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Purpose. To investigate the physical and mechanical properties of a granite outcrop for a quarry at Onikoko community in Oyo State, South-Western Nigeria. Methods. Samples of granite rock were collected from the outcrop for the laboratory determination of their physical and mechanical properties required for determining its suitability for construction and engineering purposes, and the desired properties were determined. Findings. Results from the tests conducted on the granite samples indicated the various values of physical and mechanical properties of the outcrop in the study area. The results obtained are found to be within the acceptable international standards. Hence, the granite outcrop is found to be suitable for establishing a quarry in the study area based on the results obtained. Originality.The results in this study have affirmed the fact that granite rocks must possess adequate physical and mechanical characteristics to make them suitable for construction and engineering purposes. The physico-mechanical properties of the granite outcrop evaluated in this study having their values within the international standards attest to high strength cha-racterization of the granite rock. The life span of the proposed quarry is established to be forty years, which is also an indication of rich mineralization of the area. Practical implications. Results of this study can be a useful source of information to potential investors and policy makers for the establishment of a quarry in the study area. Hence, government’s attention can be drawn to the needs of the host community for the provision of basic infrastructures. Keywords: granite outcrop, physical and mechanical properties, quarrying operation

Background/objective Sickle cell disease (SCD) is a monogenic disease with multiple phenotypic expressions. Previous studies describing SCD clinical phenotypes in Nigeria were localized, with limited data, hence the need to understand how SCD varies across Nigeria. Method The Sickle Pan African Research Consortium (SPARCO) with a hub in Tanzania and collaborative sites in Tanzania, Ghana and Nigeria, is establishing a single patient-consented electronic database with a target of 13,000 SCD patients. In collaboration with the Sickle Cell Support Society of Nigeria, 20 hospitals, with paediatric and adult SCD clinics, are participating in patient recruitment. Demographic and clinical information, collected with uniform case report forms, were entered into Excel spreadsheets and uploaded into Research Electronic Data Capture software by trained data clerks and frequency tables generated. Result Data were available on 3622 patients enrolled in the database, comprising 1889 (52.9%) females and 1434 (39.6%) children ≤15 years. The frequencies of Hb SS, Hb SC and Hb Sβ thalassemia in this data set were 97.5%, 2.5% and 0% respectively. Sixty percent, 23.8%, 5.9%, 4.8% and 2.5% have had bone pain crisis, dactylitis, acute chest syndrome, priapism and stroke respectively. The most frequent chronic complications were: leg ulcers (6.5%), avascular necrosis of bone (6.0%), renal (6.3%) and pulmonary hypertension (1.1%). Only 13.2% had been hospitalized while 67.5% had received blood transfusion. Conclusion These data on the spectrum of clinical phenotypes of SCD are useful for planning, improving the management of SCD across Nigeria and provide a foundation for genomic research on SCD.

Transcranial Doppler ultrasonography (TCD) measures blood flow velocities in the large cerebral vessels and thus, detects the risk of stroke. This report describes a capacity building program which enabled the use of TCD for detecting stroke risk and also describes the pattern of non-imaging TCD examinations seen in Nigerian children with sickle cell anaemia (SCA).Ten university graduates were trained on the use of TCD in a 5-day capacity building workshop after which, the three best candidates were employed to provide a 5-day a week TCD screening service in Lagos. Data from TCD examination collected between March 2011 and September 2013 were analysed and reported.Between March 2011 and September 2013, 2,331 children with SCA aged 2-16 years had TCD studies. TCD's findings were classified as normal (standard risk) in 70.4%, conditional in 19% and abnormal (high risk) in 9.3%. The majority of children (76.9%) in the high risk category were aged 2-8 years. TCD study was inadequate for risk categorisation in 1.3% of the patients.Effective capacity building of middle level manpower is feasible and can provide a credible TCD screening service to communities with a high demand and a shortage of trained professionals. The pattern of TCD abnormalities seen in Africa are comparable to those obtained in several previous worldwide reports.