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There is little research on the relationship between phthalates exposure and sleep problems in adult females, with existing studies only assessing the association between exposure to individual phthalates with sleep problems. We aimed to analyse the relationship between phthalates and sleep problems in 1366 US females aged 20 years and older from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) by age stratification. Multivariate logistic regression showed that the fourth quartile of MECPP increased the risk of sleep problems in females aged 20–39 compared with the reference quartile (OR: 1.87, 95% CI: 1.14, 3.08). The WQS index was significantly associated with the sleep problems in females aged 20–39. In the BKMR, a positive overall trend between the mixture and sleep problems in females aged 20–39. In this study, we concluded that phthalates might increase the risk of sleep problems in females aged 20–39.

Additional file 7: Figure S2. The expression levels of the fifteen RsbHLHs at the fifth stage of GF and WF by qRT-PCR andRNA-seq. qRT-PCR were normalized to the expression of Actin

Additional file 1: Fig S1. The restricted cubic spline model was used to analyze the relationship between Bisphenols and the risk of CVD. A BPS; B BPF; C BPA. The analysis adjusted for gender, age, race, education level, PIR, physical activity, alcohol drinking status, smoking status, BMI, blood pressure, cancer, diabetes, LDL-C, energy, urine creatinine.

Additional file 2: FigureS1. Sequencelogos of 19 conserved motifs. The height of a letter indicates its relativefrequency at the given position

The purpose of this paper is to investigate coupling vibration characteristics of the flexible functionally graded material (FGM) shaft-disk coupling system with variable thickness disk. The mathematical model of the shaft-disk system is based on the first-order shear deformation theory, combined with the Voigt model and the four-parameter power-law distribution. The energy expression is discretized by the differential quadrature finite element method, and furthermore the differential equation of the shaft-disk system is derived. In order to verify the convergence and calculation accuracy of the current model, a series of numerical examples are introduced. In addition, the influence of geometrical and material parameters on vibration results is discussed, while the boundary conditions and the cross-sectional shape of the disk are considered. It can be seen that the variation of the FGM parameters will affect the vibration characteristics within a certain range, while the frequency parameter with different disk cross-sectional shapes is different in sensitivity to parameter changes. The parametric analysis can provide reference for the determination of structure and material parameters.

OBJECTIVE To investigate the safety profiles of Motherwort injection (MI). METHODS A multi-center, prospective and drug-derived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications. This study was based on a very large population after the injection was approved and marketed in China. All patients using the injection in participating hospitals were monitored to determine the incidence, pattern, severity and outcome of associated adverse events. RESULTS The post-marketing surveillance was performed in 10 094 female patients from April to December, 2015. The incidence of adverse drug reactions (ADRs) was 0.79‰ (8/10 094). Among the 8 patients, the reported adverse events mainly included systemic abnormalities, such as fever, chills and eyelid edema; skin and appendages disorders, such as pruritus and rash; gastrointestinal disorders, such as nausea, abdominal distension and pain; heart rate and rhythm disorders, such as palpitation and increased heart rate. All of these ADRs were mild in severity. CONCLUSION In this study the ADRs incidence rate of MI is very low, which supports that it is generally safe for use in obstetric and gynecological diseases. However, the total number of 8 ADRs recorded over a relatively short time span seems limited, and the low number of reports could not represent an absolute guarantee of safety.

Objective To monitor current production in Qi-deficient liver cells, and to study how cellular proton leakage might affect electric current production. Methods Cells were placed in an microbial fuel cells (MFC) anode and the electric current was measured. Mitochondrial-affecting chemicals, 2,4-dinitrophenol (DNP) and resveratrol (RVT), were used to induce proton leakage in cells and their effect on current production observed. MCF-7 breast cancer cells exhibited higher proton leakage relative to normal liver cells. A mouse model for Qi-deficiency was prepared according to the Methodology of Animal Experiment in Chinese medicine. The Qi-tonics Buzhongyiqi Tang (BZYQT), which is used to treat the Qi-deficiency condition, was applied to Qi-deficient liver cells to examine how current production was altered. Results Adding either DNP or RVT to normal liver cells increased current production. MCF-7 cells that possessed high proton leakage were also found to produce higher currents than normal liver cells. Higher current production, lower cellular glucose content, and lower adenosine triphosphate (ATP) production rate were found in Qi-deficient liver cells, in which the use of DNP or RVT further increased current production. The use of BZYQT to treat Qi-deficient liver cells decreased current production, counteracted the action of DNP, and also improved cellular glucose content. Conclusion High electric current production was found in liver cells with high cellular proton leakage. Positive current responses to both mitochondria-affecting chemicals, DNP and RVT, appeared to indicate proper mitochondrial function. The high proton leakage detected in Qi-deficient liver cells might have caused high energy losses, which served to explain the observed lower cellular glucose content and ATP production rate than in normal cells. These results might also explain the exhibited syndromes of low energy and fatigue in Qi-deficient patients. Proton leakage, induced by DNP or the Qi-deficient condition, was possibly caused by unusual uncoupling of oxidative phosphorylation and appeared to be inhibited by treatment with BZYQT, such that decreased current production was observed after BZYQT treatment.

Objectives: The aim of this study was to assess the effect of the pro-inflammatory interleukin (IL)-17A in deep venous thrombosis (DVT) resolution. Materials and Methods: A total of 45 DVT patients, 30 primary deep venous insufficiencies (DVI) patients, and 18 healthy volunteers were divided into three groups: (a) Control group, (b) DVT group, and (c) DVI group. The venous blood samples of the lower extremity with DVT were collected to evaluate the expression of IL-17A in plasma. Samples of superficial venous thrombus and superficial vein without thrombosis were collected to evaluate the expression of IL-17A in tissue. Male C57/BL mice DVT model was established and was randomly divided into five groups: (1) Control group, no treatment or surgical intervention; (2) Sham group, no treatment and sham operation; (3) DVT group, each mouse intravenous (iv) injected with phosphate-buffered saline (PBS); (4) IL-17A group, each mouse was iv injected with IL-17A; and (5) IL-17A-neutralizing antibody (NA) group, each mouse was iv injected with IL17A NA. Inferior vena cava (IVC) with thrombi were collected to measure their length and weight and analysis CD31(+) endothelial cells in thrombus of internal cerebral vein. Results: Western blot suggested that the expression of IL-17A in superficial vein with thrombosis was higher than superficial vein without thrombosis from human samples (P

To evaluate the technical aspects and early clinical results of combined stent placement for the management of postthrombotic syndrome (PTS) in chronic total occlusions (CTOs) of the iliofemoral veins.A total of 81 consecutive patients (mean age, 57 y; 37 men; 81 limbs; 65 left limbs) with postthrombotic CTO of the iliofemoral veins treated with combined stent placement in a single institution from January 2013 to December 2014 were retrospectively analyzed. Wallstents were used for femoral inflow and E-Luminexx stents for iliac outflow. Technical aspects, quality of life (QOL), stent patency, and Villalta scores were recorded at follow-up. Primary, primary assisted, and secondary patency rates were estimated with Kaplan-Meier methods with the log-rank test.Percutaneous recanalization was successful in 77 of 81 limbs (95.1%). Stents were deployed in all iliofemoral occlusions, with two stents in 63 lesions (77.8%) lesions and three stents in 18 lesions (22.2%). Venous perforation occurred in 32 patients (37.4%) and was resolved in all cases after stent placement. Back pain occurred during balloon angioplasty (93.8%) and persisted after stent placement in 56.8% of patients. However, the symptoms were self-limiting without further therapy. QOL and Villalta scores were significantly improved during a median follow-up of 19 months (range, 1-38 mo; P.01). The 2-year primary, primary assisted, and secondary cumulative stent patency rates were 81.5%, 91.4%, and 93.8%, respectively.Combined stent placement is an effective, safe, and feasible method of management of PTS in iliofemoral CTO until commercial venous stents designed for PTS become available.

In this study, the dynamic changes in thyroid 131I retention (RiT(t), fraction of intake) and urinary excretion rate (Eiu(t), fraction of intake per hour) of 33 normal people within 7 days of taking oral 131I were observed. The changes with time may be expressed by the following two equations:RiT(t) = 0.356 exp(-2.58 × 10-3t) - 0.236 exp (-0.133t)Eiu(t) = 0.65 × 10-1 exp(-0.165t) + 0.11 × 102 exp(-0.0158t)(t is the time after taking 131I in hours). When the thyroid maximum retention of 131I is taken as 1, the relative activity of thyroid 131I may be expressed by the equationrt(t) = exp(-3.98 × 10-3t) - 0.76 exp(-0.224t). The influence of age, sex, locality and other factors was analysed by referring to the data reported in China of thyroid 131I retention in 3461 normal people 2 days after taking 131I. Based on the results of this study, an equation for the estimation of acute 131I intake in persons taking in radioactive iodine released from a nuclear power station accident was derived. Using this equation, the amount of 131I contaminating the bodies of 29 persons irradiated in a nuclear accident and their thyroid irradiation doses were estimated.