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We introduce the half-cycle formulation (HCF), a new integer programming (IP) model for the kidney exchange problem, which has life-saving applications. In HCF, a cycle (i.e., set of kidney swaps) is represented by two compatible halves. After giving several algorithmic enhancements for HCF, we show through extensive computational experiments with an IP solver that our new model outperforms existing formulations when the cycle size limit is set to 4, 5, or 6, depending on the density of the compatibility graph.

BackgroundAround 30% of cancer survivors suffer from chemotherapy-induced peripheral neuropathy (CIPN) ≥6 months after completion of chemotherapy, which comes with limitations in daily functioning and worsened quality of life(QoL). Treatment options are scarce. Our aim was to develop an online self-help intervention based on Acceptance and Commitment Therapy (ACT) to reduce pain interference in cancer survivors experiencing painful chronic CIPN.Material and methodsThis article applied a patient-centered design process using the Center for eHealth Research (CeHRes) roadmap. User needs were examined using online semi-structured interviews with patients and experts (N = 23). Interviews were transcribed verbatim and analyzed using thematic analysis. Personas were created based on interviews. Intervention content was based on identified user needs and ACT. Content and design were finalized using low-fidelity prototype testing (N = 5), and high-fidelity prototype testing (N = 7).ResultsPatients appreciated and agreed with the elements of ACT, had varying guidance needs, and wanted to have autonomy (e.g., moment and duration of use). Additionally, it was important to be aware that patients have had a life-threatening disease which directly relates to the symptoms they experience. Patients reported to prefer a user-friendly and accessible intervention. Similar points also emerged in the expert interviews. The final intervention, named Embrace Pain, includes six sessions. Session content is based on psychoeducation and all ACT processes. Further interpretation of the intervention (such as quotes, guidance, and multimedia choices) is based on the interviews.ConclusionThis development demonstrated how a patient-centered design process from a theoretical framework can be applied. Theory-driven content was used as the basis of the intervention. Findings show an online ACT intervention designed for cancer survivors with painful chronic CIPN.

Purpose A significant proportion of cancer patients suffer from chemotherapy-induced peripheral neuropathy (CIPN). This descriptive study aimed to examine patients’ experience of CIPN symptoms, daily limitations, involvement of healthcare professionals, and social support. Methods Cross-sectional data have been collected in the Netherlands via a national online questionnaire comprising closed items only (February 2021). Results Out of 3752 respondents, 1975 received chemotherapy only (i.e., without targeted therapy) and were therefore included. The majority (71.2%) reported symptoms in both hands and feet (e.g., tingling and loss of sensation or diminished sensation). Participants reported most limitations in household chores, social activities, hobbies, sports, walking, and sleeping and least in family/(taking care of) children, cycling, driving, self-care, eating and drinking, and sexuality and intimacy. Many patients indicated that their healthcare professionals informed them about the possibility of CIPN development before treatment (58.4%), and they paid attention to CIPN during and after treatment (53.1%). However, many patients (43%) reported a lack of information on what to do when CIPN develops. Few participants (22%) visited their general practitioner (GP) for CIPN. In general, patients’ social environments sometimes to always showed empathy to patients. Conclusions Symptoms of CIPN are frequently reported and can result in various daily limitations. Support from professionals and peers is crucial in managing CIPN, which is sometimes lacking. Appropriate guidance and support should be provided to patients to decrease the impact of CIPN on daily life. Future research should investigate differences in chemotherapeutic agents and the resulting symptoms and consequences.

Intrusive memories can be downregulated using intentional memory control, as measured via the ‘Think/No-Think’ paradigm. In this task, participants retrieve or suppress memories in response to an associated reminder cue. After each suppression trial, participants rate whether the association had intruded into awareness. Using linear modelling, previous research has found that repeatedly exerting intentional control over memory intrusions reduces their frequency. This paper discusses the differences in methodology and analytical approaches used by studies in the past 10 years investigating intrusion control via the T/NT paradigm. In addition, by reanalysing published datasets, we demonstrate large individual variability within studies in the number of intrusions reported within each block of the T/NT task. Results revealed that the change in intrusion frequencies across time is not linear, but quadratic. We propose the Index of Intrusion Control (IIC) to measure the change in intrusion frequencies across time. Furthermore, we demonstrate how this metric has superior predictive value for subsequent forgetting effects, when compared to approaches used in previous studies. We conclude with recommendations for improving the validity of the design and results of future studies and streamlining methodology and analyses between studies investigating intrusion control in the laboratory.

Research indicates that fear was an important factor in determining individual responses to COVID-19, predicting relevant behaviors such as compliance to preventive measures (e.g., hand washing) and stress reactions (e.g., poor sleep quality). Given this central role of fear, it is important to understand more about its temporal changes during the COVID-19 pandemic. This article describes a publicly available dataset that contains longitudinal assessment of fear of COVID-19 and other relevant constructs during the first 15 months of the pandemic. Particularly, the dataset contains data from two different samples. The first sample consists predominantly of Dutch respondents (N = 439) who completed a cross-sectional survey in March 2020. The second sample consists of a large-scale longitudinal survey (N = 2000 at T1), including respondents with a broad range of nationalities (though predominantly residing in Europe and North America; 95.6%). The respondents of the second sample completed the survey between April 2020 and August 2020 using the Prolific data collection platform. In addition, one follow-up assessment was completed in June 2021. The measures included in the survey were fear of COVID-19, demographic information (age, gender, country of residence, education level, and working in healthcare), anxious traits (i.e., intolerance of uncertainty, health anxiety, and worrying), media use, self-rated health, perceived ability to prevent infection, and perceived risk for loved ones. Additionally, at the follow-up assessment in June 2021, respondents were asked whether they were vaccinated against COVID-19 or were planning to get vaccinated. The datafiles of this study have been made available through the Open Science Framework and can be freely reused by psychologists, social scientists, and other researchers who wish to investigate the development, correlates, and consequences of fear of COVID-19.

Acute stress has been found to impair the flexible updating of stimulus-outcome associations. However, there is a lack of studies investigating the effect of acute stress on the flexible updating of stimulus-response associations, like active avoidance responses. The current study used an avoidance reversal learning paradigm to address this question. Sixty-one participants learned that a red dot was associated with an aversive sound, whereas a green dot was not (Pavlovian Acquisition phase). Next, they were trained to avoid the aversive stimulus by selectively pressing a button in response to the red, but not the green, dot (Avoidance Acquisition phase). Subsequently, participants either underwent a stress induction task or a no-stress control task. The flexible updating of expectancies of the US and avoidance responses were assessed after reversal of the original contingencies (Reversal Test). Acute stress did not impair the flexible updating of avoidance responses during the Reversal Test. In contrast, results showed that in the stress group the expectancies of the aversive sound were more in accordance with the reversed contingencies compared to the ratings of control participants. Additionally, cortisol responders avoided less often in comparison to cortisol non-responders. Increased noradrenergic activity in stressed participants was related to impairments in the flexible updating of avoidance responses after contingency reversal, while this association was absent in the control participants. In conclusion, our results suggest that the autonomic response might account for shifting the balance towards inflexible updating of stimulus-outcome awareness while stress does not impair flexible updating of avoidance responses.

Combining recall of an emotional memory with simultaneous horizontal eye movements (i.e., Recall + EM) reduces memory aversiveness. However, the long-term persistence of this effect is inconsistent across studies. Given that stress may aid in the consolidation of memories, we examined whether acute stress can boost the long-term effects of degraded memories. To test this, participants recalled two negative memories, which were assigned to a Recall + EM or Recall Only condition. Before and after each intervention they rated memory aversiveness (i.e., immediate effects) followed by a stress-induction or control procedure. After a 24h-period, participants rated each memory again (i.e., long-term effects). We found that Recall + EM produces immediate effects but that these effects dissolve over time. Moreover, acute stress did not boost potential long-term effects of Recall + EM. Degraded memories were not retained better by applying stress. We discuss these results and how long-term effectiveness may still be achieved. published

Acute stress is associated with a shift from goal-directed to habitual behavior. This stress-induced preference for habitual behavior has been suggested as a potential mechanism by which binge eating disorder (BED) patients succumb to eating large amounts of high-caloric foods in an uncontrolled manner (i.e., binge episodes). While in healthy subjects the balance between goal-directed and habitual behavior is subserved by the anterior cingulate cortex (ACC), insular cortex, orbitofrontal cortex (OFC), anterior caudate nucleus, and posterior putamen, the brain mechanism that underlies this (possibly amplified) stress-induced behavioral shift in BED patients is currently unknown. In the current study, 76 participants (38 BED, 38 healthy controls (HCs)) learned six stimulus-response-outcome associations in a well-established instrumental learning task. Subsequently, three outcomes were selectively devalued, after which participants underwent either a stress induction procedure (Maastricht Acute Stress Test; MAST) or a no-stress control procedure. Next, the balance between goal-directed and habitual behavior was assessed during functional magnetic resonance imaging. Findings show that the balance between goal-directed and habitual behavior was associated with activity in the ACC, insula, and OFC in no-stress HCs. Although stress and BED did not modulate the balance between goal-directed and habitual behavior, BED participants displayed a smaller difference in putamen activation between trials probing goal-directed and habitual behavior compared with HCs when using a ROI approach. We conclude that putamen activity differences between BED and HC could reflect changes in monitoring of response accuracy or reward value, albeit perhaps not sufficiently to induce a measurable shift from goal-directed to habitual behavior. Future research could clarify potential boundary conditions of stress-induced shifts in instrumental behavior in BED patients.

Research has demonstrated the spreading of fear from threat-related stimuli to perceptually similar, but innocuous, stimuli. Less is known, however, about the generalization of avoidance behavior. Given that stress is known to affect learning and memory, we were interested in the effect of acute stress on (over)generalization of fear and avoidance responses. On the first day, one geometrical shape was paired with a mild electrical stimulus (CS+), whereas another shape was not (CS-). One day later, after participants had been exposed to the Maastricht Acute Stress Test or a control task, generalization of avoidance responses and fear (shock expectancy and skin conductance responses) was tested to a range of perceptual generalization stimuli. Generalization gradients were observed across different outcome measures. Stress enhanced generalization of shock expectancy to the stimulus most similar to the CS+. Our findings confirm that stress can affect the generalization of fear, but further studies are warranted. ispartof: BIOLOGICAL PSYCHOLOGY vol:164 ispartof: location:Netherlands status: published

Purpose Our aim was to investigate prospective associations of consumption of total dairy and dairy types with incident prediabetes in a Dutch population-based study. Methods Two enrolment waves of the Hoorn Studies were harmonized, resulting in an analytic sample of 2262 participants without (pre-) diabetes at enrolment (mean age 56 ± 7.3 years; 50% male). Baseline dietary intake was assessed by validated food frequency questionnaires. Relative risks (RRs) were calculated between dairy, fermented dairy, milk, yogurt (all total/high/low fat), cream and ice cream and prediabetes. Additionally, substituting one serving/day of dairy types associated with prediabetes with alternative dairy types was analysed. Results During a mean 6.4 ± 0.7 years of follow-up, 810 participants (35.9%) developed prediabetes. High fat fermented dairy, cheese and high fat cheese were associated with a 17% (RR 0.83, 95% CI 0.69–0.99, ptrend = 0.04), 14% (RR 0.86, 95% CI 0.73–1.02, ptrend = 0.04) and 21% (RR 0.79, 95% CI 0.66–0.94, ptrend = 0.01) lower risk of incident prediabetes, respectively, in top compared to bottom quartiles, after adjustment for confounders. High fat cheese consumption was continuously associated with lower prediabetes risk (RRservings/day 0.94, 95% CI 0.88–1.00, p = 0.04). Total dairy and other dairy types were not associated with prediabetes risk in adjusted models, irrespective of fat content (RR ~ 1). Replacing high fat cheese with alternative dairy types was not associated with prediabetes risk. Conclusion The highest intake of high fat fermented dairy, cheese and high fat cheese were associated with a lower risk of prediabetes, whereas other dairy types were not associated. Cheese seems to be inversely associated with type 2 diabetes risk, despite high levels of saturated fatty acids and sodium.

The COVID-19 pandemic has a substantial impact on mental health. Prior reports have shown that depression, anxiety, and stress have increased throughout the pandemic. Nonetheless, not everyone is affected by these negative consequences and some people may be relatively unaffected. In this online study in a predominantly Dutch and Belgian sample (N = 546), we investigated whether positive personality traits such as optimism, mindfulness, and resilience may protect against the negative mental health consequences (i.e., fear of the coronavirus, depression, stress, and anxiety) of the COVID-19 pandemic. We found that fear of COVID-19 was related to higher depression, stress, and anxiety. However, for participants scoring high on mindfulness, optimism, and resilience, this relationship was weakened. In addition to these findings, we present the results of network analyses to explore the network structure between these constructs. These results help to identify possible ways through which psychological well-being can be promoted during the COVID-19 pandemic.

Being exposed to acute stress may cause people to behave more habitual, which purportedly is associated stress-induced increased dopamine release. In contrast, experimental rises in systemic dopamine levels have been shown to increase goal-directed behaviour and, thus, decrease habitual control. Whether experimentally increased dopamine functioning can modulate stress-induced reductions in goal-directed behaviour and its neural substrates, is currently unknown. To assess whether increased dopamine functioning reduces stress effects on goal-directed behaviour, 100 participants were recruited who were randomly assigned to one of four conditions in a 2x2 between participants design. Participants underwent a stress induction protocol (Maastricht Acute Stress Test; MAST) or a control procedure and received methylphenidate (40 mg, oral) or placebo. In a well-established instrumental learning paradigm, participants were trained to learn stimulus-response-outcome associations, after which rewards were selectively devalued and participants’ goal-directed behaviour was assessed at peak cortisol/methylphenidate concentrations in a magnetic resonance imaging scanner to assess brain activation. The MAST effectively increased physiological measures of stress (salivary cortisol, blood pressure) and subjective stress. Methylphenidate also increased cortisol levels over time. While stress selectively reduced goal-directed behaviour, this effect was not modulated by methylphenidate. However, methylphenidate modulated stress effects on activation in paracingulate, orbitofrontal cortex, and anterior cingulate associated with expected value representation in goal-directed behaviour. Our neuroimaging data suggest increased dopamine levels reverse stress-induced changes in brain activation associated with goal-directed behaviour. These effects may be relevant for preventing stress-induced relapse in addictive behaviour.

The goal of the present experiment was to examine the effect of certain (deceptive) strategies (e.g., false denial) on memory. Specifically, participants were shown a traumatic virtual reality (VR) video of an airplane crash. Following this, participants (N= 94) received questions concerning details from the VR scene in a baseline memory task. Then, participants could choose from 3 options how to cope in response to having experienced the VR scene: tell the truth, falsely deny, or fabricate. The majority opted to tell the truth (n = 81). A subsample of truth tellers were instructed to falsely deny having seen certain details. One week later, all participants received a source monitoring task in which they were asked (1) whether they remembered talking about these details during an interview, and (2) whether they remembered seeing certain details during the VR experience the week before. Participants had to tell the truth during this task. Participants who were instructed to falsely deny showed impaired memory for presented details that had previously been discussed (i.e., denial-induced forgetting) and seen in the VR scene. Also, the presentation of certain details in the baseline memory task seemed to inoculate participants who were instructed to falsely deny from experiencing memory impairment. The current experiment suggests that false denials can have adverse ramifications for memory for what is discussed and seen. ispartof: MEMORY & COGNITION vol:47 issue:3 pages:485-495 ispartof: location:United States status: published

Since the outbreak of the coronavirus disease (COVID-19), several reports have shown that fear relating to COVID-19 has sharply increased. To measure fear of COVID-19, various questionnaires have been developed in parallel. However, fear concerning COVID-19 is not necessarily a uniform construct and the different questionnaires may cover diverse aspects. To examine the underlying structure of fear of COVID-19, we conducted structural equation modelling and network analyses on four scales in an online convenience sample (N = 829). Particularly, the Fear of COVID-19 Scale (Ahorsu et al., 2020), the Fear of the Coronavirus Questionnaire (Mertens et al., 2020), and the COVID Stress Scales (Taylor, Landry, Paluszek, Fergus et al., 2020, Taylor, Landry, Paluszek, Rachor et al., 2020) were included in our study, along with a new scale that also assessed socio-economic worries relating to COVID-19. We found that fear of COVID-19 was best classified into four clusters: Fear of health-related consequences, fear of supplies shortages and xenophobia, fear about socio-economic consequences, and symptoms of fear (e.g., compulsions, nightmares). We also find that a central cluster of items centered on fear of health, which likely represents the core of fear of COVID-19. These results help to characterize fear due to COVID-19 and inform future research.

In the eyewitness identification literature, stress and arousal at the time of encoding are considered to adversely influence identification performance. This assumption is in contrast with findings from the neurobiology field of learning and memory, showing that stress and stress hormones are critically involved in forming enduring memories. This discrepancy may be related to methodological differences between the two fields of research, such as the tendency for immediate testing or the use of very short (1-2 hours) retention intervals in eyewitness research, while neurobiology studies insert at least 24 hours. Other differences refer to the extent to which stress-responsive systems (i.e., the hypothalamic-pituitary-adrenal axis) are stimulated effectively under laboratory conditions. The aim of the current study was to conduct an experiment that accounts for the contemporary state of knowledge in both fields. In all, 123 participants witnessed a live staged theft while being exposed to a laboratory stressor that reliably elicits autonomic and glucocorticoid stress responses or while performing a control task. Salivary cortisol levels were measured to control for the effectiveness of the stress induction. One week later, participants attempted to identify the thief from target-present and target-absent line-ups. According to regression and receiver operating characteristic analyses, stress did not have robust detrimental effects on identification performance. Copyright © 2016 John Wiley & Sons, Ltd. © 2016 The Authors Behavioral Sciences & the Law Published by John Wiley & Sons Ltd.

Contains fulltext : 150751.pdf (Publisher’s version ) (Open Access) Frontal asymmetry in alpha oscillations is assumed to be associated with psychopathology and individual differences in emotional responding. Brain-activity-based feedback is a promising tool for the modulation of cortical activity. Here, we validated a neurofeedback protocol designed to change relative frontal asymmetry based on individual alpha peak frequencies (IAF), including real-time average referencing and eye-correction. Participants (N=60) were randomly assigned to a right, left, or placebo neurofeedback group. Results show a difference in trainability between groups, with a linear change in frontal alpha asymmetry over time for the right neurofeedback group during rest. Moreover, the asymmetry changes in the right group were frequency and location specific, even though trainability did not persist at one week and one month follow-ups. On the behavioral level, subjective stress on the second test day was reduced in the left and placebo neurofeedback groups, but not in the right neurofeedback group. We found individual differences in trainability that were dependent on training group, with participants in the right neurofeedback group being more likely to change their frontal asymmetry in the desired direction. Individual differences in trainability were also reflected in the ability to change frontal asymmetry during the feedback. 11 p.

BACKGROUND: Acute stress can have an effect on pain sensitivity, yet the direction of the effect - whether it is hypoalgesic or hyperalgesic - is mixed across studies. Moreover, which part of the stress response influences pain sensitivity is still unclear. In the current experimental study, we aim to examine the effect of acute stress on heat pain thresholds and pain tolerance levels in healthy participants, while taking into account individual differences in stress responses. METHODS: Forty-two healthy participants were randomly assigned to either a well-validated stress paradigm: the Maastricht Acute Stress Task (MAST; combining physical and psychological stressors) or to a nonstressful version of the task. Heat pain thresholds and tolerance levels were assessed at three times: prior to the MAST, immediately after the MAST during the presumed sympatho-adrenal medullary (SAM) response, and 15 min after MAST to cover the presumed hypothalamus-pituitary-adrenal (HPA) axis response. Stress responses were assessed both subjectively and physiologically. RESULTS: We observed that the acute stress induction led to increased heat pain thresholds, an effect that was present only in participants showing a cortisol response following stress induction and only in the presumed HPA axis time window. The strength of this hypoalgesic effect was further predicted by the change in cortisol and by fear of pain levels. CONCLUSIONS: Our findings indicate that the HPA axis - and not the autonomic - stress response specifically underlies this stress-induced hypoalgesic effect, having important implications for clinical states with HPA axis dysfunctions. SIGNIFICANCE: This experimental study shows that an acute stress induction - that combines physical and psychological stressors - increases heat pain thresholds, but not tolerance in healthy participants. Furthermore, the magnitude of this stress-induced hypoalgesic effect is predicted by cortisol reactivity and fear of pain, revealing specific involvement of the HPA axis stress system and interactions with pain-related psychosocial aspects. ispartof: EUROPEAN JOURNAL OF PAIN vol:22 issue:7 pages:1291-1303 ispartof: location:England status: published

Item does not contain fulltext Studies suggest that frontal alpha asymmetry is closely linked to psychological adjustment following stressful experiences, such that more left-sided frontal activation during symptom provocation might predict lower levels of posttraumatic stress disorder (PTSD). Here, we tested whether frontal asymmetry at rest and during exposure to neutral, positive, negative, and trauma-related images would be associated with PTSD, and particularly with characteristic reexperiencing symptoms. Symptoms were assessed in trauma victims with (n = 24) and without PTSD (n = 15), using both retrospective measures and 1-week ambulatory assessments with a diary and a smartphone. While resting frontal asymmetry was unrelated to all retrospective measures, left-sided activation in response to the negative picture correlated with lower levels of psychopathology. Left-sided activation in the trauma-related picture condition was more specifically associated with less emotionally intense intrusions and responses to viewing the picture, even when corrected for other symptoms of psychopathology. These effects tended to increase when participants with possible overreporting tendencies were removed from the analyses. Moreover, trauma victims without PTSD (i.e., relatively more resilient individuals) displayed higher left-sided frontal activation in response to the negative picture, also when compared with a third group of healthy, trauma-free individuals (n = 15). Our findings suggest that state-dependent changes in frontal asymmetry could serve as a biological marker of PTSD symptoms and could eventually be used for diagnostic purposes or as a target for neuromodulation interventions. Future studies should establish whether this marker can serve as an early predictor of psychopathology in recently traumatized individuals. 21 p.

Summary: The Self-Administered Interview© (SAI) serves to elicit eyewitness statements directly after the crime. Witnesses could still experience stress then. Because stress during retrieval produces memory-impairing effects, this study sought to compare the SAI with free recall under stress. An interaction between stress and interview was expected such that the SAI would elicit more comprehensive accounts than free recall in the control, but not in the stress group. One hundred and twenty-seven participants underwent a stress or control task. They witnessed a live staged crime and completed an SAI or a free recall. The SAI elicited a higher number of correct verifiable event details and a higher number of correct and incorrect perpetrator details than free recall. Accuracy rates were unaffected. Unexpectedly, despite causing moderate stress-induced cortisol elevations, stress exposure did not influence memory performance and did not interact with interview type. Hence, the SAI can safely be used, when witnesses are moderately stressed.Copyright © 2015 John Wiley & Sons, Ltd. When witnesses observe a crime, they may experience heightened stress levels. During the investigations, however, the police are likely to approach all witnesses to obtain eyewitness evidence, irrespective of their stress levels. A novel eyewitness interview procedure that is likely to be employed shortly after the incident when witnesses may still be stressed is the recently developed Self-Administered Interview© (Gabbert, Hope, & Fisher, 2009; see Hope, Gabbert, & Fisher, 2011, for a detailed description). To avoid problems of delayed interviewing (e.g., forgetting, Rubin & Wenzel, 1996, or misinformation effects, Gabbert, Memon, Allan, & Wright, 2004), this self-administered booklet is independently completed in writing by the witnesses at the crime scene. Its purpose is to secure an early witness statement when limited police resources do not allow conducting an immediate personal interview. The SAI is based on the cognitive interview (Fisher & Geiselman, 1992) and adopts some of its memory-enhancing techniques, such as mental context reinstatement, the report everything component, and multiple and varied retrieval. The tool hence provides ample retrieval support. The SAI is often compared with written free recall (FR) that provides only little retrieval support. Relative to FR, the SAI elicits a higher number of correct details—which usually amount to a large effect— but also a higher number of incorrect details. Importantly, however, accuracy rates (number of correct details reported divided by all reported details; Meissner, Sporer, & Susa, 2008) do not differ between the SAI and FR (Gabbert et al., 2009; Gawrylowicz, Memon, & Scoboria, 2014; Gawrylowicz, Memon, Scoboria, Hope, & Gabbert, 2014). That accuracy rates are unaffected by the SAI is essential because it shows that information gain does not compromise the amount of correct information that is elicited. In other words, the SAI increases information output relative to FR, while high accuracy rates are maintained. The SAI also pre

Summary Defendants and witnesses are often intoxicated by alcohol. We investigated whether memory and resistance to suggestive cues are undermined at blood alcohol concentrations (BACs) that were (close to) zero (MBAC = 0.01%), moderate (MBAC = 0.06%), or high (MBAC = 0.16%). Participants (N = 67) were approached in bars and instructed to commit a mock crime. Immediately after this, their memory and susceptibility to suggestive questions were tested, and these were re-tested during a sober follow-up 3–5 days later. Compared with sober participants, moderate and severe intoxication was associated with lower levels of correctly recalled crime details during both test sessions (i.e. intoxicated and sober). Also, during both sessions, severely intoxicated participants displayed a greater tendency to go along with suggestive cues compared with sober participants. Thus, intoxication impaired memory and increased suggestibility during an immediate interview, and both effects persisted when sober again. Copyright © 2015 John Wiley & Sons, Ltd.

BACKGROUND AND OBJECTIVES: Cognitive and information processing theories of Post-Traumatic Stress Disorder (PTSD) assert that trauma intrusions are characterized by poor contextual embedding of visuospatial memories. Therefore, efficient encoding of visuospatial contextual information might protect against intrusions. We tested this idea using indices of visuospatial memory embedding along with the trauma film paradigm. METHODS: Individual differences in spatial configuration learning, as well as the degree to which visual recognition memory depends on its visual encoding context (i.e., memory contextualization), were assessed in 81 healthy participants. Next, participants viewed a distressing film. Intrusions and other PTSD analogue symptoms were assessed subsequently. RESULTS: Participants displaying stronger memory contextualization developed fewer intrusions and PTSD analogue symptoms. Spatial configuration learning was unrelated to memory contextualization and, contrary to prior findings, predicted higher levels of intrusions. LIMITATIONS: Due to the analogue design, our findings may not translate directly to clinical populations. Furthermore, due to the correlational design of the study, causal relations remain to be tested. CONCLUSIONS: Our results suggest a protective role for the ability to integrate memories in their original visual learning context against the development of PTSD symptoms. publisher: Elsevier articletitle: Visuospatial context learning and configuration learning is associated with analogue traumatic intrusions journaltitle: Journal of Behavior Therapy and Experimental Psychiatry articlelink: http://dx.doi.org/10.1016/j.jbtep.2016.07.010 content_type: article copyright: © 2016 Elsevier Ltd. All rights reserved. ispartof: Journal of Behavior Therapy and Experimental Psychiatry vol:54 pages:120-127 ispartof: location:Netherlands status: published

Evidence suggests that asymmetry in frontal electrical activity predicts responses to aversive experiences, such that higher left-sided activity might dampen responses to trauma reminders. We measured frontal asymmetry at rest and during viewing of a trauma film, and assessed startle responses to film-reminder images. To explore potential moderators, we compared two films (Study 1; N = 64) and modulated reappraisal (Study 2; N = 72). As expected, left frontal activation during film viewing predicted dampened responses in individuals who viewed a staged road accident. However, this effect tended to be reversed when a genocide documentary was used. In Study 2, all participants viewed the genocide film. Left frontal activity at rest again predicted higher startle responses, while reappraisal did not moderate the effects. Thus, the type of trauma film plays a crucial role in the effects of frontal asymmetry, which warrants further critical investigation. Descriptors: Eye-blink startle, Frontal alpha asymmetry, Trauma film, Aversive memories, Post-traumatic stress disorder

Several protocols have been developed for inducing acute stress in laboratory settings. Still, effectively eliciting stress in a neuroimaging environment remains challenging. Here, we describe the evaluation of a combined physical and psychosocial stress protocol (n = 42). The imaging Maastricht Acute Stress Test (iMAST) consists of a 5-min preparation phase and a 10-min acute stress phase, with alternating trials of cold pressor stress generated through an advanced thermal stimulator and mental arithmetic challenges along with social-evaluative pressure (i.e., negative feedback). Results demonstrate that participants displayed meaningful subjective stress responses, as well as significant increases in salivary alpha-amylase and cortisol levels. Our data show that the iMAST may prove to be a potent alternative to existing imaging stress paradigms to explore poststress neuronal changes and brain determinants of resilience.

We report on the 1st experimental elicitation of nonbelieved memories for childhood events in adults (Study 1) and children (Study 2) using a modified false memory implantation paradigm. Participants received true (trip to a theme park) and false (hot air balloon ride) narratives and recalled these events during 2 interviews. After debriefing, 13% of adults and 15% of children reported nonbelieved memories. While phenomenal ratings were higher for true than for nonbelieved memories immediately after the debriefing, after a month nonbelieved memories behaved as true memories. Also following debriefing, 23% of adults and 15% of children retracted their false memory claims. Prior to debriefing, participants with nonbelieved memories were most likely to indicate remembering the event, whereas participants with false memories who retracted their claim were most likely to endorse believing but not remembering the event. This research suggests that debriefings in previous false memory studies can lead to the development of nonbelieved memories. Additional findings regarding the correspondence between subjective belief, subjective memory, and objective memory judgments prior to and following debriefing are discussed.

SummaryStress-related research has employed several procedures to activate the human stress system. Two of the most commonly used laboratory paradigms are the Trier Social Stress Test (TSST) and the Cold Pressor Test (CPT). We combined their most stressful features to create a simple laboratory stress test capable of eliciting strong autonomic and glucocorticoid stress responses. In comparison with the CPT and its variations, our stress tool (labeled the Maastricht Acute Stress Test; MAST) was found to yield superior salivary cortisol responses, while being equally effective in eliciting subjective stress reactions and (systolic and diastolic) blood pressure increases (study 1; N=80). In study 2 (N=20), we directly compared the effectiveness of the MAST and TSST and found that both methods elicited similar subjective, salivary alpha-amylase, and salivary cortisol stress responses. Finally, we developed and evaluated an appropriate no-stress control version of the MAST that was similar to the stress version, although it did not comprise stressful components (study 3; N=40). Collectively, our results confirm the effectiveness of the MAST in terms of subjective, autonomic, and – most importantly – glucocorticoid stress responses. Thus, as a brief and simple stress protocol, the MAST holds considerable promise for future research.

The aim of this paper is twofold. First, it explores delayed effects of high endogenously evoked cortisol concentrations on visuo-spatial declarative memory. Subsequently, it applies multiple mediation (MM) analyses to reveal path processes between stress and cognitive performance in a sample of 24 male Special Forces (SF) candidates (mean age = 27.0 years, SD = 4.1). The SF candidates were randomly assigned to a control (n = 12) or an intense stress group (n = 12), and cortisol secretion for the intense stress condition was triggered by a brusque 60 min prisoner of war exercise. Stress exposure provoked robust increases in cortisol concentrations and a significant decline in immediate recall performance, measured with the Rey-Osterrieth Complex Figure (ROCF). The relative retrieval differences in regard to the ROCF persisted even after a recovery period of 24 h, as both groups showed similar levels of memory decline over 24 h. Next, the study applied a MM design that involved distribution-independent asymptotic and resampling strategies to extend traditional bivariate analyses. MM results showed that ROCF performance was mediated by increases in cortisol concentrations. Considering the studied variables, the current analysis was the first to provide statistical support for the generally accepted thesis that cortisol secretion in itself, rather than subjective strain or the experimental treatment, affects cognitive performance. The revelation of such path processes is important because it establishes process identification and may refine existing paradigms.

A limited number of studies have shown that adults and adolescents with psychopathic traits suffer from emotional memory impairment. The present study examined whether this finding could be replicated in a sample of children between 8 and 12?years of age with callous-unemotional (CU) traits. Children with high CU traits (n?=?24) were compared with children with low CU traits (n?=?18) with regard to performance on a peripheral memory recognition test that examined memory for central and peripheral components of neutral and negative pictures. Results showed that overall recognition rates did not differ between the high- and low-CU groups. For negative pictures, both groups demonstrated better recognition of the central component at the expense of the peripheral component, while for neutral pictures, the peripheral component was better recognized than the central component. This study is the first to demonstrate that children with high CU traits do not suffer from an impaired emotional memory. Copyright (C) 2012 John Wiley & Sons, Ltd.

Summary: The present study examined whether repeatedly providing additional script knowledge of an event would boost the development of children’s implanted false memories. Seventy-two 7- to 9-year-old children listened to a true narrative about their first day at school and a false narrative describing that they went to a burns centre when they were four years old. Children were randomly allocated to one of three groups: one group without additional script knowledge and two groups that received a video about the two events to promote additional event-related script knowledge of which one group had to view the video repeatedly (i.e. once a day). Across two interviews, children were encouraged to tell everything they remembered about the events. Results showed that at the second interview, children who were presented with the additional script knowledge were more likely to develop a false memory than the children who did not receive additional script knowledge. Copyright © 2012 John Wiley & Sons, Ltd. Several studies have shown that it is possible to implant false memories in children as well as in adults (e.g. Otgaar, Candel, & Merckelbach, 2008; Pezdek, Finger, & Hodge, 1997). The interest in this false-memory research was inspired by several high-profile cases in which the authenticity

Corticosteroids, released in high amounts after stress, exert their effects via two different receptors in the brain: glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs). GRs have a role in normalizing stress-induced effects and promoting consolidation, while MRs are thought to be important in determining the threshold for activation of the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the effects of MR blockade on HPA axis responses to stress and stress-induced changes in cognitive function. In a double-blind, placebo-controlled study, 64 healthy young men received 400 mg of the MR antagonist spironolactone or placebo. After 1.5 h, they were exposed to either a Trier Social Stress Test or a non-stressful control task. Responses to stress were evaluated by hormonal, subjective, and physiological measurements. Afterwards, selective attention, working memory, and long-term memory performance were assessed. Spironolactone increased basal salivary cortisol levels as well as cortisol levels in response to stress. Furthermore, spironolactone significantly impaired selective attention, but only in the control group. The stress group receiving spironolactone showed impaired working memory performance. By contrast, long-term memory was enhanced in this group. These data support a role of MRs in the regulation of the HPA axis under basal conditions as well as in response to stress. The increased availability of cortisol after spironolactone treatment implies enhanced GR activation, which, in combination with MR blockade, presumably resulted in a decreased MR/GR activation ratio. This condition influences both selective attention and performance in various memory tasks. Neuropsychopharmacology (2011) 36, 2720-2728; doi: 10.1038/npp.2011.162; published online 31 August 2011

Studies have shown that survival processing leads to superior memorability. The aim of the present study was to examine whether this survival recall advantage might result from stereotype activation. To test this hypothesis, we conducted a pilot study and two experiments in which participants were primed with stereotypes (Experiment 1, professor and elderly person; Experiment 2, survival-stereotype). In Experiment 1, 120 undergraduates were randomly assigned to a survival, professor stereotype, elderly person stereotype, or moving scenario and rated words for their relevance to the imagined scenario. In Experiment 2, 75 undergraduates were given a survival, survival-stereotype (based on our pilot study), or moving scenario. Both experiments showed that survival processing leads to a greater recall advantage over the stereotype groups and control group. These data indicate that the mere activation of stereotypes cannot explain the survival recall advantage.

Individuals who report to have recovered memories of childhood sexual abuse (CSA) almost by definition believe that these memories were previously inaccessible for them. We examined whether poor autobiographical memory specificity for all kinds of events (i.e., events not necessarily related to CSA) may underlie such impressions of amnesia. Thus, we examined whether people who report recovered memories of CSA (n = 44) would exhibit more difficulty retrieving specific autobiographical memories compared to people who never forgot their abuse experiences (continuous memory group; n = 42) and people without a history of abuse (controls; n = 26). The standard Autobiographical Memory Test (AMT) was administered to these 3 groups along with measures of depression and posttraumatic stress disorder symptomatology. Controls were significantly better at retrieving specific autobiographical memories relative to individuals with continuous and recovered CSA memories, who did not differ from each other. Thus, reduced autobiographical memory specificity was not particularly pronounced in people with recovered memories of CSA. Poor autobiographical memory specificity is unlikely to explain the impression of amnesia reported by this group. (C) 2010 Elsevier Ltd. All rights reserved.

Bij ernstige geweldsdelicten wil de rechter doorgaans weten hoe de verdachte tot zijn daad is gekomen. Daartoe doet de rechter een beroep op forensisch psychologen en psychiaters. Deze experts hebben de neiging om verklaringen te zoeken in de richting van complexe psychodynamiek. Daaraan kleeft het risico van eenzijdigheid: soms zijn er andere – bijvoorbeeld psychofarmacologische – verklaringen voor gewelddadig gedrag. In dit artikel illustreren we dit probleem aan de hand van een casus.

Op een zondagochtend in het najaar van 2001 wordt op een braakliggend terrein vlakbij een parkeerplaats in Maastricht het levenloze lichaam aangetroffen van een jonge vrouw.

Using a simulation design, we tested in 486 undergraduates whether different case vignettes differentially affect the sensitivity of a self-report instrument designed to detect malingering (the Wildman Symptom Checklist). One group of participants (n = 387) was instructed to respond honestly, while three groups instructed to malinger (each n = 33) each received a different case vignette: in the manslaughter and the wrongful death vignettes malingering of symptoms was for the purpose of reducing criminal responsibility, while in the personal injury vignette malingering would lead to the acquisition of compensation money. The criminal case vignettes elicited malingering behaviour that was easier to detect than the civil case vignette, sensitivity rates being .82/.73 and .55, respectively. Thus, when testing the diagnostic qualities of such instruments it may be wise to rely on multiple case vignettes, including civil cases.

Purpose. The Gudjonsson Suggestibility Scale (GSS; Gudjonsson, 1984, 1997) is a well-established forensic tool for measuring interrogative suggestibility. However, one restriction of this tool is that it requires an extensive testing procedure. The present study examined whether shorter versions of the GSS yield similar results as the original GSS procedure. Methods. One group (N = 20) was given a shortened version of the GSS that consisted of an immediate recall test and the specific questions. GSS scores in this group were compared with those in a group (N = 20) that had the standard procedure which includes a retention interval and immediate and delayed recall tests. A third group (N = 20) was administered a shortened procedure in which the 20 GSS questions immediately followed the GSS story. In the fourth group (N = 20), participants were given the retention interval, but no recall tests were administered. Results. ANOVA showed no differences in GSS scores amongst the four groups. Post hoc power analyses indicated that these non-significant findings were not the result of a power problem and that larger sample sizes are expected to yield comparable results. Further analyses showed that neither the retention delay nor the recall tests affected suggestibility scores. Conclusions. These results suggest that shortened procedures for administering the GSS may be employed in situations where time is a key factor.

Wanneer we in een stressvolle situatie terecht komen, reageert ons lichaam met een aantal fysiologische responsen, die ervoor zorgen dat we klaar zijn voor fight-or-flight (vechten-of-vluchten). Deze automatische en primitieve toestand heeft in de eerste plaats uiteraard een beschermende functie. Maar wat zijn de fysiologische mechanismen die eraan ten grondslag liggen en welke invloed hebben ze op ons geheugen? heeft de verwerking van nieuwe informatie of het ophalen van oude herinneringen te lijden onder acute stress en zo ja, welke rol speelt het stresshormoon cortisol hierin? over deze kwesties gaat dit artikel.

The present study investigated the relationship between trait dissociation and peritraumatic dissociation during acute painful stimulation. In a sample of 70 undergraduate students, peritraumatic dissociation was induced by means of a cold pressor test, which basically consists of participants holding an arm in ice water for as long as possible. Results indicate that heightened trait dissociation scores were related to shorter durations that participants could sustain the task. However, trait dissociation was not associated with increases in acute dissociative symptoms (i.e., peritraumatic dissociation). These findings are in sharp contrast to the defensive function ascribed to both types of dissociation and also the commonly held assumption that peritraumatic and trait dissociation are intimately linked.

Source monitoring refers to cognitive processes involved in making attributions about the origins of memories, knowledge, and beliefs. One particular type of source monitoring with ample practical significance is reality monitoring, i.e., the ability to discriminate between internally vs. externally generated memories. Abundant evidence indicates that exposure to acute stress enhances declarative memory consolidation. To date, no study has looked at whether exposure to acute stress during the consolidation phase may promote reality monitoring performance. The authors examined this by administering cold pressor stress (CPS) or a control procedure to participants (N = 80) after they had either performed or only imagined performing simple motor acts, and assessing reality monitoring 24 h later. When compared with the control condition, CPS significantly elevated salivary free cortisol concentrations and enhanced reality monitoring. Stress-induced cortisol responses, however, were found not to be related to improved reality monitoring performance. Our findings are consistent with the view that post-learning stress hormone-related activity may modulate source memory consolidation.

Traumatic stress associated with childhood sexual abuse (CSA) may result in chronic alterations of stress-sensitive neurochemical systems (e.g., the hypothalamic-pituitary-adrenal axis and sympathetic-adrenal medullary activity). Some authors have suggested that these alterations might help explain why some individuals, after a period of inability to remember, demonstrate delayed recall of CSA memories (i.e., "recovered" memories). The present study is the first study that explored morning cortisol responses and circadian cortisol profiles among women with recovered (n = 7), repressed (n = 8), or continuous (n = 6) memories of CSA and women without a history of CSA (n = 9). Although there were group differences in current depression and post-traumatic stress symptoms, we found no differences in cortisol awakening response or daytime profile between women reporting recovered, repressed, or continuous memories of CSA as compared to women without a history of CSA. Implications for neurobiological models intended to explain the delayed recall of CSA are discussed.

In the eyewitness identification literature, stress and arousal at the time of encoding are considered to adversely influence identification performance. This assumption is in contrast with findings from the neurobiology field of learning and memory, showing that stress and stress hormones are critically involved in forming enduring memories. This discrepancy may be related to methodological differences between the two fields of research, such as the tendency for immediate testing or the use of very short (1–2 hours) retention intervals in eyewitness research, while neurobiology studies insert at least 24 hours. Other differences refer to the extent to which stress‐responsive systems (i.e., the hypothalamic–pituitary–adrenal axis) are stimulated effectively under laboratory conditions. The aim of the current study was to conduct an experiment that accounts for the contemporary state of knowledge in both fields. In all, 123 participants witnessed a live staged theft while being exposed to a laboratory stressor that reliably elicits autonomic and glucocorticoid stress responses or while performing a control task. Salivary cortisol levels were measured to control for the effectiveness of the stress induction. One week later, participants attempted to identify the thief from target‐present and target‐absent line‐ups. According to regression and receiver operating characteristic analyses, stress did not have robust detrimental effects on identification performance. Copyright © 2016 John Wiley & Sons, Ltd. © 2016 The Authors Behavioral Sciences & the Law Published by John Wiley & Sons Ltd

Item does not contain fulltext Frontal alpha asymmetry, a biomarker derived from electroencephalography (EEG) recordings, has often been associated with psychological adjustment, with more left-sided frontal activity predicting approach motivation and lower levels of depression and anxiety. This suggests high relevance to post-traumatic stress disorder (PTSD), a disorder comprising anxiety and dysphoria symptoms. We review this relationship and show that frontal asymmetry can be plausibly linked to neuropsychological abnormalities seen in PTSD. However, surprisingly few studies (k=8) have directly addressed frontal asymmetry in PTSD, mostly reporting that trait frontal asymmetry has little (if any) predictive value. Meanwhile, preliminary evidence suggest that state-dependent asymmetry during trauma-relevant stimulation distinguishes PTSD patients from resilient individuals. Thus, exploring links between provocation-induced EEG asymmetry and PTSD appears particularly promising. Additionally, we recommend more fine-grained analyses into PTSD symptom clusters in relation to frontal asymmetry. Finally, we highlight hypotheses that may guide future research and help to fully apprehend the practical and theoretical relevance of this biological marker.

Research on the effect of acute stress and high levels of glucocorticoids on memory has largely focused on memory tasks involving the medial temporal lobe (e.g., declarative memory). Less is known, however, about the effects of stress and glucocorticoids on more strategic memory processes regulated by the prefrontal cortex (e.g., source monitoring). In the current study, the authors investigated whether exposure to acute psychosocial stress would result in altered source monitoring performance relative to the performance of a nonstressed control group. To this end, the authors assigned nonsmoking, healthy, young men to either a stress (n = 22) or a control (n = 18) condition, after which the men were given an internal source monitoring test. Results show that relative to control participants, stressed participants made fewer source monitoring errors. This study suggests that stress may have differential effects on memory, depending on whether the memory test is regulated by the prefrontal cortex or the medial temporal lobe.

Summary Brewin and Andrews recently argued that expert witnesses should be cautious when informing the legal arena about the potential for false memories. We argue that memory researchers—whose studies often were inspired by miscarriages of justice due to erroneous statements provided by witnesses, victims, or defendants—can and should emphasize the base rates of false memories. After all, even if Brewin and Andrews' estimate of 15% is an accurate higher bound estimate of false memories in real life cases, neglecting the science of false memories could lead to many more unnecessary miscarriages of justice.Copyright © 2016 John Wiley & Sons, Ltd.

Brewin and Andrews (2016) reviewed the literature on false memory propensity for childhood events. In this commentary, we critically evaluate their basic claim that proneness to false memories of childhood experiences is more limited than has been articulated in the literature. We show that Brewin and Andrews were selective in their inclusion of false memory studies, thereby ignoring relevant research related to autobiographical false memories. Equally important, and in contrast to what Brewin and Andrews claim, we show that implanted false memories elicited by misinformation are characterized by high confidence.

Asymmetry in frontal electrical activity has been suggested to index tendencies in affective responding and thus may be associated with hormonal stress responses. To assess the functional role of frontal asymmetry (FA) in stress, we measured FA at rest and following exposure to acute stress induced with the Maastricht Acute Stress Task (MAST; N = 70) in the standard 8-13 Hz band as well as based on individual alpha frequency (IAF) band. IAF-based resting FA(F4-F3) was associated with the stress induced neuroendocrine response, such that left individual frontal activity predicted smaller total cortisol increases in response to the MAST. Like previous studies, we found resting left-sided FA(F8-F7) to predict trait behavioural activation measured with the BIS/BAS scales. FA remained unaffected by stress-induced cortisol response. These findings suggest that individual FA might reflect a trait-like characteristic that moderates the stress response. Our results underscore the utility of IAF in studying individual differences in stress responding. (C) 2014 Elsevier B. V. All rights reserved.

A middle-aged man presented with Ganser symptoms. He had been involved in a car crash and was seeking disability insurance benefits. Extensive testing with malinger instruments revealed that he performed below chance on simple memory tests and endorsed a variety of nonexistent symptoms. With this in mind, the authors collected collateral information which showed that the patient was involved in high level sports activities that were difficult to reconcile with the severe cognitive dysfunctions that he claimed to suffer from. The case demonstrates that Ganser-like symptoms deserve close scrutiny, preferably with malinger tests.