142 results on '"Tongxin Liu"'
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2. Molecularly Homogenized Composite Membranes Containing Solvent-Soluble Metallocavitands for CO2/CH4 Separation
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Tongxin Liu, Ruili Zhang, Guang-Rui Si, Bin Liu, Yabo Xie, Lin-Hua Xie, and Jian-Rong Li
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Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Environmental Chemistry ,General Chemistry - Published
- 2022
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Catalog
3. Adjusting the Fertilizer Application Structure for Nutrient Saving and Yield Increase in Potato
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Jing Yin, Zhi Song, Xinsong Guo, Fangjun Ding, Yang Shen, Jing Zhang, Chongqiang Zhao, Tongxin Liu, and Xuewen Ma
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Plant Science ,Agronomy and Crop Science - Published
- 2023
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4. Supplemental Table 1 from Dual PI3K/mTOR Inhibitors, GSK2126458 and PKI-587, Suppress Tumor Progression and Increase Radiosensitivity in Nasopharyngeal Carcinoma
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Wei Wang, Longhua Chen, Yawei Yuan, Dong Xiao, Xiaoshan Lin, Rong Wang, Yuqin Zhang, Hua Yang, Qi Li, Quanquan Sun, and Tongxin Liu
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Supplementary Table 1: Radiosensitivity parameters of nasopharyngeal carcinoma cell lines
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- 2023
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5. Legend for Supplementary Figures from Dual PI3K/mTOR Inhibitors, GSK2126458 and PKI-587, Suppress Tumor Progression and Increase Radiosensitivity in Nasopharyngeal Carcinoma
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Wei Wang, Longhua Chen, Yawei Yuan, Dong Xiao, Xiaoshan Lin, Rong Wang, Yuqin Zhang, Hua Yang, Qi Li, Quanquan Sun, and Tongxin Liu
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Supplementary Figure legends
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- 2023
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6. The Application of Beamforming Technology in Ionospheric Oblique Incidence Sounding With Wuhan Multi-Channel Ionospheric Sounding System (WMISS)
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Guobin Yang, Wuyong Zhang, Yaogai Hu, Chunhua Jiang, Ting Lan, Tongxin Liu, Zhengyu Zhao, and Xiaoli Zhu
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Antenna array ,Beamforming ,Depth sounding ,Interference (communication) ,Computer science ,Ionogram ,Acoustics ,Electrical and Electronic Engineering ,Geotechnical Engineering and Engineering Geology ,Signal ,Adaptive beamformer ,Ionospheric sounding - Abstract
Improving the quality of the oblique sounding ionogram under the low transmit power and miniaturized antenna array structure has always been a meaningful research content. Here we try to use the adaptive beamforming technology combined with Wuhan Multi-channel Ionospheric Sounding System (WMISS) to improve the situation effectively. First, an L-shaped antenna array is employed to receive the oblique sounding signal; subsequently, the precise angle of the arrival signal is estimated by the multiple signal classification (MUSIC) algorithm. Then three typical adaptive beamforming algorithms are employed to synthesize the multi-channel signals. The experimental results show that for the ionospheric signals of oblique incidence sounding (OIS), SNR can be improved to tens of dBs, and the interference can be significantly suppressed. Especially for the swept-frequency ionogram of OIS, the trace gets clearer and more continuous, which will provide great convenience for further interpretation and ionospheric parameter inversion. In addition, by comparing the application effects of the three typical beamforming algorithms, this letter provides a reference for selecting the synthesized methods of the ionospheric signals of OIS received by the miniaturized array. more...
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- 2022
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7. Overexpression of the aldehyde dehydrogenase AhALDH3H1 from Arachis hypogaea in soybean increases saline-alkali stress tolerance
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Yingxue Cao, Jing Wang, Siqi Zhao, Qingxi Fang, Jingwen Ruan, Shuanglin Li, Tongxin Liu, Yuxin Qi, Ling Zhang, Xiaoming Zhang, and Fanli Meng
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Plant Science - Abstract
Soybean production is severely hampered by saline-alkaline stress caused by saline-alkalization. Plants have aldehydrogenase (ALDH) family members that convert reactive aldehydes to carboxylic acids to remove active aldehyde molecules. However, little is known about the increased saline-alkali tolerance caused by the ALDH function in soybean. Here, we introduced a previously identified ALDH coding gene AhALDH3H1 from Arachis hypogaea into the soybean genome to investigate its critical role in response to saline-alkali stress. Transgenic soybean with increased aldehyde dehydrogenase activity showed significant tolerance to saline-alkali stress. It reduced malondialdehyde (MDA) content compared to its receptor, suggesting that over-expression of AhALDH3H1 accelerated soybean tolerance to saline-alkali stress by increasing aldehyde dehydrogenase activity, which is responsible for scavenging toxic MDA. To further analyze the inner mechanisms that allow transgenic plants to tolerate saline-alkali stress, we sequenced the transcriptome and metabolome of P3 (wild type, WT) and transgenic lines which were separately treated with water and a saline-alkali solution. When subjected to saline-alkali stress, the integrated analysis of the transcriptome and metabolome suggested that several genes related to cell wall structure crucial for preserving cell wall extensibility and plasticity were largely responsible for restoring homeostasis within the transgenic cells compared to WT. Metabolites, including both necessary ingredients for cell wall genesis and harmful production produced during the saline-alkali stress response, could be transported efficiently with the help of the ABC transporter, reducing the negative effects of saline-alkali stress. These findings suggest that introducing AhALDH3H1 increases transgenic soybean tolerance to saline-alkali stress may through cell wall structure maintenance and metabolites transport. more...
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- 2023
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8. Assessing farmland suitability for agricultural machinery in land consolidation schemes in hilly terrain in China: A machine learning approach
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Heng Yang, Wenqiu Ma, Tongxin Liu, and Wenqing Li
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Plant Science - Abstract
Identifying available farmland suitable for agricultural machinery is the most promising way of optimizing agricultural production and increasing agricultural mechanization. Farmland consolidation suitable for agricultural machinery (FCAM) is implemented as an effective tool for increasing sustainable production and mechanized agriculture. By using the machine learning approach, this study assesses the suitability of farmland for agricultural machinery in land consolidation schemes based on four parameters, i.e., natural resource endowment, accessibility of agricultural machinery, socioeconomic level, and ecological limitations. And based on “suitability” and “potential improvement in farmland productivity”, we classified land into four zones: the priority consolidation zone, the moderate consolidation zone, the comprehensive consolidation zone, and the reserve consolidation zone. The results showed that most of the farmland (76.41%) was either basically or moderately suitable for FCAM. Although slope was often an indicator that land was suitable for agricultural machinery, other factors, such as the inferior accessibility of tractor roads, continuous depopulation, and ecological fragility, contributed greatly to reducing the overall suitability of land for FCAM. Moreover, it was estimated that the potential productivity of farmland would be increased by 720.8 kg/ha if FCAM were implemented. Four zones constituted a useful basis for determining the implementation sequence and differentiating strategies for FCAM schemes. Consequently, this zoning has been an effective solution for implementing FCAM schemes. However, the successful implementation of FCAM schemes, and the achievement a modern and sustainable agriculture system, will require some additional strategies, such as strengthening farmland ecosystem protection and promoting R&D into agricultural machinery suitable for hilly terrain, as well as more financial support. more...
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- 2023
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9. High‐Resolution Sporadic E Layer Observation Based on Ionosonde Using a Cross‐Spectrum Analysis Imaging Technique
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Tongxin Liu, Guobin Yang, and Chunhua Jiang
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Atmospheric Science - Published
- 2023
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10. Identification and functional validation of super-enhancers in
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Hainan, Zhao, Mingyu, Yang, Jade, Bishop, Yuhan, Teng, Yingxue, Cao, Brandon D, Beall, Shuanglin, Li, Tongxin, Liu, Qingxi, Fang, Chao, Fang, Haoyang, Xin, Hans-Wilhelm, Nützmann, Anne, Osbourn, Fanli, Meng, and Jiming, Jiang more...
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Mammals ,Arabidopsis ,Animals ,Regulatory Sequences, Nucleic Acid ,Triterpenes ,Chromatin - Abstract
Super-enhancers (SEs) are exceptionally large enhancers and are recognized to play prominent roles in cell identity in mammalian species. We surveyed the genomic regions containing large clusters of accessible chromatin regions (ACRs) marked by deoxyribonuclease (DNase) I hypersensitivity in more...
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- 2022
11. Identification and functional validation of super-enhancers in Arabidopsis thaliana
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Hainan Zhao, Mingyu Yang, Jade Bishop, Yuhan Teng, Yingxue Cao, Brandon D. Beall, Shuanglin Li, Tongxin Liu, Qingxi Fang, Chao Fang, Haoyang Xin, Hans-Wilhelm Nützmann, Anne Osbourn, Fanli Meng, and Jiming Jiang more...
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Multidisciplinary - Abstract
Super-enhancers (SEs) are exceptionally large enhancers and are recognized to play prominent roles in cell identity in mammalian species. We surveyed the genomic regions containing large clusters of accessible chromatin regions (ACRs) marked by deoxyribonuclease (DNase) I hypersensitivity in Arabidopsis thaliana . We identified a set of 749 putative SEs, which have a minimum length of 1.5 kilobases and represent the top 2.5% of the largest ACR clusters. We demonstrate that the genomic regions associating with these SEs were more sensitive to DNase I than other nonpromoter ACRs. The SEs were preferentially associated with topologically associating domains. Furthermore, the SEs and their predicted cognate genes were frequently associated with organ development and tissue identity in A. thaliana . Therefore, the A. thaliana SEs and their cognate genes mirror the functional characteristics of those reported in mammalian species . We developed CRISPR/Cas-mediated deletion lines of a 3,578-bp SE associated with the thalianol biosynthetic gene cluster (BGC). Small deletions (131–157 bp) within the SE resulted in distinct phenotypic changes and transcriptional repression of all five thalianol genes. In addition, T-DNA insertions in the SE region resulted in transcriptional alteration of all five thalianol genes. Thus, this SE appears to play a central role in coordinating the operon-like expression pattern of the thalianol BGC. more...
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- 2022
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12. Mixed matrix membranes based on soluble perfluorinated metal-organic cage and polyimide for CO2/CH4 separation
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Tongxin Liu, Ruili Zhang, Guangcan Huang, Yabo Xie, Lin-Hua Xie, and Jian-Rong Li
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Filtration and Separation ,Analytical Chemistry - Published
- 2023
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13. Characteristics and response to next-generation sequencing-guided therapy in locally advanced or metastatic esophageal cancer
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Yueyun Ma, Wenjie Li, Shiyu Chen, Shuimiao Lin, Sijie Ding, Xiaomei Zhou, Tongxin Liu, Rong Wang, and Wei Wang
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Cancer Research ,Oncology - Abstract
Esophageal cancer (EC) is a main cause of cancer-related deaths. However, genomic alterations and the clinical value of next-generation sequencing (NGS) in advanced or metastatic EC for precision therapy remain largely unclear. Herein, we performed comprehensive analyses on a cohort of 47 individuals with advanced or metastatic EC who underwent NGS between May 2017 and February 2020. Eventually, 227 mutated genes were identified in the cohort. TP53, NQO1, DPYD, GSTM1, XRCC1 and ERCC1 were the most mutated genes and associated with immune cell infiltration, autophagy and hypoxia. Patients who received NGS-guided treatments exhibited better objective remission rate (ORR) (72.22%), disease control rate (DCR) (88.89%), overall survival (OS) (P = .0019) and progression-free survival (PFS) (P = .0077) than those not receiving NGS-guided therapies. The multivariate analyses further demonstrated that the NGS-guided therapy was an independently prognostic factor (OS: hazard radio [HR] 0.31, 95% coincidence interval [CI] 0.1-0.97, P = .04). In conclusion, we depicted a comprehensive mutational landscape of 47 patients with locally advanced or metastatic EC and illustrated the utility of NGS testing to guide clinical management in improving ORR, DCR, OS and PFS. more...
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- 2022
14. Acupuncture combined with TCM Bonesetting in the treatment of distal radius fractures: A protocol for systematic review and meta-analysis
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Tongxin, Liu and Zhou, Liangrong
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Rehabilitation and Therapy ,distal radius fracture ,Medicine and Health Sciences ,TCM bonesetting ,acupuncture - Abstract
This protocol was developed to conduct a systematic review and meta-analysis to evaluate the clinical efficacy and other relevant factors of acupuncture combined with TCM bonesetting in the treatment of distal radius fractures, compared to western medicine therapy such as operation. more...
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- 2022
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15. Acupuncture combined with TCM Bonesetting in the treatment of distal radius fractures
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Tongxin, Liu and Zhou, Liangrong
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Rehabilitation and Therapy ,distal radius fracture ,Medicine and Health Sciences ,TCM bonesetting ,acupuncture - Abstract
This protocol was developed to conduct a systematic review and meta-analysis to evaluate the clinical efficacy and other relevant factors of acupuncture combined with TCM bonesetting in the treatment of distal radius fractures, compared to western medicine therapy such as operation. more...
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- 2022
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16. Clinical efficacy and safety of acupuncture in the treatment of Herpes Zoster A protocol for systematic review and meta-analysis
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Yu, Xia, Sainan, Tian, and Tongxin, Liu
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Medicine and Health Sciences - Abstract
Acupuncture is an effective and more acceptable treatment method for herpes zoster, this study aims to systematically evaluate the clinical efficacy and safety of acupuncture in the treatment of this disease. more...
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- 2022
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17. Radiomics based on pretreatment MRI for predicting distant metastasis of nasopharyngeal carcinoma: A preliminary study
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Tingting, Jiang, Yalan, Tan, Shuaimin, Nan, Fang, Wang, Wujie, Chen, Yuguo, Wei, Tongxin, Liu, Weifeng, Qin, Fangxiao, Lu, Feng, Jiang, and Haitao, Jiang
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Cancer Research ,Oncology - Abstract
ObjectiveTo explore the feasibility of predicting distant metastasis (DM) of nasopharyngeal carcinoma (NPC) patients based on MRI radiomics model.MethodsA total of 146 patients with NPC pathologically confirmed, who did not exhibit DM before treatment, were retrospectively reviewed and followed up for at least one year to analyze the DM risk of the disease. The MRI images of these patients including T2WI and CE-T1WI sequences were extracted. The cases were randomly divided into training group (n=116) and validation group (n=30). The images were filtered before radiomics feature extraction. The least absolute shrinkage and selection operator (LASSO) regression was used to develop the dimension of texture parameters and the logistic regression was used to construct the prediction model. The ROC curve and calibration curve were used to evaluate the predictive performance of the model, and the area under curve (AUC), accuracy, sensitivity, and specificity were calculated.Results72 patients had DM and 74 patients had no DM. The AUC, accuracy, sensitivity and specificity of the model were 0. 80 (95% CI: 0.72~0. 88), 75.0%, 76.8%, 73.3%. and0.70 (95% CI: 0.51~0.90), 66.7%, 72.7%, 63.2% in training group and validation group, respectively.ConclusionThe radiomics model based on logistic regression algorithm has application potential for evaluating the DM risk of patients with NPC. more...
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- 2022
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18. Large-Scale Ionospheric Irregularities Detected by Ionosonde and GNSS Receiver Network
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Guobin Yang, Lehui Wei, Chunhua Jiang, Ting Lan, Zhengyu Zhao, Ercha Aa, Tongxin Liu, and Jing Liu
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Total electron content ,TEC ,Equator ,0211 other engineering and technologies ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Geodesy ,Ionospheric sounding ,GNSS applications ,Middle latitudes ,Electrical and Electronic Engineering ,Ionosphere ,Ionosonde ,Geology ,021101 geological & geomatics engineering - Abstract
Large-scale ionospheric irregularities, which occurred on September 8, 2017, were detected by the ionosonde and the Global Navigation Satellite System (GNSS) receiver network in this letter. The Wuhan ionospheric sounding system (WISS), deployed at Puer (PUR, 22.7°N, 101.05°E), Leshan (LSH, 29.6°N, 103.7°E), and Zhangye (ZHY, 39.4°N, 100.13°E), detected these large-scale ionospheric irregularities. The 2-D maps of the rate of the GNSS total electron content (TEC) index (ROTI) further confirmed that the large-scale ionospheric irregularities can cover a broad area (from the equator to middle latitude, ~80°E to ~120°E, ~20°N to ~45°N). The ionospheric variation recorded by the WISS shows that the large-scale ionospheric irregularities were driven by the super eastward electric field, which was formed by the eastward prompt penetration electric field during a storm superimposed on the normal prereversal enhancement during the postsunset hours. Moreover, observations by the WISS show the higher the latitudes at which the ionospheric irregularities/spread F occurred, the shorter the duration time. more...
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- 2021
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19. Revealing the effect of anion-tuning in bimetallic chalcogenides on electrocatalytic overall water splitting
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Yibo Dou, Jian-Rong Li, Xue-Qian Wu, Tongxin Liu, Tao He, Jian Zhou, Xiang-Jing Kong, and Awu Zhou
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Materials science ,Chalcogenide ,Alkaline water electrolysis ,Oxygen evolution ,Oxide ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Photochemistry ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Transition metal ,chemistry ,Water splitting ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology ,Bimetallic strip - Abstract
Enhancing electrocatalytic water splitting performance by modulating the intrinsic electronic structure is of great importance. Here, porous bimetallic oxide and chalcogenide nanosheets grown on carbon paper denoted as NiCo2X4/CP (X = O, S, and Se) are prepared to demonstrate how the anion components affect the electronic structures and thereby disclose the correlation between their intermediates interaction and catalytic activities. The experimental characterization and theoretical calculation demonstrate that Se and S substitution can promote the ratio of Co3+/Co2+ and thereby modulate the electronic structure accompanied with the upshift of d band centers, which not only enhance the inner conductivity but also regulate the interaction between the catalyst surface and intermediates, especially for the adsorption of absorbed H and hydroperoxy intermediates towards respective hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). As a result, a full alkaline electrolyzer using NiCo2Se4/CP and NiCo2S4/CP as cathode and anode delivers a low voltage of 1.51 V at 10 mA·cm−2, which is comparable even superior to most transition metal-based electrolyzers. more...
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- 2021
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20. A Novel Land-Based High-Frequency Geolocation System
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Guobin Yang, Chunhua Jiang, Yaogai Hu, Anqi Zhou, Binbin Ni, Zhengyu Zhao, and Tongxin Liu
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Skywave ,Computer science ,Transmitter ,0211 other engineering and technologies ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Signal ,Antenna array ,Geolocation ,Transmission (telecommunications) ,Angle of arrival ,Computer Science::Networking and Internet Architecture ,Electrical and Electronic Engineering ,Ionosphere ,Computer Science::Information Theory ,021101 geological & geomatics engineering ,Remote sensing - Abstract
A novel land-based high-frequency (HF) geolocation system is proposed. The geolocating signals are transmitted from the stations with known geographic coordinates. Because of the ionospheric refraction, the signals propagate as skywave in the over-the-horizon (OTH) manner. Therefore, a wide spatial coverage can be achieved. The receiving station uses a small 2-D antenna array to estimate the angle of arrival (AOA) of each transmitter’s signal. An intersecting geolocation algorithm based on the geometric relations between the transmitters, and the receiver is described, which only relies on the coordinates of the transmission stations and the azimuth angles of the signals. A novel specific multichannel system structure is also described. It has a simple structure and low hardware cost, as well as good flexibility. The preliminary experimental results prove the feasibility of this geolocation method and its engineering application significance. more...
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- 2021
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21. APOBEC3B Improves Response to PD-1 Blockade Through DSBs–ATR–CHK1 Pathway
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Hong Yang, Shiyu Chen, Yueyun Ma, Rong Wang, Yanxia Wang, Qin Zeng, Wei Guo, Bin Xie, Xiaomei Zhou, Tongxin Liu, Ziyi Luo, Shuai Chu, and Wei Wang
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Background Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family enzymes are considered to induce base substitutions and strand breaks, which contribute significantly to mutation and genomic instability. In the APOBEC family, APOBEC3B (A3B) is a major mutational source in multiple cancers, which fuels tumor diversity and subclonal evolution. Although the APOBEC mutational signature is enriched in immune checkpoint inhibitor responders, it remains unclear whether and how APOBEC influences the immunotherapy. Methods The association between A3B and anti-PD-1 treatment sensitivity was evaluated with mouse bearing subcutaneous Hepa1-6 and 4T1 tumors which was trasfected with mouse APOBEC3, immunohistochemical staining and flow cytometry were utilized to estimated the tumor immune microenvironment. The effects of A3B on programmed cell death-ligand 1 (PD-L1) expression and mechanistic detection were investigated with bioinformatics analysis, the results were validated in vitro and in vivo. Results High A3B expression increased sensitivity to anti-PD-1 antibody, accompanied by PD-L1 upregulation, and improved tumor-infiltrating T cells and NK cells. We further clarified that A3B induced double-stranded DNA breaks, thereby activating the ATR–Chk1–STAT–IRF1 pathway and resulting in PD-L1 overexpression in tumor. Moreover, Chk1 inhibitor, MK8776, notably reversed the PD-L1 upregulation, aggravated the tumor microenvironment, and eventually abrogated the enhanced sensitivity to anti-PD-1 antibody. Conclusions There findings support the notion that A3B had increased sensitivity to anti-PD-1 antibody, providing direct evidence to illustrate the potential of A3B as a marker of response to immunotherapy. more...
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- 2022
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22. High performance nanofiltration in BUT-8(A)/PDDA mixed matrix membrane fabricated by spin-assisted layer-by-layer assembly
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Yingshuang Meng, Lin-Hua Xie, Lun Shu, Tongxin Liu, Jian-Rong Li, and Min-Jian Zhao
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chemistry.chemical_classification ,Materials science ,General Chemical Engineering ,Layer by layer ,Membrane fouling ,Polyacrylonitrile ,02 engineering and technology ,General Chemistry ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Polyelectrolyte ,0104 chemical sciences ,Biofouling ,chemistry.chemical_compound ,Membrane ,chemistry ,Chemical engineering ,Nanofiltration ,0210 nano-technology - Abstract
The membrane fouling is a notorious problem in the practical application of separation membranes. In this study, a mixed matrix membrane based on the MOF BUT-8(A) and the polymer polydiallyldimethylammonium chloride (PDDA) has been prepared on a hydrolyzed polyacrylonitrile (HPAN) substrate by the spin-assisted layer-by-layer assembly (spin-LbL) method. Thanks to the high porosity, high stability, moderate hydrophilicity, and electronegative nature of BUT-8(A), and the good compatibility between BUT-8(A) particles and PDDA polyelectrolytes, the prepared (BUT-8(A)/PDDA)3-HPAN membrane showed high water permeances (over 164 L m−2 h−1 MPa−1) and high rejection rates (over 91.4%) for many dyes in water. Furthermore, the membrane exhibited superior antifouling performance in nanofiltration (NF) with a high flux recovery rate (95.5%) when humic acid (HA) was used as foulant. The high antifouling performance is resulted from tuning hydrophilicity and electronegativity of the membrane surface. These results suggest that the nanofiltration performance of a MOF-based membrane can be well adjusted by a judicious choice of the membrane components and fabrication methods. more...
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- 2020
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23. Outcome and Optimal Treatment for Esthesioneuroblastoma in the Era of Intensity-Modulated Radiation Therapy: A Single-Center Experience
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Weifeng Qin, Xiaozhong Chen, Qiaoying Hu, Tongxin Liu, and Quanquan Sun
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Chemotherapy ,Multivariate analysis ,business.industry ,Optimal treatment ,medicine.medical_treatment ,Retrospective cohort study ,Single Center ,medicine.disease ,Radiation therapy ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Esthesioneuroblastoma ,030220 oncology & carcinogenesis ,Internal medicine ,Medicine ,business ,Chemoradiotherapy - Abstract
Purpose Esthesioneuroblastoma (ENB) is a type of rare malignant neoplasm of the sinonasal cavity. Optimal treatment for ENB is still controversial. A retrospective study was conducted to identify the clinical outcome and optimal treatment for ENB in the era of intensity-modulated radiation therapy (IMRT). Patients and methods Between December 2006 and August 2018, 37 patients with ENB without distant metastasis who underwent neoadjuvant chemotherapy followed by chemoradiotherapy (C+RC) or surgery followed by radiotherapy or chemoradiotherapy (S+R/RC) were retrospectively reviewed at our center. Results The median follow-up period was 63.7 months (range, 13.2-111.5 months). Five-year overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) were similar between treatment arms (P values > 0.05). With a multivariate analysis, a Karnofsky Performance Status (KPS) of ≤80 was a prognostic factor for poor five-year OS. A KPS of ≤80 and Kadish class C-D tumors were prognostic factors for poor PFS. A KPS of ≤80 was a prognostic factor for poor LRFS. When KPS was ≤80 and tumors were Kadish class C-D, T3-4 and N1 were prognostic factors for poor DMFS. Subgroup analyses also demonstrated that the two treatment arms exhibited similar trends for OS, PFS, LRFS, and DMFS, excluding patients with N1 or Kadish class A-B tumors (P values > 0.05). Conclusion In the era of IMRT, S+R/RC failed to improve the outcomes of patients with ENB. C+RC may be a feasible treatment option for patients with ENB. more...
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- 2020
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24. The Hofmann reaction involving annulation of o-(pyridin-2-yl)aryl amides selectively and rapidly leads to potential photocatalytically active 6H-pyrido[1,2-c]quinazolin-6-one derivatives
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Tongxin Liu, Zhiguo Zhang, Guisheng Zhang, Yameng Wan, Hao Wu, and Wenjing Gao
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Reaction conditions ,chemistry.chemical_compound ,Annulation ,Fluorophore ,chemistry ,Reagent ,Aryl ,Functional group ,Photocatalysis ,Environmental Chemistry ,Substrate (chemistry) ,Pollution ,Combinatorial chemistry - Abstract
A highly efficient PIFA-mediated Hofmann reaction of o-(pyridin-2-yl)aryl amides has been developed to selectively and rapidly construct various potential photocatalytically active 6H-pyrido[1,2-c]quinazolin-6-one derivatives. The use of a nontoxic and eco-friendly organoiodine reagent, operational simplicity, short reaction time, mild reaction conditions, broad substrate scope, high functional group tolerance, and excellent yields make this protocol very simple, practical, and easy to handle. It provides a feasible platform for developing novel organic fluorophore structures. Preliminary research for this purpose shows that the N5-methylated pyridoquinazolinone 3a could be used as a photocatalyst in several organic transformations, indicating that it is a very promising lead fluorophore for developing new superior photocatalysts. more...
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- 2020
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25. Gross Tumor Volume Predicts Survival and Pathological Complete Response of Locally Advanced Esophageal Cancer After Neoadjuvant Chemoradiotherapy
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Rong Wang, Xiaomei Zhou, Tongxin Liu, Shuimiao Lin, Yanxia Wang, Xiaogang Deng, and Wei Wang
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Cancer Research ,Oncology - Abstract
BackgroundNeoadjuvant chemoradiotherapy (neo-CRT) plus surgery has greatly improved the prognosis of locally advanced esophageal cancer (EC) patients. But which factors may influence the pathological tumor response and long-term survival remains unclear. The purpose of this study was to identify the prognostic biomarkers of locally advanced EC patients receiving neo-CRT.MethodsWe reviewed the data of 72 patients with cT2-4N0-3M0 EC who underwent neo-CRT at our hospital. The patients received intensity-modulated radiation therapy with a total radiation dose of 41.4–60.0 Gy. Most patients received platinum + paclitaxel-based combination regimens every three weeks for 2–4 cycles. The recorded data included age, sex, smoking history, alcohol use, histology, tumor location, clinical TNM stage, tumor length, gross tumor volume (GTV), GTV of primary tumor (GTVp), GTV of lymph nodes (GTVn), radiation dose, and number of chemotherapy cycles. Overall survival (OS), progression-free survival (PFS), and pathological complete response (pCR) were analyzed.ResultsThe 3-year OS and PFS rates of these patients who underwent neo-CRT were 51.14% and 43.28%, respectively. In the univariate analyses, smoking history, clinical stage, GTV, GTVp, and GTVn were significantly associated with OS, whereas alcohol use, GTV, GTVp, and GTVn were significantly associated with PFS. Furthermore, in the multivariate analysis, GTV was an independent prognostic predictor of OS (hazard ratio (HR): 14.14, 95% confidence interval (CI): 3.747–53.33, P < 0.0001) and PFS (HR: 6.090, 95% CI: 2.398–15.47, P < 0.0001). In addition, GTV < 60.50 cm3 compared to > 60.50 cm3 was significantly associated with higher pCR rate (59.3% and 27.8%, respectively, P = 0.038). High dose (> 50 Gy) and increased number of chemotherapy cycles (≥ 3) didn’t improve the OS or PFS in patients with GTV > 60.50 cm3.ConclusionGTV was an independent prognostic factor of long-term survival in EC patients, which may be because GTV is associated with histological response to neo-CRT. Additionally, patients with GTV > 60.50 cm3 didn’t benefit from increased radiation dose or increased number of chemotherapy cycles. more...
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- 2022
26. Heterologous Expression of Arabidopsis
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Zhipeng, Hong, Yang, Li, Yang, Zhao, Mingyu, Yang, Xiaoming, Zhang, Yuhan, Teng, Linjie, Jing, Danxun, Kong, Tongxin, Liu, Shuanglin, Li, Fanli, Meng, Qi, Wang, and Ling, Zhang
- Abstract
Salt damage is an important abiotic stress affecting the agronomic traits of soybean. Soybeans rapidly sense and transmit adverse signals when salt-damaged, inducing a set of response mechanisms to resist salt stress. more...
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- 2022
27. Model-based process intensification of dilute acid pre-hydrolysis of oil palm empty fruit bunch biomass for pretreatment and furfural production
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Denghao Ouyang, Tongxin Liu, Abdul Aziz Astimar, Harrison Lik Nang Lau, Soek Sin Teh, Jalil Nursyairah, Dehua Liu, and Xuebing Zhao
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Environmental Engineering ,Renewable Energy, Sustainability and the Environment ,Bioengineering ,General Medicine ,Waste Management and Disposal - Published
- 2023
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28. Funding allocations for disaster preparation considering catastrophe insurance
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Tongxin Liu, Jianfang Shao, and Xihui Wang
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Economics and Econometrics ,Strategy and Management ,Geography, Planning and Development ,Management Science and Operations Research ,Statistics, Probability and Uncertainty - Published
- 2022
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29. Step scheme nickel-aluminium layered double hydroxides/biochar heterostructure photocatalyst for synergistic adsorption and photodegradation of tetracycline
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Yidan Luo, Yu Han, Ying Hua, Mingshan Xue, Shuohan Yu, Longshuai Zhang, Zuozhu Yin, Xibao Li, Xuewen Ma, Hongyan Wu, Tongxin Liu, Yang Shen, and Bin Gao
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Photolysis ,Environmental Engineering ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Aluminum Hydroxide ,General Medicine ,General Chemistry ,Tetracycline ,Pollution ,Anti-Bacterial Agents ,Nickel ,Hydroxides ,Environmental Chemistry ,Adsorption ,Water Pollutants, Chemical ,Aluminum - Abstract
Improving the adsorption ability of layered double hydroxide (LDH) has been considered as a promising strategy to promote its photodegradation of aqueous pollutants. In this work, nickel-aluminium layered double hydroxides (NiAl-LDH)/biochar nanocomposites were prepared using a simple coprecipitation method, and then applied in synergistic adsorption-photodegradation of tetracycline (TC) in aqueous solutions. In addition, the governing TC removal mechanisms by the nanocomposites were revealed. All NiAl-LDH/BC samples showed strong adsorption and photodegradation of TC. The Langmuir maximum TC adsorption capacity of optimized NiAl-LDH/BC-0.5 reached 124.2 mg/g, which was much better than that of NiAl-LDH (56.1 mg/g) and biochar (11.1 mg/g). Besides, TC photodegradation rate constant of NiAl/BC-0.5 was 3.6 and 4.4 times of that of NiAl-LDH and BC, respectively. The NiAl/BC-0.5 exhibited the maximum TC adsorption-photodegradation efficiency 94.4% in 90 min compared to NiAl-LDH (73.7%) and BC (48.2%). The rate constant of modified Elovich kinetic model for synergistic adsorption and photodegradation on NiAl/BC-0.5 (9.477 min more...
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- 2022
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30. Palladium-Catalyzed Three-Component Tandem Coupling–Carboannulation Reaction Leading to Polysubstituted [60]Fullerene-Fused Cyclopentanes
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Tongxin Liu, Guisheng Zhang, Jinliang Ma, and Qingfeng Liu
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Coupling ,Cyclopentanes ,Fullerene ,Tandem ,010405 organic chemistry ,Aryl ,Organic Chemistry ,chemistry.chemical_element ,010402 general chemistry ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,Polymer chemistry ,Physical and Theoretical Chemistry ,Palladium - Abstract
The first example of transition-metal catalyzed multicomponent carboannulation of [60]fullerene has been developed. [60]Fullerene, 2-(2,3-allenyl)malonates, and (hetero)aryl iodides undergo a Pd(0)-catalyzed tandem coupling-carboannulation process for regioselective access to novel polysubstituted [60]fullerene-fused cyclopentane derivatives with a wide range of substrate scope and high functional group compatibility. A plausible mechanism involving the formation of a fullerene-π-allylpalladium complex with the characteristic of a fullerene cation as a key intermediate has been proposed. more...
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- 2019
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31. Copper-Catalyzed N–H/C–H Sequential Relay Oxidative Radical Carboannulation: Construction of Diversely Substituted [60]Fullerene-Fused Tetrahydrocyclopenta[b]indoles
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Nana Ma, Xingjie Zhang, Juan Wei, Guisheng Zhang, Pengling Zhang, Jinliang Ma, Yifei Ru, and Tongxin Liu
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Fullerene ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Copper catalyzed ,Oxidative phosphorylation ,Physical and Theoretical Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences - Abstract
Reported herein is a new copper-catalyzed N-H/C-H sequential relay oxidative radical carboannulation of [60]fullerene with C2-functionalized free indoles for the direct construction of novel [60]fullerene-fused tetrahydrocyclopenta[ more...
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- 2019
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32. Cu(II)/Mn(III)-Promoted Synergistic Radical N-Heteroannulation Reaction: Synthesis of [60]Fullerene-Fused Tetrahydroquinoline Derivatives
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Guisheng Zhang, Tongxin Liu, Ruoya Wang, Nana Ma, Chenhao Tu, and Qingfeng Liu
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Fullerene ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,010402 general chemistry ,Electrochemistry ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,Adduct - Abstract
Cu(II)/Mn(III)-mediated synergistic radical N-heteroannulation reaction of [60]fullerene with N-sulfonylated o-amino-arylmalonates has been developed for the direct and efficient construction of [60]fullerene-fused tetrahydroquinoline derivatives. A plausible mechanism for the formation of fullerotetrahydroquinolines is proposed, and the electrochemical properties of the obtained fullerene adducts are investigated. more...
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- 2019
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33. Palladium-catalyzed decarboxylative heterocyclizations of [60]fullerene: preparation of novel vinyl-substituted [60]fullerene-fused tetrahydrofurans/pyrans/quinolines
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Xue Zhu, Yifei Ru, Qingfeng Liu, Guisheng Zhang, and Tongxin Liu
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Fullerene ,Metals and Alloys ,chemistry.chemical_element ,General Chemistry ,Combinatorial chemistry ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Materials Chemistry ,Ceramics and Composites ,Heterocyclic derivatives ,Palladium - Abstract
A general and practical methodology for the preparation of novel vinyl-substituted [60]fullerene-fused tetrahydrofurans/pyrans/quinolines through palladium-catalyzed decarboxylative heterocyclizations of [60]fullerene with vinylethylene/2-alkylidenetrimethylene carbonates and vinyl carbamates was developed. Without additives or ligands, the Pd(PPh3)4-catalyzed transformations undergo decarboxylative O- and N-heteroannulation processes to efficiently furnish structurally diverse [60]fullerene-fused heterocyclic derivatives. more...
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- 2019
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34. Second-order nonlinear optical properties of [60]fullerene-fused dihydrocarboline derivates: a theoretical study on switch effect
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Yan Liu, Nana Ma, Guisheng Zhang, Tongxin Liu, Mingyue Lv, and Mengxiao Song
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Fullerene ,Materials science ,Infrared ,Substituent ,Hyperpolarizability ,02 engineering and technology ,General Chemistry ,Time-dependent density functional theory ,Electronic structure ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Molecular physics ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,0210 nano-technology ,Absorption (electromagnetic radiation) ,Excitation - Abstract
Designing multi-state nonlinear optical (NLO) switch systems has been proposed aiming at the improvement of the multiple storage capacity of the optical memories. However, it is still a challenge to get high first hyperpolarizability (β) contrasts for the molecular second-order NLO switches. In this study, due to their rich electrochemical features, [60]fullerene-fused dihydrocarboline derivatives with a donor (D)–π–acceptor (A) electronic structure were studied for the second-order NLO response and switch effect via different computational approaches. The calculated results showed that significantly high contrasts were displayed on the tot values between the neutral and reduced states. Particularly, the system in which the substituent group was –NO2 had only a calculated βtot value of 0.6 × 10−30 esu, but one-electron reduction enlarged the βtot value to 5689 × 10−30 esu (evaluated at ωB97XD/6-31+G(d) level). Furthermore, the TDDFT calculations demonstrated that the large second-order NLO response of the reduced state resulted from the low energy absorption in the infrared region and the excitation transition from C60 to strong electron-acceptor. more...
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- 2019
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35. [Standardized management of platelet derivatives for tissue regeneration research and applications]
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Xingqin, Xie, Yi, Zhang, Xinxin, Zhao, Tongxin, Liu, and Liping, Sun
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Blood Platelets ,Tendons ,Wound Healing ,Bone Regeneration ,Platelet-Rich Plasma ,综 述 - Abstract
OBJECTIVE: To summary the standardized management in research and applications of platelet derivatives for tissue regeneration. METHODS: The related literature about bottlenecks and standardized management of platelet derivatives in recent years was reviewed and analyzed. RESULTS: Although the platelet derivatives are increasingly used to accelerate the regenerative processes of injured joint, skin, nerve, ligament/tendon, and alveolar bone, etc., the large variation in preparation methods, diverse nomenclature, incomplete reporting system, and lack of quantitative and standardized management of the preparation process have caused uncertainty and incomparability of research and application results. In recent years, there has been a trend towards standardized research and management of platelet derivatives. CONCLUSION: The implementation of standardized research and quality management will contribute to promote the research and application of platelet derivatives in the field of tissue regeneration. more...
- Published
- 2021
36. Metal-Free-Catalyzed Three-Component [2+2+2] Annulation Reaction of [60]Fullerene, Ketones, and Indoles: Access to Diverse [60]Fullerene-Fused 1,2-Tetrahydrocarbazoles
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Guisheng Zhang, Tongxin Liu, Jinliang Ma, Pengling Zhang, and Xuna Zhao
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Annulation ,Fullerene ,010405 organic chemistry ,Chemistry ,Component (thermodynamics) ,Organic Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,Metal free ,Physical and Theoretical Chemistry - Abstract
The first example of metal-free-catalyzed multicomponent annulation reaction of [60]fullerene has been developed for concise and efficient construction of novel [60]fullerene-fused 1,2-tetrahydrocarbazoles. Using inexpensive and readily available I more...
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- 2021
37. Comparative Study of the Es Layer between the Plateau and Plain Regions in China
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Wenxuan Wang, Chunhua Jiang, Lehui Wei, Qiong Tang, Wengeng Huang, Hua Shen, Tongxin Liu, Guobin Yang, Chen Zhou, and Zhengyu Zhao
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General Earth and Planetary Sciences - Abstract
The lower atmosphere forcing plays an important role in forming the sporadic E (Es) layer in the ionosphere. In this study, a comparative study of the Es layer recorded by ionosondes at the middle latitude regions was carried out between the plateau and plain regions in China. The two ionosonde stations (Zhangye, 39.21°N, 100.54°E and Beijing, 40.25°N, 116.25°E) are located at the Qinghai–Tibet Plateau and North China Plain, respectively. The data during the year 2018 were used to reveal the characteristics of the Es layer. The occurrence probability, the critical frequency (foEs) and the base virtual height (h’Es) were considered in this study. Results show that: (1) The diurnal and seasonal variations of the occurrence probability between these two regions are similar. The maximum occurrence probability is at noontime and in the summer season. However, the Es at Zhangye occurred more frequently than Beijing at nighttime and in winter to early spring. (2) Similar to previous studies, the maximum value of foEs at Beijing mainly occurred in summer. Interestingly, the maximum value is in winter at Zhangye station. (3) The characteristics of the anomaly of the Es layer at Zhangye are mostly consistent with the characteristics of atmospheric gravity waves in the Qinghai–Tibet Plateau. Therefore, compared with observations at Beijing, the anomalies of the Es layer at Zhangye (at night and in winter to spring) might be attributed to gravity waves in the lower atmosphere over the Qinghai–Tibet Plateau. more...
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- 2022
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38. Anlotinib combined with induction chemotherapy followed by chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: A phase II study
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Feng Jiang, Xiaozhong Chen, Tongxin Liu, WeiFeng Qin, Shuang Huang, Caineng Cao, Ting Jin, and Qifeng Jin
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Cancer Research ,Oncology - Abstract
e18071 Background: Necrotic lesion is a negative prognostic factor for nasopharyngeal carcinoma (NPC) while there are few treatment options for it. This study investigated the efficacy and safety of anlotinib (a multi-target tyrosine kinase inhibitor) in combination with induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) in treatment of liquefactive necrosis of NPC. Methods: This is an open-label, single-arm, phase II trial (NCT05232552). Patients with histologically confirmed stage T3-4N2/T1-4N3M0 NPC (AJCC 8th) who had measurable lesions per RECISTv1.1 and received no previous treatment for cancer were enrolled. Other inclusion criteria included 18-70 years old and ZPS 0-2. All patients received docetaxel (75 mg/m², iv, d1), cisplatin (75 mg/m², iv, d1) and anlotinib (12mg, oral, qd, d1-14) every 3 weeks for 3 cycles before CCRT. Chemoradiotherapy was 2 cycles of cisplatin (100 mg/m², iv, d1) and anlotinib (12mg, oral, qd, d1-14) every 3 weeks, concurrently with intensity-modulated radiotherapy (GTV > 66Gy). The primary endpoint was progression-free survival rate at 3 years. Here we report the results of a preliminary analysis. Results: Between January 2021 and September 2021, 34 patients (28 males and 6 females) were enrolled, and the median age was 54 years old. At the data cutoff date on January 24, 2022, all patients were eligible for the evaluation of tumor response with primary and lymph node lesions. 79.4% of the patients (27 of 34) had a response each for primary and lymph node lesions after IC, while 70.6% (20 of 34) achieved complete response in lymph node lesions compared with 29.4% (10 of 34) in primary lesions. At 6 weeks after CCRT, 100.0% of the patients (34 of 34) had a response in primary lesions and 97.1% (33 of 34) in lymph node lesions. The incidence of liquefactive necrosis was 58.8% (20 of 34) and there were 51 necrotic lesions in all. Among those necrotic lesions, 56.9% (29 of 51) and 80.4% (41 of 51) had complete response after IC and CCRT. The average area shrinkage of necrotic lesion after IC and CCRT was 84.5%±0.25, 97.7%±0.06, respectively. The most common adverse events of grade 3 was leucopenia (17.6%) and mucositis (17.6%), and there was 1 patient (2.9%) occurred neutropenia of grade 4. Conclusions: This preliminary analysis indicated that anlotinib combined with IC and CCRT had promising efficacy and favorable tolerance as treatment of liquefactive necrosis of locoregionally advanced NPC. more...
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- 2022
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39. Improved Ionosonde Monitoring of the Sporadic E Layer Using the Frequency Domain Interferometry Technique
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Tongxin Liu, Guobin Yang, Chen Zhou, Chunhua Jiang, Wei Xu, Binbin Ni, and Zhengyu Zhao
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General Earth and Planetary Sciences - Abstract
The sporadic E (Es) layer is a thin layer of ion plasma enhancement in the E-region ionosphere, typically at altitudes of 90–120 km with vertical and horizontal extent of several or several tens of kilometers. As the transition region between the lower and upper atmosphere, this layer is of critical importance for ionospheric studies. The most economical but effective method to observe this layer is using ionosonde, which, however, is incapable of capturing the finer structure or the internal inhomogeneity of the Es layer as the range resolution is on the order of kilometers. To overcome this limitation, we employ the frequency domain interferometry (FDI) technique, a technique that has been successfully applied to the analysis of some radar and sonar measurements. Here, we use the Es layer measurements near Wuhan, China (114°22′E, 30°30′N) on 8 June 2021 as examples to showcase the capability of this technique. Our results show that the spatial resolution of ionosonde imaging is remarkably increased: the complexity of the internal fine structure in the Es layer can be well observed in the FDI-processed ionograms, whereas the intrinsic range resolution is several kilometers. Moreover, by comparing the ionograms obtained with and without the FDI technique, it is found that the FDI-processed ionogram is particularly suitable for the observation of evolutional processes in the Es layer, as well as the identification of different types of Es layer. With this level of spatial resolution, ionosonde, in combination with the FDI technique, opens the possibility for more refined observations of the Es layer. more...
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- 2022
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40. Promoting transfer of endogenous electrons well increases the carbon and energy efficiency of lignocellulosic biomass conversion to fuels and chemicals
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Fangqian Wang, Denghao Ouyang, Bo Li, Tongxin Liu, and Xuebing Zhao
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Fuel Technology ,Nuclear Energy and Engineering ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology - Published
- 2022
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41. Palladium-catalyzed domino spirocyclization of [60]fullerene: synthesis of diverse [60]fullerene-fused spiro[4,5]/[5,5] derivatives
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Chuanjie Zhang, Jinliang Ma, Guisheng Zhang, Tongxin Liu, and Pengling Zhang
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chemistry.chemical_classification ,Fullerene ,Chemistry ,Metals and Alloys ,Substrate (chemistry) ,chemistry.chemical_element ,General Chemistry ,Combinatorial chemistry ,Catalysis ,Domino ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Materials Chemistry ,Ceramics and Composites ,Alkyl ,Palladium - Abstract
Herein a new, general and practical method for the spirocyclization of [60]fullerene through a palladium-catalyzed domino Heck/C-H activation reaction is presented. A wide range of novel [60]fullerene-fused spirocyclic derivatives can be easily and flexibly synthesized with a broad substrate scope and excellent functional-group tolerance. A plausible mechanism involving an alkyl Pd(ii) species as a key intermediate has been proposed. more...
- Published
- 2020
42. Iron-Catalyzed Redox-Neutral Radical Cascade Reaction of [60]Fullerene with γ,δ-Unsaturated Oxime Esters: Preparation of Free (N-H) Pyrrolidino[2',3':1,2]fullerenes
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Guisheng Zhang, Pengling Zhang, Tongxin Liu, Conghui Wu, and Xue Zhu
- Subjects
Fullerene ,010405 organic chemistry ,Organic Chemistry ,Intermolecular force ,Substrate (chemistry) ,010402 general chemistry ,Oxime ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,Redox ,0104 chemical sciences ,chemistry.chemical_compound ,Hydrolysis ,chemistry ,Cascade reaction ,Functional group ,Physical and Theoretical Chemistry - Abstract
Herein an unprecedented iron(II)-catalyzed redox-neutral radical cascade reaction of [60]fullerene with γ,δ-unsaturated oxime esters is reported for the preparation of novel free (N-H) pyrrolidino[2',3':1,2]fullerenes. The transformation undergoes an intramolecular cyclization/intermolecular cyclization/oxidation/hydrolysis cascade, and features simple operation, broad substrate scope/high functional group compatibility as well as suitable for scale-up synthesis, providing a facile and practical access to a range of free pyrrolidino[2',3':1,2]fullerenes. more...
- Published
- 2020
43. Design of Multifunctional Mesosphere-Ionosphere Sounding System and Preliminary Results
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Tongxin Liu, Chen Zhou, Binbin Ni, Zhengyu Zhao, Chunhua Jiang, Yi Liu, Peng Zhu, Guobin Yang, and Yaogai Hu
- Subjects
010504 meteorology & atmospheric sciences ,Computer science ,Acoustics ,0211 other engineering and technologies ,02 engineering and technology ,Interference (wave propagation) ,lcsh:Chemical technology ,01 natural sciences ,Biochemistry ,Medium frequency ,Article ,Analytical Chemistry ,law.invention ,Mesosphere ,Antenna array ,ionospheric sounding ,law ,lcsh:TP1-1185 ,pseudo-random phase-code ,Electrical and Electronic Engineering ,Radar ,Instrumentation ,021101 geological & geomatics engineering ,0105 earth and related environmental sciences ,Transmitter ,mesospheric sounding ,Atomic and Molecular Physics, and Optics ,Ionospheric sounding ,Depth sounding ,Pulse compression ,Monopulse radar ,miniaturized antennas ,Ionosphere ,Ionosonde - Abstract
This paper describes a novel sounding system for which the functions of the medium frequency (MF) radar and the ionosonde are integrated on the same hardware platform and antenna structure, namely the middle atmosphere-ionosphere (MAI) system. Unlike the common MF radar, MAI system adopts the pseudo-random (PRN) phase-coded modulation technology, which breaks the limitation of the traditional monopulse mode. Through the pulse compression, only a small peak power is needed to achieve the signal-to-noise ratio (SNR) requirement. The excellent anti-jamming performance is also very suitable for the ionospheric sounding. One transmitting and six receiving modes are adopted for the MF sounding. While neglecting the structure of the T/R switches, the coupling interference between the transmitter and the receiver may also be avoided. Moreover, by employing a miniaturized antenna array composed of progressive-wave antennas for the MF receiving and ionospheric sounding, the MAI system takes account of the requirements of the inversion algorithms of MF radar and the large bandwidth need for the ionospheric sounding concurrently. Such an antenna structure can also greatly simplify the system structure and minimize the difficulty of deployment. The experiments verified the availability of the system scheme and its engineering application significance. Through further analysis of the sounding data, the wind field of the mesosphere, the electron density of D layer and electron density profile from layers E to F were obtained at the identical location. The capability of MAI system can play an important role in studying the interaction and coupling mechanism between the mesosphere and ionosphere. more...
- Published
- 2020
44. A Method for Automatic Inversion of Oblique Ionograms
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Chunhua Jiang, Cong Zhao, Xuhui Zhang, Tongxin Liu, Ziwei Chen, Guobin Yang, and Zhengyu Zhao
- Subjects
General Earth and Planetary Sciences - Abstract
In this study, a method is proposed to carry out automatic inversion of oblique ionograms to extract the parameters and electron density profile of the ionosphere. The proposed method adopts the quasi-parabolic segments (QPS) model to represent the ionosphere. Firstly, numerous candidate electron density profiles and corresponding vertical traces were, respectively, calculated and synthesized by adjusting the parameters of the QPS model. Then, the candidate vertical traces were transformed to oblique traces by the secant theorem and Martyn’s equivalent path theorem. On the other hand, image processing technology and characteristics of oblique echoes were adopted to automatically scale the key parameters (the maximum observable frequency and minimum group path, etc.) from oblique ionograms. The synthesized oblique traces, whose parameters were close to autoscaled parameters, were selected as the candidate traces to produce a correlation with measured oblique ionograms. Lastly, the proposed algorithm searched the best-fit synthesized oblique trace by comparing the synthesized traces with oblique ionograms. To test its feasibility, oblique ionograms were automatically scaled by the proposed method and these autoscaled parameters were compared with manual scaling results. The preliminary results show that the accuracy of autoscaled maximum observable frequency and minimum group path of the ordinary trace of the F2 layer is, respectively, about 91.98% and 86.41%, which might be accurate enough for space weather specifications. It inspires us to improve the proposed method in future studies. more...
- Published
- 2022
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45. Upwelling coherent backscatter plumes observed with ionosondes in low-latitude region
- Author
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Chunhua Jiang, Lehui Wei, Tatsuhiro Yokoyama, Jiyao Xu, Kun Wu, Wei Yuan, Jing Liu, Tongxin Liu, Guobin Yang, and Zhengyu Zhao
- Subjects
Atmospheric Science ,Space and Planetary Science - Abstract
Investigations of upwelling backscatter plumes are mostly from observations of VHF radars. This study reports the first observation of upwelling backscatter plumes (backscatter echoes beyond the critical frequency of the F2 layer, foF2) recorded by ionosondes at low latitudes on 13 March 2015. With a pair of ionosondes (Puer, 22.7° N, 101.05° E, Dip Lat 12.9° N, and Chiang Mai, 18.76° N, 98.93° E, Dip Lat 9.04° N), Swarm satellites flying side-by-side (longitudinal separation of about 1.4°, about 150 km), and an all-sky imager (25° N, 104° E, Dip Lat 15.1° N), the evolution of plasma bubbles is presented in this study. Observations show that ionosonde backscatter plumes originating from a local-scale upwelling could be observed. In addition, this study also reported ionosonde backscatter plumes from other regions with approaching and receding characteristics. Results show that characteristics of backscatter plumes with ionosondes are consistent with observations from VHF radars. It suggests that ionosonde backscatter plumes might also be used to study the characteristics of upwelling backscatter plumes. more...
- Published
- 2022
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46. Metal organic frameworks as platforms for the nanostructuring of Mn3 single molecule magnets
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Zhen-Jun Fan, Tongxin Liu, Xiaohui Song, Zhen-Yu Mi, Weijun Du, Haocheng Wang, Yanjing Du, and Rongzhao Liu
- Subjects
Thermogravimetric analysis ,Materials science ,chemistry.chemical_element ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,Inorganic Chemistry ,Adsorption ,chemistry ,Chemical engineering ,Aluminium ,Materials Chemistry ,Ceramics and Composites ,Molecule ,Metal-organic framework ,Thermal stability ,Physical and Theoretical Chemistry ,Mesoporous material ,Powder diffraction - Abstract
In this paper, we report incorporation of the nanostructuration Single-Molecule Magnets (SMMs) Mn3 into mesoporous aluminum-based metal-organic framework (MOF) [Al(OH)(SDC)]n (H2SDC = 4,4′-stilbenedicarboxylic acid), known as CYCU-3. The successful incorporation was confirmed by PXRD, N2 adsorption measurements and thermogravimetric analysis. EDX analysis indicated average 15 mol% insertion of SMMs, which is substantial higher than what was previously reported for SMM@silica composites. TGA measurements suggest that MOF can increase the SMM's thermal stability. Magnetic measurements reveal the preservation of the magnetic properties of SMMs inside MOF pores. The AC susceptibility data suggest an effective energy barrier of about 40 K for SMM@MOFs composites, slightly lower than those of pristine Mn3 SMMs, which is about 55 K. more...
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- 2022
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47. Low temperature storage reduces aroma-related volatiles production during shelf-life of banana fruit mainly by regulating key genes involved in volatile biosynthetic pathways
- Author
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Rong Wang, Xueping Li, Weixin Chen, Qiumian Li, Xiaoyang Zhu, Tongxin Liu, Jun Li, and Jun Luo
- Subjects
chemistry.chemical_classification ,biology ,food and beverages ,Fatty acid ,Fruit Flavor ,04 agricultural and veterinary sciences ,Horticulture ,biology.organism_classification ,Shelf life ,040401 food science ,040501 horticulture ,Amino acid ,Lipoxygenase ,Metabolic pathway ,0404 agricultural biotechnology ,Enzyme ,chemistry ,parasitic diseases ,biology.protein ,Food science ,0405 other agricultural sciences ,Agronomy and Crop Science ,Aroma ,Food Science - Abstract
Banana fruit is sensitive to chilling injury, which not only causes physical damage but also dramatically reduces fruit flavor. In this work, we evaluated the influence of non-chilling low temperature (NCT, 13 °C) and chilling temperature (CT, 5 °C) storage on volatiles production in banana in comparison to control conditions (20 °C) and evaluated the possible mechanisms. We found that CT storage caused chilling injury, which negatively affected the physical appearance of the fruit and dramatically reduced volatiles production, especially fruity note volatiles, such as esters. In contrast, NCT storage only reduced the production of a few specific volatiles. Both NCT and CT affected volatile-related amino acid and biosynthetic precursors of fatty acid compositions. The expression levels of the volatiles biosynthesis-related genes, MaHPL, MaLOX, and MaAAT, were repressed by low temperature (NCT and CT), particularly chilling temperature, while MaADH and MaPDC were up-regulated. These results suggest that CT significantly reduces volatiles production by regulating different key enzymes and genes involved in volatiles biosynthetic pathways and is mainly mediated via the repression of the lipoxygenase and amino acid metabolic pathways. more...
- Published
- 2018
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48. A comparison of neoadjuvant chemotherapy with gemcitabine versus docetaxel plus cisplatin in locoregionally advanced nasopharyngeal carcinoma: a propensity score matching analysis
- Author
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Fangzheng Wang, Fujun Hu, Bin Li, Tongxin Liu, Quanquan Sun, Jing Chen, Weifeng Qin, and Zhimin Ye
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,concurrent chemoradiotherapy ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,IMRT ,Original Research ,Cisplatin ,Chemotherapy ,business.industry ,nasopharyngeal carcinoma ,medicine.disease ,Gemcitabine ,Concurrent chemoradiotherapy ,Regimen ,030104 developmental biology ,Nasopharyngeal carcinoma ,Docetaxel ,Cancer Management and Research ,030220 oncology & carcinogenesis ,Propensity score matching ,business ,neoadjuvant chemotherapy ,medicine.drug - Abstract
Tongxin Liu,1–3,* Quanquan Sun,1,2,* Jing Chen,1–3 Fangzheng Wang,1–3 Bin Li,1–3 Weifeng Qin,1–3 Zhimin Ye,1–3 Fujun Hu1–3 1Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China; 2Key Laboratory of Radiation Oncology in Zhejiang Province, Hangzhou, China; 3Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China *These authors contributed equally to this work Purpose: To compare the efficacy and safety of neoadjuvant chemotherapy (NACT) with gemcitabine (GEM) vs docetaxel plus cisplatin (CDDP) in locoregionally advanced nasopharyngeal carcinoma (NPC).Methods: A total of 222 patients with locoregionally advanced NPC between February 2012 and May 2014 in our hospital who received NACT with GEM or docetaxel plus CDDP combined with concurrent chemoradiotherapy (CCRT) were retrospectively analyzed. Fifty-two patients treated with GEM plus CDDP (GP) combined with CCRT were matched with 52 patients who received docetaxel plus CDDP (TP) combined with CCRT.Results: With a median follow-up time of 60 months (range, 14–72 months), the 5-year overall survival, progression-free survival (PFS), local relapse-free survival and distant metastasis-free survival (DMFS) rates were 78.8%, 66.0%, 81.0% and 75.9%, respectively, in the GP group and 79.4%, 60.5%, 79.6% and 73.6%, respectively, in the TP group. No statistically significant survival differences were found between the two groups. In multivariate analysis, T3–4 and N2–3 were prognostic factors for poor 5-year PFS and DMFS (all P-values 0.05).Conclusion: NACT with GP or TP regimen achieved comparable clinical outcome with acceptable toxicities. Both regimens might be a treatment option for patients with locoregionally advanced NPC. Keywords: nasopharyngeal carcinoma, IMRT, neoadjuvant chemotherapy, concurrent chemoradiotherapy more...
- Published
- 2018
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49. N-Heterocyclic Carbene-Catalyzed α,β-Unsaturated Aldehydes Umpolung in Fullerene Chemistry: Construction of [60]Fullerene-Fused Cyclopentan-1-ones and Cyclohex-2-en-1-ones
- Author
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Jingjing Bi, Guisheng Zhang, Qingfeng Liu, Pengling Zhang, Beibei Hu, Lei Shi, Zhiguo Zhang, and Tongxin Liu
- Subjects
chemistry.chemical_classification ,Fullerene chemistry ,Fullerene ,010405 organic chemistry ,Chemistry ,Aryl ,Organic Chemistry ,Substrate (chemistry) ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,0104 chemical sciences ,Catalysis ,Umpolung ,chemistry.chemical_compound ,Physical and Theoretical Chemistry ,Carbene ,Alkyl - Abstract
The first umpolung strategy for the cycloacylation of fullerene using a N-heterocyclic carbene organocatalyst is reported. The coupling of [60]fullerene with different structural α,β-unsaturated aldehydes efficiently furnishes interesting [60]fullerene-fused cyclopentan-1-ones or cyclohex-2-en-1-ones in good to excellent yields. This new reaction displays a wide substrate scope and excellent functional-group tolerance, and diverse substituents such as aryl, heteroaryl, alkenyl, alkyl, and ester can be installed by using the corresponding enals. more...
- Published
- 2018
- Full Text
- View/download PDF
50. Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-α-Iodomethyl Vinylsulfones
- Author
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Guisheng Zhang, Ning Lu, Zhiguo Zhang, Nana Ma, Tongxin Liu, Conghui Wu, and Qingfeng Liu
- Subjects
Sulfonyl ,chemistry.chemical_classification ,010405 organic chemistry ,Organic Chemistry ,Regioselectivity ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,chemistry ,Copper catalyzed ,Stereoselectivity ,Physical and Theoretical Chemistry ,Selectivity - Abstract
A highly regioselective iodosulfonylation of allenes in the presence of CuI and 1,10-phenanthroline has been developed for the synthesis of various useful ( E)-α-iodomethyl vinylsulfones in moderate to excellent yields. This practical reaction is fast, operationally simple, and in particular, proceeds under very mild conditions to afford the target products with high regio- and stereoselectivity. The selectivity was illustrated by a conceptual DFT analysis. more...
- Published
- 2018
- Full Text
- View/download PDF
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