1. How Space-Filling Is a Pyridine Lone Pair?
- Author
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Lodovico Lunazzi, Manfred Schlosser, Renzo Ruzziconi, Susan Lepri, Andrea Mazzanti, A. Mazzanti, L. Lunazzi, S. Lepri, R. Ruzziconi, and M. Schlosser
- Subjects
Steric effects ,BIPHENYLS ,Nitrogen ,Substituent ,Density ,Steric hindrance ,Molecular physics ,chemistry.chemical_compound ,NMR spectroscopy ,Computational chemistry ,Pyridine ,Molecule ,Microwave-Spectrum ,Biaryls ,Physical and Theoretical Chemistry ,Lone pair ,Molecular-Structure ,Torsional energy diagrams ,Internal-Rotation ,Organic Chemistry ,Nuclear magnetic resonance spectroscopy ,DFT CALCULATIONS ,Fluoroaromatic Systems ,Density functional calculations ,chemistry ,Torsional Barriers ,Organic-Compounds ,Compressibility ,Density functional theory ,Conformational-Analysis - Abstract
The torsional barriers of 2'-substituted 2-arylpyridines have been probed experimentally (by using dynamic NMR spectroscopy) and computationally (by using density functional theory). Due to the compressibility of the lone pair, the torsional barriers of the arylpyridines are up to 4.2 kcal/mol smaller than those of the carba-analogous biphenyls. Furthermore, the ground states of the 2-arylpyridines are less twisted than those of the biphenyls. Finally, due to an out-of-collinearity distortion, the intramolecular repulsion is attenuated in both rotational transition states, in the syn coplanar conformer (in which the pyridine nitrogen and the substituent R face each other) and in the anti coplanar conformer (in which they are on opposite sides of the molecule).