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2. Classification of osteosarcoma by 85-Sr scintimetry

Author

Thiery Jp, Gongora G, Gongora R, B. Perdereau, and Mazabraud A

Subjects
Adult, Male, musculoskeletal diseases, Osteosarcoma, Pathology, medicine.medical_specialty, Adolescent, business.industry, Low activity, Middle Aged, medicine.disease, Radiography, Osteoid Formation, Strontium Radioisotopes, Histologic type, Humans, Scintillation Counting, Medicine, Female, Orthopedics and Sports Medicine, Surgery, Biopsy material, Child, business
Abstract

The histologic type of a classical osteosarcoma may be difficult to determine because of insufficient biopsy material and polymorphism of the tumour. Since osteoformation is directly related to the differentiation and functional capacity of the tumour cells, 85-Sr scintimetry was used to evaluate osteoid formation in 90 patients with classical osteosarcoma. Measurements over an 8-day period from isotope injection revealed a separation of the lesions into three groups, with high, medium and low activity. Compared to histologic classification into osteoblastic, chondroblastic/fibroblastic, and anaplastic variants, scintimetry revealed that only half of the 41 tumours classified as osteoblastic had a high 85-Sr uptake. The anaplastic lesions belonged to the group with low 85-Sr uptake. Scintimetric determination of the functional differentiation of tumoral cells may possibly be of prognostic value in osteosarcoma.

Published
1986
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3. The first World Cell Race

Author

Maiuri, Paolo, Terriac, Emmanuel, Paul-Gilloteaux, Perrine, Vignaud, Timothée, Mcnally, Krista, Onuffer, James, Thorn, Kurt, Nguyen, Phuong A, Georgoulia, Nefeli, Soong, Daniel, Jayo, Asier, Beil, Nina, Beneke, Jürgen, Hong Lim, Joleen Chooi, Pei-Ying Sim, Chloe, Chu, Yeh-Shiu, Renseigné, Non, Jiménez-Dalmaroni, Andrea, Joanny, Jean-François, Thiery, Jean-Paul, Erfle, Holger, Parsons, Maddy, Mitchison, Timothy J, Lim, Wendell A, Lennon-Duménil, Ana-Maria, Piel, Matthieu, Théry, Manuel, Compartimentation et dynamique cellulaires (CDC), Centre National de la Recherche Scientifique (CNRS)-Institut Curie-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de physiologie cellulaire végétale (LPCV), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Department of Cellular and Molecular Pharmacology (UCSF), UCSF, Harvard Medical School [Boston] (HMS), King‘s College London, BioQuant, Heidelberg University, Institute of Molecular and Cell Biology, Proteos, Physico-Chimie-Curie (PCC), Institut Curie, Fellowship from the Fondation pour la Recherche Médicale, Royal Society University Research Fellowship, CellNetworks- Cluster of Excellence (EXC81), NIH (PN2EY016546, GM23928), INCA (PLBIO-2011-141), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Curie [Paris], Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC), Maiuri, P, Terriac, E, Paul-Gilloteaux, P, Vignaud, T, Mcnally, K, Onuffer, J, Thorn, K, Nguyen, Pa, Georgoulia, N, Soong, D, Jayo, A, Beil, N, Beneke, J, Lim, Jch, Sim, Cpy, Chu, Y, Jimenez-Dalmaroni, A, Joanny, Jf, Thiery, Jp, Erfle, H, Parsons, M, Mitchison, Tj, Lim, Wa, Lennon-Dumenil, Am, Piel, M, and Thery, M

Subjects
Cell type, Cell, Morphogenesis, Motility, 02 engineering and technology, large scale analysis, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, cell motility, General Biochemistry, Genetics and Molecular Biology, Article, Race (biology), 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, Cell Movement, medicine, Animals, Humans, rat, human, mouse, Cells, Cultured, 030304 developmental biology, 0303 health sciences, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Gender studies, Cell migration, 021001 nanoscience & nanotechnology, In vitro, Cell biology, Rats, medicine.anatomical_structure, Cancer cell, Current (fluid), First World, 0210 nano-technology, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery
Abstract

In Authors: WCR participants World Wide, listed in Supplemental Information; International audience; Motility is a common property of animal cells. Cell motility is required for embryogenesis [1], tissue morphogenesis [2] and the immune response [3] but is also involved in disease processes, such as metastasis of cancer cells [4]. Analysis of cell migration in native tissue in vivo has yet to be fully explored, but motility can be relatively easily studied in vitro in isolated cells. Recent evidence suggests that cells plated in vitro on thin lines of adhesive proteins printed onto culture dishes can recapitulate many features of in vivo migration on collagen fibers [5,6]. However, even with controlled in vitro measurements, the characteristics of motility are diverse and are dependent on the cell type, origin and external cues. One objective of the first World Cell Race was to perform a large-scale comparison of motility across many different adherent cell types under standardized conditions. To achieve a diverse selection, we enlisted the help of many international laboratories, who submitted cells for analysis. The large-scale analysis, made feasible by this competition-oriented collaboration, demonstrated that higher cell speed correlates with the persistence of movement in the same direction irrespective of cell origin.

Published
2012
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10. [Tuberculin allergy induced in bovines by injection of tubercle bacilli rendered avirulent by formol and heat and suspended in aluminum hydroxide; consequences].

Author

ROMAN G, DEBRE R, RICHOU R, COSTIL L, THIERY JP, and GERBEAUX C

Subjects
Animals, Cattle, Aluminum Hydroxide, Anti-Bacterial Agents pharmacology, Antibiotics, Antitubercular, Bacillus, Formaldehyde, Gram-Positive Bacteria, Hot Temperature, Hypersensitivity, Lacticaseibacillus casei, Mycobacterium tuberculosis, Tuberculin
Published
1951

12. [Equine infectious anemia].

Author

THIERY JP and LUCAS A

Subjects
Animals, Horses, Anemia, Equine Infectious Anemia
Published
1950

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