52 results on '"T. D'Amato"'
Search Results
2. Clinical efficacy of implementing a Patient Blood Management (PBM) Protocol in joint replacement surgery: a retrospective cohort study in a national referral center
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M, Scardino, B, Di Matteo, A, De Angelis, G, Anzillotti, F, Martorelli, V, Simili, G, Monteleone, M, Bovio, F, Tasso, M E, Laino, T, Tommasini, V, Savevski, G, Grappiolo, E, Kon, and T, D'Amato
- Abstract
The aging of population has dramatically broadened the total number of Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA) performed worldwide. To optimize the number of blood transfusions performed, a multimodal and multidisciplinary approach was introduced, called Patient Blood Management (PBM). The aim of the present retrospective study is to evaluate the feasibility and clinical outcomes of a PBM protocol applied in a national referral center for joint replacement surgery. Clinical reports of 9,635 patients undergoing primary THA or TKA, from 2014 to 2019, were screened. The trends of hemoglobin value at admission and at day 4 after surgery were analyzed. Furthermore, the trend of blood bags' requests and blood transfusions was longitudinally evaluated to assess the efficacy of our PBM protocol and its potential impact in reducing the length of stay in the hospital.In 2014, mean hemoglobin (Hb) levels at postoperative day 4 were 10.3 g/dl and 10.2 g/dl for TKA (unilateral and bilateral, respectively), and in 2019 were 11.3 g/dl and 11.6 g/dl (unilateral and bilateral, respectively, p=0.001). Total requested red blood cell (RBC) transfusions by each surgery over time have decreased for THA (277 in 2014 vs. 120 in 2019, p=0.001). A correlation matrix analysis between Hb level, body mass index (BMI), age, days spent in orthopedic (OR) ward and number of requested transfusions showed that RBC bags transfusions were related to the length of the hospital stay.A timely application of a PBM protocol in the perioperative period of TKA and THA was significantly associated to the reduction of blood transfusions and total length of hospital stay, with clear benefits for both the patients and the hospital.
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- 2023
3. Assessing the impact of organic versus conventional agricultural management on soil hydraulic properties in a long‐term experiment
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Daniel Giménez, Abdelrahman Alfahham, Alain F. Plante, Emmanuel Omondi, and Matthew T. Amato
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Agricultural management ,Soil Science ,Environmental science ,Agricultural engineering ,Long-term experiment - Published
- 2021
4. Between two pandemics: Older, gay men's experiences across HIV/AIDS and COVID-19
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Ingrid Handlovsky, Tessa Wonsiak, Anthony T. Amato, Michael Halpin, Olivier Ferlatte, and Hannah Kia
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- 2023
5. How We Work Now: Preliminary Review of a Pediatric Neuropsychology Hybrid Model in the Era of COVID-19 and Beyond
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Erica N Pollock, Jonathan D. Lichtenstein, Kelsey Grodner, Emily Z Holding, Kelsea P Marschall, Jennifer T. Amato, and Sara Scull
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Quality management ,Service delivery framework ,Context (language use) ,Telehealth ,Assessment ,Neuropsychological Tests ,AcademicSubjects/SCI02190 ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Neuropsychology ,Humans ,Medicine ,0501 psychology and cognitive sciences ,Neuropsychological assessment ,Children and behavioral disorders ,Child ,Pandemics ,Professional issues ,medicine.diagnostic_test ,AcademicSubjects/SCI01870 ,SARS-CoV-2 ,business.industry ,05 social sciences ,COVID-19 ,General Medicine ,Neuropsychological test ,Childhood neurologic disorders ,Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology ,Pediatric neuropsychology ,Original Empirical Article ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Objective Although telehealth has become a central component of medical care in response to the coronavirus disease 2019 (COVID-19) pandemic, comprehensive pediatric neuropsychological assessment over virtual platforms lacks empirical efficacy. This paper presents: a) the results of a quality improvement project examining the feasibility of in-person evaluation in the context of safety measures that alter test standardization, b) the impact such changes had upon neuropsychological test scores, and c) how using a hybrid model of clinical service delivery affected access to care. Method We compared demographic and outcome variables between patients seen during the pandemic (N = 87) to a group of patients seen in our service immediately prior to COVID-19 (N = 87). A subset of those patients were case-matched for age and diagnosis (N = 39 per group). Children seen for neuropsychological re-evaluation during the pandemic (N = 10) were examined using pairwise comparison. Results Groups did not differ on age, sex, or FSIQ. Despite changes to standardized administration, no group differences were found for any selected neuropsychological test variables in the larger sample or subsamples. In fact, all variables were moderately to highly correlated in the re-evaluation subgroup. The hybrid model expedited feedback sessions and increased face-to-face (telehealth) feedbacks. Conclusions A hybrid model incorporating modified in-person testing and intake and feedback encounters via telehealth may be a feasible and effective way to provide pediatric neuropsychological services. These preliminary findings suggest such novel aspects of neuropsychological evaluation could represent an improvement over pre-COVID models, especially in rural settings.
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- 2021
6. A rapid recovery protocol for hip and knee replacement surgery: a report of the outcomes in a referral center
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F, Tasso, V, Simili, B, Di Matteo, G, Monteleone, F, Martorelli, A, De Angelis, T, D'Amato, M, Bovio, D, Altomare, G, Campofreda, M, Marcacci, and M, Scardino
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Arthroplasty, Replacement, Hip ,Humans ,Length of Stay ,Arthroplasty, Replacement, Knee ,Referral and Consultation ,Retrospective Studies - Abstract
The number of joint replacements is expected to dramatically increase, and the optimization of the available resources is fundamental to maintain high clinical standards while providing an efficient treatment to an increasing number of patients. The present study describes the outcomes of the application of a rapid recovery (RR) protocol in a referral center for hip and knee replacement surgery.The medical records of every patient undergoing primary hip or knee replacement in 2019 were identified and all the relevant data were retrospectively extracted and compared to those of year 2016 (the last year before the onset of the rapid recovery protocol). The following outcomes were considered: 1) length of stay (LOS); 2) total number of TKR and THR; 3) pre- and post-operative subjective questionnaires; 4) NRS for pain at day 1 following surgery; 5) mean hemoglobin value at discharge; 6) number of blood transfusion performed; 7) complications following surgery.The mean LOS was significantly lower for patients managed through the rapid recovery protocol: 5.1 ± 1.4 days vs. 10.4 ± 2.3 days (p0.0001). The earlier discharge of patients promoted an overall increase in the total number of joint replacement procedures performed (2,806 in year 2019 vs. 2,236 in year 2016; p0.0001). Higher hemoglobin values at discharge were found in the RR group (10.6 ± 1.4 g/dl vs. 9.6 ± 1.2 g/dl, p = 0.049). No difference was observed in terms of clinical scores and overall complication rate.The application of a multimodal RR protocol for THR and TKR patients was able to reduce the length of stay and optimize the use of blood products, without increasing the risk of complications or jeopardizing the functional recovery.
- Published
- 2022
7. A multi-dimensional approach to the relationship between insight and aggressiveness in schizophrenia: Findings from the FACE-SZ cohort
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A. Schandrin, J. Norton, S. Raffard, B. Aouizerate, F. Berna, L. Brunel, I. Chereau-Boudet, T. D'Amato, H. Denizot, C. Dubertret, J. Dubreucq, C. Faget, G. Fond, F. Gabayet, P.M. Llorca, J. Mallet, D. Misdrahi, C. Passerieux, R. Rey, F. Schurhoff, M. Urbach, S. Bonnet, D. Capdevielle, M. Andrianarisoa, N. Bazin, O. Blanc, E. Bulzacka, G. Chesnoy-Servanin, J.M. Danion, A. Deloge, C. Delorme, J.M. Dorey, C. Fluttaz, S. Fonteneau, E. Giraud-Baro, D. Lacelle, C. Lançon, H. Laouamri, M. Leboyer, T. Le Gloahec, Y. Le Strat, E. Metairie, I. Offerlin-Meyer, P. Peri, S. Pires, C. Portalier, L. Ramet, L. Rey, C. Roman, F. Schürhoff, A. Tessier, A.M. Tronche, F. Vaillant, A. Vehier, P. Vidailhet, E. Vilà, H. Yazbek, A. Zinetti-Bertschy, Université Montpellier 1 (UM1), Fondation FondaMental [Créteil], Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut Européen des membranes (IEM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA), Psychopathologie et pharmacologie de la cognition, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier le Vinatier [Bron], Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA), Mécanique des Fluides, Energies et Environnement (EDF R&D MFEE), EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Aix Marseille Université (AMU), Assistance Publique-Hôpitaux de Marseille (AP-HM), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique moléculaire de la neurotransmission et des processus neurodégénératifs (LGMNPN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Centre Hospitalier Universitaire [Grenoble] (CHU), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), CCSD, Accord Elsevier, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital de la Colombière, Centre hospitalier Charles Perrens [Bordeaux], Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, CHU Strasbourg, Pôle de psychiatrie et d'addictologie des Hôpitaux Universitaires Henri-Mondor [Créteil], Centre hospitalier universitaire Henri-Mondor [Créteil], CHU Clermont-Ferrand, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère], Centre Hospitalier Alpes Isère, Centre Hospitalier de Versailles André Mignot (CHV), Laboratoire de recherches cliniques et en santé publique sur les handicaps psychique, cognitif et moteur (HANDIReSP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Montpellier (UM), FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group: M Andrianarisoa 16 , B Aouizerate 17 , N Bazin 18 , F Berna 19 , O Blanc 20 , L Brunel 16 , E Bulzacka 16 , D Capdevielle 21 , I Chereau-Boudet 20 , G Chesnoy-Servanin 22 , J M Danion 19 , T D'Amato 22 , A Deloge 23 , C Delorme 24 , H Denizot 20 , J M Dorey 22 , C Dubertret 25 , J Dubreucq 24 , C Faget 26 , C Fluttaz 24 , G Fond 27 , S Fonteneau 18 , F Gabayet 24 , E Giraud-Baro 24 , D Lacelle 20 , C Lançon 26 , H Laouamri 27 , M Leboyer 16 , T Le Gloahec 16 , Y Le Strat 25 , P M Llorca 20 , J Mallet 25 , E Metairie 26 , D Misdrahi 23 , I Offerlin-Meyer 19 , C Passerieux 18 , P Peri 26 , S Pires 20 , C Portalier 25 , L Ramet 18 , L Rey 22 , C Roman 24 , A Schandrin 28 , F Schürhoff 16 , A Tessier 23 , A M Tronche 20 , M Urbach 18 , F Vaillant 26 , A Vehier 22 , P Vidailhet 19 , E Vilà 23 , H Yazbek 21 , A Zinetti-Bertschy 19, Hôpital Charles Perrens, Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Université d'Auvergne - Clermont-Ferrand I (UdA)-CHU Clermont-Ferrand, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie de la Plasticité Neuronale (Neurocentre Magendie - U1215 Inserm), and Centre de Psychiatrie et Neurosciences (U894)
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Adult ,Male ,Adolescent ,media_common.quotation_subject ,[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Hostility ,Anger ,Cohort Studies ,Diagnostic Self Evaluation ,Young Adult ,03 medical and health sciences ,Aggressiveness ,0302 clinical medicine ,medicine ,Humans ,Spectrum disorder ,ComputingMilieux_MISCELLANEOUS ,Biological Psychiatry ,media_common ,Aggression ,Middle Aged ,Awareness ,030227 psychiatry ,3. Good health ,Psychiatry and Mental health ,Psychotic Disorders ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Cohort ,Schizophrenia ,Multi dimensional ,Female ,medicine.symptom ,Insight ,Psychology ,030217 neurology & neurosurgery ,Diagnosis of schizophrenia ,Clinical psychology - Abstract
International audience; Background: Aggressiveness is a stigma frequently associated with schizophrenia. The role of insight as a risk factor of aggressiveness remains contradictory; mainly because single measures of these states mask their complexity and heterogeneity.Methods: This study was conducted on 666 patients aged 15 and above with a DSM-IV-TR diagnosis of schizophrenia spectrum disorder, drawn from the French national network of schizophrenia expert center database. Collected data comprised socio-demographics and standardized psychiatric assessments. Aggressiveness was evaluated using the Buss-Perry Aggression Questionnaire and insight using the Scale to assess Unawareness of Mental Disorder (SUMD) and Birchwood Insight Scale (BIS).Results: Hostility was the aggressiveness dimension the most strongly associated with SUMD insight dimensions. Patients aware of their illness were nearly twice as likely to show hostility than those seriously unaware (OR = 1.95, 95% CI.: 1.08-3.5), but not when further adjusting for depression. Similarly, those aware of the consequences of their illness and of their symptoms were more hostile. Patients moderately aware of illness consequences had a higher risk of both anger and physical aggressiveness than those unaware (OR = 2.63, 95% CI.: 1.42-4.86, OR = 2.47, 95% CI.: 1.33-4.60, respectively), even when adjusting for depression for anger.Conclusion: Our study confirms that a multi-dimensional approach to insight and aggressiveness is essential to understand the types of links between these clinical states. Insight may trigger the expression of an underlying hostile tendency, maybe via depression and self-stigmatisation. This should be taken into account in therapeutic approaches to improve insight.
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- 2019
8. Dielectric permittivity-water content relationships in woodchips: Particle size and temperature effects
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Daniel Giménez, Uta Krogmann, Vandana Subroy, Peter F. Strom, and Matthew T. Amato
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Materials science ,010504 meteorology & atmospheric sciences ,0207 environmental engineering ,Analytical chemistry ,02 engineering and technology ,01 natural sciences ,Power law ,Particle-size distribution ,Calibration ,Range (statistics) ,Woodchips ,Particle size ,020701 environmental engineering ,Reflectometry ,Water content ,0105 earth and related environmental sciences ,Water Science and Technology - Abstract
Information on the amount of water held by woodchips in the field is needed to assess environmental risks when they are kept in stockpiles or for inferring their efficiency as denitrifying bioreactors. Reflectometry is a widely used method for estimating volumetric water content ( θ ) in permeable media, but material-specific calibration functions should be developed. This study aimed at developing relationships between the bulk dielectric permittivity ( e b ) and θ in woodchips considering their particle size distribution (PSD), temperature ( T ) and the dielectric permittivity of the dry material plus air ( e sa ). The e b of fine, medium and coarse PSDs were measured with CS616-L water content reflectometers up to θ of 0.83 cm3/cm3 and at T (°C) of 10°, 24°, 37°, 55° and 70°. Calibration equations were developed using a multivariate power law function fitted to the data with a hierarchical Bayesian inference procedure. The best fit ( R 2 = 0.96; RMSE =0.04 cm3/cm3) was obtained for the fine PSD ( e sa ∼ 1.09); while medium ( e sa ∼ 1.09) and coarse ( e sa ∼ 1.03) PSDs were more influenced by T and the presence of large air voids ( R 2 ∼ 0.92; RMSE ∼0.06 cm3/cm3). A modified calibration equation independent of PSD ( e sa = 1) reduced only slightly the goodness-of-fit ( R 2 = 0.90; RMSE =0.07 cm3/cm3). The equations developed in this study are well suited for field applications as they cover a wider range of θ than previously published functions and they are applicable within the range of T found in field applications.
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- 2019
9. Le syndrome sérotoninergique : une revue actualisée de la littérature
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T. d’Amato, M. Nourredine, Benjamin Rolland, Jean-Michel Dorey, Bruno Mégarbane, and L. Jurek
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medicine.medical_specialty ,business.industry ,Gastroenterology ,Cognition ,Therapeutic education ,Serotonergic ,030226 pharmacology & pharmacy ,Serotonin syndrome ,03 medical and health sciences ,0302 clinical medicine ,Clinical heterogeneity ,Internal Medicine ,medicine ,Drug adverse effect ,medicine.symptom ,business ,Intensive care medicine ,030217 neurology & neurosurgery ,Pharmacogenetics - Abstract
The serotonin syndrome is a potentially deadly complication resulting from drug adverse effect, drug-drug interaction or overdose involving one or more serotonergic molecules, e.g., antidepressants, psychostimulants and sometimes an "ignored" serotonergic compound. The serotonin syndrome typically consists of a clinical triad including cognitive/behavioral, neurovegetative and neuromuscular features. However, this syndrome is characterized by major clinical heterogeneity, making the diagnosis difficult in practice. Moreover, many practitioners are quite unaware of this syndrome. Available scores and classifications can help physicians in their diagnosis approach. Knowing the responsible molecules, their potential interactions and mechanisms of action can help preventing this complication allowing therapeutic education among patients. This updated article reviews the clinical presentation, prevention, management, and pathophysiology of the serotonin syndrome, and addresses the most recent advances in pharmacogenetics regarding this syndrome.
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- 2019
10. Immune Signatures of Treatment-Resistant Schizophrenia: A FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Study
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Guillaume Fond, Philippe Le Corvoisier, F Schürhoff, A Szöke, Face-Sz Groups, I Offerlin-Meyer, Ryad Tamouza, T D′Amato, I Chéreau, J Dubreucq, E Vilà, F Gabayet, Julien Dubreucq, C Fluttaz, Wahid Boukouaci, D Misdrahi, P Vidailhet, David Misdrahi, J Mallet, B Pignon, Caroline Barau, A Vehier, C Lançon, Myrtille André, Jasmina Mallet, Baptiste Pignon, H Yazbek, Julie Clauss-Kobayashi, Christine Passerieux, J M Dorey, Caroline Dubertret, Sylvain Leignier, K Souryis, P Peri, Isabelle Chereau, F Berna, O Blanc, G Chesnoy-Servanin, S Pires, D Lacelle, A Deloge, Franck Schürhoff, Hakim Laouamri, P M Llorca, O Godin, Bruno Aouizerate, C. Portalier, Pierre-Michel Llorca, R Rey, A Zinetti-Bertschy, H Denizot, Mathieu Urbach, M Jarroir, V Barteau, C Roman, B Aouizerate, C Passerieux, S Esselin, R M Honciuc, C Dubertret, Christophe Lançon, H. Laouamri, F Vaillant, Andrei Szöke, E Metairie, Marion Leboyer, Ching-lieng Lu, M Urbach, Fabrice Berna, C Faget, Romain Rey, Ophélia Godin, E Haffen, M Leboyer, D Capdevielle, Delphine Capdevielle, Thierry D′Amato, S Bensalem, and Emilie Terro
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profile ,medicine.medical_specialty ,AcademicSubjects/MED00800 ,clozapine ,Positive and Negative Syndrome Scale ,immuno-inflammatory ,Schizophrenia (object-oriented programming) ,treatment-resistant ,030227 psychiatry ,schizophrenia ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Immune system ,signatures ,medicine ,Treatment resistant schizophrenia ,Psychology ,Psychiatry ,030217 neurology & neurosurgery ,Clozapine ,Regular Articles ,medicine.drug - Abstract
Treatment-resistant schizophrenia (TRS) affects around 30% of patients with schizophrenia (SZ) resulting in poor functioning, relapses, and reduced quality of life. Convergent findings show that inflammation could contribute to resistance. We thus search for immune signatures of patients with TRS/ultra TRS (UTRS) in a sample of community-dwelling outpatients with SZ. In total, 195 stabilized SZ patients (mean age = 31.2 years, 73% male gender) were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia in France and received a thorough clinical assessment. At inclusion, psychotic symptomatology was evaluated by the Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Circulating serum/plasma levels of a large panel of markers reflecting the main inflammatory pathways were evaluated. TRS was defined by current treatment by clozapine (CLZ) and UTRS by current CLZ treatment + PANSS total score ≥ 70. The frequency of TRS and UTRS patients was, respectively, 20% and 7.7% and was defined using multivariable analysis elevated by high levels of interleukin (IL)-12/IL-23p40, IL-17A, IL-10, and beta 2 microglobulin (B2M) and IL-12/IL-23p40, IL-17A, IL-6, IL-10, IFNγ, and B2M, respectively. These observations suggest that resistance and ultra resistance to CLZ treatment are underpinned by pro-inflammatory molecules mainly belonging to the T helper 17 pathway, a finding making sense given the interplay between inflammation and antipsychotic treatment responses. If confirmed, our findings may allow us to consider IL-23/IL-17 pathway as a therapeutic target for patients with resistance to antipsychotics.
- Published
- 2021
11. Effect of intravenous ferric carboxymaltose supplementation in non-anaemic iron deficient patients undergoing hip and knee arthroplasty
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T, D'Amato, E, Kon, F, Martorelli, G, Monteleone, V, Simili, F, Tasso, B, Di Matteo, and M, Scardino
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Hemoglobins ,Arthroplasty, Replacement, Hip ,Iron ,Dietary Supplements ,Humans ,Arthroplasty, Replacement, Knee ,Maltose ,Ferric Compounds ,Retrospective Studies - Abstract
Preoperative anaemia and non-anaemic iron deficiency are independent risk factors for perioperative blood transfusion, morbidity, and mortality. Although the efficacy to treat anaemia with iron infusion before elective surgery has been widely studied, the literature offers few data about the efficacy of treating iron deficient, non-anaemic patients before elective surgery. This retrospective study assessed the effect of preoperative ferric carboxymaltose (FC) administration on the concentration of Haemoglobin (Hb) in iron deficient, non-anaemic individuals following total knee or hip arthroplasty. A treatment group of 83 non-anaemic iron deficient individuals scheduled for arthroplasty were administered a 1000mg FC infusion over 15 minutes 4 weeks prior to surgery. In the control group (n=62) FC was not administered preoperatively. No individual from either group was given any iron supplement following the pre-operative visit. Blood tests were performed and analysed 4-weeks before surgery, on admission, and then 2-days, 4-days and 4-weeks postoperatively. Number of blood transfusions performed and adverse events were recorded. Hb concentration did not change substantially after iron supplementation prior to surgery. No difference in the number of blood transfusions was observed. In the treatment, group postoperative Hb concentration recovered significantly more quickly compared to control (p=0.0047). No adverse event was reported. The administration of FC in non-anaemic iron deficient individuals quickens the restoration of Hb concentration following THA or TKA procedures.
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- 2020
12. Comparison of three scales (BIS, SUMD and BCIS) for measuring insight dimensions and their evolution after one-year of follow-up: Findings from the FACE-SZ Cohort
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Delphine Capdevielle, Joanna Norton, Bruno Aouizerate, Fabrice Berna, Isabelle Chereau, Thierry D'Amato, Caroline Dubertret, Julien Dubreucq, Guillaume Fond, Lançon C, Jasmina Mallet, David Misdrahi, Catherine Passerieux, Romain Rey, Franck Schurhoff, Mathieu Urbach, Pierre-Michel Llorca, Stéphane Raffard, B. Aouizerate, F. Berna, O. Blanc, D. Capdevielle, I. Chereau-Boudet, N. Coulon, T. D'Amato, J.M. Dorey, C. Dubertret, G. Fond, F. Gabayet, D. Lacelle, C. Lançon, H. Laouamri, M. Leboyer, P.M. Llorca, J. Mallet, E. Metairie, D. Misdrahi, C. Passerieux, B. Pignon, P. Peri, C. Portalier, R. Rey, C. Roman, F. Schürhoff, A. Szöke, M. Urbach, A. Zinetti-Bertschy, Fondation FondaMental [Créteil], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Bordeaux [Bordeaux], Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Les Hôpitaux Universitaires de Strasbourg (HUS), Neuropsychologie Cognitive et Physiophatologie de la Schizophrénie (Inserm U1114 - UNISTRA), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, CHU Clermont-Ferrand, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes (UGA), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Centre Hospitalier de Versailles André Mignot (CHV), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Paul-Valéry - Montpellier 3 (UPVM), This work was funded by AP-HP (Assistance Publique des Hôpitaux de Paris), Fondation FondaMental (RTRS Santé Mentale), by the Investissements d'Avenir program managed by the ANR under reference ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut National de la Santé et de la Recherche Médicale)., Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, Centre de recherche en neurosciences de Lyon (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
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Psychometrics ,Composite score ,[SDV]Life Sciences [q-bio] ,Clinical state ,Cognitive Insight ,03 medical and health sciences ,Cognitive dimensions of notations ,0302 clinical medicine ,medicine ,Humans ,Biological Psychiatry ,Psychiatric Status Rating Scales ,Cognition ,Awareness ,medicine.disease ,030227 psychiatry ,3. Good health ,Psychiatry and Mental health ,Psychotic Disorders ,Clinical Insight ,Schizophrenia ,Cohort ,Schizophrenic Psychology ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Insight ,Psychology ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,030217 neurology & neurosurgery ,Treatment need ,Clinical psychology - Abstract
International audience; The aim of our study was to compare the performance of three different instruments measuring clinical and cognitive dimensions of insight. Data on 182 outpatients with schizophrenia and one-year follow-up assessments was drawn from the FACE-SZ cohort. Awareness of clinical state (« clinical insight ») was measured using both a clinician-rated measure (the Scale to assess Unawareness of Mental Disorder (SUMD)), and a self-report measure (the Birchwood Insight Scale (BIS). Cognitive insight was measured using a self-report measure (the Beck Cognitive Insight Scale (BCIS)). For each scale, change in insight was examined at the follow-up. Correlations between SUMD and BIS subscales measuring same dimensions were significant. BIS-BCIS correlations were weak for all combinations except between BIS illness dimension and BCIS composite score. At the follow-up, BIS and SUMD awareness of treatment need improved whereas illness and symptom awareness increased only on the SUMD. Conversely, cognitive insight composite scores decreased. Despite relatively good overall agreement between the two clinical insight instruments, considerable variability for similar insight dimensions measured by different instruments was found. Agreement between cognitive and clinical insight is moderate. Our study strengthens the argument that insight is harder to operationalize than other symptoms and may explain why it is so seldom explicitly targeted in schizophrenia treatment.
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- 2021
13. Comment aider les proches ?
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T. d’Amato, C. Lourioux, and R. Rey
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- 2019
14. Forecasting leachate generation from pilot woodchip stockpiles using a three-dimensional transient flow model
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Uta Krogmann, Matthew T. Amato, Robert Miskewitz, Peter F. Strom, Sarat Kannepalli, and Daniel Giménez
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Environmental Engineering ,0208 environmental biotechnology ,Flow (psychology) ,Bayes Theorem ,Soil science ,02 engineering and technology ,General Medicine ,Numerical models ,Stormwater management ,010501 environmental sciences ,Management, Monitoring, Policy and Law ,01 natural sciences ,Refuse Disposal ,020801 environmental engineering ,Markov chain monte carlo algorithm ,Transient flow ,Environmental science ,Recycling ,Woodchips ,Leachate ,Pile ,Waste Management and Disposal ,Ecosystem ,0105 earth and related environmental sciences - Abstract
Leachate generation from open stockpiles of recycled woodchip materials is potentially harmful to aquatic ecosystems. There is growing interest in using numerical models to simulate leachate generation from outdoor piles, but this requires information about the hydraulic properties of the materials. The objectives of this study were to simulate leachate from woodchip piles with the numerical model HYDRUS-3D and to optimize subsets of parameters for single (SPM) and dual (DPM) pore flow models with the Bayesian Markov Chain Monte Carlo algorithm DREAMZS. Three experimental piles, each approximately 30 m3, were setup with mixtures of either once (coarse) or twice (fine) ground woodchips. Leachate continuously collected over a period of six months was similar across piles. As a result, subsets of optimized flow parameters for the coarse and fine woodchips were not different. Leachate predictions by the two pore flow models were similar and agreed reasonably with the field measurements, as indicated by Nash-Sutcliffe efficiency values greater than 0.6. This result suggests the simpler SPM is adequate for field predictions of leachate. However, leachate was consistently under-predicted by both pore models by 13–27% during rainfall events with more than 1 cm in 6 h. The optimized flow models can be used as a tool for studying pile management strategies.
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- 2020
15. Psychiatric disability as mediator of the neurocognition-functioning link in schizophrenia spectrum disorders: SEM analysis using the Evaluation of Cognitive Processes involved in Disability in Schizophrenia (ECPDS) scale
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Paul Roux, Mathieu Urbach, Sandrine Fonteneau, Fabrice Berna, Lore Brunel, Delphine Capdevielle, Isabelle Chereau, Julien Dubreucq, Catherine Faget-Agius, Guillaume Fond, Sylvain Leignier, Claire-Cécile Perier, Raphaëlle Richieri, Priscille Schneider, Franck Schürhoff, Anne-Marie Tronche, Hanan Yazbek, Anna Zinetti-Bertschy, Christine Passerieux, Eric Brunet-Gouet, M. Andrianarisoa, B. Aouizerate, N. Bazin, F. Berna, O. Blanc, L. Brunel, E. Bulzacka, D. Capdevielle, I. Chereau-Boudet, G. Chesnoy-Servanin, Jm Danion, T. D'Amato, A. Deloge, C. Delorme, H. Denizot, J.M. Dorey, C. Dubertret, J. Dubreucq, C. Faget, C. Fluttaz, G. Fond, S. Fonteneau, F. Gabayet, E. Giraud-Baro, D. Lacelle, C. Lançon, H. Laouamri, M. Leboyer, T. Le Gloahec, Y. Le Strat, null Llorca, J. Mallet, E. Metairie, D. Misdrahi, I. Offerlin-Meyer, C. Passerieux, P. Peri, S. Pires, C. Portalier, L. Ramet, R. Rey, C. Roman, A. Schandrin, F. Schürhoff, A. Tessier, Am Tronche, M. Urbach, F. Vaillant, A. Vehier, P. Vidailhet, E. Vilà, H. Yazbek, A. Zinetti-Bertschy, Fondation FondaMental [Créteil], Laboratoire de recherches cliniques et en santé publique sur les handicaps psychique, cognitif et moteur (HANDIReSP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre Hospitalier de Versailles André Mignot (CHV), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de psychiatrie adulte, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital La Colombière, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère], Centre Hospitalier Alpes Isère, Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] (Hôpitaux Sud), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud )-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Psychometrics ,media_common.quotation_subject ,Metacognition ,Remediation ,Cohort Studies ,03 medical and health sciences ,Disability Evaluation ,Young Adult ,0302 clinical medicine ,Cognition ,Visual memory ,Neuropsychology ,medicine ,Humans ,Effects of sleep deprivation on cognitive performance ,Functioning ,Psychiatry ,Biological Psychiatry ,media_common ,Psychiatric Status Rating Scales ,Disability ,Middle Aged ,030227 psychiatry ,Psychiatry and Mental health ,Cross-Sectional Studies ,Psychotic Disorders ,Cognitive remediation therapy ,Latent Class Analysis ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,Schizophrenia ,Female ,Schizophrenic Psychology ,Psychology ,Neurocognitive ,030217 neurology & neurosurgery ,Vigilance (psychology) - Abstract
International audience; The functional outcome in schizophrenia spectrum disorders is affected by multiple factors such as cognitive performance and clinical symptoms. Psychiatric disability may be another important determinant of functional outcome. The purpose of this study was to test whether schizophrenia symptoms and psychiatric disability mediated the association between cognition and functioning. Between April 2013 and July 2017, we included 108 community-dwelling adults with stable schizophrenia spectrum disorder in a multicenter study. Psychiatric disability was assessed with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia (ECPDS) scale by relatives of patients. ECPDS focused on the broad array of motivational, neurocognitive, sociocognitive, and metacognitive impairments that result in activity restrictions. We used a battery of tests to assess seven cognition domains (processing speed, attention/vigilance, working, verbal and visual memory, reasoning and problem solving, and executive functioning) and cross-sectional structural equation modeling (SEM) for the mediation analyses. We estimated the one-year temporal stability of ECPDS scores in 45 participants. The model provided showed good fit and explained 43.9% of the variance in functioning. The effect of neurocognition on functioning was fully mediated by symptoms (proportion mediated: 36.5%) and psychiatric disability (proportion mediated: 31.3%). The ECPDS score had acceptable one-year temporal stability. The ECPDS scale has satisfactory psychometric properties, and shows significant convergence with neurocognition and functioning, suggesting a role for this tool in the routine evaluation of cognitive remediation needs. Our model validates psychiatric disability as a crucial step from cognitive impairment to restricted participation in life situations.
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- 2018
16. Supplemental_Material – Supplemental material for Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale
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Roux, Paul, Urbach, Mathieu, Fonteneau, Sandrine, Berna, Fabrice, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubreucq, Julien, Faget-Agius, Catherine, Fond, Guillaume, Leignier, Sylvain, Claire-Cécile Perier, Richieri, Raphaëlle, Schneider, Priscille, Schürhoff, Franck, Tronche, Anne Marie, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, Brunet-Gouet, Eric, M Andrianarisoa, B Aouizerate, N Bazin, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, JM Danion, T D’Amato, A Deloge, C Delorme, H Denizot, JM Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, PM Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, L Ramet, R Rey, C Roman, A Schandrin, F Schürhoff, A Tessier, AM Tronche, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek, and A Zinetti-Bertschy
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FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,110904 Neurology and Neuromuscular Diseases ,110314 Orthopaedics - Abstract
Supplemental material, Supplemental_Material for Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale by Paul Roux, Mathieu Urbach, Sandrine Fonteneau, Fabrice Berna, Lore Brunel, Delphine Capdevielle, Isabelle Chereau, Julien Dubreucq, Catherine Faget-Agius, Guillaume Fond, Sylvain Leignier, Claire-Cécile Perier, Raphaëlle Richieri, Priscille Schneider, Franck Schürhoff, Anne Marie Tronche, Hanan Yazbek, Anna Zinetti-Bertschy, the FondaMental Advanced Centers of Expertise in Schizophrenia (FACE-SCZ) Collaborators, Christine Passerieux, Eric Brunet-Gouet, M Andrianarisoa, B Aouizerate, N Bazin, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, JM Danion, T D’Amato, A Deloge, C Delorme, H Denizot, JM Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, PM Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, L Ramet, R Rey, C Roman, A Schandrin, F Schürhoff, A Tessier, AM Tronche, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek and A Zinetti-Bertschy in Clinical Rehabilitation
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- 2018
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17. Supplementary_Informatiion_2 – Supplemental material for Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale
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Roux, Paul, Urbach, Mathieu, Fonteneau, Sandrine, Berna, Fabrice, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubreucq, Julien, Faget-Agius, Catherine, Fond, Guillaume, Leignier, Sylvain, Claire-Cécile Perier, Richieri, Raphaëlle, Schneider, Priscille, Schürhoff, Franck, Tronche, Anne Marie, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, Brunet-Gouet, Eric, M Andrianarisoa, B Aouizerate, N Bazin, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, JM Danion, T D’Amato, A Deloge, C Delorme, H Denizot, JM Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, PM Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, L Ramet, R Rey, C Roman, A Schandrin, F Schürhoff, A Tessier, AM Tronche, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek, and A Zinetti-Bertschy
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FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,110904 Neurology and Neuromuscular Diseases ,110314 Orthopaedics - Abstract
Supplemental material, Supplementary_Informatiion_2 for Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale by Paul Roux, Mathieu Urbach, Sandrine Fonteneau, Fabrice Berna, Lore Brunel, Delphine Capdevielle, Isabelle Chereau, Julien Dubreucq, Catherine Faget-Agius, Guillaume Fond, Sylvain Leignier, Claire-Cécile Perier, Raphaëlle Richieri, Priscille Schneider, Franck Schürhoff, Anne Marie Tronche, Hanan Yazbek, Anna Zinetti-Bertschy, the FondaMental Advanced Centers of Expertise in Schizophrenia (FACE-SCZ) Collaborators, Christine Passerieux, Eric Brunet-Gouet, M Andrianarisoa, B Aouizerate, N Bazin, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, JM Danion, T D’Amato, A Deloge, C Delorme, H Denizot, JM Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, PM Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, L Ramet, R Rey, C Roman, A Schandrin, F Schürhoff, A Tessier, AM Tronche, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek and A Zinetti-Bertschy in Clinical Rehabilitation
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- 2018
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18. Supplementary_Information_1 – Supplemental material for Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale
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Roux, Paul, Urbach, Mathieu, Fonteneau, Sandrine, Berna, Fabrice, Brunel, Lore, Capdevielle, Delphine, Chereau, Isabelle, Dubreucq, Julien, Faget-Agius, Catherine, Fond, Guillaume, Leignier, Sylvain, Claire-Cécile Perier, Richieri, Raphaëlle, Schneider, Priscille, Schürhoff, Franck, Tronche, Anne Marie, Yazbek, Hanan, Zinetti-Bertschy, Anna, Passerieux, Christine, Brunet-Gouet, Eric, M Andrianarisoa, B Aouizerate, N Bazin, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, JM Danion, T D’Amato, A Deloge, C Delorme, H Denizot, JM Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, PM Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, L Ramet, R Rey, C Roman, A Schandrin, F Schürhoff, A Tessier, AM Tronche, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek, and A Zinetti-Bertschy
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FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,110904 Neurology and Neuromuscular Diseases ,110314 Orthopaedics - Abstract
Supplemental material, Supplementary_Information_1 for Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale by Paul Roux, Mathieu Urbach, Sandrine Fonteneau, Fabrice Berna, Lore Brunel, Delphine Capdevielle, Isabelle Chereau, Julien Dubreucq, Catherine Faget-Agius, Guillaume Fond, Sylvain Leignier, Claire-Cécile Perier, Raphaëlle Richieri, Priscille Schneider, Franck Schürhoff, Anne Marie Tronche, Hanan Yazbek, Anna Zinetti-Bertschy, the FondaMental Advanced Centers of Expertise in Schizophrenia (FACE-SCZ) Collaborators, Christine Passerieux, Eric Brunet-Gouet, M Andrianarisoa, B Aouizerate, N Bazin, F Berna, O Blanc, L Brunel, E Bulzacka, D Capdevielle, I Chereau-Boudet, G Chesnoy-Servanin, JM Danion, T D’Amato, A Deloge, C Delorme, H Denizot, JM Dorey, C Dubertret, J Dubreucq, C Faget, C Fluttaz, G Fond, S Fonteneau, F Gabayet, E Giraud-Baro, D Lacelle, C Lançon, H Laouamri, M Leboyer, T Le Gloahec, Y Le Strat, PM Llorca, J Mallet, E Metairie, D Misdrahi, I Offerlin-Meyer, C Passerieux, P Peri, S Pires, C Portalier, L Ramet, R Rey, C Roman, A Schandrin, F Schürhoff, A Tessier, AM Tronche, M Urbach, F Vaillant, A Vehier, P Vidailhet, E Vilà, H Yazbek and A Zinetti-Bertschy in Clinical Rehabilitation
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- 2018
- Full Text
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19. Influence of Venus and Mars in the cognitive sky of schizophrenia. Results from the first-step national FACE-SZ cohort
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G. Fond, L. Boyer, M. Leboyer, O. Godin, P.M. Llorca, M. Andrianarisoa, F. Berna, L. Brunel, B. Aouizerate, D. Capdevielle, I. Chereau, T. D'Amato, C. Dubertret, J. Dubreucq, C. Faget, F. Gabayet, J. Mallet, D. Misdrahi, R. Rey, C. Lancon, C. Passerieux, P. Roux, P. Vidailhet, H. Yazbek, F. Schürhoff, E. Bulzacka, O. Blanc, I. Chereau-Boudet, G. Chesnoy-Servanin, Jm Danion, A. Deloge, C. Delorme, H. Denizot, J.M. Dorey, C. Fluttaz, S. Fonteneau, E. Giraud-Baro, M.C. Hardy-Bayle, D. Lacelle, C. Lançon, H. Laouamri, T. Le Gloahec, Y. Le Strat, null Llorca, E. Metairie, I. Offerlin-Meyer, P. Peri, S. Pires, C. Portalier, C. Roman, M. Sebilleau, A. Schandrin, F. Schurhoff, A. Tessier, Am Tronche, M. Urbach, F. Vaillant, A. Vehier, E. Vilà, A. Zinetti-Bertschy, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Université Montpellier 1 (UM1), Génétique moléculaire de la neurotransmission et des processus neurodégénératifs (LGMNPN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), ONERA - The French Aerospace Lab [Toulouse], ONERA, Information – Technologies – Analyse Environnementale – Procédés Agricoles (UMR ITAP), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [APHP], Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre Hospitalier d'Annecy, Centre hospitalier d'Annecy, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Psychiatrie et Neurosciences (U894), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, and CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2
- Subjects
Adult ,Male ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Neuropsychological Tests ,Verbal learning ,Developmental psychology ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Borderline intellectual functioning ,medicine ,Verbal fluency test ,Humans ,Biological Psychiatry ,ComputingMilieux_MISCELLANEOUS ,Psychiatric Status Rating Scales ,Analysis of Variance ,Sex Characteristics ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,[SCCO.NEUR]Cognitive science/Neuroscience ,Neuropsychology ,Cognitive flexibility ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Cognition ,Middle Aged ,medicine.disease ,Executive functions ,030227 psychiatry ,3. Good health ,Psychiatry and Mental health ,Schizophrenia ,Female ,Schizophrenic Psychology ,Independent Living ,Psychology ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Objectives Sex differences can yield important clues regarding illness pathophysiology and its treatment. Schizophrenia (SZ) has a lower incidence rate, and a better prognosis, in women versus men. The present study investigated the cognitive profiles of both sexes in a large multi-centre sample of community-dwelling SZ patients. Method 544 community-dwelling stable SZ subjects (141 women and 403 men; mean age 34.5 ± 12.1 and 31.6 ± 8.7 years, respectively) were tested with a comprehensive battery of neuropsychological tests. Results Although community-dwelling SZ men had more risk factors for impaired cognition (including first-generation antipsychotics administration and comorbid addictive disorders), women had lower scores on a wide range of cognitive functions, including current and premorbid intellectual functioning, working memory, semantic memory, non-verbal abstract thinking and aspects of visual exploration. However, women scored higher in tests of processing speed and verbal learning, as well as having a lower verbal learning bias. No sex difference were evident for visuospatial learning abilities, cued verbal recall, sustained attention and tests of executive functions, including cognitive flexibility, verbal abstract thinking, verbal fluency and planning abilities. Conclusion Sex differences are evident in the cognitive profiles of SZ patients. The impact on daily functioning and prognosis, as well as longitudinal trajectory, should be further investigated in the FACE-SZ follow-up study. Sex differences in cognition have implications for precision-medicine determined therapeutic strategies. Limits Given the restricted age range of the sample, future research will have to determine cognitive profiles across gender in late onset SZ.
- Published
- 2017
20. Freshwater Crayfish: A Potential Benthic-Zone Indicator of Nanosilver and Ionic Silver Pollution
- Author
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Nhi H. Lam, Seth W. Brittle, Matthew T. Amato, Sesha L. A. Paluri, Ioana E. Sizemore, Daniel P. Foose, Matthew T. Ruis, Zofia E. Gagnon, and Bryan Buttigieg
- Subjects
Gill ,Pollution ,Silver ,media_common.quotation_subject ,Orconectes virilis ,Metal Nanoparticles ,Fresh Water ,02 engineering and technology ,Astacoidea ,010501 environmental sciences ,01 natural sciences ,Silver nanoparticle ,Environmental Chemistry ,Animals ,0105 earth and related environmental sciences ,media_common ,Procambarus clarkii ,biology ,Ecology ,General Chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,Crayfish ,Benthic zone ,Environmental chemistry ,Hepatopancreas ,0210 nano-technology ,Water Pollutants, Chemical - Abstract
Nowadays, silver nanoparticles (AgNPs) are utilized in numerous applications, raising justified concerns about their release into the environment. This study demonstrates the potential to use freshwater crayfish as a benthic-zone indicator of nanosilver and ionic silver pollution. Crayfish were acclimated to 20 L aquaria filled with Hudson River water (HRW) and exposed for 14 days to widely used Creighton AgNPs and Ag(+) at doses of up to 360 μg L(-1) to surpass regulated water concentrations. The uptake and distribution of Ag in over 650 exoskeletons, gills, hepatopancreas and muscles samples were determined by inductively coupled plasma optical emission spectroscopy (ICP-OES) in conjunction with two complementary U.S. EPA-endorsed methods: the external calibration and the standard additions. Reflecting the environmental plasticity of the two investigated species, Orconectes virilis accumulated in a dose-dependent manner more Ag than Procambarus clarkii (on average 31% more Ag). Both species showed DNA damage and severe histological changes in the presence of Ag. However, Ag(+) generally led to higher Ag accumulations (28%) and was more toxic. By the harvest day, about 14 ± 9% of the 360 μg L(-1) of AgNP exposure in the HRW oxidized to Ag(+) and may have contributed to the observed toxicities and bioaccumulations. The hepatopancreas (1.5-17.4 μg of Ag g(-1) of tissue) was identified as the best tissue-indicator of AgNP pollution, while the gills (4.5-22.0 μg g(-1)) and hepatopancreas (2.5-16.7 μg g(-1)) complementarily monitored the presence of Ag(+).
- Published
- 2016
21. Flexible information sampling in vibrational assessment of predation risk by red-eyed treefrog embryos
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Karen M. Warkentin, Michael S. Caldwell, Alison T. D'Amato, Timothy D. Siok, and J. Gregory McDaniel
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Embryo, Nonmammalian ,animal structures ,Physiology ,Hatching ,Ecology ,Sampling (statistics) ,Zoology ,Snakes ,Aquatic Science ,Biology ,Vibration ,Predation ,Escape Reaction ,Insect Science ,embryonic structures ,Red-eyed treefrog ,Animals ,Perception ,Animal Science and Zoology ,Anura ,Cues ,Molecular Biology ,Predator ,Ecology, Evolution, Behavior and Systematics - Abstract
SUMMARYPrey assessing risk may miss cues and fail to defend themselves, or respond unnecessarily to false alarms. Error rates can be ameliorated with more information, but sampling predator cues entails risk. Red-eyed treefrogs have arboreal eggs and aquatic tadpoles. The embryos use vibrations in snake attacks to cue behaviorally mediated premature hatching, and escape, but vibrations from benign sources rarely induce hatching. Missed cues and false alarms are costly; embryos that fail to hatch are eaten and hatching prematurely increases predation by aquatic predators. Embryos use vibration duration and spacing to inform their hatching decision. This information accrues with cycles of vibration, while risk accrues over time as snakes feed. We used vibration playback experiments to test if embryos adjust sampling of information based on its cost, and measured latency to initiate hatching in videotaped snake attacks. Embryos did not initiate hatching immediately in attacks or playbacks, and the delay varied with the rate at which information accrued. Embryos started hatching sooner in response to stimuli with shorter cycles but sampled fewer cycles (less information) of longer-cycle stimuli before hatching. This flexible sampling is consistent with embryos balancing a trade-off between the value and cost of information.
- Published
- 2007
22. Mutational analysis of the inhibin alpha gene in preeclamptic women
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S Boschi, Chiara Benedetto, Stefania Battistini, Luca Marozio, Pasquale Florio, Felice Petraglia, Daniela Grasso, Pasquapina Ciarmela, and T Amato
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Adult ,medicine.medical_specialty ,gene polymorphism ,placenta ,Endocrinology, Diabetes and Metabolism ,DNA Mutational Analysis ,Population ,preeclampsia ,pregnancy ,Biology ,Preeclampsia ,Endocrinology ,Pre-Eclampsia ,Polymorphism (computer science) ,Internal medicine ,Placenta ,medicine ,Humans ,Inhibins ,education ,DNA Primers ,education.field_of_study ,Pregnancy ,Polymorphism, Genetic ,Reverse Transcriptase Polymerase Chain Reaction ,DNA ,medicine.disease ,Exact test ,medicine.anatomical_structure ,Female ,gene polimorphism ,Gene polymorphism ,Restriction fragment length polymorphism ,Polymorphism, Restriction Fragment Length - Abstract
Background: Preeclampsia (PE) is a disorder that occurs in at least 5% of pregnancies and affects both the mother and the unborn baby. A dramatic increase of maternal serum inhibin A concentration in the second and third trimester of pregnancy is a common feature of PE and inhibin A measurement may add significant prognostic information for predicting PE in pregnant women. Design: We evaluated the presence and prevalence of gene polymorphisms for inhibin a subunit (INHα) in patients affected by PE (no.=50; study group), and in the general population (control group composed of 103 women and 42 men). Methods: DNA extraction, single strand conformation polymorphism analysis, DNA sequencing, restriction fragment length polymorphism analysis, and Fisher’s exact test were used. Results: A 769G→A transition was found in INHα1, but not in INHα2 or INHα3 fragment. This variant was found in 10/145 normal controls (7,6%), and in 1/50 preeclamptic patients (2%), without significant difference between the two groups (p=0.29). Conclusions: The prevalence of INHα gene variants is not increased in PE. Due to its frequency, the 769G→A transition may be considered a polymorphism present in the general Italian population.
- Published
- 2005
23. Reversible brainstem dysfunction from spinal arterio-venous fistula
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A. Baig, Y. Joshi, T. Amato-Watkins, Malik Zaben, R. Corkill, and Mark Willis
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Male ,medicine.medical_specialty ,Ataxia ,Fistula ,Arteriovenous fistula ,Myelopathy ,otorhinolaryngologic diseases ,medicine ,Humans ,Diplopia ,Central Nervous System Vascular Malformations ,business.industry ,Angiography, Digital Subtraction ,General Medicine ,Cerebral Arteries ,Middle Aged ,medicine.disease ,Spinal cord ,Pons ,Surgery ,medicine.anatomical_structure ,Spinal Cord ,Arteriovenous Fistula ,Cervical Vertebrae ,Neurology (clinical) ,Brainstem ,medicine.symptom ,business ,Brain Stem - Abstract
A 45-year-old man presented with subacute onset of ataxia, diplopia, urinary retention and paraparesis. MR scan of brain showed abnormal T2 hyperintense signal within the cervical cord, medulla and lower pons and vascular appearances suggesting an arterio-venous fistula. The fistula was surgically explored and successfully disconnected with good clinical outcome. Brainstem or cervical dural arterio-venous fistulae more typically present as a myelopathy; only a handful of cases have presented with brainstem dysfunction. This is a rare but reversible cause of subacute brainstem dysfunction.
- Published
- 2014
24. A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families: further support for a susceptibility locus for schizophrenia at 22q12
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Derek J. Nancarrow, G Kalsi, Dermot Walsh, Hugh Gurling, J Brynjolfsson, Hannes Petursson, Jeremy M. Silverman, Kenneth S. Kendler, Robin M. Murray, T. d'Amato, Lynn R. Goldin, Hiroshi Kunugi, Robert B. Freedman, M. Jay, T. Sigmundson, W. Muri, Wolfgang Maier, William Byerley, J. Mallet, L. Yang, A. E. Pulver, C J MacLean, P. C. Sham, L. He, Raymond R. Crowe, R. E. Straub, Margot Albus, Dominique Campion, Michael John Owen, Richard P. Ebstein, Elliot S. Gershon, H. Donis-Keller, Hans W. Moises, Gerald Nestadt, D. H. R. Blackwood, Haig H. Kazazian, D. StClair, Claudine Laurent, Joachim Hallmayer, Claudia Wiese, D. B. Wildenauer, Stylianos E. Antonarakis, Bryan J. Mowry, Michael Gill, Homero Vallada, David E. Housman, H. Kristbjarnarson, R. Lofthouse, C. M. Read, Shinichiro Nanko, Mihael H. Polymeropoulos, P. McGuffin, Nicholas K. Hayward, H-G Hwu, S. Bodeau-Pean, Manfred Ackenheil, B. Lerer, David A. Collier, Douglas F. Levinson, Hilary Coon, Lynn E. DeLisi, J. H. Zhao, David Curtis, and S. Maguire
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musculoskeletal diseases ,Genetics ,Linkage disequilibrium ,Pedigree chart ,Biology ,Psychiatry and Mental health ,Genetic linkage ,Genotype ,Allele ,skin and connective tissue diseases ,HLA-DRB1 ,Genotyping ,Biological Psychiatry ,Genetic association - Abstract
Patients with schizophrenia rarely develop rheumatoid arthritis, an autoimmune disease that exhibits genetic association with the HLA DRB1*04 gene. We previously investigated the hypothesis that schizophrenia is negatively associated with DRB1*04, and found that only half the expected number of schizophrenic patients had this gene when compared with controls. We now report the results of DRB1*04 genotyping in pedigrees multiply affected with schizophrenia. Polymerase chain reaction amplification and sequence-specific oligonucleotide probes were used to determine the DRB1 genotypes of the 187 members of 23 pedigrees multiply affected with RDC schizophrenia. DQA1, DQB1 and DPB1 genotypes were similarly determined. We analysed data using the extended transmission/disequilibrium test and found a trend for the preferential non-transmission of DRB1*04 alleles from heterozygous parents to their schizophrenic offspring (16 of 23 alleles not transmitted, chi 2 = 3.5, p = 0.06). We found no evidence for a gene of major effect using GENEHUNTER for parametric and non-parametric linkage analysis. The results from this small sample need to be interpreted with caution, but they are in keeping with previous reports and suggest that HLA DRB1*04 alleles may be associated with a reduced risk of schizophrenia.
- Published
- 1998
25. Investigatión cerebral de hermanos sanos de pacientes esquizofrénicos
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A. Mourot, J. Dalery, J. P. Martin, M Marie-Cardine, T. Rochet, T. D'amato, and C. Artéaga
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03 medical and health sciences ,0302 clinical medicine ,030212 general & internal medicine ,030227 psychiatry - Abstract
ResumenLos estudios de tomografía computerizada (TC) han demostrado que el tamaño de los ventrículos laterales medido por la proporción ventrículo-cerebro (PVC), así como la anchura del tercer ventrículo, son estadísticamente mayores en los pacientes esquizofrénicos. Además, estas anomalías cerebrales difieren según los síntomas valorados con una escala de síntomas positivos y negativos. El propósito de este estudio era investigar, utilizando exploraciones de TC, a hermanos sanos de pacientes esquizofrénicos y relacionar los resultados con sus hermanos enfermos. Diecinueve hermanos sanos de 12 esquizofrénicos que habían sido estudiados con anterioridad sufrieron exploraciones de TC, que se compararon con las de su hermano esquizofrénico y con 17 sujetos de control no relacionados. Los resultados mostraron que, en 10 de las 12 familias, los esquizofrénicos tienen ventrículos (laterales y tercero) más grandes que sus hermanos sanos. La dilatatión ventricular de los hermanos sanos estaba correlacionada con la gravedad de los síntomas negativos de su hermano enfermo. Se debaten las implicaciones de una contributión familiar al tamaño ventricular y los síntomas negativos.
- Published
- 1998
26. La estimulación magnética transcraneal repetitiva no potencia el tratamiento antidepresivo
- Author
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Mohamed Saoud, Jerome Brunelin, J. Dalery, Emmanuel Poulet, T. D’Amato, C. Boeuve, and J. Lerond
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business.industry ,Medicine ,business - Abstract
ResumenEn un estudio controlado doblemente ciego, la estimulación magnética transcraneal repetitiva (EMTr) provoca un efecto antidepresivo similar a la EMTr simulada en combinación con paroxetina. Ambos grupos tuvieron el mismo intervalo hasta la mejoría de las puntuaciones de la escala. La EMTr no parece ser eficaz como tratamiento auxiliar a la medicación farmacológica en la depresión mayor no resistente al tratamiento.
- Published
- 2005
27. Evidence for a Pseudoautosomal Locus for Schizophrenia
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T. D'Amato, D. Campion, Ph. Gorwood, M. Jay, O. Sabate, C. Petit, M. Abbar, A. Malafosse, M. Leboyer, D. Hillaire, F. Clerget-Darpoux, J. Feingold, G. Waksman, and J. Mallet
- Subjects
Male ,Psychosis ,Pseudogene ,Pseudoautosomal region ,Locus (genetics) ,Biology ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Genetic linkage ,medicine ,Humans ,030212 general & internal medicine ,Allele ,Alleles ,Genetics ,Sex Chromosomes ,Chromosome Mapping ,medicine.disease ,030227 psychiatry ,Blotting, Southern ,Psychiatry and Mental health ,Schizophrenia ,Susceptibility locus ,Female ,Lod Score ,DNA Probes - Abstract
Because of an association between sexual aneuploidies and schizophrenia, and because schizophrenic siblings have been found to be more often of the same than of the opposite sex, the susceptibility locus for schizophrenia is thought to lie within the pseudoautosomal region of the sex chromosomes. We analysed 33 sibships comprising 18 pairs, 13 trios, and 2 quartets of affected siblings, and found support for non-random segregation of alleles at the DXYS14 locus in affected siblings. These findings are consistent with the pseudoautosomal hypothesis for schizophrenia and favour a genetic linkage between DXYS 14 and the disease.
- Published
- 1992
28. SELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA
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F. Forconi, T. Amato, E. Sozzi, E. Cencini, D. Raspadori, and F. Lauria
- Published
- 2009
29. 178 The Feasibility of Combining Trans-tracheal Catheter Ventilation With Needle-Based Seldinger Cricothyrotomy Into a Single, Sequential Procedure: Can We Decrease Time to Ventilation in Critical Situations?
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Michael Cassara, Andrew E. Sama, T. Amato, Rashmeet Gujral, Mary Frances Ward, J.A. D'Amore, and A. Lomibao
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Catheter ,medicine.medical_specialty ,law ,business.industry ,Anesthesia ,medicine.medical_treatment ,Ventilation (architecture) ,Emergency Medicine ,medicine ,Cricothyrotomy ,business ,law.invention ,Surgery - Published
- 2012
30. Handling Behavior of Racing Karts
- Author
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T. Amato, Massimo Guiggiani, and Francesco Frendo
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Acceleration ,Steady state (electronics) ,Computer science ,Control theory ,Diagram ,Linear model ,Simple linear model ,Differential (mechanical device) ,Function (mathematics) ,Stability (probability) - Abstract
A theoretical analysis of the cornering behaviour of vehicles with locked differential is presented in this paper. In particular, attention is focused on karts, which, being characterised by the lack of any differential and suspension system, show a peculiar dynamic behaviour. A linear model for cornering dynamics is obtained in the first part of the paper: the yaw equilibrium is affected by the absence of the differential, since the longitudinal forces acting on the rear tyres are no longer equal. The steady state behaviour and the handling stability are then investigated using the developed model and discussed in comparison with those of an ordinary vehicle. The understeer gradient is shown to be a function of a steering parameter, such as, for example, the longitudinal speed, in addition to the lateral acceleration; as a consequence, the handling diagram is dependent on the manoeuvres used to obtain it. Even if obtained by means of a simple linear model, these results can give some indications for racing vehicles, such as formula cars, whose differential is frequently completely or partially locked.
- Published
- 2002
31. An integrated approach to dissolved air flotation
- Author
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T, Amato, J K, Edzwald, J E, Tobiason, J, Dahlquist, and T, Hedberg
- Subjects
Solubility ,Water Supply ,Air ,Pilot Projects ,Filtration ,Water Purification - Abstract
DAFRapide techniques utilising reduced flocculation times, of the order of 5 minutes, together with flotation loading rates of up to 40 m/h, can be incorporated with conventional filtration systems operating at up to 20 m/h. Product quality of typically1 NTU and0.1 NTU after flotation and filtration respectively can be achieved.
- Published
- 2001
32. Création d’un support psycho-éducatif d’« entraînement aux habiletés parentales »
- Author
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C. Demily, T. D’Amato, P. Pitoizet, S. Rouvière, B. Masson, N. Elbaz, C. Rodriguez, and E. Tafen
- Subjects
Psychiatry and Mental health - Abstract
Un infirmier de secteur psychiatrique a élaboré en collaboration avec les personnels soignants d’une unité de soins ambulatoires « mère-bébé », un groupe d’entraînement aux « habiletés parentales » (adaptation du jeu « compétences » de J. Favrod) pour 6 à 8 parents souffrant de schizophrénie (DSM-IV). Des « habiletés sociales » aux « habiletés parentales », il n’y a qu’un pas… qui peut être travaillé de manière originale à partir des standards d’un groupe psychoéducatif :– cartes « questions » (apport de connaissances) ;– cartes « situations en jeux de rôle » (développement de savoir-faire) ;– cartes « situations problèmes » (résolution de problème).À partir de situations cliniques repérées comme problématiques, une soixantaine de cartes permettent d’aborder des contenus spécifiques à partir d’un support ludique : exemple : manque figure. Lors des séances hebdomadaires d’1 h 30, les participants sont amenés tour à tour à tirer une carte du jeu dans les 3 catégories concernées. S’ensuit un travail de réflexion individuel puis groupal sur la meilleure façon de répondre à la consigne. À l’issue, le joueur propose une version personnalisée qui sera évaluée à travers un consensus de l’ensemble des participants. Afin de favoriser un climat propice à l’apprentissage, les animateurs exercent l’empathie, l’interactivité, le coétayage groupal et le renforcement positif. Les sessions de 8 séances sont renouvelables sur tacite reconduction.
- Published
- 2013
33. DNA/nuclear protein content in the evaluation of cell cycle modifications during colon carcinogenesis
- Author
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S A, Tripodi, C, Minacci, T, Amato, P, Mangiavacchi, A, Perrone, P, Luzi, and P, Tosi
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Adenoma ,G2 Phase ,Cell Cycle ,G1 Phase ,Mitosis ,Nuclear Proteins ,DNA ,DNA, Neoplasm ,Adenocarcinoma ,Aneuploidy ,Flow Cytometry ,Diploidy ,Resting Phase, Cell Cycle ,Cell Transformation, Neoplastic ,Humans ,Intestinal Mucosa ,Colorectal Neoplasms - Abstract
To investigate the colorectal adenomacarcinoma sequence by biparametric DNA/nuclear protein flow cytometry with the aim of evaluating cell cycle modifications during carcinogenesis.Paraffin-embedded specimens of 27 adenomas with mild/moderate dysplasia, 20 adenomas with severe dysplasia/intramucosal adenocarcinomas, 28 adenocarcinomas and 14 normal colon mucosa specimens were analyzed by biparametric DNA/nuclear protein content flow cytometric analysis in order to evaluate cell cycle modifications during colorectal carcinogenesis.The mean G0-G1A fraction of the cell cycle was 50.6% (SD +/- 17.2), 25.7% (SD +/- 15.1), 27.8% (SD +/- 11.7) and 29% (SD +/- 13.8) for normal mucosa, adenomas with mild/moderate dysplasia, adenomas with severe dysplasia and adenocarcinomas, respectively. The difference between normal mucosa and the other groups was statistically significant (P.05), while no significant differences were detectable between adenomas with different degrees of dysplasia and adenocarcinomas.Our results show a decrease in G0-G1A in adenomas with mild/moderate dysplasia, suggesting that modification of the cell cycle may represent an early step in colon carcinogenesis, and they support the hypothesis that disregulation of cell cycle-controlling genes is an early event in the adenoma-carcinoma sequence.
- Published
- 2000
34. Serological diagnosis of respiratory viral infections. A five-year study of hospitalised patients
- Author
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D, Donati, C, Cellesi, A, Rossolini, V, Lorusso, D, Moschettini, T, Amato, and P E, Valensin
- Subjects
Male ,Adolescent ,Adenoviridae Infections ,Complement Fixation Tests ,Infant ,Respiratory Syncytial Virus Infections ,Antibodies, Viral ,Orthomyxoviridae ,Antibodies, Bacterial ,Adenoviridae ,Mycoplasma pneumoniae ,Parainfluenza Virus 1, Human ,Respiratory Syncytial Viruses ,Orthomyxoviridae Infections ,Neutralization Tests ,Child, Preschool ,Pneumonia, Mycoplasma ,Humans ,Female ,Child ,Fluorescent Antibody Technique, Indirect ,Respiratory Tract Infections - Abstract
The results of a five-year study of paired sera from 410 hospitalised patients-mainly children-with respiratory illness are reported. Samples were divided into groups based on clinical diagnosis. The data of each group were analysed in relation to patient age (under or over 1 year of age). The percentage of positive serological diagnoses ranged from 29.4% in the respiratory viral illness group to 46.2% in the bronchiolitis group. Each group showed a prevalent serological diagnosis. Respiratory viral illness patients over 1 year were diagnosed mainly with Influenza virus infection (73.8% positive diagnosis), pharyngotonsillitis patients with Adenovirus infection (72.2%), laryngitis patients with Parainfluenza virus infection (100%), pneumonia patients with Mycoplasma pneumoniae infection (56.7%), and bronchiolitis patients with Respiratory Syncytial virus infection (100%). The serological diagnosis patterns of each group or subgroup were statistically significant with respect to the other groups (chi 2 or Fisher exact tests). Unlike previous reports, none of the patients under 1 year in our study was diagnosed with Influenza virus infection or Parainfluenza virus type 3. Conversely, Respiratory Syncytial virus infection data were in line with previous reports, being the most frequently diagnosed infection in the bronchiolitis group and in the subgroups of patients under 1 year of age. The present report provides new information on patterns of respiratory infections.
- Published
- 1998
35. 518 – Intermittent theta burst stimulation (iTBS) for the treatment of negative symptoms in schizophrenia
- Author
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C. Damasceno, Emmanuel Poulet, T. D’Amato, Jerome Brunelin, and R. Bation
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Trail Making Test ,Audiology ,Placebo ,medicine.disease ,Transcranial magnetic stimulation ,Psychiatry and Mental health ,Schizophrenia ,medicine ,Memory span ,Psychiatry ,Psychology ,Scale for the Assessment of Negative Symptoms ,Neurocognitive ,Depression (differential diagnoses) - Abstract
Introduction High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) has been shown effective for reducing persistant negative symptoms of schizophrenia. Intermittent theta burst stimulation (iTBS) is a new paradigm of rTMS that allowed more sustained facilitation effect. Aims The aim of this study is to investigate the effect of theta burst in reduction of persistant negative symptoms in schizophrenia. Methods 24 adult schizophrenia outpatients were assigned to receive iTBSat 80% motor threshold, or sham TMS over the left DLPFC, daily; for 20 sessions. The primary outcome measure was the Scale for the Assessment of Negative Symptoms (SANS).score. Secondary outcomes included depression as measured with the Calgary Depression Scale (CDS), and cogntion as assessed with digit span and trail making test. Patients were followed-up 6 months afterwards. Results The primary outcome measure (change in Scale for Assessment of Negative Symptoms score) showed a statistically significant drop at month 1, 3 and 6 for the iTBS group, but not ther placebo groups. Digit span and trail making test score were also significally improved after treatment in iTBS group. Calgary depression scale score did not demontrate any significant change. Conclusions iTBS may serve as a relatively noninvasive treatment of the negative and neurocognitive deficits associated with schizophrenia. ClinicalTrials.gov Identifier: NCT00875498
- Published
- 2013
36. Chronic hypoxia induces adaptive metabolic changes in neonatal myocardium
- Author
-
Mark P. Anstadt, Paul J. Hendry, Mark Plunkett, James D. St. Louis, James E. Lowe, Mary T. Amato, and Enrico M. Camporesi
- Subjects
Pulmonary and Respiratory Medicine ,Adenosine monophosphate ,medicine.medical_specialty ,Swine ,Ischemia ,Ventricular Function, Left ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Energy charge ,Hypoxia ,Glycogen ,business.industry ,Myocardium ,Hypoxia (medical) ,Ischemic Contracture ,medicine.disease ,Myocardial Contraction ,Surgery ,Adenosine diphosphate ,Disease Models, Animal ,Endocrinology ,chemistry ,Animals, Newborn ,Chronic Disease ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Adenosine triphosphate - Abstract
The effect of chronic hypoxia on neonatal myocardial metabolism remains undefined. With a new neonatal piglet model, we determined changes in myocardial metabolism during global ischemia after chronic hypoxia. Five-day-old piglets ( N = 30) were randomly assigned to two groups and exposed to an atmosphere of 8% oxygen or to room air for 28 days before they were killed. Left ventricular myocardium was then analyzed at control and at 15-minute intervals during 60 minutes of global normothermic ischemia to determine high-energy phosphate levels, glycogen stores, and lactate accumulation. Time to peak ischemic myocardial contracture was measured with intramyocardial needle-tipped Millar catheters as a marker of the onset of irreversible ischemic injury. Results showed an initially greater level of myocardial adenosine triphosphate in the hypoxic group (27 ± 1.2 vs 19 ± 1.8 μmol/gm dry wt, p = 0.001) and a delay in adenosine triphosphate depletion during 60 minutes of global ischemia compared with the control group. Initial energy charge ratios ( ½ adenosine diphosphate + adenosine triphosphate/adenosine monophosphate + adenosine diphosphate + adenosine triphosphate) were also greater in the hypoxic group (0.96 ± 0.01 vs 0.81 ± 0.04, p = 0.01) and remained so throughout global ischemia. Initial glycogen stores were greater in the hypoxic group (273 ± 13.3 vs 215 ± 14.7 μmol/gm dry weight, p = 0.02) when compared with the control group. Lactate levels in the hypoxic group were initially higher (19.1 ± 6.4 vs 8.9 ± 3.1 μmol/gm dry weight, p = 0.001) compared with control levels and remained elevated throughout 60 minutes of ischemia. Time to peak ischemic contracture was prolonged in the hypoxic group (69.5 ± 1.8 vs 48.9 ± 1.4 minutes, p = 0.001) compared with the controls group. These data show that chronic hypoxia results in significant myocardial metabolic adaptive changes, which in turn result in an improved tolerance to severe normothermic ischemia. These beneficial effects are associated with elevated baseline glycogen storage levels and an accelerated rate of anaerobic glycolysis during ischemia. (J Thorac Cardiovasc Surg 1996;112:8-13)
- Published
- 1996
37. Improved donor myocardial recovery with a new lazaroid lipid antiperoxidant in the isolated canine heart
- Author
-
P J, Hendry, M P, Anstadt, M D, Plunkett, M T, Amato, J A, Menius, and J E, Lowe
- Subjects
Lipid Peroxides ,Dogs ,Time Factors ,Adenine Nucleotides ,Myocardium ,Animals ,Heart Transplantation ,Heart ,Myocardial Reperfusion Injury ,Organ Preservation ,Cardioplegic Solutions ,Pregnatrienes ,Ventricular Function, Left - Abstract
U74006F is a new 21-amino steroid (lazaroid) that prevents lipid peroxidation without glucocorticoid or mineralocorticoid side effects. Reperfusion injury has been reduced by the addition of various free radical scavengers and antiperoxidants to the reperfusate. To assess the effect of U74006F on reperfusion of donor hearts subjected to prolonged hypothermic ischemia, 21 isolated canine hearts were divided into three groups: control (group 1), drug (2 mg/kg) injected into the oxygenated blood perfusate immediately before 4 hours of preservation (group 2), and drug (2 mg/kg) injected 1 hour before heart isolation and again 15 minutes before reperfusion (group 3). After control left ventricular function studies (with an intraventricular balloon) and biopsy for high-energy phosphates and dry/wet ratios, the hearts were arrested with cold cardioplegia and cooled for 4 hours then reperfused for 3 hours. Left ventricular work was calculated by systolic and diastolic pressure curves, which showed a better return of function in group 3 hearts (1625, 2150, and 3493 mm Hg/ml in groups 1, 2, and 3, respectively, at 180 minutes of reperfusion; p = 0.02). This was likely the result of improved diastolic compliance in group 3. Dry/wet ratios showed increased tissue edema in all hearts at the end of reperfusion. Although high-energy phosphate concentrations were not different between groups, adenosine was best preserved in group 3 (p = 0.03), suggesting reduced washout of this precursor. In conclusion, administration of U74006F before preservation and reperfusion may be useful for donor heart protection.
- Published
- 1992
38. CA 72-4 measurement of tumor-associated glycoprotein 72 (TAG-72) as a serum marker in the management of gastric carcinoma
- Author
-
F, Guadagni, M, Roselli, T, Amato, M, Cosimelli, P, Perri, V, Casale, M, Carlini, E, Santoro, R, Cavaliere, and J W, Greiner
- Subjects
Adult ,Aged, 80 and over ,Male ,Stomach Diseases ,Middle Aged ,Carcinoembryonic Antigen ,Antigens, Neoplasm ,Stomach Neoplasms ,Biomarkers, Tumor ,Humans ,Female ,Longitudinal Studies ,Aged ,Glycoproteins ,Neoplasm Staging - Abstract
The presence of three distinct serum markers of carcinoma, tumor-associated glycoprotein 72 (TAG-72; as measured by the CA 72-4 assay), CA 19-9, and carcinoembryonic antigen (CEA), was evaluated in 194 patients diagnosed with either malignant (n = 94) or benign (n = 100) gastric disease. Of the 94 patients diagnosed with gastric carcinoma, the percentage of patients whose serum samples were positive for TAG-72, CA 19-9, or CEA was 42.6, 31.9, and 20.2%, respectively. Furthermore, fewer false positive samples were observed for TAG-72 than either CA 19-9 or CEA. The analysis of serum TAG-72, CA 19-9, and CEA levels in patients diagnosed with early (stage I and II) versus advanced (stage III and IV) disease revealed a significantly higher level of TAG-72 and CA 19-9 in the serum of patients with advanced stage gastric carcinoma. The serum samples were also analyzed to determine whether any advantage might be gained by simultaneously measuring two or more of the tumor markers. The data clearly indicate that the measurement of TAG-72 with CA 19-9 significantly increased the percentage of gastric carcinoma patients with positive serum levels of either antigen. This advantage was achieved with no significant increase in the number of false positives. Twenty-one patients were followed postsurgically for up to 3 years to determine whether the appearance or reappearance of TAG-72, CA 19-9, or CEA accurately predicted disease recurrence. Positive serum TAG-72 levels correlated with disease recurrence in 7 of 10 patients, compared with 5 and 2 patients for CA 19-9 and CEA, respectively. The findings suggest that serum TAG-72 as measured by the CA 72-4 assay may be a useful marker for late stage gastric carcinoma and its measurement alone or in combination with CA 19-9 may have utility in the clinical management of gastric carcinoma.
- Published
- 1992
39. Erratum to 'the stop null mouse model for schizophrenia displays cognitive and social deficits partly alleviated by neuroleptics'
- Author
-
M. Bégou, J. Volle, J.-B. Bertrand, P. Brun, null Job, A. Schweitzer, M. Saoud, T. D'Amato, A. Andrieux, and M.-F. Suaud-Chagny
- Subjects
General Neuroscience ,Schizophrenia (object-oriented programming) ,Cognition ,Null Mouse ,Psychology ,Neuroscience - Published
- 2009
40. Tumor-associated glycoprotein-72 serum levels complement carcinoembryonic antigen levels in monitoring patients with gastrointestinal carcinoma. A longitudinal study
- Author
-
F, Guadagni, M, Roselli, T, Amato, M, Cosimelli, E, Mannella, P, Perri, M R, Abbolito, R, Cavaliere, D, Colcher, and J W, Greiner
- Subjects
Male ,Radioimmunoassay ,Adenocarcinoma ,Middle Aged ,Carcinoembryonic Antigen ,Antigens, Neoplasm ,Monitoring, Immunologic ,Recurrence ,Stomach Neoplasms ,Biomarkers, Tumor ,Humans ,Female ,Longitudinal Studies ,Colorectal Neoplasms ,Glycoproteins ,Neoplasm Staging - Abstract
Eighty-two patients diagnosed with gastrointestinal (GI) adenocarcinoma were evaluated before and for 26 months after primary tumor resection for the presence of two serum tumor markers: tumor-associated glycoprotein-72 (TAG-72) and carcinoembryonic antigen (CEA). Elevated TAG-72 and CEA serum levels were found preoperatively in 32 (39%) and 34 (41.5%) of the 82 patients, respectively. The percentage of patients with elevated serum levels of either TAG-72 or CEA was 56.1% (46 of 82). Twelve (15%) patients who had normal CEA serum levels had elevated TAG-72 serum levels, and conversely, serum from 14 (17%) patients who were TAG-72 negative were CEA positive. Forty-five of the 82 patients were diagnosed with advanced disease (i.e., Stages C and D for colorectal, Stages III and IV for stomach), and 29 (64.4%) and 26 (57.8%) of those patients had elevated serum levels of TAG-72 or CEA, respectively. Elevated levels of either TAG-72 or CEA, however, were found in sera of 82.2% of patients with advanced GI cancer, which is an increase of 24.4% over the use of CEA antigen alone as a marker of disease. The measurement of both TAG-72 and CEA may improve the diagnosis of patients with GI malignant disease due to the apparent complementary association which exists between these tumor markers. Serum TAG-72 and CEA levels were monitored in 31 patients for varying lengths of time after resection of the carcinoma; 11 patients developed recurrent disease. Sera from nine of 11 (81.8%) of these patients had elevated TAG-72 levels and six of 11 (54.5%) had elevated CEA levels. Tumor marker elevations were observed either before (35 to 166 days) or at the time of diagnosis of recurrence. The elevation of one or both markers correlated with the clinical status in ten of 11 (90.9%) patients with recurrence. In addition, 20 patients who were clinically free of disease after more than 700 days' follow-up had normal serum levels of both TAG-72 and CEA. These findings suggest that the combined use of serum TAG-72 and CEA measurements may improve detection of recurrence in patients with GI cancer and may be useful in the postsurgical management of GI adenocarcinoma patients.
- Published
- 1991
41. Clinical evaluation of the new tumor marker TAG-72
- Author
-
F, Guadagni, M, Roselli, P, Ferroni, T, Amato, D, Colcher, J W, Greiner, and J, Schlom
- Subjects
Antigens, Neoplasm ,Rectal Neoplasms ,Stomach Neoplasms ,Colonic Neoplasms ,Biomarkers, Tumor ,Radioimmunoassay ,Humans ,Longitudinal Studies ,Adenocarcinoma ,Carcinoembryonic Antigen ,Gastrointestinal Neoplasms ,Glycoproteins ,Neoplasm Staging - Abstract
Tumor-associated glycoprotein-72 (TAG-72) is a high molecular weight glycoprotein found in the sera of patients diagnosed with gastrointestinal and other malignancies. TAG-72 was detected in the serum of a significant percentage of patients whose CEA levels were negative which underscores the possibility of exploiting the complementarity of the two tumor markers in the diagnosis of gastrointestinal (G.I.) carcinoma. Moreover, the measurement of TAG-72 may also be clinically useful in discriminating malignant from benign effusions. Serum TAG-72 and CEA levels were evaluated longitudinally in a series of patients following resection of primary G.I. carcinomas. A consistent relationship between efficacy of the surgery and serum TAG-72 clearance was observed, and TAG-72 alone or in combination with CEA accurately predicted recurrence of malignant disease in greater than 90% of the patients. The results indicate that TAG-72 is a new human serum tumor marker which, measured alone or in combination with other well established markers, may improve the diagnosis and/or clinical management of malignant disease.
- Published
- 1991
42. Evaluation of TAG-72 and CEA tumor markers in sera of patients with gastrointestinal adenocarcinomas
- Author
-
F, Guadagni, M, Roselli, T, Amato, M R, Abbolito, M, Cosimelli, E, Mannella, J W, Greiner, and J, Schlom
- Subjects
Male ,Antigens, Neoplasm ,Biomarkers, Tumor ,Humans ,Female ,Longitudinal Studies ,Adenocarcinoma ,Middle Aged ,Carcinoembryonic Antigen ,Follow-Up Studies ,Gastrointestinal Neoplasms ,Glycoproteins - Published
- 1990
43. [A case of inguinal endometriosis secondary to homolateral ovarian endometriosis]
- Author
-
T, D'Amato and G, Mignemi
- Subjects
Adult ,Ovarian Neoplasms ,Lymphatic Metastasis ,Humans ,Inguinal Canal ,Female - Abstract
Following the observation of a case of inguinal endometriosis secondary to homolateral ovarian endometriosi, the paper describes the possibilities of the disease spreading to areas and organs which are unconnected to the pelvis. Published reports by other Authors are cited to support this hypothesis.
- Published
- 1990
44. Characteristics of a new bacteriophage, Psp231a, infecting Pseudomonas phaseolicola HB10Y
- Author
-
T d'Amato, N DeLuca, T Doman, K Vollherbst, W D Taylor, and W Snipes
- Subjects
viruses ,Immunology ,Microbiology ,Bacteriophage ,Viral Proteins ,chemistry.chemical_compound ,Pseudomonas ,Virology ,Centrifugation, Density Gradient ,Bacteriophages ,Gel electrophoresis ,Strain (chemistry) ,biology ,Virion ,Bacteriophage phi 6 ,biology.organism_classification ,Molecular biology ,Molecular Weight ,Sedimentation coefficient ,chemistry ,Insect Science ,DNA, Viral ,Nucleic acid ,Biophysics ,DNA ,Research Article - Abstract
Bacteriophage Psp231a infects Pseudomonas phaseolicola, strain HB10Y, which is the host cell for the enveloped bacteriophage phi 6. This paper describes the biophysical characteristics of Psp231a and the physical properties of its nucleic acid. In electron micrographs the virion appears as an icosahedral structure, approximately 55 nm in diameter, with a short tail. The virion density is 1.48 g/cm3 in CsCl, and the sedimentation coefficient is approximately 407S. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed the presence of 12 polypeptides ranging in molecular weight from 5,000 to 117,000. The nucleic acid of Psp231a is linear, double-stranded DNA of molecular weight 28 X 10(6). Its density in CsCl is 1.716 g/cm3, and its sedimentation coefficient in 3 M CsCl is 20.0S, corresponding to an S020,W of 34S.
- Published
- 1980
45. Shielding effectiveness before and after the effects of environmental stress on metalized plastics
- Author
-
D.J. Mis, B.B. Willard, and T. Amato
- Subjects
Measurement method ,Materials science ,Metal coating ,Enclosure ,chemistry.chemical_element ,engineering.material ,Condensed Matter Physics ,Environmental stress ,Atomic and Molecular Physics, and Optics ,Coating ,chemistry ,Aluminium ,Electromagnetic shielding ,Forensic engineering ,engineering ,Electrical and Electronic Engineering ,Composite material ,Electrical conductor - Abstract
Empirical shielding effectiveness data are discussed. Measurements were made on a number of 2-ft-square metalized plastic test samples before and after exposure to environmental stress. It is concluded that metalized plastic enclosures can never provide the shielding effectiveness of a solid aluminium enclosure. However, if a plastic material is to be used, conductive coatings can provide a limited degree of shielding. If the cost can be justified, zinc arc coating provides the greatest degree of shielding. >
- Published
- 1988
46. [The problem of the diagnosis of adenocarcinoma of the endometrium]
- Author
-
T, D'Amato
- Subjects
Adult ,Risk ,Uterine Neoplasms ,Humans ,Female ,Adenocarcinoma ,Middle Aged ,Aged - Published
- 1985
47. Evaluation of a rapid latex agglutination test for detection of group B streptococci in vaginal specimens
- Author
-
T. Amato, L. Lotz-Nolan, W. Wallen, J. Iltis, and B. Packer
- Subjects
Microbiology (medical) ,Vaginal Smears ,Streptococcus ,business.industry ,General Medicine ,Cervix Uteri ,medicine.disease_cause ,Predictive value ,Group B ,Microbiology ,Latex fixation test ,Serology ,Streptococcus agalactiae ,Carrier rate ,Infectious Diseases ,Predictive Value of Tests ,Direct agglutination test ,Vagina ,medicine ,Humans ,Female ,business ,Latex Fixation Tests - Abstract
A rapid latex agglutination test (Bactigen Group B Streptococcus Cervical Screen) for detection of group B streptococci in cervical-vaginal specimens was evaluated using two different slide systems, the traditional serologic slide and capilliary action track (Trak) slide. Culture was used as reference method. A total of 344 cervical-vaginal specimens were tested. The group B streptococci carrier rate was found by culture to be 10.8 %, 56.8 % of these specimens being heavily colonized. The sensitivity and specificity of the latex agglutination test in heavily colonized specimens was 95.2 % and 99.3 % for the serologic and track slides respectively. The overall sensitivity, including lightly colonized specimens, was 62.2 %. The positive predictive value was 92 % for both slide systems, and the negative predictive value 95.4 % and 95.6 % for the serologic and track slides respectively. The latex agglutination test, used with either slide, provides a rapid and effective method for identification of specimens heavily colonized with group B streptococci. The track slide may provide a convenient alternative to serologic slides since it does not require rotation.
- Published
- 1989
48. [Clinico-surgical considerations on circlage of the uterine cervix in pregnancy]
- Author
-
F, Cappello and T, D'Amato
- Subjects
Pregnancy ,Humans ,Female ,Uterine Cervical Incompetence ,Cervix Uteri - Published
- 1975
49. [Tubal sterilization by vaginal approach]
- Author
-
T, D'Amato
- Subjects
Sterilization, Tubal ,Humans ,Female - Published
- 1987
50. [Colposcopic and colpocytological observations on vesicular mole and chorioepithelioma]
- Author
-
T, D'Amato
- Subjects
Adult ,Vaginal Smears ,Adolescent ,Colposcopy ,Pregnancy ,Uterine Neoplasms ,Humans ,Female ,Choriocarcinoma ,Hydatidiform Mole ,Middle Aged - Published
- 1975
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