1. Higher memory responses in HIV-infected and kidney transplanted patients than in healthy subjects following priming with the pandemic vaccine
- Author
-
Cécile Delhumeau, Christian van Delden, Christophe Combescure, Claire-Anne Siegrist, Olivier F. Clerc, Paola M. Soccal, Karine Hadaya, Matthias Cavassini, Sara Meier, Laurent Kaiser, Alexandra Calmy, Michael Bel, Bernard Hirschel, Sabine Yerly, H1N1 Study Group, Swiss HIV Cohort Study (SHCS), Siegrist, CA., Posfay-Barbe, K., Meier, S., Bel, M., Grillet, S., Sealy, G., Demeules, J., Charvat, S., Verdon, M., Combescure, C., Hirschel, B., Calmy, A., Delhumeau-Cartier, C., Gabay, C., Guerne, PA., Seebach, J., Ribi, C., Villard, J., Dietrich, PY., George, AC., Favet, L., van Delden, C., Morard, I., Mentha, G., Giostra, E., Hadaya, K., Martin, PY., Soccal, P., Berney, T., Noble, S., Mohty, B., Nagy, M., Chalandon, Y., Roosnek, E., Passweg, J., Kaiser, L., Yerly, S., Thomas, Y., Wunderli, W., Barth, J., Battegay, M., Bernasconi, E., Böni, J., Bucher, HC., Burton-Jeangros, C., Cavassini, M., Cellerai, C., Egger, M., Elzi, L., Fehr, J., Fellay, J., Flepp, M., Francioli, P., Furrer, H., Fux, CA., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, HH., Hösli, I., Kahlert, C., Keiser, O., Kind, C., Klimkait, T., Kovari, H., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Metzner, K., Müller, N., Nadal, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schmid, P., Schultze, D., Schöni-Affolter, F., Schüpbach, J., Speck, R., Taffé, P., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Posfay Barbe, Klara, and Grillet, Stéphane
- Subjects
Male ,lcsh:Medicine ,Adult ,Aged ,Antibodies, Viral/blood ,Antibodies, Viral/immunology ,Female ,HIV Infections/blood ,HIV Infections/immunology ,Humans ,Immunocompromised Host ,Immunologic Memory/drug effects ,Influenza Vaccines/administration & dosage ,Influenza, Human/blood ,Influenza, Human/immunology ,Kidney Transplantation/immunology ,Middle Aged ,Pandemics ,HIV Infections/blood/immunology ,HIV Infections ,ddc:616.07 ,Antibodies, Viral ,0302 clinical medicine ,Pandemic ,030212 general & internal medicine ,lcsh:Science ,Prospective cohort study ,Kidney transplantation ,ddc:616 ,0303 health sciences ,Multidisciplinary ,ddc:617 ,biology ,Vaccination ,Antibody titer ,HIV diagnosis and management ,3. Good health ,Titer ,Influenza, Human/blood/immunology/prevention & control ,Influenza Vaccines ,Medicine ,Infectious diseases ,HIV clinical manifestations ,Antibody ,Research Article ,Retrovirology and HIV immunopathogenesis ,Viral diseases ,03 medical and health sciences ,Immune system ,Influenza, Human ,medicine ,Antibodies, Viral/blood/immunology ,030306 microbiology ,business.industry ,lcsh:R ,Immunity ,HIV ,medicine.disease ,Kidney Transplantation ,Institutional repository ,Immunology ,biology.protein ,lcsh:Q ,Clinical Immunology ,business ,Immunologic Memory - Abstract
BACKGROUND: Memory responses require immune competence. We assessed the influence of priming with AS03-adjuvanted pandemic vaccine (Pandemrix®) on memory responses of HIV patients, kidney recipients (SOT) and healthy controls (HC). METHOD: Participants (HIV: 197, SOT: 53; HC: 156) were enrolled in a prospective study and 390/406 (96%) completed it. All had been primed in 2009/2010 with 1 (HC) or 2 (patients) doses of Pandemrix®, and were boosted with the 2010/2011 seasonal influenza vaccine. Geometric mean titres and seroprotection rates were measured 12 months after priming and 4 weeks after boosting. Primary and memory responses were directly compared in 191 participants (HCW: 69, HIV: 71, SOT: 51) followed during 2 consecutive seasons. RESULTS: Most participants (HC: 77.8%, HIV: 77.6%, SOT: 66%) remained seroprotected at 12 months post-priming. Persisting A/09/H1N1 titers were high in HIV (100.2) and HC (120.1), but lower in SOT (61.4) patients. Memory responses reached higher titers in HIV (507.8) than in HC (253.5) and SOT (136.9) patients. Increasing age and lack of HAART reduced persisting and memory responses, mainly influenced by residual antibody titers. Comparing 2009/2010 and 2010/2011 titers in 191 participants followed for 2 seasons indicated lower post-2010/2011 titers in HC (240.2 vs 313.9), but higher titers in HIV (435.7 vs 338.0) and SOT (136 vs 90.3) patients. CONCLUSIONS: Priming with 2 doses of Pandemrix® elicited persistent antibody responses and even stronger memory responses to non-adjuvanted seasonal vaccine in HIV patients than 1 dose in healthy subjects. Adjuvanted influenza vaccines may improve memory responses of immunocompromised patients. TRIAL REGISTRATION: ClinicalTrials.gov NCT01022905.
- Published
- 2012