1. A meta-analysis on the prevalence of chronic kidney disease in liver transplant candidates and its associated risk factors and outcomes
- Author
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Darren Jun Hao Tan, Ryan Rui Yang Heng, Eunice Xiang Xuan Tan, Phoebe Wen Lin Tay, Vathsala Anantharaman, Yuki Ong, Daniel Huang, Cheng Han Ng, Vanessa Xin Yi Teo, Mark D. Muthiah, and En Ying Tan
- Subjects
Transplantation ,medicine.medical_specialty ,business.industry ,Hazard ratio ,Fatty liver ,Disease ,Hepatology ,medicine.disease ,Liver Transplantation ,Cross-Sectional Studies ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Cohort ,medicine ,Prevalence ,Humans ,Renal Insufficiency, Chronic ,business ,Viral hepatitis ,Kidney disease ,Aged - Abstract
BACKGROUND AND AIMS Pre-liver transplant (LT) chronic kidney disease (CKD) has emerged as a leading cause of postoperative morbidity. We aimed to report the prevalence, associated risk factors and clinical outcomes in patients with pre-LT CKD. METHODS Meta-analysis and systematic review were conducted for included cohort and cross-sectional studies. Studies comparing healthy and CKD patients pre-LT were included. Outcomes were assessed with pooled hazard ratios. RESULTS 15 studies were included, consisting of 82,432 LT patients and 26,754 with pre-LT CKD. Pooled prevalence of pre-LT CKD was 22.35% (CI: 15.30% - 32.71%). Diabetes mellitus, hypertension, viral hepatitis and non-alcoholic fatty liver disease, and older age were associated with increased risk of pre-LT CKD: (OR 1.72 CI: 1.15- 2.56, p = 0.01), (OR 2.23 CI: 1.76 - 2.83, p
- Published
- 2021