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New di-and tri- n-butyl tin(IV) hydroxamate complexes of composition [n-Bu2Sn(C6H3(3-NH2)(4-Cl)CONHO)2](I) and [n-Bu3Sn(C6H3(3-NH2)(4-Cl)CONHO)] (II) have been synthesized by the reactions of n-Bu2SnCl2 and n-Bu3SnCl with potassium 3-amino-4-chlorido benzohydroxamate(KHL) in predetermined metal:ligand 1:2 and 1:1 molar ratios respectively in MeOH+THF solvent medium and characterized by physiochemical, spectroscopic (IR,1 H and 13 C NMR) studies and mass spectrometry. The bidentate nature of hydroxamate ligand involving bonding through carbonyl and hydroxamic oxygen atoms (O,O coordination) has been inferred from IR spectra. The distorted octahedral and trigonal bipyramidal geometry around tin for (I) and (II) respectively have tentatively been proposed. The electrochemical behavior of complexes studied by cyclic voltammetric technique has shown two electron tin metal centered reductions. The in vitro antibacterial activity of (I) and (II) assayed against pathogenic gram -ve bacteria E.coli , P.aeruginosa; gram +ve bacteria S.aureus, B.cereus by MIC method has revealed these to be promising antibacterial agents relative to parent ligand.

Himalayan tahr is a group-living animal of high-altitude Himalaya, distributed all across the subalpine range that also formed an important prey base for large carnivores in Himalaya. The species is threatened due to habitat fragmentation, illegal poaching, and anthropogenic activities. We undertook population genetic assessment of Himalayan tahr from Western Himalaya and observed comparable genetic diversity at both mitochondrial and nuclear microsatellite loci. Bayesian skyline plots showed stable demography in the past several thousand years. We identified 27 unique individuals with a select panel of seven loci and the Bayesian structure analysis inferred two genetic clusters. The present study is the first report on the population genetic make-up of Himalayan tahr and can be used for long-term genetic monitoring of the species.

The field of Machine Learning (ML) brought a massive revolution and change in how normal day operations used to happen in various businesses. The idea of ML was quite simple, merging two separate fields, Mathematics and Computer Science. This simple idea is the very reason that so many predictive and classification-based applications exist today. The development of such applications is a time-consuming process and is very computationally heavy because in the corporate world, a very large amount of historical data is used and processed. The training processes such as pre-processing, data engineering and transformations, deep learning, training and testing are themselves time consuming. A very new field of computer science deals with solving this exact problem of time consumption. Quantum Computing (QC) tries to solve these problems by using the concepts of Quantum Mechanics during computations. The QC technology claims to be not only fast in its computational speed but also more efficient and accurate as well. The following article consists of an experiment conducted where a machine learning model is trained in a classical computing environment using K-Nearest Neighbors (KNN) algorithm versus in a quantum computing environment using Quantum K-Nearest Neighbors (QKNN) algorithm.

Malaria is a life-threatening parasitic disease transmitted by the infected female Anopheles mosquito. The development of drug tolerance and challenges related to the drugs' pharmacodynamic and pharmacokinetic parameters limits the antimalarial therapeutics response. Currently, nanotechnology-based drug delivery system provides an integrative platform for antimalarial therapy by improving the drug physicochemical properties, combating multidrug resistance, and lowering antimalarial drug-related toxicity. In addition, surface engineered nanocarrier systems offer a variety of alternatives for site-specific/targeted delivery of antimalarial therapeutics, anticipating better clinical outcomes at low drug concentrations and low toxicity profiles, as well as reducing the likelihood of the emergence of drug resistance. So, constructing nano carrier-based approaches for drug delivery has been considered the foremost strategy to combat malaria. This review focuses on the numerous nanotherapeutic strategies utilized to treat malaria as well as the benefits of nanotechnology as a potentially effective therapeutic.

Security application of Er3+/Yb3+ doped NaGd(WO4)2 phosphor upon 980 nm excitation and absolute and relative sensitivity of Er3+/Yb3+ doped NaGd(WO4)2 phosphor and PIG.

Russula lakhanpalii is a wild edible mushroom, collected from Pedkhal block of Pauri Garhwal, India. The nutritional composition, antioxidant activity (AOA), and antibacterial activity (ABA) of R. lakhanpalii were analyzed for the first time in this study. Dried fruiting bodies of R. lakhanpalii were reported to contain 17.7% ash, 10% crude fiber, 13.4% protein, 30.9% carbohydrate, and 5% unsaturated lipids. In addition, 10.22-72.56% DPPH scavenging activity also confirmed the good antioxidant nature of R. lakhanpalii. The methanolic extract of R. lakhanpalii fruiting bodies inhibited the growth of five pathogenic bacteria in vitro; Klebsiella pneumoniae (MTCC 4030), Micrococcus luteus (MTCC 1809), Staphylococcus aureus (MTCC 1144), Escherichia coli (MTCC 68), and Streptococcus pneumoniae (MTCC 655). The maximum and minimum zone of inhibitions (ZOIs) reported were 17.8 ± 1.04 mm (K. pneumoniae) and 11.16 ± 0.76 mm, (E. coli), respectively. The noticeable feature of the extract was the inhibition of erythromycin-resistant E. coli and M. luteus by it, which were resistant to 15 μg/disc concentration of erythromycin. Dietary components, antibacterial and antioxidant potentials of R. lakhanpalii suggested its nutraceutical and medicinal applications.

Absolute and relative sensitivity of the developed Er3+/Yb3+/Mo6+:Bi2WO6 phosphors.

The feasibility of Bambusa vulgaris schrad. ex Wendl. has been assessed globally for a variety of uses. It is one of the fastest growing bamboo and can thrive in both moist and dry climates. To disseminate substantial baseline data on morphological variations of the species, morphological characteristics of leaf and culm sheath of Candidate Plus Clumps (CPCs) were evaluated followed by genetic analysis of growth attributes of three bamboo stands viz., MP-RJR, MH-AMR and OR-KLN, in three distinct states Madhya Pradesh, Maharashtra, and Odisha of central India. Significant differences in leaves and culm sheaths were noticed among the CPCs and bamboo stands during the investigation. OR-KLN was observed with the longest leaf (22.77 cm) and the broadest leaf lamina at the top (1.58 cm). Longest average culm sheath blade (30.37 cm) in MH-AMR and maximum average sheath diameter (33.23 cm) in OR-KLN were recorded. High values for phenotypic coefficient of variations, genotypic coefficient of variations, heritability and genetic advance as mean percentage were obtained for clump diameter and number of culms per clump. This can be used as selection criteria in the improvement programme of Bambusa vulgaris var. Green. Aims: To study morphological variation of leaf and culm sheath of Bambusa vulgaris schrad. ex Wendl. at three bamboo stands associated with genetic analysis in growth attributes. Study Design: Complete Randomised design (CRD). Place and Duration of Study: Morphological data of Candidate Plus Clumps (CPCs), leaf and culm sheath of Bambusa vulgaris was recorded at bamboo stands in Rajore, Madhya Pradesh, Kalinga, Odisha and Amravati, Maharashtra from September 2021 to November 2022. Further investigation, statistical analysis and other studies were carried out at Genetics and Tree Improvement Division, Tropical Forest Research Institute, Jabalpur, M.P., India.

The piezo-electric energy harvesting devices based on rubber composites have attracted great attention in the field of flexible electronics. These devices have the ability to provide a voltage of ∼0.5 V when subjected to mechanical strain. In this work, carbon allotropes nanofillers were used to reinforce the room-temperature vulcanized silicone rubber (RTV-SR). The nanofillers added to the rubber matrix were found to improve the compressive modulus, tensile strength, fracture strain, and tensile modulus. For example, the compressive modulus was 1.29 MPa (Virgin) and improved to 1.4 MPa (graphene), 2.3 MPa (CB), 2.2 MPa (CB–graphite hybrid), 2.17 MPa (CB–Nano graphite hybrid), and finally 2.19 MPa (CB–graphene hybrid). Similarly, the fracture strain was 146% (Virgin) and improved to 149% (graphene), 156% (CB), 160% (CB–graphite hybrid), 151% (CB–Nano graphite hybrid), and lastly 178% (CB–graphene hybrid). Moreover, the effect of three different diameters of loading tips is used for voltage production. More areas of deformation during energy harvesting can be able to produce higher voltage output. For example, a 21 mm tip can produce higher energy output than 7 mm and 14 mm. In the end, it was found that formation of cracks in the electrode while repeated loading causes a reduction in voltage output.

History of safe use, HoSU preparations are formulations mentioned in ancient literature and are according to the Ayurvedic system of medicine. Due to the advent of new technologies, there is a shift in the manufacturing methodologies of Ayurvedic medicines involving extractions and fractionations. This shift, while has helped manufacturers improve their productivity, raises a question on the equivalence to chemistry, and toxicity when compared to traditional products. As a case study, an attempt is made to establish equivalence between HoSU preparation of Terminalia chebula with commercially available aqueous and alcoholic extracts and one of its fractions. Chemical analysis of the products using principal component analysis, revealed similar chemistry whereas the LC50 values of HoSU preparation were safest followed by commercial preparations and the reference marker compound when tested on zebrafish. The generated data indicated that chemical composition of all 4 samples tested were similar qualitatively, though variations were observed quantitatively. PCA plot indicated that the HoSU extract, commercial alcoholic extract, and commercial water extract were similar whereas water acetone extract was dissimilar. This emphasizes the need for conducting an equivalence study in terms of chemistry and toxicity between HoSU products and commercially available products.

Use of energy drinks has dramatically increased in recent times. Athletes, teenagers and students being the most common population who consume it. Users believe that they are a source of instant energy but are unaware of its high Caffeine content resulting in severe adverse effects on health. We reported the case of a young boy who presented with palpitations and high blood pressure after a recent start of energy drink consumption. He had been consuming ‘monster’ energy drink on regular basis as his annual sports meet was round the corner and he had to practise for hours for an upcoming football match. His medical examination revealed Sinus tachycardia and high blood pressure on more than 3 occasions. Rest of the physical examination and lab workup was within normal limits. His pulse and blood pressure returned to normal range after discontinuing ‘monster’ energy drink usage and he was counselled on adverse effects of such products. Several studies have reported numerous health hazards including cardiac effects associated with energy drinks. Labels should be made on these drinks and Caffeine content should be mentioned along with adverse effects on health. Caution for use in children and pregnant or expecting patients should also be mentioned.

With the progress of science and technology, automatic floor scrubbers have increasingly attracted the attention of researchers, bringing convenience to human life. Theconcept is growing in economic countries but is not popular due to the design complexity of the, the cost of the machine and the operating costs in terms of electricity tariffs. In this article, a semi-automatic floor cleaning machine is presented. It effectively cleans floors in wet and dry-cleaning tasks. The floor cleaning machine was designed with fundamental considerations of reducing cost and workload, while the is environmentally friendly and easyto use. The machine will run on electricity and consist of simple fabrications. These jobs are very useful to improve the lifestyle of human beings.it is very in construction and easy to operate anybody can operate this machine easily.

Health care workers (HCWs) are the frontline workers working tirelessly during the pandemic of coronavirus disease-2019 (COVID-19). The same HCW, after duty, is exposed to his/ her community which again increases the risk of infection. Hence, with an increased risk of exposure, we cannot afford to lose our frontline workers due to sickness or more. In the absence of any definitive antiviral treatment, unclear modes of transmission, burnout working hours, fatigue, societal stigma related to disease etc., a HCW is exposed to psychological distress and many a time develops an anxiety/panic condition which can increase the chances of work-place error and thus can increase the likelihood of infection. In this article, we have shared our experience with contact tracing among HCWs, what we have learned in the past two years, and proposed a way forward.

This manuscript analyses a case study of a wind-integrated power plant where an Arithmetic Optimization Algorithm-based Model Predictive Controller (AOA-MPC) has been employed for the combined control of voltage and frequency. The work in this manuscript considers stochastic variations in wind output caused by the small stochastic drifts and sudden deterministic shifts in the wind turbine output. The proposed controller’s performance has been judged after assessing the time response performance specifications/indices and comparing it with the existing recent methodologies available in the literature. Further improvement in frequency oscillations reduction has been obtained while considering the Redox Flow Battery (RFB) loop as an auxiliary Load Frequency Control loop. Moreover, the computational potential of the presented algorithm has been tested under different nonlinearities and time delay cases in the Area Control Error (ACE) of the load frequency control (LFC) loop.

Objectives: Heat stress is one of the major stressors in military aviation with the potential to adversely affect the efficiency of the aircrew and hence flight safety. Metabolic rate (MR) increases on exposure to heat and metabolic gases are considered as a proxy for MR. This study examined the influence of heat stress on metabolic gas kinetics in healthy Indian males and assessed the duration of attaining normal baseline values of metabolic gases post-exposure. Materials and Methods: In 16 healthy male volunteers, cardiorespiratory variables, including metabolic gases (oxygen uptake [VO2], carbon dioxide output [VCO2], minute ventilation [VE], breathing frequency [BF], and heart rate [HR]), were recorded before and approximately 2 h after a standard meal. The subjects were then exposed to a simulated temperature of 40°C with a relative humidity of 70% for 1 h in the environmental chamber. Same physiological parameters were recorded at the end of 30 min and 60 min during heat exposure and up to 90 min following exposure to heat stress at an interval of 30 min. Results: A significant increase (P < 0.001) in mean VO2 (ml/Kg/min) was observed post-meal (1.49 ± 0.95) as well as at 30 min (1.17 ± 0.96) and at 60 min (2.14 ± 1.19) of heat exposure. A similar increase (P < 0.05) in mean VCO2 was observed post-meal and following heat exposure. VE (L/min) increased by 12.12% post-meal (P = 0.01), 16.16% (P < 0.001) at 30 min, and 19.65% (P < 0.001) at 60 min of heat exposure. There was a significant increase in mean BF (per min) during heat exposure (2.31 ± 1.24 at 30 min and 3.53 ± 1.05 at 60 min) and till 60 min of the recovery period compared to baseline (P < 0.001). HR (bpm) increased by 14 bpm at 30 min and 17 bpm at 60 min of exposure and till 30 min after elimination of heat stress (P < 0.001). Conclusion: A statistically significant increase was observed in VO2, VCO2, VE, BF, and HR on exposure to heat stress. Optimal recovery was observed after 30 min of eliminating the heat stress for VO2 and VCO2. Similar recovery was observed after 60 min of eliminating the heat stress for HR and following 90 min for VE and BF. Hence, if the crew is required to continue to operate in the heat stress environment, a minimum period of 90 min of a break in between the sorties must be ensured in a relatively cooler environment.

Background Irreversible pulpitis is a painful and debilitating condition. Root canal treatment (RCT) provides prompt relief and salvages the affected tooth/teeth. It has classically been performed as a multivisit procedure. A relatively newer approach constitutes performing all the steps in one single visit. This study was designed to explore if single-visit RCT could be confidently used as an effective and preferred treatment modality for irreversible pulpitis in the Indian Armed forces. Methods The study compared the incidence of postoperative pain, tenderness on percussion (TOP), flare-ups, and the analgesic drug use in 60 cases of acute irreversible pulpitis who were treated by either single or multiple visit root canal therapy. Each treatment group included 30 patients who were evaluated preoperatively and postoperatively at 24 h, one week and one month. Results The study found statistically higher incidence of postoperative pain (mild variant) and TOP in single visit therapy, 24 h after the obturation while the difference was insignificant at one week and one month after therapy. Analgesic use was significantly higher after the single visit therapy in the first 24 h. No flare-ups were recorded in either group. Significant pain and tenderness was observed after chemo-mechanical preparation (appointment 2) in multivisit regimen. Conclusion Single visit therapy is a safe, practical, and effective approach. The treatment results are similar to the multivisit regimen. It should therefore be considered for wider adoption and application.

Introduction- The long-term effects of SARS-CoV-2 infection are becoming a signicant burden on society and healthcare systems. Data on post-COVID-19 syndrome in the general population is needed to organise healthcare treatments and resources in a timely manner.(1) In adults hospitalised with severe coronavirus illness, long-term symptom duration and impairment are typical (COVID-19). Understanding the complete spectrum of COVID-19–associated disease and adjusting public health messages, treatments, and policies requires characterising return to baseline health among outpatients with milder COVID-19 illness.(2) Aims and Objectives This study aims to nd incidence and assess progression and burden of long covid among post covid patients. Methodology- A cross sectional interview-based study was conducted for a period of 3 months among post covid patients to nd the incidence of long Covid. The list of respondents was obtained from health departments records listing post covid patients from March 2021 to November 2021. Results- Our study found that symptoms of Covid persisted long after patient was declared Covid negative. Majority of the patients 78 patients reported dermatological symptom of hairfall along with memory loss and muscle weakness. Conclusion- This study will help the public health care providers, clinicians and the policymakers to be prepared for the symptoms faced in post COVID-19 and general public in the coming months and years. It will also throw light into the possible factors which are associated with persistent post-acute COVID-19 infection.

ConspectusA radical shift toward energy transfer photocatalysis from electron transfer photocatalysis under visible-light photoirradiation is often due to the greener prospects of atom and process economy. Recent advances in energy transfer photocatalysis embrace unique strategies for direct small-molecule activation and sometimes extraordinary chemical bond formation in the absence of additional/sacrificial reagents. Selective energy transfer photocatalysis requires careful selection of substrates and photocatalysts for a perfect match with respect to their triplet energies while having incompatible redox potentials to prevent competitive electron transfer pathways. Substrates containing labile N-O bonds are potential targets for generating reactive key intermediates via photocatalysis to access a variety of functionalized molecules. Typically, the differential electron densities of N and O heteroatoms have been exploited for generation of either N- or O-centered radical intermediates from the functionalized substrates by the electron transfer pathway. However, the latest developments involve direct N-O bond homolysis via energy transfer to generate both N- and O-centered radicals for their subsequent utilization in diverse organic transformations, also in the absence of sacrificial redox reagents. In this Account, we highlight our key contributions in the field of N-O bond activation via energy transfer photocatalysis to generate reactive radical intermediates, with coverage of useful mechanistic insights. More specifically, well-designed N-O bond-containing substrates such as 1,2,4-oxadiazolines, oxime esters

Context Soybeans (Glycine max. (L.) Merr.) are a major source of phospholipids, which are vital to human and animal nutrition, as well having many pharmaceutical and industrial applications. Identification of quantitative trait loci (QTLs) is a prerequisite for the development of high-phospholipid soybean genotypes through marker-assisted breeding. Aims We aimed to identify QTLs associated with biosynthesis of four phospholipids in soybean. Methods We developed two F2 populations comprising 233 and 254 plants, respectively, from two crosses (JS20-34 × AVKS215 and JS20-98 × AVKS215), and used 208 polymorphic simple sequence repeat markers found common to both F2 populations for linkage map construction. QTLs associated with four phospholipids, phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylinositol (PI) and phosphatidylcholine (PC), were analysed via inclusive composite interval mapping of additive QTLs using QTL IciMapping software. Key results In the respective F2 populations, we identified seven and six QTLs for PE, seven and nine QTLs for PA, and nine and eight QTLs for PC. Six QTLs were associated with PI in each population. Five QTLs for each of PA and PC, three QTLs for PE, and four QTLs for PI were found common to both F2 populations. Conclusions The results showed that some genomic regions such as Sat_341–Satt331 on chromosome 10, and Satt325–Sat_387 and Sat_229–Satt510 on chromosome 13, were associated with all four phospholipids in both F2 populations. QTLs associated with phospholipids were also found to be annotated with genes involved in phospholipid biosynthesis. Implications The QTLs identified may be useful in marker-assisted breeding for the development of soybean genotypes with high levels of phospholipids of interest and for identifying functional genes involved in phospholipid biosynthesis.

Tone-evoked synaptic excitation and inhibition are highly correlated in many neurons with V-shaped tuning curves in the primary auditory cortex of pentobarbital-anesthetized rats. In contrast, there is less correlation between spontaneous excitation and inhibition in visual cortex neurons under the same anesthetic conditions. However, it was not known whether the primary auditory cortex resembles visual cortex in having spontaneous excitation and inhibition that is less correlated than tone-evoked excitation and inhibition. Here we report whole-cell voltage-clamp measurements of spontaneous excitation and inhibition in primary auditory cortex neurons of pentobarbital-anesthetized rats. The larger excursions of both spontaneous excitatory and inhibitory currents appeared to consist of distinct events, with the inhibitory event rate typically lower than the excitatory event rate. We use the ratio of the excitatory event rate to the inhibitory event rate, and the assumption that the excitatory and inhibitory synaptic currents can each be reasonably described as a filtered Poisson process, to estimate the maximum spontaneous excitatory-inhibitory correlation for each neuron. In a subset of neurons, we also measured tone-evoked excitation and inhibition. In neurons with V-shaped tuning curves, although tone-evoked excitation and inhibition were highly correlated, the spontaneous inhibitory event rate was typically sufficiently lower than the spontaneous excitatory event rate to indicate a lower excitatory-inhibitory correlation for spontaneous activity than for tone-evoked responses.

Rotavirus is the leading cause of severe dehydrating gastroenteritis among children younger than 5 years in low-income and middle-income countries. Two vaccines-Rotavac and Rotasiil-are used in routine immunisation in India. The safety and immunogenicity of these vaccines administered in a mixed regimen is not documented. We therefore aimed to compare the safety and seroresponse of recipients of a mixed regimen versus a single regimen.We did a multicentre, open-label, randomised, controlled, phase 4, non-inferiority trial at two sites in India. We recruited healthy infants aged 6-8 weeks. Infants with systemic disorders, weight-for-height Z scores of less than minus three SDs, or a history of persistent diarrhoea were excluded. Eligible infants were randomly allocated to six groups in equal numbers to receive either the single vaccine regimen (ie, Rotavac-Rotavac-Rotavac [group 1] or Rotasiil-Rotasiil-Rotasiil [group 2]) or the mixed vaccine regimen (ie, Rotavac-Rotasiil-Rotavac [group 3], Rotasiil-Rotavac-Rotasiil [group 4], Rotavac-Rotasiil-Rotasiil [group 5], or Rotasiil-Rotavac-Rotavac [group 6]). Randomisation was done using an online software by site in blocks of at least 12. The primary outcome was seroresponse to rotavirus vaccine, measured using rotavirus-specific serum IgA antibodies 4 weeks after the third dose. The seroresponse rates were compared between recipients of the four mixed vaccine regimens (consisting of various combinations of Rotavac and Rotasiil) with recipients of the single vaccine regimens (consisting of Rotavac or Rotasiil only for all three doses). The non-inferiority margin was set at 10%. Safety follow-ups were done for the duration of study participation. This trial was registered with the Clinical Trials Registry India, number CTRI/2018/08/015317.Between March 25, 2019, and Jan 15, 2020, a total of 1979 eligible infants were randomly assigned to receive a single vaccine regimen (n=659; 329 in group 1 and 330 in group 2) or a mixed vaccine regimen (n=1320; 329 each in groups 3 and 4, and 331 each in groups 5 and 6). All eligible participants received the first dose, 1925 (97·3%) of 1979 received the second dose, and 1894 (95·7%) received all three doses of vaccine. 1852 (93·6%) of 1979 participants completed the follow-up. The immunogenicity analysis consisted of 1839 infants (1238 [67·3%] in the mixed vaccine regimen and 601 [32·7%] in the single vaccine regimen; 13 samples were insufficient in quantity) who completed vaccination and provided post-vaccination sera. The seroresponse rate in the mixed vaccine regimen group (33·5% [95% CI 30·9-36·2]) was non-inferior compared with the single vaccine regimen group (29·6% [26·1-33·4]); the seroresponse rate difference was 3·9% (95% CI -0·7 to 8·3). The proportion of participants with any type of solicited adverse events was 90·9% (95% CI 88·4-93·0) in the single vaccine regimen group and 91·1% (89·5-92·6) in the mixed vaccine regimen group. No vaccine-related serious adverse events or intussusception were reported during the study.Rotavac and Rotasiil can be safely used in an interchangeable manner for routine immunisation since the seroresponse was non-inferior in the mixed vaccine regimen compared with the single vaccine regimen. These results allow for flexibility in administering the vaccines, helping to overcome vaccine shortages and supply chain issues, and targeting migrant populations easily.Ministry of Health and Family Welfare, Government of India.For the Hindi translation of the abstract see Supplementary Materials section.

India still has one of the world’s greatest burdens of infectious illnesses, driven by variables such as massive population, significant poverty, subpar sanitation, and impedances in access to basic health care. To overcome this burden, the Integrated Disease Monitoring Project (IDSP), funded by the World Bank, was established by the Union Minister of Health and Family Welfare in November 2004 to strengthen the country’s monitoring and response system. Several challenges in the effective utilization of IDSP and the need for elaborated epidemiological data for quick response led to the development and design of a novel Integrated Health Information Platform (IHIP). This platform’s future impacts include better surveillance coverage, improved continuous monitoring, better-automated analysis, visualization and displaying of near-real-time data, and closed network linkage of various reporting units such as field staff, medical officers, and laboratory personnel. Data collection under IDSP was paper-based and it produced a weekly surveillance report this includes case-centric data with demographic, clinical, and laboratory details, and links it with IDSP’s S, P, and L formats. Developed by the Government of India, with the support from the WHO, this platform integrates the electronic health records of individuals from all parts of India, allowing greater continuity of the treatment, secure and confidential storage of data/records, enhanced illness diagnostics, reduction, and even prevention of medical errors. This paper is intended to study this novel IHIP model of the Government of India, highlight its current challenges, propose possible solutions, and predict future possibilities.

Objective: To comprehend the evolution and spread of the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) virus and also to prevent the future spread of the same, sequencing and analyzing the genomic data of SARS CoV-2 are essential. The objective of the present study is to describe the scope of improvement identified by the state of Madhya Pradesh in the data flow chain and the methodology designed to address the identified shortcomings. Methods: The number of sources of sample data collection was altered as well as a series of Google Sheets were formulated as an open-source tool, to implement an efficient sample data-sharing platform. The application of the proposed tool (Google Sheets as a source of data collection and information sharing) was within the state of Madhya Pradesh, India. Result: After utilizing this mechanism, the state was able to trace more than 80% VOCs and 3341 primary contacts and was also able to communicate this result to all stakeholders without much delay. Conclusion: Based on successful implementation and results, the authors suggest widening the domain of the proposed tool to other states.

Breast cancer (BC) is the deadliest malignant disorder globally, with a significant mortality rate. The development of tolerance throughout cancer treatment and non-specific targeting limits the drug's response. Currently, nano therapy provides an interdisciplinary area for imaging, diagnosis, and targeted drug delivery for BC. Several overexpressed biomarkers, proteins, and receptors are identified in BC, which can be potentially targeted by using nanomaterial for drug/gene/immune/photo-responsive therapy and bio-imaging. In recent applications, magnetic iron oxide nanoparticles (IONs) have shown tremendous attention to the researcher because they combine selective drug delivery and imaging functionalities. IONs can be efficaciously functionalised for potential application in BC therapy and diagnosis. In this review, we explored the current application of IONs in chemotherapeutics delivery, gene delivery, immunotherapy, photo-responsive therapy, and bio-imaging for BC based on their molecular mechanism. In addition, we also highlighted the effect of IONs' size, shape, dimension, and functionalization on BC targeting and imaging. To better comprehend the functionalization potential of IONs, this paper provides an outline of BC cellular development. IONs for BC theranostic are also reviewed based on their clinical significance and future aspects.Graphical Abstract[Formula: see text].Current Breast cancer treatment resists due to the development of drug tolerance throughout cancer treatment and non-specific drug targeting.Magnetic IONs are being utilised for the therapy and bio-imaging of breast cancer by targeting overexpressed biomarkers, proteins, and receptors in breast cancer progression.Physical properties of IONs, such as size, shape, and dimensions, also alter their therapeutic and imaging responses.Iron oxide nanoparticles can be efficaciously functionalised based on breast cancer molecular mechanisms for potential application in breast cancer drug delivery, gene delivery, immunotherapy, photo responsive therapy, and bio-imaging.