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8 results on '"Verrijp, Kiek"'

1. Additional file 4: of Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Author

Bourgonje, Annika, Verrijp, Kiek, Schepens, Jan, Navis, Anna, Piepers, Jolanda, Palmen, Chantal, Eijnden, Monique Van Den, Huijsduijnen, Rob Hooft Van, Wesseling, Pieter, Leenders, William, and Wiljan Hendriks

Subjects
body regions, nervous system, fungi
Abstract

Immunohistochemical staining for PTPRT on formalin-fixed paraffin-embedded materials. (PDF 303Â kb)

Published
2016
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2. Additional file 3: of Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Author

Bourgonje, Annika, Verrijp, Kiek, Schepens, Jan, Navis, Anna, Piepers, Jolanda, Palmen, Chantal, Eijnden, Monique Van Den, Huijsduijnen, Rob Hooft Van, Wesseling, Pieter, Leenders, William, and Wiljan Hendriks

Abstract

Î Î Ct values of 2nd cohort of diffuse glioma samples run for 36 validated primer sets judged as candidates in the 1st cohort. (PDF 470Â kb)

Published
2016
Full Text
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3. Additional file 1: of Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Author

Bourgonje, Annika, Verrijp, Kiek, Schepens, Jan, Navis, Anna, Piepers, Jolanda, Palmen, Chantal, Eijnden, Monique Van Den, Huijsduijnen, Rob Hooft Van, Wesseling, Pieter, Leenders, William, and Wiljan Hendriks

Subjects
body regions, nervous system, fungi, neoplasms, nervous system diseases
Abstract

Molecular pathological characteristics of glioma samples used in this study. (PDF 309Â kb)

Published
2016
Full Text
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4. Additional file 2: of Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Author

Bourgonje, Annika, Verrijp, Kiek, Schepens, Jan, Navis, Anna, Piepers, Jolanda, Palmen, Chantal, Eijnden, Monique Van Den, Huijsduijnen, Rob Hooft Van, Wesseling, Pieter, Leenders, William, and Wiljan Hendriks

Abstract

Î Î Ct values of 1st cohort of diffuse glioma samples run for 91 validated primer sets. (PDF 490Â kb)

Published
2016
Full Text
View/download PDF

5. Additional file 3: of Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Author

Bourgonje, Annika, Verrijp, Kiek, Schepens, Jan, Navis, Anna, Piepers, Jolanda, Palmen, Chantal, Eijnden, Monique Van Den, Huijsduijnen, Rob Hooft Van, Wesseling, Pieter, Leenders, William, and Wiljan Hendriks

Abstract

Î Î Ct values of 2nd cohort of diffuse glioma samples run for 36 validated primer sets judged as candidates in the 1st cohort. (PDF 470Â kb)

Published
2016
Full Text
View/download PDF

6. Additional file 1: of Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Author

Bourgonje, Annika, Verrijp, Kiek, Schepens, Jan, Navis, Anna, Piepers, Jolanda, Palmen, Chantal, Eijnden, Monique Van Den, Huijsduijnen, Rob Hooft Van, Wesseling, Pieter, Leenders, William, and Wiljan Hendriks

Subjects
body regions, nervous system, fungi, neoplasms, nervous system diseases
Abstract

Molecular pathological characteristics of glioma samples used in this study. (PDF 309Â kb)

Published
2016
Full Text
View/download PDF

7. Additional file 4: of Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma

Author

Bourgonje, Annika, Verrijp, Kiek, Schepens, Jan, Navis, Anna, Piepers, Jolanda, Palmen, Chantal, Eijnden, Monique Van Den, Huijsduijnen, Rob Hooft Van, Wesseling, Pieter, Leenders, William, and Wiljan Hendriks

Subjects
body regions, nervous system, fungi
Abstract

Immunohistochemical staining for PTPRT on formalin-fixed paraffin-embedded materials. (PDF 303Â kb)

Published
2016
Full Text
View/download PDF

8. Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Author

Weiss, Lea, Weiden, Jorieke, Dolen, Yusuf, Grad, Emilia M., van Dinther, Eric A. W., Schluck, Marjolein, Eggermont, Loek J., van Mierlo, Guido, Gileadi, Uzi, Bartolo-Ibars, Ariadna, Raave, Rene, Gorris, Mark A. J., Maassen, Lisa, Verrijp, Kiek, Valente, Michael, Deplancke, Bart, Verdoes, Martijn, Benitez-Ribas, Daniel, Heskamp, Sandra, van Spriel, Annemiek B., Figdor, Carl G., and Hammink, Roel

Subjects
nivolumab, vesicles, chimeric antigen receptor, efficacy, t cell expansion, immunofilaments, presenting cells, expansion, expression, melanoma, antitumor activity, immunotherapy, car t cells, infiltrating lymphocytes, antigen-specifict cells, synthetic dendritic cells
Abstract

Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their therapeuticpotential. We propose a radically different approach aimed at directexpansion of T cells in vivo, thereby omitting the need for large-scaleex vivo T cell production. We engineered nanosized immunofilaments(IFs), with a soluble semiflexible polyisocyanopeptide backbone thatpresents peptide-loaded major histocompatibility complexes and costimulatorymolecules multivalently. IFs readily activated and expanded antigen-specificT cells like natural APCs, as evidenced by transcriptomic analysesof T cells. Upon intravenous injection, IFs reach the spleen and lymphnodes and induce antigen-specific T cell responses in vivo. Moreover,IFs display strong antitumor efficacy resulting in inhibition of theformation of melanoma metastases and reduction of primary tumor growthin synergy with immune checkpoint blockade. In conclusion, nanosizedIFs represent a powerful modular platform for direct activation andexpansion of antigen-specific T cells in vivo, which can greatly contributeto cancer immunotherapy.

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