Search

Breast cancer remains the most common malignancy in women and constantly threatens the lives of patients worldwide. State-of-the-art renewal has indicated the involvement of RUNX-associated transcription factor 2 (RUNX2) in tumorigenesis and cancer progression, yet the detailed information during breast cancer is largely obscure. Herein, we took advantage of breast cancer cell lines and in vivo tumorigenicity test as well as multifaceted phenotypic analyses (e.g., RNA-sequencing, ChIP and qRT-PCR assay) to verify the pathogenic mechanism of RUNX2 in triple negative breast cancer aggressiveness and chemoresistance. Strikingly, the proliferation, migration, invasion and chemoresistance of resistant cell lines in triple negative breast cancer was effectively suppressed by RUNX2 silencing, and the in vivo tumorigenicity was significantly weakened as well. Furthermore, with the aid of transcriptomic and bioinformatic analyses, we found MMP1 was highly expressed in triple negative breast cancer (TNBC) and showed a strong correlation with the poor prognosis of the patients, which was consistent with the expression pattern of RUNX2. Finally, by conducting ChIP and qRT-PCR assessment, we verified that RUNX2 functioned via directly binding to the specific motifs in the promoter of MMP1 and thus activating the transcriptional process. Collectively, our data demonstrated the facilitating effect of RUNX2 during triple negative breast cancer progression by directly orchestrating the expression of MMP1, which supplied overwhelming new references for RUNX2-MMP1 axis serving as a novel candidate for breast cancer diagnosis and treatment.

Studies on the factors that influence farmers’ pro-environmental behavior could promote environmental management in rural areas. Jinan of China was selected as the case study area in this study. A structural equation model and multiple hierarchical regression analysis were applied to analyze the influence mechanism of ecological value cognition on pro-environmental behavior. Environmental attitudes were set as the mediating variable and place attachment was selected as the moderating variable. The results showed that (1) ecological value cognition exhibited a positive influence on pro-environmental behavior in both direct and indirect ways. The indirect influence was mediated by environmental attitude. (2) Place identity and place dependence showed a positive direct influence on pro-environmental behavior. (3) It is suggested that in order to improve pro-environmental behavior, enhancing ecological value cognition, cultivating farmers’ positive environmental attitude, increasing farmers’ place attachment, and releasing reward and punishment measures are good strategies. The findings in this study are important to the improvement of the rural ecological environment and the quality of life of farmers. Meanwhile, the findings shed light on the construction process of ecological civilization and the improvement of public welfare.

For more than 20 years, disaster dynamic monitoring and early warning have achieved orderly and sustainable development in China, forming a systematic academic research system and top-down policy design, which are inseparable from the research of China’s scientific community and the promotion of government departments. In the past, most of the research on dynamic disaster monitoring and early warning focused on specific research in a certain field, scene, and discipline, while a few studies focused on research review or policy analysis, and few studies combined macro and meso research reviews in academia with national policy analysis for comparative analysis. It is necessary and urgent to explore the interaction between scholars’ research and policy deployment, which can bring theoretical contributions and policy references to the top-down design, implementation promotion, and academic research of China’s dynamic disaster monitoring and early warning. Based on 608 international research articles on dynamic disaster monitoring and early warning published by Chinese scholars from 2000–2021 and 187 national policy documents published during this period, this paper conducts a comparative analysis between the knowledge maps of international research hotspots and the co-occurrence maps of policy keywords on dynamic disaster monitoring and early warning. The research shows that in the stage of initial development (2000–2007), international research articles are few and focused, and research hotspots are somewhat alienated from policy keywords. In the stage of rising development (2008–2015), after the Wenchuan earthquake, research hotspots are closely related to policy keywords, mainly in the fields of geology, engineering disasters, meteorological disasters, natural disasters, etc. Meanwhile, research hotspots also focus on cutting-edge technologies and theories, while national-level policy keywords focus more on overall governance and macro promotion, but the two are gradually closely integrated. In the stage of rapid development (2016–2021), with the continuous attention and policy promotion of the national government, the establishment of the Ministry of Emergency Management, and the gradual establishment and improvement of the disaster early warning and monitoring system, research hotspots and policy keywords are integrated and overlapped with each other, realizing the organic linkage and mutual promotion between academic research and political deployment. The motivation, innovation, integration, and transformation of dynamic disaster monitoring and early warning are promoted by both policy and academic research. The institutions that issue policies at the national level include the State Council and relevant departments, the Ministry of Emergency Management, the Ministry of Water Resources, and other national ministries and commissions. The leading affiliated institutions of scholars’ international research include China University of Mining and Technology, Chinese Academy of Sciences, Wuhan University, Shandong University of Science and Technology, and other institutions. The disciplines involved are mainly multidisciplinary geosciences, environmental sciences, electrical and electronic engineering, remote sensing, etc. It is worth noting that in the past two to three years, research and policies focusing on COVID-19, public health, epidemic prevention, environmental governance, and emergency management have gradually increased.

The entrepreneurship of college students is an important issue related to the harmony and sustainable development of society as a whole. At present, the existing research in the industry pays less attention to the influence mechanism of non-cognitive ability and social support perception on college students’ entrepreneurial intention. Using 450 survey data, this paper examines the relationship between non-cognitive ability and college students’ entrepreneurial intention in terms of five dimensions: openness, conscientiousness, extraversion, agreeableness, and emotional stability. At the same time, it focuses on the role of social environmental factors, namely, social support perception in the relationship between the non-cognitive ability and entrepreneurial intention, and explores the influence path. The results show that openness, conscientiousness, extroversion, and emotional stability have significant positive effects on entrepreneurial intention; agreeableness has no significant effect on entrepreneurial intention; openness, conscientiousness, extraversion, agreeableness, and emotional stability have significant positive effects on social support perception. The mediating effect of social support perception is as follows—it is part of the intermediary effect between openness, conscientiousness, extraversion, and emotional stability on entrepreneurial intention; within the influence of agreeableness on entrepreneurial intention, it plays a complete intermediary role. This paper enriches the research results on the impact of non-cognitive ability on entrepreneurial intention, reveals the intermediary effect of social support perception on the impact of non-cognitive ability on college students’ entrepreneurial intention, and broadens the field of vision for the study of college students’ entrepreneurial intention. The research results can provide a decision-making reference for the promotion of the entrepreneurial intention of college students, alleviating the employment pressure of college graduates in China and promoting sustainable economic development.

Pro-environmental behavior can promote the optimization of the living environment and sustainable social development. This paper constructs a theoretical analysis framework of “environmental consciousness, habitat environment-social capital- pro-environmental behavior”. By using structural equation modeling and 1005 instances of microscopic research data, we analyzed the influence of environmental awareness and habitat environment on the pro-environmental behavior of community residents. The results of the analysis were combined with the Bootstrap method to verify the mediating role of social capital dimensions in the influence of environmental awareness and habitat quality on the pro-environmental behavior of community residents. The results show that: Firstly, environmental awareness, habitat quality, and social capital have positive effects on the pro-environmental behavior of community residents. Secondly, environmental awareness and habitat quality have positive effects on the five dimensions of social capital. Thirdly, among the five dimensions of social capital, four dimensions of social trust, social norms, sense of community belonging, and community voluntarism play a partially mediating role between environmental awareness, habitat quality, and pro-environmental behavior. This paper enriches the research on the influence of environmental awareness and habitat environment on pro-environmental behavior, reveals the mediating effect of each dimension of social capital, and broadens the horizon for the study of pro-environmental behavior. The results of the study can provide a reference for decision making to promote the implementation of pro-environmental behavior among community residents.

Breast cancer remains the most common malignancy in women and constantly threatens the lives of patients worldwide. State-of-the-art renewal has indicated the involvement of RUNX-associated transcription factor 2 (RUNX2) in tumorigenesis and cancer progression, yet the detailed information during breast cancer is largely obscure. Herein, we took advantage of breast cancer cell lines and

The driving mechanism of expansion is the basis for policymaking in urban land management and control. In this study, Yangzhou city in China was used as an example. Based on the supply and demand theory of land, a framework was constructed to analyze the driving factors behind urban land expansion. Path analysis was used to determine the direct and indirect factors driving urban land expansion. The results showed the following: (1) Urban land in Yangzhou city expanded 32,831.10 hm2 from 2005 to 2018, mainly in terms of farmland. This rapid expansion arose from the contraction of rural residential areas, threatening ecological spaces such as water bodies. (2) Path analysis indicated that fixed-asset investment, the added value of secondary and tertiary industries, urban population, distance to the city center, and farmland area are the direct factors driving urban land expansion. Land finance, technology input, and transportation ability indirectly influence urban land by affecting other driving factors. (3) Increasing the level of urban land-use intensification, properly adjusting economic development goals, reasonably controlling the population, exploring the retention of construction land in city centers, and optimizing farmland and basic farmland plans need to be considered in the management and control of urban land expansion. Furthermore, to guide the orderly expansion of urban land, improving land management systems, promoting scientific and technological progress, and scientifically designing transportation land are necessary strategies.

The STK (Systems Tool Kit) is used to study the space target detection capability of ground-based radar. Based on radar equation, the influencing factors of radar detection ability are analyzed from three kinds of parameters: system constant, statistical variable and atmospheric environment. The quantitative relationship between radar range, radar elevation and target height is calculated and given. In view of the limitation of STK phased array antenna model, considering the size constraints of mobile radar, a parabolic antenna is selected and a STK-based ground radar model is constructed by combining radar mode, transmitter, receiver and other components. The main performance parameters of the radar system are given. Case simulation is carried out for FIA5 satellite, the simulation results show that the ground-based radar can effectively detect and track the target 158s and the detection range of the target is 1094.8-1223.5km.

Background As microRNA-34a (miR-34a) has been suggested to be associated with breast cancer (BC), this study was proposed to explore the underlying mechanism of miR-34a in suppressing BC progression. Methods A total of 123 pairs of tumor tissues and matched nontumor tissues were obtained from patients. Reverse transcription polymerase chain reaction and in situ hybridization were used to detect the differences in miR-34a expression in tissues and cells. Whether Wnt1 is a direct downstream target of miR-34a was confirmed by both bioinformatics target gene prediction and dual-luciferase report assay. Wnt1 and other gene expressions that are related to Wnt/β-catenin signaling pathway were assessed by reverse transcription polymerase chain reaction and western blot when MCF-7A cells were transfected with miR-34a mimic or miR-34a inhibitor. The proliferation, invasion and migration status of MCF-7 cells after transfection were assessed by MTT assay, wound healing assay and transwell assays, respectively. Breast tumor xenograft models on mice were also constructed to determine the effect of miR-34a on breast tumor growth in vivo . Results MiR-34a expression was remarkably down-regulated in BC tissues and cell lines compared with normal tissues and cell lines. Wnt1 was a direct downstream target of miR-34a and low expression of miR-34a contributed to the Wnt/β-catenin signaling pathway activation in MCF-7A cells. MiR-34a inhibited the proliferation, invasion and migration of BC in vitro and breast tumor growth in vivo through deactivating the Wnt/β-catenin signaling pathway. Conclusion MiR-34a may suppress the proliferation and progression of BC via mediating the Wnt/β-catenin signaling pathway.