1. <scp>l</scp>-Phenylalanine-Imprinted Electrochemical Sensor Based on WS2 Nanoflowers on N,B-Doped Graphene and Its Application to Milk Samples
- Author
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Melike Yıldırım, Ömer Saltuk Bölükbaşı, Zeynep Parlak Özer, İlknur Polat, Necip Atar, Mehmet Lütfi Yola, HKÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Yıldırım, Melike, and Yola, Mehmet Lütfi
- Subjects
Synthesised ,amino acids ,Morphological features ,diagnosis ,Molecularly imprinted ,General Chemical Engineering ,graphene ,electrochemical sensors ,Higher efficiency ,nanoflowers ,amino acid metabolism ,General Chemistry ,Milk sample ,Analytical method ,cyclic voltammetry ,Industrial and Manufacturing Engineering ,Template molecules ,Electrochemical electrodes ,hydrothermal synthesis ,ITS applications ,reusability ,tungsten compounds ,Structural feature - Abstract
Phenylketonuria (PKU) is a critical disease in the disorder of amino acid metabolism, which mostly emerges in children. The most common method used in PKU treatment is the detection of L-phenylalanine (PHEA) as the biomarker of PKU. In the present work, a new molecularly imprinted electrochemical electrode based on WS2 nanoflowers (NFs) on N,B-doped graphene (WS2 NFs/N,B-GR) is presented for PHEA assay in milk samples. First of all, WS2 NFs/N,B-GR was synthesized via a high-efficiency hydrothermal synthesis. Cyclic voltammetry was applied to the electrochemical cell, including PHEA as a template molecule and pyrrole as a monomer, to form PHEA-imprinted electrochemical electrodes. Then, the structural and morphological features of WS2 NFs and WS2 NFs/N,B-GR were investigated in detail by various analytical methods. The limit of quantification and limit of detection values were obtained as 1.0 × 10-11 and 3.0 × 10-12 M, respectively, by a PHEA-imprinted electrochemical electrode. Finally, a PHEA-imprinted electrochemical sensor having a high degree of selectivity, stability, and reusability is presented in the literature for early diagnosis of PKU. © 2022 American Chemical Society. All rights reserved.
- Published
- 2022
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