a RE-AIM approach

Author

Welch, Alyssa, Healy, Genevieve, Straker, Leon, Comans, Tracy, O’Leary, Shaun, Melloh, Markus, Sjøgaard, Gisela, Pereira, Michelle, Xiaoqi Chen, and Johnston, Venerina

Abstract

Additional file 1: Table S1. Reach and representativeness across 14 organisations (adjusted income) Table S2. Comparison of baseline responses of participants with and without 12 week or 12 month data. Table S3. Reasons for discontinuation during implementation and maintenance periods

Published
2020
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21. Additional file 1 of Development of a Human Activity Recognition System for Ballet Tasks

Author

Hendry, Danica, Chai, Kevin, Amity Campbell, Hopper, Luke, O’Sullivan, Peter, and Straker, Leon

Subjects
Computer Science::Hardware Architecture, Quantitative Biology::Neurons and Cognition, Computer Science::Neural and Evolutionary Computation, Computer Science::Operating Systems
Abstract

Additional file 1: Detailed convolutional neural network model architecture.

Published
2020
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23. Additional file 1: of Correlates of physical activity and sedentary time in young adults: the Western Australian Pregnancy Cohort (Raine) Study

Author

Howie, Erin, McVeigh, Joanne, Winkler, Elisabeth, Healy, Genevieve, Bucks, Romola, Eastwood, Peter, and Straker, Leon

Abstract

Table S1. Description of variables included as potential correlates. Table S2. Individual correlates (unadjusted except for weartime and number of valid days). Table S3. Description of sample comparing included sample with available sample. (DOCX 45Â kb)

Published
2018
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24. Physical literacy: do our kids have all the tools? The 2016 Active Healthy Kids Australia report card on physical activity for children and young people

Author

Schranz, Natasha, Olds, Tim, Boyd, Roslyn, Evans, John, Gomersall, Sjaan, Hardy, Louise, Hesketh, Kylie, Lubans, David, Ridgers, Nicky, Straker, Leon, Ziviani, Jenny, Tomkinson, Grant, Tomkinson, Grant, Schranz, Natasha, Olds, Tim, Boyd, Roslyn, Evans, John, Gomersall, Sjaan, Hardy, Louise, Hesketh, Kylie, Lubans, David, Ridgers, Nicky, Straker, Leon, Vella, Stewart, and Ziviani, Jenny

Subjects
physical activity, behaviours, young people
Abstract

Background: This year marks the release of Active Healthy Kids Australia’s (AHKA) second Report Card on Physical Activity of Children and Young People. The purposes of the Report Card are: to improve the health of all young Australians by encouraging them to be more physically active; to inform policy decisions; and to identify where more research is needed. Methods: The 2016 AHKA Report Card was developed using the best available national- and state/territory-based physical activity data, which were evaluated by the AHKA Research Working Group (13 children’s physical activity and health researchers from 9 universities) using pre-determined weighting criteria and benchmarks in order to assign letter grades to 12 Report Card indicators. Key findings: As in 2014, Australia was assigned a failing grade (D−) for Overall Physical Activity Levels, with less than 20 per cent of 5–17 year olds meeting there commended national physical activity guidelines of 60 minutes of moderate to vigorous physical activity every day. Organised Sport and Physical Activity Participation improved to a B (from a B− in 2014) while Active Transport declined to a C− (was C). Australia continued to perform well in the settings and sources of influence (ranging from a C+ to an A−), however Strategies and Investments declined from a C+ in 2014 to a Din 2016. The traits associated with physical activity (e.g., Physical Fitness and Movement Skills) were also graded poorly (C− to a D) (see Table 1). Conclusions and Recommendations: Australia is lucky in having excellent physical activity facilities in both communities and in schools: we are well equipped with grassed playing fields, indoor and outdoor courts, and swimming pools, with an abundance of play areas and walk- and cycle-ways.But why are we still failing when it comes to our children and young people “moving more and sitting less”? Perhaps we need to ask: “Do our kids have all the tools they need to be physically literate and engage in physical activity now and in the future?”Active Healthy Kids Australia advocates for a coordinated national response to the current physical inactivity pandemic. There is no single solution to this problem. We need a united effort across many sectors in order to see real improvement in children’s physical activity levels.Specifically, an overarching National Physical Activity Plan would unify the country and help encourage the cultural shift needed to make physical activity a daily priority. We need to develop the Physical Literacy ‘toolkits’ of all Australian children and young people so they acquire the physical, social, emotional and cognitive capabilities they need to make the choice to be active (for fun, enjoyment, and better health and wellbeing) at an appropriate level throughout their life.

Published
2016
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26. Additional file 1: Table S1. of The Raine study had no evidence of significant perinatal selection bias after two decades of follow up: a longitudinal pregnancy cohort study

Author

White, Scott, Eastwood, Peter, Straker, Leon, Adams, Leon, Newnham, John, Lye, Stephen, and Pennell, Craig

Subjects
fungi, parasitic diseases, geographic locations
Abstract

Perinatal characteristics of the Raine Study Birth Cohort, the contemporaneous Western Australian population, and the evolving Raine Study. (PDF 194Â kb)

Published
2017
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27. Additional file 1: Table S1. of The Raine study had no evidence of significant perinatal selection bias after two decades of follow up: a longitudinal pregnancy cohort study

Author

White, Scott, Eastwood, Peter, Straker, Leon, Adams, Leon, Newnham, John, Lye, Stephen, and Pennell, Craig

Subjects
fungi, parasitic diseases, geographic locations
Abstract

Perinatal characteristics of the Raine Study Birth Cohort, the contemporaneous Western Australian population, and the evolving Raine Study. (PDF 194Â kb)

Published
2017
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28. Additional file 1: Table S1. of Objectively measured patterns of sedentary time and physical activity in young adults of the Raine study cohort

Author

McVeigh, Joanne, Winkler, Elisabeth, Howie, Erin, Tremblay, Mark, Smith, Anne, Abbott, Rebecca, Eastwood, Peter, Healy, Genevieve, and Straker, Leon

Abstract

Socio-demographic comparison of participants in this study (nâ =â 773) (Raine year 22 follow up) with contemporaneous Western Australian 22Â year olds (2011 Census data). Table S2. Correlations matrix showing correlations between days of the week in linear mixed models examining daily variation in sedentary time (sedentary/light ratio) and MVPA. Figure S1. Sedentary accumulation in all Raine young women (top) and men (bottom), with usual sedentary bout duration [59]. (DOCX 110592 kb)

Published
2016
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29. Associations of autozygosity with a broad range of human phenotypes

Author

Clark, David W, Okada, Yukinori, Moore, Kristjan HS, Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Mattsson, Hannele, Barnes, Catriona LK, Lin, Kuang, Zhao, Jing Hua, Deelen, Patrick, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M, Baumbach, Clemens, Biino, Ginevra, Bixley, Matthew J, Brumat, Marco, Chai, Jin-Fang, Corre, Tanguy, Cousminer, Diana L, Dekker, Annelot M, Eccles, David A, Van Eijk, Kristel R, Fuchsberger, Christian, Gao, He, Germain, Marine, Gordon, Scott D, De Haan, Hugoline G, Harris, Sarah E, Hofer, Edith, Huerta-Chagoya, Alicia, Igartua, Catherine, Jansen, Iris E, Jia, Yucheng, Kacprowski, Tim, Karlsson, Torgny, Kleber, Marcus E, Li, Shengchao Alfred, Li-Gao, Ruifang, Mahajan, Anubha, Matsuda, Koichi, Meidtner, Karina, Meng, Weihua, Montasser, May E, Van Der Most, Peter J, Munz, Matthias, Nutile, Teresa, Palviainen, Teemu, Prasad, Gauri, Prasad, Rashmi B, Priyanka, Tallapragada Divya Sri, Rizzi, Federica, Salvi, Erika, Sapkota, Bishwa R, Shriner, Daniel, Skotte, Line, Smart, Melissa C, Smith, Albert Vernon, Van Der Spek, Ashley, Spracklen, Cassandra N, Strawbridge, Rona J, Tajuddin, Salman M, Trompet, Stella, Turman, Constance, Verweij, Niek, Viberti, Clara, Wang, Lihua, Warren, Helen R, Wootton, Robyn E, Yanek, Lisa R, Yao, Jie, Yousri, Noha A, Zhao, Wei, Adeyemo, Adebowale A, Afaq, Saima, Aguilar-Salinas, Carlos Alberto, Akiyama, Masato, Albert, Matthew L, Allison, Matthew A, Alver, Maris, Aung, Tin, Azizi, Fereidoun, Bentley, Amy R, Boeing, Heiner, Boerwinkle, Eric, Borja, Judith B, De Borst, Gert J, Bottinger, Erwin P, Broer, Linda, Campbell, Harry, Chanock, Stephen, Chee, Miao-Li, Chen, Guanjie, Chen, Yii-Der I, Chen, Zhengming, Chiu, Yen-Feng, Cocca, Massimiliano, Collins, Francis S, Concas, Maria Pina, Corley, Janie, Cugliari, Giovanni, Van Dam, Rob M, Damulina, Anna, Daneshpour, Maryam S, Day, Felix R, Delgado, Graciela E, Dhana, Klodian, Doney, Alexander SF, Dörr, Marcus, Doumatey, Ayo P, Dzimiri, Nduna, Ebenesersdóttir, S Sunna, Elliott, Joshua, Elliott, Paul, Ewert, Ralf, Felix, Janine F, Fischer, Krista, Freedman, Barry I, Girotto, Giorgia, Goel, Anuj, Gögele, Martin, Goodarzi, Mark O, Graff, Mariaelisa, Granot-Hershkovitz, Einat, Grodstein, Francine, Guarrera, Simonetta, Gudbjartsson, Daniel F, Guity, Kamran, Gunnarsson, Bjarni, Guo, Yu, Hagenaars, Saskia P, Haiman, Christopher A, Halevy, Avner, Harris, Tamara B, Hedayati, Mehdi, Van Heel, David A, Hirata, Makoto, Höfer, Imo, Hsiung, Chao Agnes, Huang, Jinyan, Hung, Yi-Jen, Ikram, M Arfan, Jagadeesan, Anuradha, Jousilahti, Pekka, Kamatani, Yoichiro, Kanai, Masahiro, Kerrison, Nicola D, Kessler, Thorsten, Khaw, Kay-Tee, Khor, Chiea Chuen, De Kleijn, Dominique PV, Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter, Krämer, Bernhard K, Kutalik, Zoltán, Kuusisto, Johanna, Langenberg, Claudia, Launer, Lenore J, Lawlor, Deborah A, Lee, I-Te, Lee, Wen-Jane, Lerch, Markus M, Li, Liming, Liu, Jianjun, Loh, Marie, London, Stephanie J, Loomis, Stephanie, Lu, Yingchang, Luan, Jian'an, Mägi, Reedik, Manichaikul, Ani W, Manunta, Paolo, Másson, Gísli, Matoba, Nana, Mei, Xue W, Meisinger, Christa, Meitinger, Thomas, Mezzavilla, Massimo, Milani, Lili, Millwood, Iona Y, Momozawa, Yukihide, Moore, Amy, Morange, Pierre-Emmanuel, Moreno-Macías, Hortensia, Mori, Trevor A, Morrison, Alanna C, Muka, Taulant, Murakami, Yoshinori, Murray, Alison D, De Mutsert, Renée, Mychaleckyj, Josyf C, Nalls, Mike A, Nauck, Matthias, Neville, Matt J, Nolte, Ilja M, Ong, Ken K, Orozco, Lorena, Padmanabhan, Sandosh, Pálsson, Gunnar, Pankow, James S, Pattaro, Cristian, Pattie, Alison, Polasek, Ozren, Poulter, Neil, Pramstaller, Peter P, Quintana-Murci, Lluis, Räikkönen, Katri, Ralhan, Sarju, Rao, Dabeeru C, Van Rheenen, Wouter, Rich, Stephen S, Ridker, Paul M, Rietveld, Cornelius A, Robino, Antonietta, Van Rooij, Frank JA, Ruggiero, Daniela, Saba, Yasaman, Sabanayagam, Charumathi, Sabater-Lleal, Maria, Sala, Cinzia Felicita, Salomaa, Veikko, Sandow, Kevin, Schmidt, Helena, Scott, Laura J, Scott, William R, Sedaghati-Khayat, Bahareh, Sennblad, Bengt, Van Setten, Jessica, Sever, Peter J, Sheu, Wayne H-H, Shi, Yuan, Shrestha, Smeeta, Shukla, Sharvari Rahul, Sigurdsson, Jon K, Sikka, Timo Tonis, Singh, Jai Rup, Smith, Blair H, Stančáková, Alena, Stanton, Alice, Starr, John M, Stefansdottir, Lilja, Straker, Leon, Sulem, Patrick, Sveinbjornsson, Gardar, Swertz, Morris A, Taylor, Adele M, Taylor, Kent D, Terzikhan, Natalie, Tham, Yih-Chung, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tillander, Annika, Tracy, Russell P, Tusié-Luna, Teresa, Tzoulaki, Ioanna, Vaccargiu, Simona, Vangipurapu, Jagadish, Veldink, Jan H, Vitart, Veronique, Völker, Uwe, Vuoksimaa, Eero, Wakil, Salma M, Waldenberger, Melanie, Wander, Gurpreet S, Wang, Ya Xing, Wareham, Nicholas J, Wild, Sarah, Yajnik, Chittaranjan S, Yuan, Jian-Min, Zeng, Lingyao, Zhang, Liang, Zhou, Jie, Amin, Najaf, Asselbergs, Folkert W, Bakker, Stephan JL, Becker, Diane M, Lehne, Benjamin, Bennett, David A, Van Den Berg, Leonard H, Berndt, Sonja I, Bharadwaj, Dwaipayan, Bielak, Lawrence F, Bochud, Murielle, Boehnke, Mike, Bouchard, Claude, Bradfield, Jonathan P, Brody, Jennifer A, Campbell, Archie, Carmi, Shai, Caulfield, Mark J, Cesarini, David, Chambers, John C, Chandak, Giriraj Ratan, Cheng, Ching-Yu, Ciullo, Marina, Cornelis, Marilyn, Cusi, Daniele, Smith, George Davey, Deary, Ian J, Dorajoo, Rajkumar, Van Duijn, Cornelia M, Ellinghaus, David, Erdmann, Jeanette, Eriksson, Johan G, Evangelou, Evangelos, Evans, Michele K, Faul, Jessica D, Feenstra, Bjarke, Feitosa, Mary, Foisy, Sylvain, Franke, Andre, Friedlander, Yechiel, Gasparini, Paolo, Gieger, Christian, Gonzalez, Clicerio, Goyette, Philippe, Grant, Struan FA, Griffiths, Lyn R, Groop, Leif, Gudnason, Vilmundur, Gyllensten, Ulf, Hakonarson, Hakon, Hamsten, Anders, Van Der Harst, Pim, Heng, Chew-Kiat, Hicks, Andrew A, Hochner, Hagit, Huikuri, Heikki, Hunt, Steven C, Jaddoe, Vincent WV, De Jager, Philip L, Johannesson, Magnus, Johansson, Åsa, Jonas, Jost B, Jukema, J Wouter, Junttila, Juhani, Kaprio, Jaakko, Kardia, Sharon LR, Karpe, Fredrik, Kumari, Meena, Laakso, Markku, Van Der Laan, Sander W, Lahti, Jari, Laudes, Matthias, Lea, Rodney A, Lieb, Wolfgang, Lumley, Thomas, Martin, Nicholas G, März, Winfried, Matullo, Giuseppe, McCarthy, Mark I, Medland, Sarah E, Merriman, Tony R, Metspalu, Andres, Meyer, Brian F, Mohlke, Karen L, Montgomery, Grant W, Mook-Kanamori, Dennis, Munroe, Patricia B, North, Kari E, Nyholt, Dale R, O'connell, Jeffery R, Ober, Carole, Oldehinkel, Albertine J, Palmas, Walter, Palmer, Colin, Pasterkamp, Gerard G, Patin, Etienne, Pennell, Craig E, Perusse, Louis, Peyser, Patricia A, Pirastu, Mario, Polderman, Tinca JC, Porteous, David J, Posthuma, Danielle, Psaty, Bruce M, Rioux, John D, Rivadeneira, Fernando, Rotimi, Charles, Rotter, Jerome I, Rudan, Igor, Den Ruijter, Hester M, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Robert A, Shuldiner, Alan R, Sim, Xueling, Small, Neil, Smith, Jennifer A, Sotoodehnia, Nona, Tai, E-Shyong, Teumer, Alexander, Timpson, Nicholas J, Toniolo, Daniela, Tregouet, David-Alexandre, Tuomi, Tiinamaija, Vollenweider, Peter, Wang, Carol A, Weir, David R, Whitfield, John B, Wijmenga, Cisca, Wong, Tien-Yin, Wright, John, Yang, Jingyun, Yu, Lei, Zemel, Babette S, Zonderman, Alan B, Perola, Markus, Magnusson, Patrik KE, Uitterlinden, André G, Kooner, Jaspal S, Chasman, Daniel I, Loos, Ruth JF, Franceschini, Nora, Franke, Lude, Haley, Chris S, Hayward, Caroline, Walters, Robin G, Perry, John RB, Esko, Tōnu, Helgason, Agnar, Stefansson, Kari, Joshi, Peter K, Kubo, Michiaki, and Wilson, James F

Subjects
Consanguinity, Cognition, Fertility, Inbreeding Depression, Risk-Taking, Haplotypes, Health Status, Homozygote, Body Size, Humans, Alleles, 3. Good health
Abstract

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.

30. Associations of autozygosity with a broad range of human phenotypes

Author

Clark, David W, Okada, Yukinori, Moore, Kristjan H S, Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Mattsson, Hannele, Barnes, Catriona L K, Lin, Kuang, Zhao, Jing Hua, Deelen, Patrick, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M, Baumbach, Clemens, Biino, Ginevra, Bixley, Matthew J, Brumat, Marco, Chai, Jin-Fang, Corre, Tanguy, Cousminer, Diana L, Dekker, Annelot M, Eccles, David A, Van Eijk, Kristel R, Fuchsberger, Christian, Gao, He, Germain, Marine, Gordon, Scott D, De Haan, Hugoline G, Harris, Sarah E, Hofer, Edith, Huerta-Chagoya, Alicia, Igartua, Catherine, Jansen, Iris E, Jia, Yucheng, Kacprowski, Tim, Karlsson, Torgny, Kleber, Marcus E, Li, Shengchao Alfred, Li-Gao, Ruifang, Mahajan, Anubha, Matsuda, Koichi, Meidtner, Karina, Meng, Weihua, Montasser, May E, Van Der Most, Peter J, Munz, Matthias, Nutile, Teresa, Palviainen, Teemu, Prasad, Gauri, Prasad, Rashmi B, Priyanka, Tallapragada Divya Sri, Rizzi, Federica, Salvi, Erika, Sapkota, Bishwa R, Shriner, Daniel, Skotte, Line, Smart, Melissa C, Smith, Albert Vernon, Van Der Spek, Ashley, Spracklen, Cassandra N, Strawbridge, Rona J, Tajuddin, Salman M, Trompet, Stella, Turman, Constance, Verweij, Niek, Viberti, Clara, Wang, Lihua, Warren, Helen R, Wootton, Robyn E, Yanek, Lisa R, Yao, Jie, Yousri, Noha A, Zhao, Wei, Adeyemo, Adebowale A, Afaq, Saima, Aguilar-Salinas, Carlos Alberto, Akiyama, Masato, Albert, Matthew L, Allison, Matthew A, Alver, Maris, Aung, Tin, Azizi, Fereidoun, Bentley, Amy R, Boeing, Heiner, Boerwinkle, Eric, Borja, Judith B, De Borst, Gert J, Bottinger, Erwin P, Broer, Linda, Campbell, Harry, Chanock, Stephen, Chee, Miao-Li, Chen, Guanjie, Chen, Yii-Der I, Chen, Zhengming, Chiu, Yen-Feng, Cocca, Massimiliano, Collins, Francis S, Concas, Maria Pina, Corley, Janie, Cugliari, Giovanni, Van Dam, Rob M, Damulina, Anna, Daneshpour, Maryam S, Day, Felix R, Delgado, Graciela E, Dhana, Klodian, Doney, Alexander S F, Dörr, Marcus, Doumatey, Ayo P, Dzimiri, Nduna, Ebenesersdóttir, S Sunna, Elliott, Joshua, Elliott, Paul, Ewert, Ralf, Felix, Janine F, Fischer, Krista, Freedman, Barry I, Girotto, Giorgia, Goel, Anuj, Gögele, Martin, Goodarzi, Mark O, Graff, Mariaelisa, Granot-Hershkovitz, Einat, Grodstein, Francine, Guarrera, Simonetta, Gudbjartsson, Daniel F, Guity, Kamran, Gunnarsson, Bjarni, Guo, Yu, Hagenaars, Saskia P, Haiman, Christopher A, Halevy, Avner, Harris, Tamara B, Hedayati, Mehdi, Van Heel, David A, Hirata, Makoto, Höfer, Imo, Hsiung, Chao Agnes, Huang, Jinyan, Hung, Yi-Jen, Ikram, M Arfan, Jagadeesan, Anuradha, Jousilahti, Pekka, Kamatani, Yoichiro, Kanai, Masahiro, Kerrison, Nicola D, Kessler, Thorsten, Khaw, Kay-Tee, Khor, Chiea Chuen, De Kleijn, Dominique P V, Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter, Krämer, Bernhard K, Kutalik, Zoltán, Kuusisto, Johanna, Langenberg, Claudia, Launer, Lenore J, Lawlor, Deborah A, Lee, I-Te, Lee, Wen-Jane, Lerch, Markus M, Li, Liming, Liu, Jianjun, Loh, Marie, London, Stephanie J, Loomis, Stephanie, Lu, Yingchang, Luan, Jian’an, Mägi, Reedik, Manichaikul, Ani W, Manunta, Paolo, Másson, Gísli, Matoba, Nana, Mei, Xue W, Meisinger, Christa, Meitinger, Thomas, Mezzavilla, Massimo, Milani, Lili, Millwood, Iona Y, Momozawa, Yukihide, Moore, Amy, Morange, Pierre-Emmanuel, Moreno-Macías, Hortensia, Mori, Trevor A, Morrison, Alanna C, Muka, Taulant, Murakami, Yoshinori, Murray, Alison D, De Mutsert, Renée, Mychaleckyj, Josyf C, Nalls, Mike A, Nauck, Matthias, Neville, Matt J, Nolte, Ilja M, Ong, Ken K, Orozco, Lorena, Padmanabhan, Sandosh, Pálsson, Gunnar, Pankow, James S, Pattaro, Cristian, Pattie, Alison, Polasek, Ozren, Poulter, Neil, Pramstaller, Peter P, Quintana-Murci, Lluis, Räikkönen, Katri, Ralhan, Sarju, Rao, Dabeeru C, Van Rheenen, Wouter, Rich, Stephen S, Ridker, Paul M, Rietveld, Cornelius A, Robino, Antonietta, Van Rooij, Frank J A, Ruggiero, Daniela, Saba, Yasaman, Sabanayagam, Charumathi, Sabater-Lleal, Maria, Sala, Cinzia Felicita, Salomaa, Veikko, Sandow, Kevin, Schmidt, Helena, Scott, Laura J, Scott, William R, Sedaghati-Khayat, Bahareh, Sennblad, Bengt, Van Setten, Jessica, Sever, Peter J, Sheu, Wayne H-H, Shi, Yuan, Shrestha, Smeeta, Shukla, Sharvari Rahul, Sigurdsson, Jon K, Sikka, Timo Tonis, Singh, Jai Rup, Smith, Blair H, Stančáková, Alena, Stanton, Alice, Starr, John M, Stefansdottir, Lilja, Straker, Leon, Sulem, Patrick, Sveinbjornsson, Gardar, Swertz, Morris A, Taylor, Adele M, Taylor, Kent D, Terzikhan, Natalie, Tham, Yih-Chung, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tillander, Annika, Tracy, Russell P, Tusié-Luna, Teresa, Tzoulaki, Ioanna, Vaccargiu, Simona, Vangipurapu, Jagadish, Veldink, Jan H, Vitart, Veronique, Völker, Uwe, Vuoksimaa, Eero, Wakil, Salma M, Waldenberger, Melanie, Wander, Gurpreet S, Wang, Ya Xing, Wareham, Nicholas J, Wild, Sarah, Yajnik, Chittaranjan S, Yuan, Jian-Min, Zeng, Lingyao, Zhang, Liang, Zhou, Jie, Amin, Najaf, Asselbergs, Folkert W, Bakker, Stephan J L, Becker, Diane M, Lehne, Benjamin, Bennett, David A, Van Den Berg, Leonard H, Berndt, Sonja I, Bharadwaj, Dwaipayan, Bielak, Lawrence F, Bochud, Murielle, Boehnke, Mike, Bouchard, Claude, Bradfield, Jonathan P, Brody, Jennifer A, Campbell, Archie, Carmi, Shai, Caulfield, Mark J, Cesarini, David, Chambers, John C, Chandak, Giriraj Ratan, Cheng, Ching-Yu, Ciullo, Marina, Cornelis, Marilyn, Cusi, Daniele, Smith, George Davey, Deary, Ian J, Dorajoo, Rajkumar, Van Duijn, Cornelia M, Ellinghaus, David, Erdmann, Jeanette, Eriksson, Johan G, Evangelou, Evangelos, Evans, Michele K, Faul, Jessica D, Feenstra, Bjarke, Feitosa, Mary, Foisy, Sylvain, Franke, Andre, Friedlander, Yechiel, Gasparini, Paolo, Gieger, Christian, Gonzalez, Clicerio, Goyette, Philippe, Grant, Struan F A, Griffiths, Lyn R, Groop, Leif, Gudnason, Vilmundur, Gyllensten, Ulf, Hakonarson, Hakon, Hamsten, Anders, Van Der Harst, Pim, Heng, Chew-Kiat, Hicks, Andrew A, Hochner, Hagit, Huikuri, Heikki, Hunt, Steven C, Jaddoe, Vincent W V, De Jager, Philip L, Johannesson, Magnus, Johansson, Åsa, Jonas, Jost B, Jukema, J Wouter, Junttila, Juhani, Kaprio, Jaakko, Kardia, Sharon L. R., Karpe, Fredrik, Kumari, Meena, Laakso, Markku, Van Der Laan, Sander W, Lahti, Jari, Laudes, Matthias, Lea, Rodney A, Lieb, Wolfgang, Lumley, Thomas, Martin, Nicholas G, März, Winfried, Matullo, Giuseppe, McCarthy, Mark I, Medland, Sarah E, Merriman, Tony R, Metspalu, Andres, Meyer, Brian F, Mohlke, Karen L, Montgomery, Grant W, Mook-Kanamori, Dennis, Munroe, Patricia B, North, Kari E, Nyholt, Dale R, O’connell, Jeffery R, Ober, Carole, Oldehinkel, Albertine J, Palmas, Walter, Palmer, Colin, Pasterkamp, Gerard G, Patin, Etienne, Pennell, Craig E, Perusse, Louis, Peyser, Patricia A, Pirastu, Mario, Polderman, Tinca J. C., Porteous, David J, Posthuma, Danielle, Psaty, Bruce M, Rioux, John D, Rivadeneira, Fernando, Rotimi, Charles, Rotter, Jerome I, Rudan, Igor, Den Ruijter, Hester M, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Robert A, Shuldiner, Alan R, Sim, Xueling, Small, Neil, Smith, Jennifer A, Sotoodehnia, Nona, Tai, E-Shyong, Teumer, Alexander, Timpson, Nicholas J, Toniolo, Daniela, Tregouet, David-Alexandre, Tuomi, Tiinamaija, Vollenweider, Peter, Wang, Carol A, Weir, David R, Whitfield, John B, Wijmenga, Cisca, Wong, Tien-Yin, Wright, John, Yang, Jingyun, Yu, Lei, Zemel, Babette S, Zonderman, Alan B, Perola, Markus, Magnusson, Patrik K. E., Uitterlinden, André G, Kooner, Jaspal S, Chasman, Daniel I, Loos, Ruth J. F., Franceschini, Nora, Franke, Lude, Haley, Chris S, Hayward, Caroline, Walters, Robin G, Perry, John R. B., Esko, Tōnu, Helgason, Agnar, Stefansson, Kari, Joshi, Peter K, Kubo, Michiaki, and Wilson, James F

Subjects
631/208/1397, 631/208/730, article, 631/208/205, 631/208/721, 3. Good health
Abstract

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.

31. Sedentary Behaviour, Physical Activity, and Their Associations with Health Outcomes at the Time of Diagnosis in People with Inoperable Lung Cancer

Author

Shu Ning Ch’ng, Joanne A. McVeigh, David Manners, Terry Boyle, Carolyn J. Peddle-McIntyre, Rajesh Thomas, Jeanie Leong, Samantha Bowyer, Kirsten Mooney, Leon Straker, Daniel A. Galvão, Vinicius Cavalheri, Ch'ng, Shu Ning, McVeigh, Joanne A, Manners, David, Boyle, Terry, Peddle-McIntyre, Carolyn J, Thomas, Rajesh, Leong, Jeanie, Bowyer, Samantha, Mooney, Kirsten, Straker, Leon, Galvao, Daniel A, and Cavalheri, Vinicius

Subjects
lung cancer, sedentary behaviour, physical activity, General Medicine
Abstract

This study aimed to examine sedentary behaviour (SB), physical activity (PA) and their associations with health-related measures at the time of diagnosis in people with inoperable lung cancer. People newly diagnosed with inoperable lung cancer were invited to participate in the study and asked to wear an accelerometer for seven consecutive days. Variables analysed included time spent in SB, light intensity PA (LIPA) and moderate-to-vigorous intensity PA (MVPA). Daily steps were also recorded. Data on symptoms, health-related quality of life (HRQoL), hand grip force, comorbidities and lung function were collected. Of the 120 patients referred to the study, 89 (74%) consented to participate, and SB/PA data were available for 79 (age 71 +/- 11 years; 29 females). Participants spent 71% of their waking time in SB, 28% in LIPA and 1% in MVPA. Regression models demonstrated that increased SB was associated with more symptoms of fatigue and dyspnoea (p

Published
2022

32. Reimagining physical activity for children following the systemic disruptions from the COVID-19 pandemic in Australia

Author

Leon Straker, Verity Booth, Verity Cleland, Sjaan Gomersall, David Lubans, Tim Olds, Lindsey Reece, Nicola Ridgers, Michalis Stylianou, Grant Tomkinson, Kylie Hesketh, Straker, Leon, Booth, Verity, Cleland, Verity, Gomersall, Sjaan, Lubans, David, Olds, Tim, Reece, Lindsey, Ridgers, Nicola, Stylianou, Michalis, Tomkinson, Grant, and Hesketh, Kylie

Subjects
lockdown, Coronavirus, children, public health, physical activity, COVID-19, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, General Medicine
Abstract

COVID-19-related restrictions disrupted the normal social and environmental systems within which children live, learn and play. These sudden societal changes provided opportunities for children and young people, their families, and the professionals and authorities supporting them to observe and experience a different type of world and reflect on what they value and what children’s lives could be.

Published
2022

33. Results From Australia’s 2016 Report Card on Physical Activity for Children and Youth

Author

Sjaan R. Gomersall, Jenny Ziviani, Leon Straker, Stewart A. Vella, Tim Olds, David R. Lubans, Nicola D. Ridgers, Louise L. Hardy, John R. Evans, Natasha Schranz, Grant R. Tomkinson, Roslyn N. Boyd, Kylie D. Hesketh, Schranz, Natasha K, Olds, Timothy, Boyd, Roslyn, Evans, John, Gomersall, Sjaan R, Hardy, Louise, Hesketh, Kulie, Lubans, David R, Ridgers, Nicola D, Straker, Leon, Vella, Stewart, Ziviani, Jenny, and Tomkinson, Grant R

Subjects
Male, medicine.medical_specialty, Adolescent, Health Behavior, Poison control, Health Promotion, Motor Activity, Suicide prevention, Occupational safety and health, 03 medical and health sciences, 0302 clinical medicine, sedentary behavior, Injury prevention, medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Child, Exercise, Government, Public health, public health, Australia, Human factors and ergonomics, 030229 sport sciences, Health Surveys, Play and Playthings, Female, Sedentary Behavior, Psychology, Social psychology, Report card, Program Evaluation, Sports, Demography
Abstract

Background:Two years on from the inaugural Active Healthy Kids Australia (AHKA) Physical Activity Report Card, there has been little to no change with the majority of Australian children still insufficiently active.Methods:The 2016 AHKA Report Card was developed using the best available national- and state-based physical activity data, which were evaluated by the AHKA Research Working Group using predetermined weighting criteria and benchmarks to assign letter grades to the 12 Report Card indicators.Results:In comparison with 2014, Overall Physical Activity Levels was again assigned a D- with Organized Sport and Physical Activity Participation increasing to a B (was B-) and Active Transport declining to a C- (was C). The settings and sources of influence again performed well (A- to a C+), however Government Strategies and Investments saw a decline (C+ to a D). The traits associated with physical activity were also graded poorly (C- to a D).Conclusions:Australian youth are insufficiently active and engage in high levels of screen-based sedentary behaviors. While a range of support structures exist, Australia lacks an overarching National Physical Activity Plan that would unify the country and encourage the cultural shift needed to face the inactivity crisis head on.

Published
2016

34. What does best practice care for musculoskeletal pain look like? Eleven consistent recommendations from high-quality clinical practice guidelines: systematic review

Author

Ivan Lin, Yusuf Nagree, Michael Gibberd, Christopher G. Maher, Louise Wiles, Leon Straker, Robert Waller, Peter O'Sullivan, Roger Goucke, Lin, Ivan, Wiles, Louise, Waller, Rob, Goucke, Roger, Nagree, Yusuf, Gibberd, Michael, Straker, Leon, Maher, Chris G, and O'Sullivan, Peter PB

Subjects
medicine.medical_specialty, Evidence-based practice, MEDLINE, Physical Therapy, Sports Therapy and Rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Musculoskeletal Pain, Health care, medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Quality of Health Care, Evidence-Based Medicine, business.industry, General Medicine, Guideline, Low back pain, Critical appraisal, Practice Guidelines as Topic, Physical therapy, medicine.symptom, Manual therapy, business, Psychosocial, 030217 neurology & neurosurgery
Abstract

ObjectivesTo identify common recommendations for high-quality care for the most common musculoskeletal (MSK) pain sites encountered by clinicians in emergency and primary care (spinal (lumbar, thoracic and cervical), hip/knee (including osteoarthritis [OA] and shoulder) from contemporary, high-quality clinical practice guidelines (CPGs).DesignSystematic review, critical appraisal and narrative synthesis of MSK pain CPG recommendations.Eligibility criteriaIncluded MSK pain CPGs were written in English, rated as high quality, published from 2011, focused on adults and described development processes. Excluded CPGs were for: traumatic MSK pain, single modalities (eg, surgery), traditional healing/medicine, specific disease processes (eg, inflammatory arthropathies) or those that required payment.Data sourcesFour scientific databases (MEDLINE, Embase, CINAHL and Physiotherapy Evidence Database) and four guideline repositories.Results6232 records were identified, 44 CPGs were appraised and 11 were rated as high quality (low back pain: 4, OA: 4, neck: 2 and shoulder: 1). We identified 11 recommendations for MSK pain care: ensure care is patient centred, screen for red flag conditions, assess psychosocial factors, use imaging selectively, undertake a physical examination, monitor patient progress, provide education/information, address physical activity/exercise, use manual therapy only as an adjunct to other treatments, offer high-quality non-surgical care prior to surgery and try to keep patients at work.ConclusionThese 11 recommendations guide healthcare consumers, clinicians, researchers and policy makers to manage MSK pain. This should improve the quality of care of MSK pain.

Published
2019

35. Poor overall quality of clinical practice guidelines for musculoskeletal pain: a systematic review

Author

Robert Waller, Michael Gibberd, Roger Goucke, Louise Wiles, Leon Straker, Ivan Lin, Yusuf Nagree, Christopher G. Maher, Peter O'Sullivan, Lin, Ivan, Wiles, Louise K, Waller, Robert, Goucke, Roger, Nagree, Yusuf, Gibberd, Michael, Straker, Leon, Maher, Christopher G, and O'Sullivan, Peter PB

Subjects
medicine.medical_specialty, Evidence-based practice, MEDLINE, Physical Therapy, Sports Therapy and Rehabilitation, CINAHL, Osteoarthritis, 03 medical and health sciences, 0302 clinical medicine, Musculoskeletal Pain, Medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, musculoskeletal pain, 030203 arthritis & rheumatology, Neck pain, business.industry, General Medicine, Guideline, medicine.disease, Low back pain, Critical appraisal, CPGs, Practice Guidelines as Topic, Physical therapy, medicine.symptom, business, human activities, Low Back Pain
Abstract

ObjectivesUndertake a systematic critical appraisal of contemporary clinical practice guidelines (CPGs) for common musculoskeletal (MSK) pain conditions: spinal (lumbar, thoracic and cervical), hip/knee (including osteoarthritis) and shoulder.DesignSystematic review of CPGs (PROSPERO number: CRD42016051653).Included CPGs were written in English, developed within the last 5 years, focused on adults and described development processes. Excluded CPGs were for: traumatic MSK pain, single modalities (eg, surgery), traditional healing/medicine, specific disease processes (eg, inflammatory arthropathies) or those that required payment.Data sources and method of appraisalFour scientific databases (MEDLINE, Embase, CINAHL and Physiotherapy Evidence Database) and four guideline repositories. The Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument was used for critical appraisal.Results4664 records were identified, and 34 CPGs were included. Most were for osteoarthritis (n=12) or low back pain (n=11), most commonly from the USA (n=12). The mean overall AGREE II score was 45% (SD=19.7). Lowest mean domain scores were for applicability (26%, SD=19.5) and editorial independence (33%, SD=27.5). The highest score was for scope and purpose (72%, SD=14.3). Only 8 of 34 CPGS were high quality: for osteoarthritis (n=4), low back pain (n=2), neck (n=1) and shoulder pain (n=1).

Published
2017

36. Australia and Other Nations Are Failing to Meet Sedentary Behaviour Guidelines for Children: Implications and a Way Forward

Author

Melanie Davern, Grant R. Tomkinson, Erin K. Howie, Sjaan R. Gomersall, Natasha Schranz, Lina Engelen, Jenny Ziviani, Leon Straker, Dylan P. Cliff, Tim Olds, Straker, Leon, Howie, Erin Kaye, Cliff, Dylan Paul, Davern, Melanie T, Engelen, Lina, Gomersall, Sjaan R, Ziviani, Jenny, Schranz, Natasha, Olds, Tim, and Tomkinson, Grant Ryan

Subjects
Gerontology, Male, Guidelines as Topic, Health Promotion, Motor Activity, Affect (psychology), Child health, 03 medical and health sciences, Screen time, 0302 clinical medicine, well-being, 030225 pediatrics, sedentary behaviour, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Child, Exercise, Sedentary lifestyle, Australia, indicators, Health promotion, screen time, Well-being, child health, Female, Guideline Adherence, Sedentary Behavior, Psychology, Psychosocial, Report card
Abstract

Background:Australia has joined a growing number of nations that have evaluated the physical activity and sedentary behavior status of their children. Australia received a “D minus” in the first Active Healthy Kids Australia Physical Activity Report Card.Methods:An expert subgroup of the Australian Report Card Research Working Group iteratively reviewed available evidence to answer 3 questions: (a) What are the main sedentary behaviors of children? (b) What are the potential mechanisms for sedentary behavior to impact child health and development? and (c) What are the effects of different types of sedentary behaviors on child health and development?Results:Neither sedentary time nor screen time is a homogeneous activity likely to result in homogenous effects. There are several mechanisms by which various sedentary behaviors may positively or negatively affect cardiometabolic, neuromusculoskeletal, and psychosocial health, though the strength of evidence varies. National surveillance systems and mechanistic, longitudinal, and experimental studies are needed for Australia and other nations to improve their grade.Conclusions:Despite limitations, available evidence is sufficiently convincing that the total exposure and pattern of exposure to sedentary behaviors are critical to the healthy growth, development, and wellbeing of children. Nations therefore need strategies to address these common behaviors.

Published
2015

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