1. Safety and feasibility of upper limb cardiopulmonary exercise test in Friedreich ataxia
- Author
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Francesco Giallauria, Angela Marsili, Alessandro Filla, Andrea Salzano, Assunta Trinchillo, Giovanni Defazio, Claudia Del Prete, Francesco Saccà, Vincenzo Guardasole, Giovanna De Michele, Giorgia Puorro, Rossella Vastarella, Carlo Casali, Christian Marcotulli, Chiara Pane, Antonio Cittadini, Pane, Chiara, Salzano, Andrea, Trinchillo, Assunta, Del Prete, Claudia, Casali, Carlo, Marcotulli, Christian, Defazio, Giovanni, Guardasole, Vincenzo, Vastarella, Rossella, Giallauria, Francesco, Puorro, Giorgia, Marsili, Angela, De Michele, Giovanna, Filla, Alessandro, Cittadini, Antonio, and Saccà, Francesco
- Subjects
medicine.medical_specialty ,Ataxia ,Epidemiology ,030204 cardiovascular system & hematology ,Doppler imaging ,Trial ,Upper Extremity ,03 medical and health sciences ,Oxygen Consumption ,0302 clinical medicine ,Internal medicine ,Activities of Daily Living ,medicine ,Humans ,Respiratory system ,Cardiopulmonary exercise test ,Exercise Tolerance ,business.industry ,Ultrasound ,VO2 max ,Endpoint ,Mitochondrial ,medicine.anatomical_structure ,Friedreich ataxia ,Exercise Test ,Cardiology ,Feasibility Studies ,Upper limb ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Anaerobic exercise ,Body mass index ,030217 neurology & neurosurgery - Abstract
Aims To explore the feasibility of upper limbs cardiopulmonary exercise test (CPET) in Friedreich ataxia (FRDA) patients and to compare the results with sex, age, and body mass index (BMI) matched cohort of healthy controls (HC). Methods and results Cardiopulmonary exercise test was performed using an upper limbs cycle ergometer on fasting subjects. Peak oxygen uptake (peak VO2) was recorded as the mean value of VO2 during a 20 s period at the maximal effort of the test at an appropriate respiratory exchange rate. The ventilatory anaerobic threshold (AT) was detected by the use of the V-slope method. We performed echocardiography with an ultrasound system equipped with a 2.5 MHz multifrequency transducer for complete M-mode, two-dimensional, Doppler, and Tissue Doppler Imaging analyses. We studied 55 FRDA and 54 healthy matched controls (HC). Peak VO2 showed a significant 31% reduction in FRDA patients compared to HC (15.2 ± 5.7 vs. 22.0 ± 6.1 mL/kg/min; P Conclusions Upper limb CPET is useful in the assessment of exercise tolerance and a possible tool to determine the functional severity of the mitochondrial oxidative defect in patients with FRDA. The cardiopulmonary exercise test is an ideal functional endpoint for Phases II and III trials through a simple, non-invasive, and safe exercise test.
- Published
- 2020
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