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9. Annual increase in the frequency of papillary thyroid carcinoma as diagnosed by fine-needle aspiration at a cytology unit in Sicily

Author

Rizzo, Massimo, TALAMO ROSSI, Raffaele, Sindoni, A., Panetta, Stefania, Talamo Rossi, R., Scisca, Claudio, Bonaffini, O., Altavilla, Giuseppe, Panetta, S., Denaro, Lucia, Scisca, C., Trimarchi, Francesco, Altavilla, G., Denaro, L., Benvenga, Salvatore, Sindoni, Alessandro, Rosanò, A., Saraceno, G., Trimarchi, F., and Benvenga, S.

Subjects
Adult, Male, endocrine system, medicine.medical_specialty, Pathology, Time Factors, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Hashimoto Disease, Thyroid carcinoma, Young Adult, Predictive Value of Tests, Cytology, medicine, Humans, Thyroid Neoplasms, Child, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Sicily, Aged, Aged, 80 and over, Analysis of Variance, Chi-Square Distribution, medicine.diagnostic_test, business.industry, Carcinoma, Thyroid, Medullary thyroid cancer, Nodule (medicine), General Medicine, Middle Aged, medicine.disease, Carcinoma, Papillary, Aspiration cytology, body regions, medicine.anatomical_structure, Fine-needle aspiration, Thyroid Cancer, Papillary, Linear Models, Female, Radiology, medicine.symptom, business, Lymphocytic Thyroiditis
Abstract

An increased frequency of papillary thyroid carcinoma (PTC) has been reported in the literature, including studies based on fine-needle aspiration cytology (FNAC). To substantiate our own ascertainment of such an increase, we retrieved all the diagnoses of ultrasound-guided FNAC which was performed on 11,389 patients referred for cytological evaluation of a single or dominant thyroid nodule from 1988 to 2010. FNAC yielded 11,258 adequate specimens. The number of patients with PTC was 200 (age 10–83 yrs) and increased significantly from 1988 to 2010 (r= 0.916, P

Published
2013

10. Immunoreactions for P53 isoforms are associated with ultrastructural proliferative profiles in benign thyroid nodules

Author

Concetta Trovato, Maria, Ruggeri, Rosaria Maddalena, Scardigno, Marco, Sturniolo, Giacomo, Vita, Roberto, Vitarelli, Enrica, Arena, Grazia, Gambadoro, Orazio, Sturniolo, Giovanni, Trimarchi, Francesco, Benvenga, Salvatore, Bourdon, Jean-Christophe, and Cavallari, Vittorio

Subjects
Adult, Male, endocrine system, P53, Apoptotic subcellular phenotypes, Immunohistochemistry, P53 isoforms, Proliferating subcellular profiles, Transmission electron microscopy, Ultrastructure, 2734, Histology, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Middle Aged, Microscopy, Electron, Transmission, Biomarkers, Tumor, Humans, Protein Isoforms, Female, Thyroid Nodule, Tumor Suppressor Protein p53, Aged
Abstract

Background: P53 isoforms originate from the alternative initiation of P53 gene translation through usage of an internal promoter located in intron 4. All P53 isoforms are spliced in intron 9 and may modulate cell proliferation and cell fate outcome in response to DNA damage. Aim: To examine immunoexpression of P53 isoforms in benign proliferative lesions occurring in multinodular thyroids and to assess the ultrastructural phenotype of P53 distribution in the thyrocytes of those lesions by electron microscopy. Materials and Methods: By immunohistochemistry and transmission electron microscopy (TEM), we evaluated 38 multinodular thyroids containing a total of 102 benign lesions: 38 nodular goiters (NG; colloid=20, parenchymatous=18), 52 follicular adenomas (FA) and 12 Hashimoto’s thyroditis (HT). FA were classified into 10 normo-follicular, 9 macro-follicular, 28 microfollicular and 5 solid variants. Results: Immunoreaction for P53 isoforms was observed in approximately 50% of all lesions, except macrofollicular variant FA (33%). At TEM analysis, immunoreactive NG, FA and TH lesions showed signs of proliferation by simultaneous appearance of dispersed chromatin, increased amounts of cytoplasmic organelles and dilation of the rough endoplasmic reticulum. TEM signs of apoptosis and proliferation were also detected in FA, but with different rates compared to NG. Conclusion: The immunohistochemical expression of P53 isoforms in NG, FA and HT suggests their role in the development of these lesions. Ultrastructural findings support the hypothesis that P53 immunoexpression correlates with reactive proliferative changes in thyrocytes.

Published
2016

22. Cell proliferation parameters and apoptosis indices in pituitary macroadenomas

Author

Ruggeri, Rosaria Maddalena, Costa, Gregorio, Simone, Angela, Campenni', Alfredo, Sindoni, Alessandro, Ieni, Antonio, Cavallari, Vittorio, Trimarchi, Francesco, and Curtò, L.

Subjects
Adenoma, Adult, Male, Adolescent, Ubiquitin-Protein Ligases, Apoptosis, Pituitary, Adenomas, Ploidy, DNA, Immunoenzyme Techniques, Young Adult, Biomarkers, Tumor, Mitotic Index, Humans, Pituitary Neoplasms, Aged, Cell Proliferation, Ploidies, Cell Cycle, Middle Aged, Flow Cytometry, Ki-67 Antigen, Proto-Oncogene Proteins c-bcl-2, Female, Follow-Up Studies
Abstract

Pituitary adenomas are usually well-differentiated tumors but may show locally aggressive behavior.To investigate the relationship between proliferation and apoptosis parameters and tumor recurrence in a series of 20 radically resected pituitary macroadenomas (11 functioning, 9 non-functioning).Proliferative activity and DNA ploidy were analyzed by flow cytometry (FCM) on fresh surgical specimens. Immunohistochemistry for Ki-67/MIB-1 and for the anti-apoptotic protein Bcl-2 was performed on paraffin-embedded specimens from the same tumors. Tumor regrowth was evaluated by magnetic resonance imaging (MRI).Six adenomas recurred after surgery, regardless of hormonal hypersecretion. Pre-surgical tumor size was significantly higher in recurrent than in non-recurrent adenomas (p=0.003). Pre-surgical MRI demonstrated cavernous sinus (CS) invasiveness in all recurrent tumors, while none of the non-invasive adenomas recurred (p=0.042, by Fisher's exact test). The DNA content was aneuploid in 5/20 adenomas, one of which recurred. Cell percentages in the S (%SPF) and G2+M (%G2-M) phases and proliferative index (PI) (PI=%SPF+%G2-M) were significantly higher in aneuploid than in diploid adenomas (p0.05), but no significant differences concerning all FCM parameters were observed between recurrent and non-recurrent adenomas. Similarly, MIB-1 did not show a significant difference of expression between recurrent and non-recurrent adenomas (p=0.33). Bcl-2 immunoreactivity was detected in 12/15 pituitary adenomas, involving 63±35% of tumor cells, regardless of tumor recurrence.In this group of radically resected pituitary macroadenomas, neuroradiological finding of CS invasiveness--but not FCM parameters nor MIB-1 and Bcl-2 expression--is useful for predicting tumor recurrence.

Published
2011

31. L'acromegalia

Author

Cannavo', Salvatore and Trimarchi, Francesco

Published
2010

34. Thyroid nodules in growth hormone replaced patients

Author

Marini, Fiorella, Torre, MARIA LUISA TINDARA, Curto', Lorenzo, Cotta, OANA RUXANDRA, Ragonese, Marta, Ferrau', Francesco, Cutroneo, P., Violi, A., Trimarchi, Francesco, and Cannavo', Salvatore

Published
2009

46. AFRODISIACO

Author

Trimarchi, Francesco and Benvenga, Salvatore

Published
2004

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