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Until relatively recently there had been episodes when children had been admitted into hospitals with symptoms that were similar to those expected for human respiratory syncytial virus (HRSV), but the available diagnostic procedures failed to detect the presence of HRSV, and the causative disease agent remained unidentified. Dutch scientists examined nasopharyngeal aspirates from similar patients in Holland using advanced molecular biology and imaging techniques. The conclusions of this study were published in 2001, revealing that a previously unidentified paramyxovirus was responsible for these infections. This agent was grouped within the subfamily Pneumovirinae, genus metapneumovirus, and given the name human metapneumovirus (HMPV) to distinguish it from other members of the genus Metapneumovirus that are of avian origin. Although HMPV is associated with upper respiratory tract infection, it is now recognized as a major cause of lower respiratory infection (LRTI) in children in a variety of different geographical regions. Furthermore, retrospective studies have detected the presence of HMPV in archived clinical material dating from the 1950s, suggesting that this was not a new virus, but it had remained undetected for several decades until its ‘emergence’ in 2001. This review will discuss the increasing global importance of HMPV as a cause of LRTI among young children.