1. Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe
- Author
-
Kelberman D, Hawe E, Luong LA, Mohamed Ali V, Lundman P, Tornvall P, Aillaud MF, Juhan Vague I, Yudkin JS, Margaglione M, Tremoli E, Humphries SE, HIFMECH study group, DI MINNO, GIOVANNI, Kelberman, D, Hawe, E, Luong, La, Mohamed Ali, V, Lundman, P, Tornvall, P, Aillaud, Mf, Juhan Vague, I, Yudkin, J, Margaglione, M, DI MINNO, Giovanni, Tremoli, E, Humphries, Se, and HIFMECH study, Group
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Genotype ,Myocardial Infarction ,Polymorphism, Single Nucleotide ,Gastroenterology ,Pathogenesis ,Gene Frequency ,Risk Factors ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Survivors ,Myocardial infarction ,Allele ,Promoter Regions, Genetic ,Interleukin 6 ,Allele frequency ,Inflammation ,Molecular Epidemiology ,biology ,Interleukin-6 ,business.industry ,C-reactive protein ,Case-control study ,Hematology ,Middle Aged ,medicine.disease ,Europe ,Case-Control Studies ,biology.protein ,Topography, Medical ,business ,Biomarkers - Abstract
SummaryElevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease. We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South. IL-6 and CRP levels were similar in controls in both regions, but were higher in cases. For the -174G>C polymorphism the rare -174C allele showed a regional difference in allele frequency, being more common in the North European group (0.43 vs 0.28; p < 0.0005), where -174C allele carriers showed an apparent reduced risk of MI compared to -174GG homozygotes (OR 0.53, 95%CI 0.32, 0.86). No such effect was observed in the South or with the -572G>C in either group. Neither genotype was associated with a significant effect on plasma IL-6 levels in either cases or controls. Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europe.
- Published
- 2004