1. Reassortant Group A Rotavirus from Straw-colored Fruit Bat (Eidolon helvum)
- Author
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Mathew D. Esona, Christina Conrardy, Krisztián Bányai, Jon R. Gentsch, Michael D. Bowen, Suxiang Tong, Ivan V. Kuzmin, Bernard Agwanda, Charles E. Rupprecht, Robert F. Breiman, Slavica Mijatovic-Rustempasic, and Michael Niezgoda
- Subjects
Rotavirus ,Disease reservoir ,Genes, Viral ,Epidemiology ,viruses ,Reassortment ,lcsh:Medicine ,Viral Nonstructural Proteins ,medicine.disease_cause ,Feces ,fluids and secretions ,Chiroptera ,Zoonoses ,Phylogeny ,Genetics ,NSP1 ,Eidolon helvum ,biology ,Viral Core Proteins ,Straw-colored fruit bat ,virus diseases ,heterologous genome segments ,Infectious Diseases ,podcast ,Reassortant Viruses ,Microbiology (medical) ,animal structures ,Viral protein ,Molecular Sequence Data ,Rotavirus Infections ,lcsh:Infectious and parasitic diseases ,Viral Proteins ,medicine ,Animals ,Humans ,lcsh:RC109-216 ,Amino Acid Sequence ,Gene ,Disease Reservoirs ,Glycoproteins ,Toxins, Biological ,Research ,lcsh:R ,biology.organism_classification ,Kenya ,Virology ,reassortment ,Capsid Proteins ,Sequence Alignment - Abstract
TOC summary: Bats may be reservoirs of zoonotic viruses that threaten human health., Bats are known reservoirs of viral zoonoses. We report genetic characterization of a bat rotavirus (Bat/KE4852/07) detected in the feces of a straw-colored fruit bat (Eidolon helvum). Six bat rotavirus genes (viral protein [VP] 2, VP6, VP7, nonstructural protein [NSP] 2, NSP3, and NSP5) shared ancestry with other mammalian rotaviruses but were distantly related. The VP4 gene was nearly identical to that of human P[6] rotavirus strains, and the NSP4 gene was closely related to those of previously described mammalian rotaviruses, including human strains. Analysis of partial sequence of the VP1 gene indicated that it was distinct from cognate genes of other rotaviruses. No sequences were obtained for the VP3 and NSP1 genes of the bat rotavirus. This rotavirus was designated G25-P[6]-I15-R8(provisional)-C8-Mx-Ax-N8-T11-E2-H10. Results suggest that several reassortment events have occurred between human, animal, and bat rotaviruses. Several additional rotavirus strains were detected in bats.
- Published
- 2010
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