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Satellite imagery depicts the Earth’s surface remotely and provides comprehensive information for many applications, such as land use monitoring and urban planning. Existing studies on unsupervised representation learning for satellite images only take into account the images’ geographic information, ignoring human activity factors. To bridge this gap, we propose using the Point-of-Interest (POI) data to capture human factors and designing a contrastive learning-based framework to consolidate the representation of satellite imagery with POI information. Besides, we introduce a season-invariant representation learning model on satellite imagery, considering that human factors are mostly unchanging with respect to seasons. An attention model is designed at last to merge the representations from the geographic, seasonal, and POI perspectives adaptively. On the basis of real-world datasets collected from Beijing, 1 we evaluate our method for predicting socioeconomic indicators. The results show that the representation containing POI information outperforms the geographic representation in estimating commercial activity-related indicators. Our proposed attentional framework can estimate the socioeconomic indicators with R 2 of 0.874 and outperforms the baseline methods. Furthermore, we explore the differences in the representations of satellite images with varying socioeconomic statuses. Finally, we investigate the impact of geographic and POI perspective information in the representation learning process, as well as the effect of satellite imagery on various spatial resolutions.

To evaluate the safety, tolerability, and efficacy of efdamrofusp alfa in patients with neovascular age-related macular degeneration (nAMD).Randomized, open-label, multiple ascending-dose, phase 1b study.Patients aged 50 years or older with active choroid neovascularization (CNV) secondary to nAMD were screened from two hospitals in two provinces in China. The first nine patients were randomized 2:1 to intravitreally receive efdamrofusp alfa 2 mg at week 0, 4, 8 or aflibercept 2 mg at week 0, 4, 8, 16. After the dose limiting toxicity assessment, additional nine patients were randomized 2:1 to intravitreally receive efdamrofusp alfa 4 mg at week 0, 4, 8 or aflibercept 2 mg at week 0, 4, 8, 16. All patients were followed up till week 20. Primary outcomes were safety and tolerability of efdamrofusp alfa. Secondary outcomes included changes from baseline in best corrected visual acuity (BCVA), central subfield thickness (CST) as measured by spectral domain-optical coherence tomography (SD-OCT), and CNV area as measured by fluorescein angiography (FA).A total of 18 patients were enrolled and each six of them received efdamrofusp alfa 2 mg, efdamrofusp alfa 4 mg or aflibercept 2 mg, respectively. No dose-limiting toxicity reported and all patients completed the study. No ocular serious adverse event was reported. All ocular treatment-emergent adverse events were intravitreal injection related, mild or moderate in severity. At week 20, mean changes from baseline in BCVA were 5.64±3.56, 8.93±3.59 and 7.92±3.55 letters for patients receiving efdamrofusp alfa 2 mg, efdamrofusp alfa 4 mg and aflibercept 2 mg, respectively. Meanwhile, CST and CNV area reductions indicative of anatomic improvement were observed in the majority of the patients receiving both doses of efdamrofusp alfa and aflibercept.Intravitreal efdamrofusp alfa dosed up to 4 mg every 4 weeks was well tolerated in nAMD patients with similar vision acuity and anatomic improvements.ClinicalTrials.gov identifier NCT04370379.

Excessive consumption of energy and resources is a major challenge in wastewater treatment. Here, a novel heterogeneous Fenton-like catalyst consisting of Cu-doped graphene-like catalysts (Cu-GCD NSs) was first synthesized by an enhanced carbothermal reduction of β-cyclodextrin (β-CD). The catalyst exhibits excellent Fenton-like catalytic activity for the degradation of various pollutants under neutral conditions, accompanied by low H

The article is devoted to determining the level of psychological well-being of Chinese and Russian students in a cross-cultural context. The article presents the concept of psychological well-being, its structure and factors are revealed, empirical referents of the studied phenomenon are determined. The study sample consisted of Chinese (n = 63) and Russian (n = 63) students, as representatives of different cultures. The main criterion for selecting the sample was the ontogenetic stage of personality development - early adulthood, as well as the education of respondents in provincial universities (Russian students studied at Kostroma State University, Chinese students - at Guangxi University). The methodological complex included the “Scale of psychological well-beingˮ by K. Riff in the adaptation of N.N. Lepeshinsky; “Scale of Happinessˮ Lyubomirsky, Lepper adapted by D.A. Leontiev; “Life Satisfaction Scaleˮ Diener, Emmons, Larsen, Griffin adapted by D.A. Leontieva, E.N. Aspen. Significant differences in the psychological well-being of Russian and Chinese students are shown. The author of the article concludes that the indicator of psychological well-being among Chinese and Russian students correlates with the cultural and social contexts of their lives.

Enabling surfaces with passive anti-icing properties is an emerging, facile, economical, and energy-saving strategy to mitigate the harm caused by ice accretion. However, the combination of icephobicity and robustness remains a daunting challenge. Herein, we present an ultra-robust transparent icephobic coating with high toughness, strong substrate adhesion, and self-healing capability. Hydrophobicity, smoothness, and softness of the coating guarantee low ice adhesion strength. By incorporating a spongy structure, the ice adhesion strength of the coating is lowered further down to 26.7 ± 1.1 kPa. Importantly, the coating exhibits high toughness, strong adhesion to the substrate, and self-healing capability due to the presence of multiple hydrogen bonding. Consequently, the coating maintains its icephobicity after 35 icing/deicing cycles and 600 abrasion cycles, is resilient to delamination, and is able to heal and recover its icephobicity from the mechanical damage introduced by both cuts and abrasions. Moreover, the coating sustains its icephobicity after eight months of immersion in saltwater, as well as exposure to the near-arctic weather in Trondheim (Norway). This work presents new insights into the design of robust icephobic coatings that can sustain severe mechanical loading for use in real complex environments.

Flowering time is one of the most important agronomic traits affecting the adaptation and yield of rice (Oryza sativa). Heading date 1 (Hd1) is a key factor in the photoperiodic control of flowering time. In this study, two basic helix-loop-helix (bHLH) transcription factors, Hd1 Binding Protein 1 (HBP1) and Partner of HBP1 (POH1) were identified as transcriptional regulators of Hd1. We generated knockout mutants of HBP1 and ectopically expressed transgenic lines of the two bHLH transcription factors and used these lines to investigate the roles of these two factors in regulating flowering time. HBP1 physically associated with POH1 forming homo- or heterodimers to perform their functions. Both HBP1 and POH1 bound directly to the cis-acting elements located in the promoter of Hd1 to activate its expression. CRISPR/Cas9-generated knockout mutations of HBP1, but not POH1 mutations, promoted earlier flowering time; conversely, HBP1 and POH1 overexpression delayed flowering time in rice under long-day and short-day conditions by activating the expression of Hd1 and suppressing the expression of Early heading date 1 (Ehd1), Heading date 3a (Hd3a), and Rice Flowering locus T 1 (RFT1), thus controlling flowering time in rice. Our findings revealed a mechanism for flowering time control through transcriptional regulation of Hd1 and laid theoretical and practical foundations for improving the growth period, adaptation, and yield of rice.

Background Breast cancer care has been affected by the COVID-19 pandemic. This systematic review aims to describe the observed pandemic-related changes in clinical and health services outcomes for breast screening and diagnosis. Methods Seven databases (January 2020–March 2021) were searched to identify studies of breast cancer screening or diagnosis that reported observed outcomes before and related to the pandemic. Findings were presented using a descriptive and narrative approach. Results Seventy-four studies were included in this systematic review; all compared periods before and after (or fluctuations during) the pandemic. None were assessed as being at low risk of bias. A reduction in screening volumes during the pandemic was found with over half of studies reporting reductions of ≥49%. A majority (66%) of studies reported reductions of ≥25% in the number of breast cancer diagnoses, and there was a higher proportion of symptomatic than screen-detected cancers. The distribution of cancer stage at diagnosis during the pandemic showed lower proportions of early-stage (stage 0–1/I-II, or Tis and T1) and higher proportions of relatively more advanced cases than that in the pre-pandemic period, however population rates were generally not reported. Conclusions Evidence of substantial reductions in screening volume and number of diagnosed breast cancers, and higher proportions of advanced stage cancer at diagnosis were found during the pandemic. However, these findings reflect short term outcomes, and higher-quality research examining the long-term impact of the pandemic is needed