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We have conducted interstitial chemotherapy for malignant brain tumors with slowly releasing anticancer drugs-polymer composites. We administerd either ACNU-composite or 5Fu-composite at the time of the operation in treating of 123 cases of malignant tumors. In 5Fu-composite cases, a severe local brain edema was seen in and around composite. It is thougt that this edema is due to the occurence of focal leucoencephalopathy of cause of 5Fu. This study presents the morphological change of glioma after local treatment with anticancer drugs-polymer. 6 cases of malignant gliomas, 5 glioblastoma and 1 anaplastic astrocytoma, were reoperated after this treatment. Histological exsamination revealed, (1) marked tumor tissue necrosis and no tumor cell around the drugs-polymer, (2) The viable tumor cells were seen around the tumor vessels.

Some combinatorial optimization problems can be solved on the Hopfield model which is an artificial neural network system. In this paper, an algorithmic procedure with neural networks for combinatorial optimizations is proposed which attains good (not necessarily best) solutions by systematically changing the Lagrange multipliers for the constraints in the problem. The proposed method is applicable to both linear and quadratic programming problems with discrete control variables. Numerical examples for the Hitchcock problem and for a ferry routing problem are provided to illustrate the basic properties and applicability of the proposed method.