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This paper investigates the significance of consumer opinions in relation to value in China's A-share market. By analyzing a large dataset comprising over 18 million product reviews by customers on JD.com, we demonstrate that sentiments expressed in consumer reviews can influence stock returns, indicating that consumer opinions contain valuable information that can impact the stock market. Our findings show that Customer Negative Sentiment Tendency (CNST) and One-Star Tendency (OST) have a negative effect on expected stock returns, even after controlling for firm characteristics such as market risk, illiquidity, idiosyncratic volatility, and asset growth. Further analysis reveals that the predictive power of CNST is stronger in firms with high sentiment conditions, growth companies, and firms with lower accounting transparency. We also find that CNST negatively predicts revenue surprises, earnings surprises, and cash flow shocks. These results suggest that online satisfaction derived from big data analysis of customer reviews contains novel information about firms' fundamentals., Comment: 29 pages, 9 tables

Background Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal dominant genetic disease with substantial heterogeneity in clinical manifestations. It typically starts with ataxia and can be divided into five subtypes. The fourth subtype of SCA3 is characterized by parkinsonian and peripheral neuropathy. However, this phenotype is rare, and it tends to be easily misdiagnosed as Parkinson's disease. Materials and methods We report a 51-year-old female patient who initially presented with pure parkinsonian symptoms at the age of 30. She responded well to levodopa treatment and had a diagnosis of Parkinson's disease for almost 20 years. Ataxia symptoms, symptom fluctuations and dyskinesia occurred in the late stage of the disease. A literature review was included to summarize the clinical features of the fourth subtype of SCA3 (type IV SCA3) and its relevant pathogenesis. Results Type IV SCA3 with 66 CAG repeats was diagnosed by genetic testing. It is initially characterized by a pure parkinsonian phenotype indistinguishable from PD, short CAG repeat expansions, and a good response to levodopa. Conclusion Type IV SCA3 should be considered when diagnosing Parkinson's disease, especially in those with a family history. More research is needed to detect the pathogenesis of the parkinsonism phenotype in type IV SCA3.

Most Asian economies consist of tourism attraction destinations. The traditional literature explores the cultural, social, and economic effects of tourism; thus, there exists a vacuum related to the impacts of tourism development on the human health of local people. Hence, the current study examines the impact of tourism development on health outcomes of the tourism-based selected Asian economies. The panel autoregressive distributed lag (ARDL) methodology is used to deduce the short-run and long-run impacts of tourism development on health outcomes. The results disclose that tourism activities insignificantly influence health outcomes in the short run. However, tourism development brings improvement in health outcomes in the long run. This research offers a new approach highlighting the significance of tourism development for human health and emphasizes the importance of tourism development for destination management and marketing.

Xin-Ying Cai,1 Shao-Yan Zheng,2 Zhen-Su Lin,2 Su-Zhi Chen,2 Wei-Yi Zhu,2 Jia-Jia Huang,2 Ze-Li Zheng,2 Yu-Hua Zhou2 1Clinical Research Center, Shantou Central Hospital, Shantou City, People’s Republic of China; 2Nursing Department, Shantou Central Hospital, Shantou City, People’s Republic of ChinaCorrespondence: Yu-Hua Zhou, Nursing Department, Shantou Central Hospital, Wai-ma Road 114, Shantou City, People’s Republic of China, Tel +86 0754-88903584, Fax +86 0754-88548117, Email zhouyuhua1023@163.comBackground: Medical workers have been increasingly involved in emergent public health events, which can lead to severe stress. However, no standardized, officially recognized, unified tool exists for mental distress measurement in medical workers who experienced the public health events.Purpose: In the present study, we propose the Global Health Events-Mental Stress Scale (GHE-MSS), as a revised version of the Impact of Event Scale-Revision (IES-R), for assessment of medical workers’ acute mental stress responses within one month and their chronic mental stress responses within six months after major health events.Patients and methods: The IES-R was slightly modified, developed, and its reliability and validity were tested using the Delphi survey, primary survey with 115 participants, formal survey with 300 participants, and clinical evaluation with 566 participants.Results: Exploratory factor analysis and confirmatory factor analysis confirmed a promising validity of the scale. The values of Cronbach’s alpha coefficient, the Spearman-Brown coefficient, and the retested Cronbach’s alpha coefficient of the scale applied for the clinical evaluation were 0.88, 0.87, and 0.98, respectively, which confirmed a good internal consistency and stability. The results of the goodness-of-fit test indicated a good adaptation of the model. A correlation analysis was conducted to assess the correlation between the GHE-MSS and the PCL-C, which had a correlation coefficient of 0.68 (P< 0.01).Conclusion: GHE-MSS can be applied with a promising reliability and validity for the assessment of the acute mental stress response of medical workers experiencing public health events. This method can also be used for the screening of mental stress-associated disorders.Keywords: IES-R, global health events, mental stress scale, medical workers, mental disorders, mental stress responses

The on-axis interference intensity patterns between a vortex beam and its conjugated beam can be used to measure the fractional topological charge of vortex beams. However, it is still challenging to efficiently recognize these intensity diagrams. On one hand, the difference of the patterns for adjacent modes with interval 0.1 is too subtle to be identified precisely. On the other hand, the interferograms are susceptible to undesirable experimental conditions such as the misalignment of the beams, the unequal arms of the interferometer and the deviation of splitting ratio of the beam splitters in the interferometer. Here, we propose a deep learning method to recognize these intensity diagrams with up to 97 % accuracy. In particular, our method has reference values for deep learning model training when there is not adequate experimental data.

Non-relativistic quantum chromodynamics (NRQCD) factorization formulism is an important approach to investigate the production of the heavy quarkonium. In this paper, we study the production of the $Ω_{ccc}$ and $Ω_{bbb}$ at the $e^+e^-$ collider, using the NRQCD factorization formulism. We calculate the total and differential cross sections exactly of the processes, $e^+e^-\rightarrow γ^*/Z^*\rightarrow Ω_{ccc}\bar{c}\bar{c}\bar{c}$ and $e^+e^-\rightarrow γ^*/Z^*\rightarrow Ω_{bbb}\bar{b}\bar{b}\bar{b}$, in the leading order at the $e^+e^-$ colliders with different energies. The results show that it is hard to observe them at the $e^+e^-$ collider directly.

Background:Zornia diphylla (L.) Pers. (ZDP) is a traditional Chinese herbal medicine that has been used for several decades to treat patients with liver diseases. Whether ZDP is best administered as a single agent or adjunctive therapy has yet to be determined as does the mechanism whereby it exerts its effects on antagonizing acute liver injury (ALI).Aim of the study: To investigate the protective effects of ZDP on ALI induced by carbon tetrachloride (CCl4) and the potential underlying mechanisms.Materials and Methods: Sixty adult mice were randomized into six study groups (n = 10/group). Three groups were treated with different concentrations of ZDP (2.5, 1.25, 0.625 g/kg), one with bifendate (0.0075 g/kg) alone (positive control) and one with physiologic saline (normal, negative control). All groups were treated for 14 days. Two hours after the last administration, the normal group received an intraperitoneal injection of peanut oil, and the other five groups received an intraperitoneal injection of an equal dose of CCl4 peanut oil solution. At 24 h, the liver index, histology and serum or tissue levels and/or protein expression of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), alkaline phosphatase (ALP), superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione (GSH), Akt, phosphorylated Akt (p-Akt), nuclear factor kappa B p65 (NF-κB p65), inhibitor of NF-κB α (IκB-α), interleukin-1 β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), E-cadherin and vimentin were determined.Results: Compared to the model controls, the degree of inflammatory cell infiltration and hepatocyte injury of liver tissue was relieved in the bifendate and three ZDP groups; liver index in the ZDP (2.5, 1.25 g/kg) groups and serum liver function indices in the ZDP (2.5, 1.25 and 0.625 g/kg) groups were decreased; antioxidants SOD, CAT and GSH in liver tissue were increased but the lipid peroxidation index MDA was decreased; protein expression of inflammatory cytokines Akt, p-Akt, NF-κB p65, IκB-α, IL-1β, IL-6 and TNF-α in the liver was ameliorated, and E-cadherin expression was increased. The results of liver histopathology also showed that ZDP had a significant effect on ALI.Conclusion: ZDP has obvious protective effects on CCl4-induced ALI as a single therapy and appears to act by inhibiting oxidation, reducing the release of inflammatory factors and promoting hepatocyte repair.

To compare the effect of moxibustion combined with basic treatment and simple basic treatment on the clinical symptoms, renal function and hypercoagulable state in patients with idiopathic membranous nephropathy (IMN) of low to medium risk with spleen-kidney deficiency and blood stasis.A total of 60 patients with IMN of low to medium risk with spleen-kidney deficiency and blood stasis were randomized into an observation group (30 cases, 2 cases dropped off) and a control group (30 cases, 1 case dropped off). In the control group, the conventional basic treatment of anti-hypertension, regulating blood lipid and anti-coagulation was adopted. On the basis of the control group, moxibustion was applied at Shenshu (BL 23), Pishu (BL 20), Guanyuan (CV 4), Zusanli (ST 36) and Sanyinjiao (SP 6) in the observation group, once a day, 5 days a week continuously with 2 day interval. The treatment of 6 months was required in the both groups. Before treatment and 3 and 6 months into treatment, the total TCM syndrome score, the renal function indexes (24-hour urinary protein quantity [UTP], albumin [ALB], urea nitrogen [BUN] and creatinine [Scr]), the blood coagulation indexes (fibrinogen [FIB], D-Dimer [D-D], p-selection and von Willebrand factor [vWF]), total cholesterol (TC) and triacylglycerol (TG) levels were observed, and the therapeutic efficacy was evaluated on 3 and 6 months into treatment in the two groups.The effective rates of 3 and 6 months into treatment were 78.6% (22/28) and 89.3% (25/28) in the observation group, which were higher than 62.1% (18/29) and 75.9% (22/29) in the control group respectively (Moxibustion combined with basic treatment can effectively improve the clinical symptoms, renal function and renal microcirculation in patients with idiopathic membranous nephropathy of low to medium risk with spleen-kidney deficiency and blood stasis, the therapeutic effect is superior to the simple basic treatment.

Cost-effective and high-performance electrode materials for energy storage and conversion are essential for commercial applications. In this work, the influence of solvent on the morphologies of [CH3NH3][M(HCOO)3] precursors was studied to design and synthesize two-dimensional (2D) porous NiCo2S4 nanosheets with different structures. As an electrode material for supercapacitors, Microflower-NiCo2S4 exhibits excellent capacitance (1,141 F g−1 at 1 A g−1) and stability (88.2% of initial capacitance maintained after 5,000 cycles at 5 A g−1). Moreover, an asymmetric capacitor was constructed using Microflower-NiCo2S4 and porous carbon (PC) and demonstrated an energy density of 51.25 Wh kg−1 at a power density of 397.5 W kg−1. When two Microflower-NiCo2S4//PC asymmetric supercapacitors were assembled in series, the device supplied power for an alarm clock with dimensions of 6.1 × 6.1 cm2 for more than 32 min. Therefore, the preparation of metal sulfides and metal oxides with hollow structures using a [CH3NH3][M(HCOO)3]-template has potential applications in energy storage and conversion.

CD14-positive monocytes from patients with rheumatoid arthritis (RA) are more resistant to apoptosis, which promotes their persistence at the inflammatory site and thereby contributes crucially to immunopathology. We sought to elucidate one mechanism underlying this unique pathogenesis: resistance to apoptosis and the potential involvement of miR-29b in this process. CD14-positive peripheral blood monocytes (PBMs) from RA patients were observed to be resistant to spontaneous apoptosis compared to PBMs from healthy volunteers. Intriguingly, expression of miR-29b was significantly upregulated in PBMs from RA patients than those from healthy volunteers, and this upregulation was correlated with RA disease activity. Functionally, forced expression of the exogenous miR-29b in CD14-positive Ctrl PBMs conferred resistance to spontaneous apoptosis and Fas-induced death, thereafter enhancing the production of major proinflammatory cytokines in there cells. Following identification of the potential miR-29b target transcripts using bioinformatic algorithms, we showed that miR-29b could directly bind to the 3'-UTR of the high-mobility group box-containing protein 1 (HBP1) and inhibited its transcription in PBMs. Importantly, stable expression of the exogenous HBP1 in differentiated THP-1 monocytes effectively abolished miR-29b-elicited resistance to Fas-induced apoptosis. Finally, among patients with RA and good clinical responses to immunotherapy, expression levels of miR-29b were significantly compromised in those treated with infliximab (a TNF-α inhibitor) but not in those treated with tocilizumab (a humanized mAb against the IL-6 receptor), pointing to a potential association between miR-29b activation and TNF-α induction. The available data collectively suggest that TNF-α-elicited miR-29b potentiates resistance to apoptosis in PBMs from RA patients via inhibition of HBP1 signaling, and testing patients for miR-29b/HBP1 expression ratios may provide more accurate prognostic information and could influence the recommended course of immunotherapy.

For the development of ceramic candidates for thermal barrier coatings, two kinds of new ceramics, Y3Ce7Ta2O23.5 and Yb3Ce7Ta2O23.5, were synthesized by sintering at 1873 K for 10 h. The obtained samples were composed of a single fluorite-type phase, and their relative densities are greater than 90%. Because of phonon scattering caused by the complex lattice, the large number of oxygen vacancies, and substituted atoms, the thermal conductivity is lower than that of 8YSZ. The coefficients of thermal expansion (CTEs) of these two products are located in the range of 10.22–12.57 × 10−6/K and 9.62–12.66 × 10−6/K, respectively, from 323 K to 1473 K, and they also exhibit excellent phase stability up to 1473 K. However, their thermal conductivities and CTEs are lower than those of RE2Ce2O7 (RE = La, Nd, or Sm).

In this present paper, two kinds of Ln2BTaO7 (Ln=Sm, Gd) oxides were prepared by solid state reaction at 1873 K for ten hours. The phase-composition, microstructure and thermophysical performances of sintered samples were studied. Results show that the synthesized Ln2BTaO7 oxides present onefold orthorhombic weberite lattice. Due to the phonon scattering resulted by complex crystal-lattice and numerous oxygen vacancies, the heat conductivities of obtained products are less than that of YSZ. Because of the low ionic radius of Sm3+ ions，the heat expansion quotiety of Sm2LaTaO7 is greater than that of Gd2LaTaO7.

A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method. With the procedure and method established, real case samples were analyzed and the data were compared to those obtained by a standard method. The results indicate that the desktop NMR spectrometer is a reliable and promising approach that can be used in criminology to quickly identify whether or not samples contain illegal drugs.

This electronic Aiming at the problem that the traditional Convolutional Neural Network algorithm uses the Softmax function to classify tires with poor accuracy, a convolutional neural network image classification and recognition algorithm based on improved support vector machine is proposed. This algorithm uses the support vector machine instead of the Softmax function to complete the image classification problem in the convolutional neural network algorithm. At the same time, a relaxation variable and a penalty factor are introduced into the traditional support vector machine, thereby changing the support vector machine to be used for classifier for multiple classification problems. This improved algorithm is applied to tire damage image recognition. Through a series of comparison experiments between the improved algorithm and the traditional convolutional neural network algorithm, the classification and recognition effects of the improved algorithm on the classification and recognition of damaged tire images are analyzed. The effectiveness of the proposed improved algorithm is proved.

Two new troponoides (

Two new troponoides (1–2) were isolated from a 95% ethanol extract of the stems of Juniperus formosana (Cupressaceae), together with six known compounds (3–8). The structures of the new compounds were comprehensively characterized by high resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). Compounds 1–7 were evaluated for their anti-inflammatory against the expression of IL-1β, IL-6 and TNF-α in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. The new compounds showed moderate anti-inflammatory effect, while other compounds did show no activity.

In this note, we present a new method to investigate the positronium states in ${\rm{QED_3}}$. According to the $\rm{K\ddot{a}ll\acute{e}n-Lehmann}$ spectral representation, the energy eigenvalues of bound states are poles of the correlation function. Using the chain approximation, we obtain the energy eigenvalues of the vector positronium states by taking into account the single-valued branches of multi-valued function. Using the same method, we also find the electron physical mass at some single-valued branch of multi-value function. Our results are agreement with the known ones., Comment: 11 pages, 11 figures

Transcriptional regulation of inducible nitric oxide synthase (iNOS) is critically involved in the pathogenesis and progression of rheumatoid arthritis (RA); however, the specific transcription factors that control this process remain largely unidentified. In the present study, it was discovered that expression of the key erythroid factor, globin transcription factor 1 (GATA1), is significantly greater in human RA synovial tissues than in osteoarthritis (OA) tissues. IL 6 was found to induce synovial GATA1 expression in a signal transducer and activator of transcription 3-dependent manner. Functionally, knockdown of GATA1 expression using specific small interfering RNA treatment was found to compromise immunoreaction-elicited expression of proinflammatory cytokines and thus impair invasiveness of the human fibroblast-like synovial cell line MH7A, whereas introduction of exogenous GATA1 was found to promote production of proinflammatory cytokines, leading to greater aggressiveness of MH7A cells. Mechanistically, GATA1 acts as the transcriptional coactivator of NOS2 (the gene encoding iNOS) transcription. Collectively, these data suggest that synovial GATA1 is an essential contributor to development and exacerbation of RA, presumably by inducing NOS2 transcription.

A general Matlab program is designed to simulate the Fraunhofer diffraction patterns of a vortex beam through any apertures, which are usually used to compare with the experimental results in detecting the topological charge of a vortex beam. Two significant matrices are suggested in the above program: one related to the aperture, the other concerned with the field of vortex beam. Using the fast Fourier transform function provided within the Matlab software itself to process the dot product of the above two matrices, one obtains the field on the observation screen. The program is applied to a rectangular aperture and an annular triangle aperture. The results agree well with the computational analysis of previous references. This paper is to describe how Matlab can be used to perform complex mathematical calculations without bogging down the student with the details of the numerical methods and it may be particularly useful for graduate students who engage in the study of topological charge detection and identification.

Nanostructure LiFeBO3/C composite is synthesized by sol–gel method using CH3COOLi·2H2O, Fe(NO3)3·9H2O, H3BO3 and citric acid as starting materials. The crystal structure, morphology and electrochemical properties of LiFeBO3/C composites are characterized by X-ray diffraction, transmission electron microscopy, raman spectroscopy (Raman), cyclic voltammetry, electrochemical impedance spectroscopy and charge–discharge tests. The LiFeBO3/C is comprised of individual near spherical particles of the size range 40–60 nm, and well coated by thin carbon layer. The LiFeBO3/C can deliver an initial discharge capacity of 205.8 mAh g−1 under the current density of 10 mA g−1 in the potential range 1.8–4.5 V, and it can deliver the capacity of 159.3 mAh g−1 after 20 cycles. When the current density is increased to 20 and 40 mA g−1, the capacity of LiFeBO3/C could also be retained at 120.6 and 102.6 mAh g−1. The excellent cycling performance indicates, the materials have good application prospect. The morphology and size of the sol-gel synthetic LiFeBO3 materials are characterizedby TEM were shown in the Figure. It can illustrate that the LiFeBO3/C consists of individual near spherical particles of the size range 40∼60 nm. With further investigate by HR-TEM that LiFeBO3/C showed clear crystal lattice stripes and a uniform carbon film is coated on the particle surface.

Ambient backscatter (AB) communication has emerged as an energy-preserving technology in Internet of Things (IoT). Specifically, an AB transmitter communicates with its receiver by backscattering ambient radio frequency (RF) signals instead of active information transmissions. When not operating in the communication mode, the AB transmitter can instead harvest the RF energy to replenish its battery, e.g., for supplying sensing energy consumptions. In this paper, we consider the optimal operating mode selection problem of the AB system that the transmitter decides either backscatter information or harvest energy based on the time-varying ambient RF signal strength. In particular, we aim to maximize the long-term average communication data rate given that an average energy-harvesting budget constraint is met. We formulate the optimization as a 0-1 knapsack problem and propose a dynamic programming (DP) based solution algorithm and a reduced-complexity greedy algorithm. Furthermore, we simulate under various setups, and show that the two proposed algorithms can achieve significant performance improvement over other representative benchmark methods.

During the working process of the sanitation sweeper, it needs to be parallel to the curb and keep a certain distance to complete the cleaning work, so the driver must observe whether the distance between the side of the vehicle and the curb meets the working requirements at all times while considering the longitudinal driving. This will undoubtedly increase the workload of drivers, but also bring a lot of driving difficulties, easy to drive fatigue, resulting in traffic accidents. In this case, it is necessary to use the auxiliary driving technology to assist the sanitation sweeper driver to complete the cleaning work. Based on the actual working condition of sanitation sweeper, a scheme suitable for judging the attitude of sanitation sweeper is proposed. A line laser assisted vision rangefinder is designed to judge the attitude of sanitation sweeper. This scheme is simple and easy to operate, and the image processing speed is fast, which is suitable for popularization.

In this report, a water-soluble polysaccharide was obtained from the dried stems of Dendrobium officinale Kimura et Migo by hot-water (70-75°C) extraction and 85% ethanol precipitation, and successively purification by DEAE-cellulose anion-exchange chromatography and gel-permeation chromatography. The D. officinale polysaccharide (DOP) has a molecular weight of 8500Da. Monosaccharide composition analysis reveals that DOP is composed of mannose, glucose, and arabinose with a trace of galacturonic acid in a molar ratio of 6.2:2.3:2.1:0.1. Periodate oxidation-smith degradation and 1D and 2D NMR spectroscopy analysis suggest the predominance of mannose and glucose, and it contains a 2-O-acetylglucomannan and (1→4)-linked-β-d-mannopyranosyl and (1→4)-linked-β-d-glucopyranosyl residues. Atomic force microscope shows that DOP mainly exists as rod-shaped chains, supporting high degrees of polymerization. The antioxidant activities of the polysaccharide in vitro assay indicate that DOP has good scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, higher scavenging activity of hydroxyl radical, and metal chelating activities.

As a new kind of active flow control technology, plasma flow control has a bright future, for its simple structure, fast response, and wide frequency band. The wind tunnel and flight tests were conducted with microsecond dielectric barrier discharge on a glider. For the tests, the microsecond pulse power supply and remote control system were designed and built. In the wind tunnel test, the flow separation on the glider wing surface can be controlled effectively, and static pressure at the leading edge pressure is decreases by 177%. The flow control effects under different pulse frequencies are compared, and the optimal pulse frequency for actuation is found to be 100 Hz. A significant hysteresis effect was observed with microsecond dielectric barrier discharge at small angle of attack (α ≤ 18°), which means the flow control effect can last more than 300 s after turning off the plasma actuation. In the flight test, the maximum roll angle decreases by 7.0°, and the maximum aileron deflection angle decreases by 9.4° with plasma actuation at both sides of the wing, which means the glider becomes more stable with microsecond dielectric barrier discharge. With unilateral actuation, the rolling moment generated by the plasma actuation is larger than that produced by the ailerons with the angle of attack within 12.94° ≤ α ≤ 29.77°, which shows strong rolling control ability of microsecond dielectric barrier discharge. The wind tunnel and flight tests results verified the flow control effect of microsecond dielectric barrier discharge, and paved the way for the plasma flow control technology to practical applications.

A actuation system composed of actuators, circuit board, and microsecond pulse power has been designed to conduct pulsed surface arc discharge (PSAD) actuation. The instantaneous impulse energy of PSAD is higher than that of typical dielectric barrier discharge. Schlieren imaging and particle image velocity (PIV) technique have been used to characterize the flow field changes caused by actuation in quiescent air. A localized pressure wave is induced by every actuation, propagating in the air almost at the speed of sound. Special emphasis is given on the hot air mass observed in schlieren imaging, generating thermal convection disturbances in the flow field. A pair of a weak reverse vortex is generated after discharge for each actuator, with the maximum propagation velocity of 0.1 m/s. The induced burst perturbations indicate that the mechanism of plasma flow control based on PSAD is instantaneous heat release generated by PSAD actuation. Wind tunnel experiments were conducted on a 30 ° sweep delta wing to investigate the aerodynamic control effects by using PSAD actuation. The 12-channel PSAD actuation can effectively improve the aerodynamic performance of the delta wing, delay the angle of attack from 14 ° to 18 ° and increase the maximum lift coefficient by 12.9%. In this article, PSAD actuation has the ability to control low speed fluid flow separation by releasing very strong discharge power.

Transcriptional regulation of inducible nitric oxide synthase (iNOS) is critically involved in the pathogenesis and progression of rheumatoid arthritis (RA); however, the specific transcription factors that control this process remain largely unidentified. In the present study, it was discovered that expression of the key erythroid factor, globin transcription factor 1 (GATA1), is significantly greater in human RA synovial tissues than in osteoarthritis (OA) tissues. IL 6 was found to induce synovial GATA1 expression in a signal transducer and activator of transcription 3-dependent manner. Functionally, knockdown of GATA1 expression using specific small interfering RNA treatment was found to compromise immunoreaction-elicited expression of proinflammatory cytokines and thus impair invasiveness of the human fibroblast-like synovial cell line MH7A, whereas introduction of exogenous GATA1 was found to promote production of proinflammatory cytokines, leading to greater aggressiveness of MH7A cells. Mechanistically, GATA1 acts as the transcriptional coactivator of NOS2 (the gene encoding iNOS) transcription. Collectively, these data suggest that synovial GATA1 is an essential contributor to development and exacerbation of RA, presumably by inducing NOS2 transcription.

MicroRNA (miRNA) holds promise as a novel therapeutic tool for cancer treatment. However, the transfection efficiency of current delivery systems represents a bottleneck for clinical applications. Here, we demonstrate that gap junctions mediate an augmentative effect on the antiproliferation mediated by miR-124-3p in U87 and C6 glioblastoma cells. The functional inhibition of gap junctions using either siRNA or pharmacological inhibition eliminated the miR-124-3p-mediated antiproliferation, whereas the enhancement of gap junctions with retinoic acid treatment augmented this miR-124-3p-mediated antiproliferation. A similar effect was observed in glioblastoma xenograft models. More importantly, patch clamp and co-culture assays demonstrated the transmission of miR-124-3p through gap junction channels into adjacent cells. In further exploring the impact of gap junction-mediated transport of miR-124-3p on miR-124-3p target pathways, we found that miR-124-3p inhibited glioblastoma cell growth in part by decreasing the protein expression of cyclin-dependent kinase 6, leading to cell cycle arrest at the G0 /G1 phase; moreover, pharmacological regulation of gap junctions affected this cell cycle arrest. In conclusion, our results indicate that the "bystander" effects of functional gap junctions composed of connexin 43 enhance the antitumor effect of miR-124-3p in glioblastoma cells by transferring miR-124-3p to adjacent cells, thereby enhancing G0 /G1 cell cycle arrest. These observations provide a new guiding strategy for the clinical application of miRNA therapy in tumor treatment.

It is well-known that if an E-field integral equation or an H-field integral equation is applied alone in analysis of EM scattering from a conducting body, the solution to the equation will be either nonunique or unstable at the vicinity of a certain interior frequency. An effective math model is presented here, providing an easy way to deal with this situation. At the interior resonant frequencies, the surface current density is divided into two parts: an induced surface current caused by the incident field and a resonance surface current associated with the interior resonance mode. In this paper, the presented model, based on electric field integral equation and orthogonal modal theory, is used here to filter out resonant mode; therefore, unique and stable solution will be obtained. The proposed method possesses the merits of clarity in concept and simplicity in computation. A good agreement is achieved between the calculated results and those obtained by other methods in both 2D and 3D EM scattering.

LiMnBO3 and its carbon coated material LiMnBO3/C were synthesized by a microwave method. The influences of sintering temperature and feed composition on the structure and the morphology of materials were investigated. XRD, SEM and HR-TEM were used to characterize the structure and the morphology of the materials. The electrochemical properties of materials were tested by constant charge-discharge and electrochemical impedance spectroscopy. The results show that LiMnBO3 has a hexagonal crystal structure (h-LiMnBO3). The good crystalline structure with small grain size can be obtained under the reaction conditions of 750 °C, 25 min and nLi:nB:nMn=1:1:1(molar ratio). The charge-discharge capacity and the conductivity of the carbon coated material are enhanced after carbon coating. The initial discharge capacity of LiMnBO3/C is 50.3 mAh/g.

The turbine aero-thermal design expertise has not reached the ultimate level in comparison to compressor expertise which has evolved to high loading, high pressure ratio design with a limited number of stages. For high pressure turbine section, single highly loaded stages are typically representative of wide class of advanced aero engines. The transonic turbines significantly operate at higher pressure ratios with less number of stages but at an expense of relatively lower efficiencies.

Supplemental Material, Supple_Table_1_(2) for Novel Mutations in CFAP44 and CFAP43 Cause Multiple Morphological Abnormalities of the Sperm Flagella (MMAF) by Yan-Wei Sha, Xiong Wang, Xiaohui Xu, Zhi-Ying Su, Yuanqing Cui, Li-Bin Mei, Xian-Jing Huang, Jie Chen, Xue-Mei He, Zhi-Yong Ji, Hongchu Bao, Xiaoyu Yang, Ping Li, and Lin Li in Reproductive Sciences

A compact polarization beam splitter (PBS) based on a silicon waveguide-silver nanoribbon-silicon waveguide is proposed and demonstrated numerically by utilizing the evanescent coupling between a strip-nanowire and a nanoslot waveguide. Two-dimensional (2-D) FDTD simulations were performed to elucidate the properties of surface plasmon polaritons (SPPs) in this device made from silicon-metal-silicon, and were found to agree well with the theoretical predictions. TE and TM polarized light are respectively separated into two different output ports of Y-shaped silicon waveguide in which the coupling efficiency is 62% and 45% for 1.55μm wavelength, respectively. The proposed PBS structure could be utilized to develop ultracompact optical polarization modulating device for large-scale photonic integration and optical information processing.

Two types of lanthanide thiolato-carboxylate complexes, [Type I: [Yb(dtba) (Hdtba)]n (1), Type II: [Ln(dtba)1.5(biim)]n (Ln = Pr (2a), Nd (2b), Sm (2c), Eu (2d), Gd (2e), Tb (2f), Dy (2g), H2dtba = 2,2′-dithiodibenzoic acid, bimm = diimidazole)] have been obtained by hydrothermal method and characterized by the single-crystal X-ray diffraction, IR, 2D-COS IR, TG and the luminescence analysis. The H2dtba ligand came from the in situ S–S function reaction of 2-mercaptobenzoic acid (H2mba) under the hydrothermal condition. Complex 1 is a 2D bamboo-like sqr-topology layered structure, and the 3D (4, 4, 6)-connected supramolecular frameworks is produced by the hydrogen bonds of O–H···O. Complexes of type II (from 2a to 2g) are isostructural and they are assigned to 1D rope-like chains by introducing the chelating ligand of diimidazole. These 1D rope-like chains are further linked by N–H···O hydrogen bonds into a 3D supramolecular framework with CdSO4-type topology. Photoluminescence studies reveal that complexes 2b, 2c, 2d, 2f, 2g exhibit strong lanthanide characteristic emission bands in the solid state at room temperature.

Conventional macroeconomic forecasting model must change the mixed frequency data into the same frequency data by means of aggregation and interpolation, which ignores the information of high frequency data and decreases the timeliness and accuracy of nowcasting and short-term forecasting. Using monthly and quarterly macroeconomic data, this paper apply mixed data sampling (MIDAS) model and mixed-frequency VAR model (MF-VAR) to nowcast and forecast Chinese quarterly GDP growth rate. The results show that MIDAS model considering an autoregressive item tends to perform better in shorter horizons, whereas MF-VAR model in longer horizons. Additionally, the pooled forecast of MIDAS model and MF-VAR model outperform the individual models. Finally, forecasting results reveal that China's quarterly GDP growth will rebound steadily from the beginning of the third quarter of 2012

The purpose of this study was to assay the cultivable microorganisms of Davidia involucrate in rhizosphere soil and to analyze their diversity using colony and individual morphology and genetic profiling methods. A total of 118 strains were obtained after colony characterization and a microscopic examination, including 52 bacteria strains, 27 actinomycetes strains and 39 fungi strains. Fifty-seven (57) of these strains were randomly selected for rDNA analysis and phylogenetic identification, including 23 rhizobaceria isolates, 29 fungi isolates, and five streptomyces isolates. The selected isolates were accurately identified at the genus level with consistent results using a morphology examination and phylogenetic identification. From the study, we concluded the following: (1) Bacillus, Lactobacillus, Azotobacter, and Streptomyces are predominant microorganisms of D. involucrate in rhizophere soil and Bacillus is a dominant rhizobacteria that might have potential in host growth promotion; (2) the physiological activity of dovetree could significantly influence the microorganism biomass of the rhizophere soil; and (3) the dovetree is a highly complex rhizosphere ecosystem, and additional research on this topic should be carried out in the future. Key words: Rhizosphere microorganism, Davidia involucrate, plant growth promotion, soil.

For hard, brittle and difficult-to-cut materials, the technology heating auxiliary grinding has a significant role in improving productivity and reducing costs. Using different thermal loads and different ways of cooling to load granite,we carried out surface grinding experiments. We tested and analyzed variation of the grinding force and specific grinding energy. The results showed that strengthening the thermal load continuously, the grinding force and specific grinding energy reduce. This phenomenon significantly improves grinding efficiency and reduces the wear of wheel. Studies have shown that the auxiliary heating has an important contribution to enhance the production capacity of the stone processing.

Debris flows often occur in landslide deposits during heavy rainstorms. Debris flows are initiated by surface water runoff and unsaturated seepage under rainfall conditions. A physical model based on an infinitely long, uniform and void-rich sediment layer was applied to analyze the triggering of debris-flow introduced in landslide deposits. To determine the initiation condition for rainfall-induced debris flows, we conducted a surface water runoff and saturated-unsaturated seepage numerical program to model rainfall infiltration and runoff on a slope. This program was combined with physical modeling and stability analysis to make certain the initiation condition for rainfall-introduced debris flows. Taking the landslide deposits at Wenjiagou gully as an example, the initiation conditions for debris flow were computed. The results show that increase height of surface-water runoff and the decrease of saturated sediment shear strength of are the main reasons for triggering debris-flows under heavy rainfall conditions. The debris-flow triggering is affected by the depth of surface-water runoff, the slope saturation and shear strength of the sediment.

Two manganese complexes containing 4,4′-bipyridine and methyl benzoate as ligands have been prepared and crystallized by solvent evaporation method in DMF. The single crystal X-ray crystallographic analyses reveal that the complexes crystallize in monoclinic system. Crystal of 1 [Mn2(4,4′-bipy)2 (o-MBA)4]n has space group of P21/c with unit cell parameters of a = 17.508 (A), b = 11.6229 (A), c = 27.983 (A), β = 128.123°, V = 4.4797 nm3, empirical formula: C52H44Mn2N4O8, Mr = 962.79, Z = 4, Dc = 1.428 g/cm3, μ = 0.625 mm−1, and F(000) = 1992. The crystal of 2 [Mn (4,4′-bipy)(m-MBA)2]n belongs to space group C2/c with a = 16.079 (A), b = 11.652 (A), c = 24.887 (A), β = 92.02°, V = 4.660 nm3, empirical formula: C26H22MnN2O4, Mr = 481.40, Z = 8, Dc = 1.372 g/cm3, μ = 1.179 mm−1, F(000) = 1992. The weak interactions in structures are observed from the X-ray crystallographic data. These include the C H⋯O hydrogen bonds, π–π stacking and C H⋯π interactions found in 1. The different strength of intermolecular interaction in the structures is reflected on their different thermal stability of the two complexes measured by thermal gravimetric analysis and the 2D-IR correlation spectroscopy. The study of weak interactions is meaningful to provide supporting data for potential application in molecular biology.

To explore the predictive factors of cardiorespiratory abnormality in nonsedated patients at high altitude (HA) during upper gastrointestinal endoscopy (UGIE). The pulse and saturated oxygen (SaO2) levels of 993 patients undergoing nonsedated UGIE in Tibet were monitored. Bivariate correlation and logistic regression were used to identify predictive risk factors for hypoxemia. The basal and minimum SaO2 levels during UGIE of the Tibetan group were significantly higher than those of the non-Tibetan group. The minimum SaO2 and maximum pulse in the HA transient residents groups were significantly higher than those in the HA usual residents groups. The incidences of hypoxemia and severe hypoxemia in the Tibetan groups were significantly lower than those of the non-Tibetan groups. Bivariate correlation and logistic regression showed that race, age (≥40 years), residence time in HA (

Two new cadmium thiolato-carboxylate complexes, [Cd2(mba)2(2,2′-bpy)2] (1), [Cd2(dtba)2(2,2′-bpy)4]·4H2O (2) (H2mba = 2-mercaptobenzoic acid, H2dtba = 2,2′-dithiodibenzoic acid, 2,2′-bpy = 2,2′-bipyridine) were obtained by reacting Cd(II) salts and the ligands of H2mba and 2,2′-bpy, and were characterized by the single-crystal X-ray diffraction, IR, 2D-COS IR, solid UV, TG and XRD. In complex 2, the H2dtba ligand came from the in situ S–S function reaction of H2mba under the hydrothermal conditions. Complexes 1 and 2 are both 1D chains, but the difference lies in the linkage of the ligands. The 3D super-molecular frameworks of 1 and 2 are produced by π–π stacking interaction between the 2,2′-bpy ligands and the hydrogen bonds of O–H…O with ths-type and dia-type topology, respectively. The fluorescent emissions are observed in 1 and 2 with λ em = 533 nm and λ em = 436 nm, due to the ligand-to-metal charge transfer (LMCT) and π* → π transitions, respectively.

A coordination polymer, {[Cd2(H2Me4bpz)(ntcaa)2(H2O)]·H2O}n (1), has been synthesized by hydrothermal reaction of cadmium sulfate octahydrate with a flexible ligand, 3, 3′, 5, 5′-tetramethyl-4, 4′-bipyrazole and an auxiliary O-donor ligands, naphthalene-4,5-dicarboxylic acid-1,8-anhydride. Naphthalene-4,5-dicarboxylic acid-1,8-anhydride comes from the in situ dehydration of the naphthalene-1,4,5,8-tetracarboxylic acid in the hydrothermal reaction. Complex 1 exhibits a 2D wave-like layer structure based on tetranuclear Cd4O4 cluster units. The 2D wave-like layers are further held together by face-to-face π–π interactions between the naphthalene rings and intermolecular hydrogen bonds to generate a 3D supra-molecular network. The luminescent property of complex 1 was investigated in the solid-state at room temperature. .