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Objective: We present a case of osteoarthritis in a four teen day old newborn who underwent aspiration and drainage on the fifth day after admission instead of on the first day. The aim of this case report is to describe the importance of a team approach and clinical management algorithms for the successful treatment of septic arthritis in newborn. Case report: We describe a 3200g male baby, who treated with antibiotics and underwent aspiration and drainage on the fifth day after admission to our Unit for septic arthritis of the right knee. After the surgical drainage of the joint, signs of flammation began to improve. Results of culture of pus in the knee joint is Staphylococcus aureus. The child was discharged after 14 days of treatment. Conclusion: Septic arthritis requires early diagnosis, prompt administration of antibiotics and rapid removal of pus by surgical treatment, due to joint infections can progress seriously and irreversible consequences even death. The combination of neonatal specialty and orthopedic trauma specialist is necessary to successfully treat septic arthritis in newborns.