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This study aims to investigate, the effect of organic loading rates (OLRs), nutrient ratio addition, and sludge retention time (SRT) on treating dairy wastewater in a sequencing batch reactor (SBR) system. This investigation is verified by experiments conducted in 3 phases at 3 different OLRs (1.8, 1.2, and 0.9 kg/m3d, respectively). Urea ((NH2)2CO) is added to make a suitable (COD:N:P) ratio of (100:5:1) in dairy wastewater. The SRT is adjusted from 50 days to an appropriate value of 18 days. The obtained results show that the COD, TN, and TP removal efficiencies are increased with decreasing OLRs. Sludge concentration in the SBR tank is stable at 1100 mg/L after adding (NH2)2CO. In addition, the SBR operated at a suitable SRT (i.e. 18 days) helps the biomass stably, resulting in enhancement of COD, TN, and TP removal. The results are helpful to the design of SBR for treating dairy wastewater.

In this work, ZnFe2O4 nanoparticles were synthesized by hydrothermal method while the hummer method was used to synthesize GO nanosheet. GO/ZnFe2O4 nanocomposites (GO/ZFO) were prepared by mixing of GO with ZnFe2O4 in mass ratio of 1:99, respectively. The structure, morphology, and physical – chemical characteristics were determined by Raman spectroscopy, Transform Electron Microscopy (TEM), and Fourier Transform Infrared Spectroscopy (FT-IR). The CO gas adsorption properties of GO/ZFO were investigated in the range of 25 – 200 ppm at room temperature using quartz crystal microbalance (QCM). GO/ZFO nanocomposites show great adsorption – desorption capacity, high repeatability, and the largest adsorption performance of 1.21‰ (0.098 µg.cm-2 at 200 ppm). The results show that this new approach is promising of spinel structure materials for CO adsorption at room temperature.

PurposeAlthough brand risk management (BRM) is widely acknowledged as critical concern of business leaders, there exists little empirical evidence regarding what activities firms could do to make their brand secured in the increasingly competitive market. Moreover, previous studies find out the important role of innovation stimulus in firm performance, but little attention is paid on how firm's innovation stimulates the firm's brand security. This study aims at exploring the impacts of BRM activities on brand security with the innovation stimulus as a moderator.Design/methodology/approachMixed method is applied in conducting this research. In the qualitative research, an interview with managers of 20 large-size foodstuff companies in Vietnam is conducted to obtain insights into their understanding BRM activities and brand security as well as the role of innovation stimulus in managing brand risk and developing measurements for new constructs. In the quantitative research, a sample of 258 respondents is collected for the tests of reliability and validity as well as all hypotheses using SPSS software.FindingsThe authors’ findings show that the level of implementation of BRM activities influences the brand security with the moderating effect of innovation stimulus. Specifically, four dimensions of BRM activities including: strategy, personnel, processes and investment have direct, positive and significant impact on brand security. Innovation stimulus including innovation in leadership and innovation in knowledge management could serve as a moderating variable.Originality/valueThe findings of the current study have contributed to BRM literature by highlighting the importance of the implementation of BRM activities and the key role of innovation stimulus in ensuring the brand security, on which previous studies have paid little attention. The study suggests some guidance for firms about how to improve the innovation stimulus in enhancing the effectiveness of BRM activities and, as a result, increasing the brand security of the firm.

Can Gio (CG), a mangrove forest with a dense network of tidal creeks, gradually grew and spread seaward on a coastal platform, which was built since about 8 ka before present (BP). Along with this development, a sand ridge began to form and moved back with the shoreline withdrawal landward in the Late Holocene. This mangrove environment is likely abandoned from the mainland but was, however, the place for settlement of ancient Vietnamese a few centuries BC. The CG mangrove forest was severely destroyed during the American War and was restored since 1980. However, the historical change of the landscape along the Saigon-Dong Nai River (SG-DNR) since the Late Holocene is not completely unraveled. By analyzing sediment cores with a multiproxy approach, we investigated the recent geological development with regard to the variation of the intensity of the East Asian palaeomonsoon and regarding the accommodation space, as both regulate the development of this coastal environment. A recently significant shift in the coastline, mainly due to a change of hydroclimatic factors, was observed. A continuous coastline retreat occurred over the last millennium, changing the depositional environment and reshaping the CG mangrove landscape. Along the present coast and tidal channels, partially strong erosion and bank failures occur, alternating with accretion at other coastal sections. This development tends to increase progressively.

Atezolizumab (a PD-L1 inhibitor) has shown remarkable efficacy and tolerability in various cancer types. Despite its efficacy and safety, atezolizumab monotherapy has limitations, such as acquired resistance and adverse events. Bojungikki-tang (BJIKT) is an herbal decoction widely prescribed in Asian countries and used to treat cancer-related symptoms including fatigue, appetite loss, gastrointestinal disorders, and other side effects from cancer therapy. Due to its immunomodulatory effects, Bojungikki-tang has been investigated as a combined treatment with anticancer agents. We evaluated the potential drug-drug interaction (DDI) between Bojungikki-tang and the anti-PD-L1 antibody based on the Food and Drug Administration (FDA) guidelines. In the study, we conducted an in vivo drug-drug interaction study using a syngeneic mouse model of CMT-167 in C57BL/6. We then determined the antibody concentrations to evaluate the pharmacokinetic (PK) drug-drug interaction and measured variable biomarkers related to therapeutic efficacy and immune response. The pharmacodynamic (PD) drug-drug interaction study investigated changes in response between anti-PD-L1 antibody monotherapy and combination therapy. Using the pharmacokinetic and pharmacodynamic data, we conducted a statistical analysis to assess drug-drug interaction potential. In the presence of Bojungikki-tang, the pharmacokinetic characteristics of the anti-PD-L1 antibody were not changed. This study suggested that combination treatment with Bojungikki-tang and atezolizumab is a safe treatment option for non-small cell lung cancer. Clinical studies are warranted to confirm this finding.

Lymnaeid snails are vital in transmitting trematode cercariae as an intermediate host that can infect buffalo and other ruminants and humans, causing significant economic losses. The study aimed to conduct morphological and molecular identification of snails and cercariae collected from the selected buffalo farms under palm oil integration in Perak, Malaysia. A cross-sectional study was conducted, and 35 water were investigated for the presence or absence of snails. A total of 836 lymnaeid snails were collected from three marshes wetlands. To identify the snail family and species, morphological identification was performed on each snail’s shell, and to identify trematode cercariae types; the crushing method was used to observe the cercarial stage inside each snail’s body. In addition, the Internal Transcribed Spacer 2 (ITS2) region and Cytochrome c oxidase subunit 1 (cox1) was used as the target gene to identify the snail species and cercarial types up to the species level. The result showed that the collected snails belong to the family Lymnaeidae and Radix rubiginosa species. The infection rate by cercarial emergence in snails was 8.73%. Five morphological cercarial types were observed which include: echinostome, xiphidiocercariae, gymnocephalous, brevifurcate-apharyngeate distome, and vivax. Using molecular methods, the identified cercariae belong to the three families, including Echinostomatidae, Plagiorchiidae, and Fasciolidae. This is the first report on R. rubiginosa and different types of trematodes cercariae in buffalo farms under palm oil integration in Perak. Our finding confirmed that R. rubiginosa could serve as an intermediate host for a range of parasitic trematodes in Perak.

Background To evaluate the safety and efficacy of autologous bone marrow mononuclear cell (BMMNC) infusion in the management of neurological sequelae in children with spina bifida (SB). Methods BMMNCs were harvested from bilateral anterior iliac crests. Two intrathecal BMMNC administrations were performed with an interval of 6 months. The measurements of outcomes included clinical assessments, cystomanometry and rectomanometry. Results Eleven children with SB underwent autologous BMMNC infusions from 2016 to 2020. There were no severe adverse events during the study period. The number of patients requiring assistance to expel stools decreased from 11 before cell infusion to 3 after the second cell infusion. The number of patients who had urine leakage decreased from 9 patients at baseline to 3 patients after the second BMMNC infusion. The mean bladder capacity increased from 127.7 ± 59.2 ml at baseline to 136.3 ± 54.8 ml at six months and to 158.3 ± 56.2 ml at 12 months after BMMNC infusions. Detrusor pressure (pdet) decreased from 32.4 ± 22.0 cm H2O at baseline to 21.9 ± 11.8 cm H2O after 12 months of follow-up. At baseline, six patients could walk independently. After the 2nd infusion, eight patients could walk independently. Conclusion Intrathecal infusions of autologous bone marrow mononuclear cells are safe and may improve bowel, bladder, and motor function in children with SB. Trial registration: NCT, NCT05472428. Registered July 25, 2022- Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT05472428.

To characterize the cellular stress by n-alkanols with different alkyl chain lengths in Escherichia coli, we investigated how n-alkanols damage cell envelope permeability and whether they enhance the promoter activity of the envelope stress response regulator, σE, by using variants of green fluorescent protein (GFP). By using E. coli cells having GFPuv expressing and localizing in the cytoplasm, the inner membrane, and the periplasm, after exposure to n-alkanols, the fluorescent intensity of GFPuv released from cells was examined. Our data showed that at the similar levels of cell death of about 90–97%, ethanol, a short-chain alkanol, at a concentration of 20% damaged the outer membrane more greatly than the inner membrane, whereas a longer-chain alkanol of pentanol at a concentration of 1.125% damaged both of the outer and inner membranes. Then we investigated the envelope stress response to n-alkanols by σE factor by ratiometric analysis of rpoE promoter activity for the downstream GFPuv expression referenced to that of housekeeping sigma 70 (σ70 ) recognizing lacUV5 promoter for red fluorescent protein (RFP) expression. The results indicated that the relative activity of rpoE promoter by pentanol was much greater than that of ethanol. The degree of its sensitization by rpoE deficiency was much more remarkable for cells treated with pentanol than for those with ethanol. The results suggest that the response of the σE plays a significant role in the membrane integrity and survival of E. coli cells treated with n-alkanols depending on the alkyl chain length of the molecule.

Introduction Because blaCTX-M is responsible for resistance of bacteria to the third generation cephalosporins, location of blaCTX-M could be a good indicator for classifying bacterial isolates harboring blaCTX-M in molecular epidemiology. However, determination of blaCTX-M location has been difficult when multiple copies of ISEcp1 were found on bacterial genome. We aimed to establish a high-throughput analytical method for upstream genetic structures (UGS) of ISEcp1 to facilitate determination of blaCTX-M location. Methods Extracted DNA samples obtained from 168 Escherichia coli isolates possessing blaCTX-M were digested by restriction enzyme, HaeIII, and the digested DNA fragments were ligated with homemade barcode adaptors. Then, DNA fragments containing UGS of ISEcp1 were amplified and subjected to the Nanopore sequencer. Results Nucleotide sequences and locations of 168 UGSs obtained from the examined E. coli isolates were determined. Among the 168 determined UGSs, 150 (89.3%) UGS were confirmed on plasmid and classified into eight types. Interestingly, coding sequence of ISEcp1 transposase gene in seven of the eight types were disrupted by IS26 insertion. The remaining 18 (10.7%) UGSs were observed in identical chromosomal region. The obtained nucleotide sequences the locations of UGSs were confirmed by conventional capillary sequencer and Southern blotting, respectively, and any discrepant result was not observed with these confirmation procedures. Conclusions Our results indicated that the established method was efficient for simultaneously determining at least 100 different UGS, and suggested that the determined UGSs of ISEcp1-blaCTX-M transposition unit was useful for classification of bacterial isolates harboring blaCTX-M.

Background: Evidence on associations between dietary intake and risk of breast cancer subtypes is limited and inconsistent. We evaluated associations of fruit, vegetable, meat, and fish consumption with risk of breast cancer overall and by molecular subtype in the Vietnamese Breast Cancer Study (VBCS). Method: VBCS includes 476 incident breast cancer cases and 454 age-matched controls. Dietary habits over the past 5 years were assessed by in-person interviews using a validated food frequency questionnaire. Associations of food groups with breast cancer were evaluated via logistic regression for overall and molecular subtype with adjustment for age, education, income, family history of cancer, menopausal status, body mass index, exercise, total energy intake, and other potential dietary confounders. Odds ratio (OR) was used to approximate relative risk. Results: High fruit intake was inversely associated with breast cancer risk, with adjusted ORs [95% confidence intervals (CI)] of 0.67 (95% CI, 0.47–0.95) and 0.41 (95% CI, 0.27–0.61) for second and third tertiles versus first tertile, respectively (Ptrend < 0.001). This association was stronger for triple-negative than other subtypes (Pheterogeneity < 0.001). High intake of freshwater fish was inversely associated with overall breast cancer (ORT3vsT1 = 0.63; 95% CI, 0.42–0.95; Ptrend = 0.03). An inverse association was observed between HER2-enriched subtype and red and organ meat intake (ORT3vsT1 = 0.40; 95% CI, 0.17–0.93; Ptrend = 0.04; Pheterogeneity = 0.50). Conclusions: High intakes of fruit and freshwater fish were associated with reduced breast cancer risk; association for the former was stronger for triple-negative subtype. Impact: Our findings suggest high intakes of fruit and freshwater fish may reduce breast cancer risk among Vietnamese women.

Background and objective Particulate matter (PM) is the most dangerous form of air pollution, and causes many diseases. Plants act as bio-filters to help reduce PM in the atmosphere. PM also influences the growth of plants, so selecting suitable plant species for specific environmental conditions is very important. The air pollution tolerance index (APTI) was used to determine the tolerance level of each plant species to air pollution. The purpose of this study was to determine the tolerance to air pollution of various plant species in order to identify plant species that can be grown in polluted environments; this was achieved by evaluating the APTI of plants. This study analyzed the biochemical parameters of 12 plant species at two sites with different air pollution levels (urban forest and roadside) to assess and compare the APTI of plant species. Methods The healthy leaves of 12 plant species (6 broad leaves and 6 needle leaves) that are commonly used in landscapes in Korea were chosen for this study. The same plant species were collected from two sites with different pollution levels and were analyzed immediately; one site was an urban forest (Chungcheongbuk-do Forest Environment Research Institute) with an area of 25 ha and featuring high vegetation coverage, while the other was at a high-traffic roadside next to a crossroads near the Cheongju Express Bus Terminal. We used the leaf samples to analyze four biochemical parameters of each plant: leaf extract pH (pH), relative leaf water content (RWC), total chlorophyll (TChl), and ascorbic acid. Finally, based on these values, APTI values were calculated. Results The APTI values were different between all 12 plant species at both sites with different levels of pollution. APTI had a significant correlation with the biochemical parameters of plants. Plants in the urban forest and at the roadside showed APTI values ranging from 6.89–9.37 and 7.57–9.94, respectively. The APTI of the roadside plant species tended to be higher than that of the plants from the urban forest. Among 12 plant species, Acer palmatum, Acer buergerianum, and Pinus densiflora had high APTI values. These plant species can serve as biofilters in environments with high air pollution. Conclusion The APTI of the 12 plant species in this study can aid in the selection of suitable plant species from environments with different levels of air pollution. The high APTI of some roadside plant species may show their tolerance under environmental pollution-related stress, or demonstrate their adaptability to the polluted environment. In the future, we need to examine more plant species under various environmental conditions to understand their tolerance levels to air pollution and to correlate plants with air pollution. Further, more studies on other air pollutants that can influence plant growth, such as SO2 and NOx, should be conducted.

Bimetallic metal-organic frameworks (MOFs) exhibit outstanding performance in a wide range of applications, including gas catalysis, adsorption, and luminescence sensor. The structure and properties of materials can be designed based on the variation of different metal ions, so this MOFs material system has unique properties. In this study, M/Fe-MOF bimetallic materials (M = Co, Cu, and Mg) were synthesized by solvothermal method and evaluated for photocatalytic activity in the degradation reaction of rhodamine B (RhB) organic pigments. The as-synthesized materials were characterized by using several physicochemical methods such as X-ray diffraction, fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-Vis), Brunauer–Emmett–Teller (BET), scanning electron microscopy (SEM), and UV-Vis diffuse reflectance spectra. The results show that the Co/Fe-MOF, Cu/Fe-MOF, and Mg/MOF materials have uniform grain grade, high crystallinity, with the surface area of 26.1, 25.9, and 25.9 m2/g, respectively. When modified with Co, Cu, and Mg, the crystal structure of Fe-MOF materials was unchanged, and all metal ions are inserted inside the structure of the material, as well as replacing Fe ions in the lattice crystals. At the same time, the modification also increases the light absorption in the visible light region and gives a high photocatalytic degradation of RhB organic pigments under visible light in the range of 85–92%.

California Bearing Ratio (CBR) is an essential parameter utilized to evaluate the strength of the soil subgrades and base course materials of different types of pavements. In this study, the Machine Learning (ML) approach has been adopted using Random Forest (RF) model to estimate the CBR of the soil based on 10 input parameters such as Plasticity Index (PI), Liquid Limit (LL), Silt Clay content (SC), Fine Sand content (FS), Coarse sand content (CS), Optimum Water Content (OWC), Organic content (O), Plastic Limit (PL), Gravel content (G), and Maximum Dry Density (MDD), which can be easily determined in the laboratory. An experimental database was collected from 214 soil samples, which were classified according to AASHTO M 145(clayey, gravel, sand, silty and clayey soils). The data was divided into 70% training and 30% test data in the model study. Model performance was evaluated using standard statistical measures such as coefficient of determination, correlations, and errors (relative error, MAE, and RMSE). Based on the analysis results shows the RF model is capable of correct prediction of the CBR of the Soil.

Background and objective Particulate matter (PM) has a serious impact on health. Recently, studies are conducted to reduce PM in an environmentally friendly way using plants. This study investigated the physiological responses of plants and their ability to remove PM by continuously spraying different PM sources (loam, fly ash, carbon black) to four native plant species, such as Iris sanguinea, Pteris multifida, Vitis coignetiae, and Viburnum odoratissimum var. awabuki. Methods The four plant species were randomly placed in four chambers, and 0.1 g of different PM was injected into each chamber twice a week. We measured chlorophyll, carotenoid, chlorophyll fluorescence (Fv/Fm), total leaf area, amount of leaf wax, PM10 (sPM10) and PM2.5 (sPM2.5) on the leaf surface, and PM10 (wPM10) and PM2.5 (wPM2.5) on the wax layer. Results For I. sanguinea and V. coignetiae, the sources of PM did not affect the growth response. P. multifida showed high chlorophyll a, b, total chlorophyll, and carotenoid content in carbon black as well as high Fv/Fm and total leaf area, thereby proving that carbon black helped plant growth. By PM sources, sPM10 showed a significant difference in three plant species, sPM2.5 in two plant species, and wPM10 in one plant species, indicating that sPM10 was most affected by PM sources. Conclusion Carbon black increased the leaf area by affecting the growth of P. multifida. This plant can be effectively used for PM reduction by increasing the adsorption area. I. sanguinea and V. coignetiae can be used as economical landscaping plants since they can grow regardless of PM sources.

Extended spectrum β-lactamases (ESBL)-producing Escherichia coli have been found in healthy individuals in Indonesia and Vietnam. The ISEcp1-bla CTX-M transposition unit of ESBL-producing bacterial isolates has been considered responsible for the production of CTX-M type ESBL and is important for the dissemination of bla CTX-M . This study aimed to characterize the upstream genetic structure (UGS) of E. coli isolates possessing bla CTX-M-1 group and/or bla CTX-M-9 group genes obtained from healthy individuals in Indonesia and Vietnam. A total of 501 CTX-M type ESBL-producing E. coli isolates possessing bla CTX-M-1 group and/or bla CTX-M-9 group genes were obtained from healthy individuals of the two countries in 2018. UGSs of the ISEcp1-bla CTX-M transposition unit of the 501 ESBL-producing E. coli isolates were amplified by barcode-adaptor-ligation-mediated PCR and analyzed using the Nanopore sequencer. The obtained sequence information was used to classify the UGSs of the ISEcp1-bla CTX-M transposition unit. From the 501 ESBL-producing E. coli isolates, 502 UGSs were obtained, which were classified into 85 UGS types based on the sequence. ISEcp1 of 359 (71.5%) of the 502 UGSs was disrupted by gene insertion, and ISEcp1-bla CTX-M transposition unit of most (87.1%) of the determined UGSs was confirmed as plasmidic. Only 6 (7.1%) of the 85 UGS types were common to both countries. Our results indicated that many different UGSs of ISEcp1-bla CTX-M transposition units were detected in Indonesia and Vietnam; hence, we suggest that structurally different kinds of plasmids harboring bla CTX-M were separately distributed in the two countries. This article is protected by copyright. All rights reserved.

Truc Thanh Thai,1 Thinh Huu Nguyen,2 Phuong Thu Thi Pham,3 Han Hy Thi Bui,4 Tam Ngoc Minh Bui2 1Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 2Training and Scientific Research Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam; 3Hospital for Rehabilitation - Occupational Diseases at Ho Chi Minh City, Ho Chi Minh City, Vietnam; 4Woolcock Institute of Medical Research, Hanoi, VietnamCorrespondence: Truc Thanh ThaiFaculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamTel +84 908 381 266Email thaithanhtruc@ump.edu.vnTam Ngoc Minh BuiTraining and Scientific Research Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamTel +84 906 951 668Email tam.bnm@umc.edu.vnPurpose: Healthcare workers (HCWs) are a crucial resource in the battle against the COVID-19 pandemic but are vulnerable to both SARS-CoV-2 infection and negative psychological consequences. This study evaluated HCWs’ emotions, stressor experiences and coping strategies during the pandemic.Methods: A cross-sectional study was conducted among HCWs at the University Medical Center in Ho Chi Minh City. The questionnaire was adapted from the MERS-CoV Staff Questionnaire to measure HCWs’ emotions, stressor experiences and coping strategies during the COVID-19 pandemic.Results: Among the 1423 participants eligible in the data analysis, the majority were female (71.1%) with a mean age of 34.2 (standard deviation 7.8) years. While most participants reported that they did their job because of their professionalism and duty as HCWs (87.4%), a high number reported feeling nervous and scared (86.0%). Most participants reported worry about transmitting SARS-CoV-2 to their families or friends (76.6%) and concern that a small mistake or lapse in concentration could infect themselves and others (76.7%). The most common coping strategies were following strict personal protective measures (95.3%), avoiding going out (92.5%) and reading about SARS-CoV-2 (92.3%). Females who had a higher educational level and less than 5-years work experience and those who worked at clinical departments and subclinical departments were more vulnerable.Conclusion: This study indicates an urgent need for psychological support for HCWs, especially for those at high risk of having stress. Interventions and support should utilize psychological resources and approaches effectively to adapt to the new situation during the COVID-19 pandemic.Keywords: stressor experience, coping strategy, motivational factors, health care worker, COVID-19

The selenium-binding protein 1 (SELENBP1) has been reported to be up-regulated in the prefrontal cortex (PFC) of schizophrenia patients in postmortem reports. However, no causative link between SELENBP1 and schizophrenia has yet been established. Here, we provide evidence linking the upregulation of SELENBP1 in the PFC of mice with the negative symptoms of schizophrenia. We verified the levels of SELENBP1 transcripts in postmortem PFC brain tissues from patients with schizophrenia and matched healthy controls. We also generated transgenic mice expressing human SELENBP1 (hSELENBP1 Tg) and examined their neuropathological features, intrinsic firing properties of PFC 2/3-layer pyramidal neurons, and frontal cortex (FC) electroencephalographic (EEG) responses to auditory stimuli. Schizophrenia-like behaviors in hSELENBP1 Tg mice and mice expressing Selenbp1 in the FC were assessed. SELENBP1 transcript levels were higher in the brains of patients with schizophrenia than in those of matched healthy controls. The hSELENBP1 Tg mice displayed negative endophenotype behaviors, including heterotopias- and ectopias-like anatomical deformities in upper-layer cortical neurons and social withdrawal, deficits in nesting, and anhedonia-like behavior. Additionally, hSELENBP1 Tg mice exhibited reduced excitabilities of PFC 2/3-layer pyramidal neurons and abnormalities in EEG biomarkers observed in schizophrenia. Furthermore, mice overexpressing Selenbp1 in FC showed deficits in sociability. These results suggest that upregulation of SELENBP1 in the PFC causes asociality, a negative symptom of schizophrenia.

Psoriasis (PsO), an immune-mediated inflammatory skin disorder, has substantial negative impact on patients' quality of life. Secukinumab, an approved treatment for moderate-to-severe plaque PsO, has an established long-term efficacy and safety profile. This study aims to provide real-world evidence of long-term effectiveness and retention rate of secukinumab in Vietnamese patients with PsO.This retrospective, observational study collected medical records of adult patients with moderate-to-severe PsO receiving secukinumab treatment from Ho Chi Minh City Hospital of Dermato-Venereology. The primary objective was to evaluate secukinumab effectiveness in PsO as measured by 75% improvement in psoriasis area and severity index (PASI 75) at month 12. Secondary objectives were PASI 90/100, absolute PASI ≤ 3 and ≤ 5, Dermatology Life Quality Index (DLQI), and retention rate over 48 months.In total, 232 patients with moderate-to-severe PsO met inclusion criteria; 68.1% were male, with median age and age of onset of 39 and 27.5 years, respectively. Median time from onset of PsO to secukinumab treatment was 120 months, 95.3% were prior biologics/disease-modifying antirheumatic drugs naive and 41.4% received concomitant therapies for PsO; 82.3% had national insurance coverage. At month 12, 93.9% of patients achieved PASI 75 (primary endpoint); 80.2/56.9% achieved PASI 90/100; 91.4 and 84.8% patients achieved absolute PASI ≤ 5 and ≤ 3, respectively. The response was sustained over 48 months, with 91.9%/78.0%/52.0% of patients achieving PASI 75/90/100, 89.5% and 82.1% patients achieving absolute PASI ≤ 5 and ≤ 3, respectively. At month 12, 61.4% of patients achieved DLQI 0/1 which was sustained up to month 48 (69.2%). Secukinumab adherence rate of 84.9% at month 12 dropped to 34.2% at month 48. Patients receiving concomitant therapy and national insurance showed higher adherence rate.Secukinumab demonstrated long-term effectiveness in real-world Vietnamese patients with moderate-to-severe PsO, with treatment adherence being higher in patients having concomitant therapies and national insurance.

Cutaneous ichthyosis (CI) is a collective group of monogenetic disorders of cornification demonstrating epidermal scaling, fissuring, chronic skin inflammation, and increased susceptibility to infection. In healthy individuals the skin microbiome limits growth of pathogenic organisms; however, the microbiome signature in CI is poorly characterized. To rectify this, we investigated the microbiome signature across 7 subtypes of CI in 43 individuals of Southeast Asian ethnicity, of which exome sequencing revealed 20 novel and 31 recurrent pathogenic variants. Microbiome meta-analysis revealed distinct microbial populations, reduced commensal microbiota, and higher colonization by pathogenic species. This correlated with increased production of inflammatory cytokines, including Th17 and JAK/STAT signaling, in peripheral blood mononuclear cells. Moreover, we identified microbiota and inflammation alterations in wounds of CI patients responsible for impaired wound healing. Together, this research enhances our understanding of the microbiological, immunological, and molecular properties of CI patients and provides critical information for improving therapeutic management.

Background: Although men have a higher rate of stroke than women, it is not clear whether women have a worse outcome after adjusting for confounders such as vascular risk factors, age, stroke severity, and reperfusion therapy. We evaluated sex differences on 90-day functional outcomes after stroke in a multicenter study in Vietnam. Methods: We recruited patients presenting with ischemic or hemorrhagic stroke at 10 stroke centers in Vietnam for a period of 1 month from August 1, 2022, to August 31, 2022. We reviewed the patient’s clinical demographics, time from symptom onset to hospital admission, stroke classification, stroke subtype, stroke severity, characteristics of reperfusion therapy, and 90-day clinical outcome. We compared functional outcomes and predisposing factors at day 90 between men and women after an ischemic and hemorrhagic stroke. Poor outcome was defined as mRS 3-6. Results: There were 2,300 stroke patients included. Men accounted for 61.3% (1,410) of participants. Compared with men, women were older (67.7±13.9 vs. 63.7±13.3, P There was no difference in 90-day functional outcomes between sexes. Factors associated with poor outcomes included age ≥ 50 years (adjusted OR, aOR 1.75; 95% CI, 1.16 to 2.66), history of stroke (aOR 1.50; 95% CI, 1.15 to 1.96), large artery atherosclerosis (aOR 5.19; 95% CI, 3.90 to 6.90), and cardioembolism (aOR 3.21; 95% CI, 1.68 to 6.16). Factors associated with mortality in patients with acute ischemic stroke included a history of coronary artery disease (aOR 3.04; 95% CI, 1.03 to 8.92), large artery atherosclerosis (aOR 3.37; 95% CI, 2.11 to 5.37), and cardioembolism (aOR 3.15; 95%CI, 1.20 to 8.27). Conclusion: There were no sex differences in the clinical outcome of stroke and ischemic stroke in this prospective cohort of hospitalized Vietnamese patients

Particulate matter (PM) is the most dangerous air pollutant that adversely affects health. Increasing PM in urban areas is a big problem that must be solved. This study analyzed the amount of PM that accumulated on plant leaves, as well as the leaf traits that contribute to PM accumulation, to determine the plant’s ability to accumulate PM and the impact of PM on the plants. Scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis were used to quantitatively assess metal concentrations in the particles that had accumulated on the leaf samples. Eight common plant species that grow on the roadside were used to analyze leaf traits using leaf samples. Specific leaf areas (SLA), leaf extract pH (pH), relative leaf water content (RWC), chlorophyll (Chl), and carotenoids were analyzed. PM accumulation and leaf traits varied among plant species, and Parthenocissus tricuspidata showed the highest PM accumulation on its leaf surface. The leaf’s elemental composition included C, O, Ca, K, Mg, S, P, Al, Si, Na, Cl, and Fe. Among these elements, Ca, K, and Cl made up a relatively large percentage. Fe was only detected in the leaves of Pachysandra terminalis and P. tricuspidata, while C and O were excluded as they are not relevant in determining PM metal content. Plants not only accumulate PM but also heavy metals from the atmosphere. This study found that plants with highly effective PM accumulation, such as P. tricuspidate, should be considered for optimizing the benefits of plants in improving air quality.

Introduction: Insomnia is a common disease in all societies and age groups. Among them, medical students are one of the population most susceptible to sleep problems. Studies from many countries have shown high prevalence of insomnia among medical students. Sleep diary is the gold standard for evaluating subjective insomnia and other sleep disorders. This research aims to study the prevalence of insomnia in Vietnamese medical students, associated factors, and their sleep patterns. Method: In a cross-sectional survey using stratified random sampling, a total of 176 medical students was recruited, each completed a self-administered questionnaire and a 7-consecutive-day sleep diary. Demographic data and lifestyle factors were obtained from the questionnaire, while sleep patterns and quality were collected from the sleep diary. We performed data analysis using SPSS ver 22, p

We present a generalized three-variable high order shear deformation theory (THSDT) using isogeometric analysis (IGA) to analyze free vibration of functionally graded porous (FGP) plates reinforced by graphene platelets (GPLs) in this work. It is named as FGP-GPLs for a short. The proposed theory only has got three degrees of freedom (DOFs) per node as the same way of numerically solutions in three-dimensional (3D) solids. THSDT fulfills the classical plate theory (CPT), the first-order shear deformation theory (FSDT) and even the higher-order shear deformation theory (HSDT). IGA is chosen to analyze because of its noteworthy advantages in numerical computational sides of plate problems. In addition, the displacement field of THSDT needs the high continuity in approximated formulation with high-order derivatives for a weak form of fourth order equation. According to IGA formulation based on the generalized THSDT, the shear locking phenomenon is free. The variables of THSDT are less than HSDTs which contain five DOFs per node. The influences of weight fractions, the coefficient porosity, dispersion patterns of GPLs and distribution types of porosity on structure’s natural frequencies are studied through some numerical examples. In order to prove the reliability and accuracy of present method, the numerical results are compared to available published works. Keywords: FG-porous plate; graphene platelet reinforcements; three-variable high order shear deformation theory (THSDT); isogeometric analysis; free vibration.

The occurrence and characterization of marine debris on beaches bring opportunities to track back the anthropogenic activities around shorelines as well as aid in waste management and control. In this study, the three largest beaches in Thanh Hoa (Vietnam) were examined for plastic waste, including macroplastics (≥ 5 mm) on sandy beaches and microplastics (MPs) ( 5 mm) in surface water. Among 3803 items collected on the beaches, plastic waste accounted for more than 98%. The majority of the plastic wastes found on these beaches were derived from fishing boats and food preservation foam packaging. The FT-IR data indicated that the macroplastics comprised 77% polystyrene, 17% polypropylene, and 6% high-density polyethylene, while MPs discovered in surface water included other forms of plastics such as polyethylene- acrylate, styrene/butadiene rubber gasket, ethylene/propylene copolymer, and zein purified. FT-IR data demonstrated that MPs might also be originated from automobile tire wear, the air, and skincare products, besides being degraded from macroplastics. The highest abundance of MPs was 44.1 items/m

To date, little are known about HIV-related stigma, symptoms of depression (SOD) and suicidal ideation among people living with HIV (PLHIV) in Vietnam. This study aimed to estimate the level of stigma, SOD and suicidal ideation and to explore the direction and magnitude of the relationship between stigma, SOD and suicidal ideation among Vietnamese PLHIV. A cross-sectional study was conducted in four outpatient clinics providing healthcare services including antiretroviral therapy (ART) for PLHIV in Ho Chi Minh City. At each clinic, patients were chosen using the systematic sampling technique. Participants underwent face-to-face interviews through a pre-defined structural questionnaire that included validated scales. Among 777 PLHIV in the analysis, most were male (81.1%) and the average age was 34.3 (SD = 8.8) years. Two-thirds of PLHIV had a moderate-to-high level of HIV stigma. Symptoms of depression were identified in 41.4% of PLHIV. Suicidal ideation was reported by 26.3% of PLHIV. Based on univariate and multivariate logistic regression, higher levels of SOD and HIV stigma were positively associated with suicidal ideation. For PLHIV with extreme stigma and SOD, the probability of having suicidal ideation was up to 80%. The prevalence and association found in this study indicates that interventions for SOD and stigma not only help reduce these two problems but also help address and minimize suicidal ideation in this vulnerable population. In Vietnam, to optimize such interventions, the involvement of families and communities is crucial.

The authors have requested that this preprint be removed from Research Square.

Foodborne zoonotic trematode (FZT) infections are common neglected tropical diseases in Southeast Asia. Their complicated life cycles involve freshwater snails as intermediate hosts. A cross-sectional study was conducted in Yen Bai and Thanh Hoa provinces in North and Central Vietnam, to investigate the diversity of cercariae of potential FZT and to construct the phylogenetic relationship of trematode cercariae based on the Internal Transcribed Spacer 2 (ITS2) region. Among 17 snail species collected from various habitats, 13 were infected by 10 cercarial groups among which parapleurolophocercous, pleurolophocercous, and echinostome cercariae were of zoonotic importance. The monophyletic tree separated cercarial sequences into different groups following the description of the cercariae families in which Haplorchidae, Opisthorchiidae, Echinochasmidae, and Echinostomatidae are important families of FZT. The overall prevalence was different among snail species and habitats and showed a seasonal trend. Parapleurolophocercous and echinostome cercariae emerged as the most common cercariae in snails in Yen Bai, while monostome, echinostome, and megalura cercariae were most common in Thanh Hoa. Using a molecular approach, we identified Parafossarulus striatulus as the first intermediate snail host of Clonorchis sinensis in Thac Ba Lake. Melanoides tuberculata and Bithynia fuchsiana were we identified preferred intermediate snail hosts of a diverse range of trematode species including intestinal flukes (i.e., Haplorchis pumilio and Echinochasmus japonicus) in Yen Bai and Thanh Hoa, respectively.

Hydrogen generation during wastewater treatment has remained a long-standing challenge for the environment preservation welfare. In the present work, we have fabricated a promising bifunctional thin film-based catalyst for hydrogen generation with concurrent wastewater treatment. The prepared catalyst film is a vertically oriented thin SnS (tin monosulfide) nanosheet array on a Ni-foam (SnS/NF) obtained via a solution process, demonstrating a promising electrocatalytic activity towards the generation of green H2 fuel at the cathodic side and the decomposition of urea waste at the anodic side. Notably, while assembling two identical electrodes as cathode and anode together with a reference electrode (i.e., SnS/NF∥SnS/NF vs. RHE assembly) in 1 M KOH aqueous electrolyte containing 0.33 M urea, the electrolyzer electrolyzed urea at a lower cell potential of 1.37 and 1.43 V (vs. RHE) to deliver a current density of 10 mA cm−2 and 50 mA cm−2, respectively, for the decomposition of urea at the anodic SnS/NF electrode and green hydrogen fuel generation at the cathodic SnS/NF electrode. This activity on electrocatalytic urea decomposition lies within the best performance to those of the previously reported sulfide-based and other catalytic materials. The promising catalytic activities of the SnS catalyst film are attributed to its combined effect of self-standing nanosheet array morphology and high crystallinity, which provides abundant active sites and a facile charge transfer path between the nanosheet arrays and the electrolyte. Thus, the present work offers a green avenue to the waste-urea treatment in water and sustainable hydrogen energy production.

Appraisal theory (Martin and White 2005), an approach to discourse analysis dealing with evaluative language, has been previously employed in analysing newspaper articles and spoken discourses in several earlier studies, although it is gaining in popularity as a framework for comparing first and second (L1/L2) writing. This study investigated 40 English majors’ Vietnamese and English paragraphs for evaluative language, a key component of successful academic writing, as realised under Appraisal theory. To this purpose, we collected L1 Vietnamese and L2 English data from the same student writers across the same topics and using a corpus-informed Contrastive Interlanguage Analysis approach to the annotation and analysis of appraisal. A range of commonalities were present in the use of appraisal across the two language varieties, while the results also suggest significant differences between students’ evaluative expressions in Vietnamese as a mother tongue and English as a second or foreign language. This variation includes the comparative under- and over-use of specific appraisal resources employed in L1 and L2 writing respectively, in particular, regarding writers’ employment of attitudinal features. The findings serve to inform future pedagogical applications regarding explicit instruction in stance and appraisal features for novice L2 English writers in Vietnam.

In Vietnamese high schools, learning in general and self-study in particular plays a very important role in helping learners to deeply understand, expand, consolidate and memorise lessons profoundly thanks to the ability to self-analyze, synthesize and apply existing knowledge in solving new learning tasks. The article presents some issues on guided self-studying and the method to facilitate students with math instructions at high school. To organize the implementation of guided self-studying for students effectively, teachers are required to invest considerable time as well as flexibility in the design of instructional guides to help them access the question the fastest and most suitable way to their capabilities.

Prior studies on chief executive officer (CEO) compensation focus mainly on large firms. This paper aims to suggest new factors associated with CEO compensation for small, homogeneous firms, specifically, Australian early‐stage mining exploration entities (MEEs). We document a set of predictors of CEO compensation proxying for economic performance, including geological prospectivity components of the exploration and evaluation (E&E) asset account and proceeds from equity raisings that enhances survival probabilities. We find positive associations between these predictors and CEO remuneration. In terms of CEO pay mix, we find that E&E asset acquisitions and equity proceeds are both positively associated with the proportion of option value in CEO total compensation. This suggests MEEs allocate their cash resources to investment opportunities, rather than CEO compensation. Overall, these findings, coupled with a significant and positive pay‐performance relation, provide evidence supporting efficient compensation practices in the MEE context.

The article points out the shortcomings in the labor arrangement at the 11th long wall. The analysis results have shown: (i) The actual number of employees assigned to use is often much higher than expected. It is because Ha Lam Coal Joint Stock Company only designs for good conditions, but actually, the company faces many obstacles due to the characteristic production conditions; (ii) the actual productivity is much lower than the designed labor productivity because the calculation of the number of employees is not consistent with the production conditions of the long wall; at the same time, the number of manual workers for ancillary work is too much arranged according to actual needs; (iii) The current level of direct labor productivity at the 11th long wall is still low compared to the actual capacity, not motivating workers to increase labor productivity. The solutions to overcome the problems are (i) Complete the calculation of the number of employees considering the specific production conditions and the number of auxiliary workers; (ii)Re-arrange labor in manual auxiliary production to reduce labours; (iii) Recalculate the direct labor productivity assigned to the 11th long wall. With these solutions, the company will increase the initiative in production, improve labor productivity and lower product costs.