1. Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)
- Author
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Devin Binder, Danielle Ornelas, Melissa M. Eberle, Oscar C. González, Timothy L. Myers, B. Hyle Park, Md. Hasan, Koji Hirota, Maksim Bazhenov, and Jenny I. Szu
- Subjects
genetic structures ,medicine.diagnostic_test ,business.industry ,Attenuation ,eye diseases ,Diffuse optical imaging ,Electrophysiology ,Optics ,Optical coherence tomography ,In vivo ,medicine ,sense organs ,business ,Functional magnetic resonance imaging ,Preclinical imaging ,Ex vivo ,Biomedical engineering - Abstract
Optical coherence tomography (OCT) is a label-free, high resolution, and minimally invasive imaging technique that can produce depth-resolved cross-sectional and 3D images. We sought to examine non-vascular depth-dependent optical changes directly related to neural activity in the brain using OCT. Results of this study show a significant temporal correlation between non-vascular decrease in attenuation in ex vivo and in vivo seizure models and increased electrical activity during seizure. This study allows for a more thorough and biologically relevant analysis of the optical signature of seizure activity ex vivo and in vivo using OCT.
- Published
- 2020