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Rare genetic neurological disorders (RND; ORPHA:71859) are a heterogeneous group of disorders comprising >1700 distinct genetic disease entities. However, genetic discoveries have not yet translated into dramatic increases of diagnostic yield and indeed rates of molecular genetic diagnoses have been stuck at about 30–50% across NGS modalities and RND phenotypes [1, 2]. Existence of yet unknown disease genes as well as shortcomings of commonly employed NGS technologies and analysis pipelines in detecting certain variant types are typically cited to explain the low diagnosis rates. To increase the diagnostic yield in RNDs - one of the four focus disease groups in Solve-RD - we follow two major approaches, that we will here present and exemplify: (i) systematic state-of the art re-analysis of large cohorts of unsolved whole-exome/genome sequencing (WES/WGS) RND datasets; and (ii) novel-omics approaches. Based on the way Solve-RD systematically organizes researchers’ expertise to channel this approach [3], the European Reference Network for Rare Neurological Diseases (ERN-RND) has established its own Data Interpretation Task Force (DITF) within SOLVE-RD, which is currently composed of clinical and genetic experts from 29 sites in 15 European countries. The Solve-RD project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 779257. Data were analysed using the RD‐Connect Genome‐Phenome Analysis Platform, which received funding from EU projects RD‐Connect, Solve-RD and EJP-RD (Grant Numbers FP7 305444, H2020 779257, H2020 825575), Instituto de Salud Carlos III (Grant Numbers PT13/0001/0044, PT17/0009/0019; Instituto Nacional de Bioinformática, INB) and ELIXIR Implementation Studies. The study was further funded by the Federal Ministry of Education and Research, Germany, through the TreatHSP network (01GM1905 to RS and LS), the National Institute of Neurological Diseases and Stroke (R01NS072248 to SZ and RS), the European Joint Program on Rare Diseases-EJP-RD COFUND-EJP N° 825575 through funding for the PROSPAX consortium (441409627 to MS, RS and BvW). CW was supported by the PATE program of the Medical Faculty, University of Tübingen. CEE received support from the Dutch Princess Beatrix Muscle Fund and the Dutch Spieren voor Spieren Muscle fund. Authors on this paper are members of the European Reference Network for Rare Neurological Diseases (ERN-RND, Project ID 739510)

[cat] Es presenta un estat de la qüestió descriptiu sobre les eolianites quaternàries de la península de Formentor (Illa de Mallorca). Moltes es troben dins cales que donen cap el NO, com són cala Sant Vicenç, Cala Bóquer i cala Figuera. N’hi ha d’altres que es troben a la badia de Pollença. Malgrat la presència de dunes fòssils, actualment no hi ha sistemes dunars a la zona. També es comenta breument les cavitats que hi ha a les eolianites i els maressars de la zona., [eng] A state of the art is presented on the Quaternary aeolianites of the Formentor Peninsula (Island of Mallorca). Many are located in coves that face to the NW, such as Cala Sant Vicenç, Cala Bóquer and Cala Figuera. There are others in the Bay of Pollença. Despite the presence of fossil dunes, there are currently no dune systems in the area. The cavities in the Aeolianites and quarries in the area are also briefly discussed.

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For the first time in Europe hundreds of rare disease (RD) experts team up to actively share and jointly analyse existing patient's data. Solve-RD is a Horizon 2020-supported EU flagship project bringing together >300 clinicians, scientists, and patient representatives of 51 sites from 15 countries. Solve-RD is built upon a core group of four European Reference Networks (ERNs; ERN-ITHACA, ERN-RND, ERN-Euro NMD, ERN-GENTURIS) which annually see more than 270,000 RD patients with respective pathologies. The main ambition is to solve unsolved rare diseases for which a molecular cause is not yet known. This is achieved through an innovative clinical research environment that introduces novel ways to organise expertise and data. Two major approaches are being pursued (i) massive data re-analysis of >19,000 unsolved rare disease patients and (ii) novel combined -omics approaches. The minimum requirement to be eligible for the analysis activities is an inconclusive exome that can be shared with controlled access. The first preliminary data re-analysis has already diagnosed 255 cases form 8393 exomes/genome datasets. This unprecedented degree of collaboration focused on sharing of data and expertise shall identify many new disease genes and enable diagnosis of many so far undiagnosed patients from all over Europe. The Solve-RD project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 779257. This research is supported (not financially) by four ERNs: (1) The ERN for Intellectual Disability, Telehealth and Congenital Anomalies (ERN-ITHACA)-Project ID No 869189; (2) The ERN on Rare Neurological Diseases (ERN-RND)-Project ID No 739510; (3) The ERN for Neuromuscular Diseases (ERN Euro-NMD)-Project ID No 870177; (4) The ERN on Genetic Tumour Risk Syndromes (ERN GENTURIS)-Project ID No 739547. The ERNs are co-funded by the European Union within the framework of the Third Health Programme. Open Access funding enabled and organized by Projekt DEAL. Sí

Early-onset colorectal cancer (EOCRC), defined as that diagnosed before the age of 50, accounts for 10–12% of all new colorectal cancer (CRC) diagnoses. Epidemiological data indicate that EOCRC incidence is increasing, despite the observed heterogeneity among countries. Although the cause for such increase remains obscure, ≈13% (range: 9–26%) of EOCRC patients carry pathogenic germline variants in known cancer predisposition genes, including 2.5% of patients with germline pathogenic variants in hereditary cancer genes traditionally not associated with CRC predisposition. Approximately 28% of EOCRC patients have family history of the disease. This article recapitulates current evidence on the inherited syndromes that predispose to EOCRC and its familial component. The evidence gathered support that all patients diagnosed with an EOCRC should be referred to a specialized genetic counseling service and offered somatic and germline pancancer multigene panel testing. The identification of a germline pathogenic variant in a known hereditary cancer gene has relevant implications for the clinical management of the patient and his/her relatives, and it may guide surgical and therapeutic decisions. The relative high prevalence of hereditary cancer syndromes and familial component among EOCRC patients supports further research that helps understand the genetic background, either monogenic or polygenic, behind this increasingly common disease. Laura Valle’s group receives funding from the Spanish Ministry of Science and Innovation, co-funded by FEDER funds [SAF2016-80888-R and predoctoral fellowship to IQ]; Instituto de Salud Carlos III [CIBERONC CB16/12/00234 and Sara Borrell contract (PM)]; Government of Catalonia [AGAUR 2017SGR1282, CERCA Program]; Fundación Olga Torres; and Scientific Foundation Asociación Española Contra el Cáncer [AECC Investigador contract (MT)]. Francesc Balaguer’s group receives funding from the Instituto de Salud Carlos III, cofunded by FEDER funds [PI16/00766; PI19/01867]. This study was facilitated by COST Action CA17118, supported by COST (European Cooperation in Science and Technology).

[cat] La Societat d’Història Natural de les Balears (SHNB), fundada en 1954, siempre dió acogida a colecciones naturalísticas. Entre estas hay toda una serie de colecciones que contienen moluscos fósiles de la fauna previa a la llegada de los humanos de las Illes Balears y que pueden ser útiles a los investigadores, tanto paleontólogos como arqueólogos. Se aporta una relación de los moluscos continentales fósiles presentes en estas colecciones., [spa] La Societat d’Història Natural de les Balears (SHNB), fundada en 1954, siempre dió acogida a colecciones naturalísticas. Entre estas hay toda una serie de colecciones que contienen moluscos fósiles de la fauna previa a la llegada de los humanos de las Illes Balears y que pueden ser útiles a los investigadores, tanto paleontólogos como arqueólogos. Se aporta una relación de los moluscos continentales fósiles presentes en estas colecciones., [eng] The Natural History Society of the Balearics (SHNB) founded in 1954, always welcomed naturalistic collections. Among these there is a whole series of collections containing fossil molluscs of the pre-human fauna of the Balearic Islands and which may be useful to researchers, both paleontologists and archaeologists. A list of the fossil continental molluscs present in these collections is provided.

La casa de Gran Hermano fue testigo, en 2017, de un suceso nunca visto a través de una pantalla de televisión en un programa cuando, aprovechándose del estado de embriaguez que sufría una concursante, uno de sus compañeros abuso presuntamente de ella sexualmente. Tras la expulsión del presunto agresor, se llevó a cabo un proceso de investigación que estuvo mediáticamente parado durante casi dos años, cuando la presunta víctima concedió una entrevista. Tras conocerse su testimonio, el caso volvió con fuerzas y fue aprovechado por otros medios de comunicación, incluida la competencia de este grupo empresarial, que aprovechó este caso como una guerra de intereses. Este estudio ha indagado en los hechos y todo el entorno que lo rodea para, posteriormente, realizar un minucioso estudio del tratamiento informativo que ha recibido este caso, en sus dos etapas, en el diario digital El Confidencial, el medio que más atención le ha prestado a este suceso, para determinar si lo ha desarrollado de una manera adecuada y sin alimentar el sensacionalismo y el morbo. Gracias a este análisis, se pudo determinar que la forma en que el caso ha sido abordado por El Confidencial no ha sido la correcta pues, entre otros motivos, ha indagado en temas innecesarios, llegando a vulnerar la intimidad de los implicados, y ha recurrido con frecuencia a títulos de corte sensacionalista para atraer lectores a la noticia. During the 2017 Spanish edition of Big Brother, an unprecedented event in television history took place as, allegedly, one of the participants sexually abused another participant. After the ejection of that participant, the investigation of these accusations stayed under the radar for almost two years, until the allegedly abused participant took part in an interview. As a result, the investigation appeared in the mainstream media, resulting in a conflict between the different Spanish mainstream media companies. This study attempts to investigate further into the events that happened and study how these events were reported in the online newspaper El Confidencial, which has paid the most attention to this case, and determine whether or not it has been the intention of this newspaper to further increase sensationalism around this case. 5 Thanks to this analysis it has been determined that El Confidencial has not been completely objective in the reporting of these events since, amongst many factors, this newspaper has used irrelevant topics, even breaking into the private life of some of the people implicated in this case, and has repeatedly used sensationalist titles to attract more readers. Universidad de Sevilla. Grado en Periodismo

Cardiovascular diseases are presented as the first cause of death in western world in the last decades. Creating new technologies capable of extracting relevant information from the body structures are crucial to improve prevention and diagnosis Cardiovascular parameters such as blood pressure (BP) and pulse arrival time (PAT) are strongly linked with current state of blood vessels. The objective of this project is to develop an algorithm for direct detection and qualification of the common carotid artery (CCA) to enhance the interpretation of blood vessels current state. We propose a different technique to allocate the CCA as an input of an overall wall tracking system (WTS). Matlab version R2018a was used to design and evaluate the algorithm. A dataset containing ultrasound data from 10 subjects was analyzed. The approach to detect the walls was based on the hypo-echogenic nature of the lumen. The denoising method used was The Meyer wavelet filter followed by a Hilbert transform. Further application of heuristics was needed in order to identify the wall positions and the corresponding quality indicators. The performance was evaluated in the context of wall tracking system (WTS) by comparing manually annotated references to spatial positions from a new, ECG-gated wall tracking system using a reset per heartbeat versus the conventional tracking system using only a single initial starting position prior to the recording. The results proved that this new technique can greatly detect the CCA and be an important module block in the novel WTS. The evaluation showed a significant increase in temporal efficiency (9.53 times faster than manual annotations), high spatial accuracy, and improved feature consistency. In addition, it allows for quality assessment in terms of dispersion and contrast criteria, making the algorithm dynamic and powerful. Nevertheless, problems concerning the anatomy of the vessels were encountered. Deeper lying vessels may need another localization approach such as dynamic time warping (DTW). Such that full automation remains to be implemented.

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Methods and Supplementary information (DOC 291 kb)

To assess whether Mediterranean Diet (MedDiet)-based medical nutrition therapy facilitates near-normoglycemia in women with gestational diabetes mellitus (GDMw) and observe the effects on adverse pregnancy outcomes.

Trabajo Fin de Máster que se basa en el estudio de moléculas con elevada tensión de anillo como son los ciclopropenos. En este caso se estudia la reactividad de un derivado de ciclopropeno frente a 1,3-dienos en presencia de cantidades catalíticas de un metal capaz de generar intermedios de tipo carbeno, lo cual nos dará lugar a los correspondientes divinilciclopropanos.

[cat] Els ventalls al·luvials mostren formes a la seva superfície que es poden relacionar amb processos deposicionals, erosius o de meteorització. La literatura especialitzada ha demostrat que la forma de la superfície i la morfometria dels ventalls pot utilitzar-se com un indicador de l’evolució i dels canvis en els processos geomorfològics que els formaren. En aquest estudi es presenta la caracterització morfològica de la superfície de dos ventalls al·luvials, es Caló i es Barrancar, situats a les costes nord-orientals de l’illa de Mallorca. Aquests ventalls tingueren el seu màxim desenvolupament durant períodes de refredament climàtic i nivells marins baixos del Pleistocè Superior a l’Holocè. Actualment, els processos de sedimentació al·luvial són pràcticament inexistents, localment sobre la seva superfície es produeixen processos d’aixaragallament, formació incipient de sòls i hi creix una densa coberta vegetal. A més a més, el canal que els travessa circula encaixat des de l’àpex fins a la costa. Per a la caracterització morfològica s’han utilitzat niguls de punts LIDAR explotats amb eines GIS que han permès construir models digitals d’elevacions d’alta precisió. A partir d’aquests models de la superfície dels ventalls, s’ha pogut identificar la presència de dues terrasses al·luvials adjacents al canal principal i algun paleocanal. Aquestes terrasses representen dos moments d’incisió del canal que poden relacionar-se amb canvis ambientals ocorreguts a l’inici de l’Holocè (9-4 ka), així com també a una disminució en la disponibilitat de sediment i a un progressiu ascens en el nivell de la mar., [eng] Alluvial fans show different forms that may be related to depositional, erosive or weathering processes. Specialized literature has demonstrated how the fan surface shape and morphometry can be used as an evolution indicator in terms of changes in geomorphological processes that shaped the fans. In this study, we present the morphological characterization of two alluvial fan surfaces (Es Caló and Es Barrancar) located in the Northeastern coasts of Mallorca. These fans reached their maximum development during Late Pleistocene-Holocene climate cooling periods and low sea levels. Currently, alluvial sedimentation processes on Es Caló fan and Es Barrancar fan are scarce, also locally there are gullying processes and incipient soil formation and a dense vegetation cover. The main channel run incised within the alluvial deposits from the apex until the shore. By means of LIDAR point cloud datasets analysis, a morphological fan surface characterization has been performed assisted by GIS tools. This has allowed building high-resolution digital elevation models of each fan. In this sense, using these fan surface models, presence of two alluvial terraces adjoining the main channel and some paleochannels were identified. These terraces represent two fan dissection events which could be related to environmental changes during the onset of the Holocene (9-4 ka), as well as decreasing sediment supply and rising sea level.

[spa]Las eolianitas son depósitos de areniscas de composición carbonatada que se desarrollaron en un ambiente de sedimentación eólico costero durante el Pleistoceno. Son depósitos muy abundantes alrededor del mundo, sobretodo en litorales de las latitudes medias y bajas. Una de las principales zonas, el Mediterráneo occidental, concentra importantes depósitos pleistocenos con excepcionales secuencias de eolianitas, depósitos coluviales y aluviales y depósitos de playa. Dentro del Mediterráneo, Menorca es una de las localizaciones destacadas en la cual abundan afloramientos costeros alrededor de la isla, constituidos mayoritariamente por niveles de deposición eólica con intercalaciones de depósitos de abanico aluvial-coluvial y algunos paleosuelos. Estas secuencias se sitúan cronológicamente entre el Pleistoceno medio y superior. El sedimento que constituye las eolianitas son arenas carbonatadas con un tamaño de grano de medio a grueso bien clasificadas con una elevada presencia de bioclastos. Por otra parte, los depósitos pleistocenos de Menorca se agrupan en dos ambientes deposicionales distintos: las eolianitas adosadas al frente de acantilados compuestas por secuencias dunares y algún nivel coluvial intercalado; y los depósitos de interferencia eólico-aluvial compuestos por secuencias de abanico aluvial que tienen la particularidad de estar constituidas por el sedimento eólico de dunas desmanteladas por aguas de escorrentía. La alternancia de depósitos eólicos y coluviales-aluviales responde a la variabilidad climática y a los cambios glacioeustáticos ocurridos durante el Pleistoceno. En este sentido, las cronologías más modernas realizadas mediante OSL y 14C, sitúan la deposición eólica durante períodos fríos y áridos y de niveles marinos bajos. Estos son momentos en los cuales la plataforma continental queda expuesta dejando grandes bancos de arena preparados para ser transportados por el viento hacia la costa. Durante los períodos relativamente más cálidos y húmedos predominaba la deposición coluvial y aluvial., [eng]Aeolianites are carbonate sandstone deposits developed in a coastal sedimentation environment during the Pleistocene. They are very common deposits around the world, mainly in littoral areas of mid-low latitudes. One of the main zones, the Western Mediterranean, concentrates important Pleistocene deposits with exceptional sequences of aeolianites, colluvial and alluvial deposits and beach deposits. One of the outstanding locations within the Mediterranean is Menorca, where there are many coastal outcrops consisting mainly of levels of aeolian deposition with interbedded alluvial-coluvial fan deposits and some paleosoils. These sequences are chronologically placed at Middle to Upper Pleistocene. The sediment that constitutes the aeolianites is fairly well-to-well sorted carbonate medium to coarse sands, with a high content of bioclasts. Moreover, Pleistocene deposits of Menorca are grouped into two different depositional environments: cliff-front aeolianites composed of dune sequences and some interbedded colluvial levels; and aeolian-alluvial interference deposits consisting of alluvial fan sequences which have the particularity of being constituted by aeolian sediment from dismantled dunes by runoff. The alternating aeolian and colluvial-alluvial deposits, responds to climatic variability and glacioeustatic sea level changes occurred during the Pleistocene. In this sense, modern chronologies set up by means of OSL and radiocarbon dating techniques, place aeolian deposition during cold and arid climatic periods and low sea levels. The characteristic environment of these periods was the continental shelf exposed leaving extensive surfaces covered by sand prepared to be wind-blown inland. During the relatively warmer and wetter periods, colluvial and alluvial deposition predominated.

El presente trabajo se centra en el ocio de los jóvenes en el barrio Pajarillos. Para llegar ahí, analizo primero el ocio de los jóvenes en España y el de Valladolid. Me centro en el ocio de los jóvenes de uno de los proyectos de la Fundación Juan Soñador, “El Desván” un hogar tutelado de menores que dependen de la Gerencia Territorial de Servicios Sociales de la Junta de Castilla y León. Para ello realizo un pequeño estudio y propongo un plan de intervención de cara al verano 2016., Grado en Educación Social

Resumen del póster presentado a la European Human Genetics Conference, celebrada en Barcelona (España) del 21 al 24 de mayo de 2016.-- et al., [Introduction]: Inherited factors account for over 20% of all colorectal cancers (CRC), but less than 6% can be explained by rare high-penetrance mutations in known genes. We aimed at identifying novel hereditary cancer genes by performing whole-exome sequencing in individual hereditary CRC families. Materials and Methods: Exome enrichment (Agilent SureSelect Human All Exon 50Mb) followed by massively parallel sequencing (Illumina Hi-Seq2000) was performed on blood DNA from at least 3 cancer-affected family members. Three Amsterdam-positive families were studied. Data analysis was performed using conventional algorithms. Validation studies in familial cancer series and in silico and in vitro functional studies were also carried out. [Results]: One family harbored two mutations in the MUTYH gene -known polyposis (recesive) gene-, one recurrent in the European population and nature. The family showed an atypical phenotype for MUYTH, characterized by the absence of polyps, apparent autosomal dominant inheritance, and presence of a mismatch repair-deficient tumor. The study of the second family allowed us to identify a novel hereditary CRC gene, FAN1. Functionally relevant mutations were identified in almost 3% of Amsterdam-positive families. The third family carried of two mutated genes: a splice-site mutation in a tumor suppressor gene, and a missense mutation in a previously-proposed cancer-predisposing gene. [Conclusions]: The analysis of exomes in individual high-risk families allowed us to identify two novel genes for hereditary CRC, as well as mutations in previously-known or -proposed CRC-predisposing genes., MINECO-FEDER SAF2012-38885, Asociación Española Contra el Cáncer

Nowadays, bird impact against an aircraft implies high risk for human life safety. Aerospace field covers not only the assembly of aircraft but also the safety these aircraft must gain. To guarantee human life´s safety, a parallel study regarding the impact of birds against plates and edges is developed. Since the aircraft preservation is tested under specific conditions by numerical simulations, the same will be done for the testing of the impacts. Numerical simulations consists on the exact reproduction of the bird impact regarding different scenarios as for the flat plate and the rigid edge recreating the same initial and boundary conditions. Both original tests and numerical simulations are compared for the correct analysis of the materials and characteristics to be applied on the aircraft for its safety. Ingeniería Aeroespacial

En este trabajo se expone una Unidad Didáctica basada en la inclusión de la población gitana en las aulas de Educación Infantil, en la que se busca conseguir la felicidad del niño gitano en la escuela desde el planteamiento de unas actividades divertidas de conocimiento de esta cultura., Grado en Educación Infantil

La línea ferroviaria Ferrol-Gijón transcurre por la costa cantábrica atravesando, desde el P.K. 110+500 hasta el 115+000, el municipio de Burela. Dicha línea divide el municipio en dos, creando un claro ejemplo de efecto barrera. A ambos lados de la vía se ha llevado a cabo el crecimiento del pueblo, viéndose coartado y definido por la trayectoria de las vías. Se redacta el presente anteproyecto con la finalidad de definir las actuaciones necesarias para la construcción de un soterramiento de la línea ferroviaria en el tramo urbano de Burela, para así poder conseguir mayor unificación del municipio y una disminución, en la medida de lo posible, de las características negativas del efecto barrera en el crecimiento, impacto ambiental, comunicación y transporte en el pueblo. Se ha realizado un Estudio Previo de las posibles alternativas y la elección de la alternativa óptima se ha llevado a cabo mediante un análisis multicriterio. La alternativa elegida, además de una longitud total de 2500 metros de actuación, desde el P.K. 111+900 al P.K. 114+400, consigue 1800 metros totales de soterramiento, el tramo soterrado discurre entre los P.K. 112+300 y 114+100. Cuenta con vía única métrica en todo el proyecto, a excepción del tramo de la estación que dispone de vía doble. La pendiente máxima será del 15 ‰ y el gálibo disponible de 5.90 metros. El trazado en planta no se ha visto alterado, por lo que conserva las características técnicas actuales, se puede destacar que el radio mínimo en el tramo de actuación es de 160 metros. Traballo fin de grao (UDC.ETSECCP). Tecnoloxía da Enxeñaría Civil. Curso 2014/2015

This article focuses on the teaching of English as a foreign language through a graded reader version of Macbeth and a contrastive analysis with a recent BBC television adaptation that shifts the historical context of the play from the Middle Ages to today. The activities do not just focus on reading comprehension, but also include the writing, speaking and listening skills as well as the digital, cultural and learning to learn competences. En este artículo presentamos la explotación didáctica de una lectura graduada de Macbeth a través del análisis contrastivo de una adaptación televisiva reciente que traslada el contexto histórico de la obra de la Edad Media a nuestros días. Se trata de una propuesta que no solamente se centra en la comprensión lectora sino que también integra las destrezas de comprensión auditiva, expresión oral y escrita e interacción oral, además de la competencia digital, artística y para aprender a aprender. Cet article propose l’exploitation pédagogique d’une lecture adaptée de Macbeth à travers de l'analyse contrastive d'une adaptation télévisée britannique récente qui déplace le contexte historique de l'oeuvre du Moyen Age à nos jours. Il s’agit d’une proposition qui travaille à la compréhension de la lecture mais comprend aussi le compétence culturelle, numérique et d’apprendre à apprendre.

This article contends that Roald Dahl does not write separately and distinctly for children and adults and that differences respond mostly to the varied emphasis placed on the features that make up his books. The narrative voice that appears both in his adult and children’s books suggest continuity rather than a split in his oeuvre. My examination shows that dissimilarities between his adult and children narrators amount to the different stress he places on the features that conform to the narrative voice he constructs. Thus, depending on the way Dahl understands ‘children’s literature’ or ‘adult books’ to be, he will put more or less emphasis on these particular narrative aspects. Este artículo explora las características de la voz del narrador en los libros para niños y para adultos de Roald Dahl. Se demuestra cómo en estos dos campos literarios aparentemente dispares, hay una serie de elementos comunes que sugieren una gradación en el énfasis que el autor pone en los aspectos particulares que caracterizan al narrador. Esta diferencia de énfasis responde a la concepción que tiene el autor de ‘literatura infantil’ y ‘literatura para adultos’. Si bien la crítica insiste en presentar a Dahl como un autor con dos cabezas, defendemos aquí una continuidad a lo largo de su obra y no una ruptura cuando se trata de escribir para lectores de distintas edades.Cet article analyse les caractéristiques de la voix du narrateur dans les livres pour enfants et pour adultes de Roald Dahl. On démontre comment dans ces deux domaines littéraires apparemment différents, il y a des élements communs qui suggèrent une gradation dans l’emphase que l’auteur fait dans les aspects qui caractérisent le narrateur. Cette difference d’emphase réponde aux idées que l’auteur a sur ‘la litterature de jeunesse’ et ‘la literature pour adultes’. Si la critique littéraire insiste sur la classification de Dahl comme un auteur à deux têtes, on défend ici une continuité tout au long de son oeuvre et pas une rupture quand il s’agit d’écrire pour des lecteurs de différents âges.

Objective: This study evaluated the impact of an Internet-based telematic system on the economic and clinical management of patients with type 1 diabetes mellitus. Research Design and Methods: This 6-month prospective, randomized, comparative, open, multicenter study included patients with type 1 diabetes >18 years old treated with multiple insulin doses and with a glycated hemoglobin (HbA1c) level of >8%. We compared an intervention group (IG) (two face-to-face and five telematic appointments) with a control group (CG) (seven face-to-face appointments). The variables studied were (1) patient and healthcare team costs, (2) metabolic control, (3) knowledge of diabetes, (4) quality of life, and (5) self-care treatment adherence. Results: Of the 154 patients included, 118 (76.6%) completed the study (IG, 54; CG, 64). The time used by the CG to follow the program was 823±645 min versus 353±222 min in the IG (P