1. Detection of (1,3)-β-d-Glucan in Cerebrospinal Fluid in Histoplasma Meningitis
- Author
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Myint, Thein, Chow, Felicia C, Bloch, Karen C, Raymond-Guillen, Luke, Davis, Thomas E, Wright, Patty W, Woc-Colburn, Laila, Khairy, Raed N, Street, Alan C, Yamamoto, Tomotaka, Albers, Amanda, Wheat, L Joseph, Hage, Chadi A, and Warnock, David W
- Subjects
Adult ,beta-Glucans ,Agricultural and Veterinary Sciences ,Clinical Laboratory Techniques ,Histoplasma ,Neurosciences ,meningitis ,Biological Sciences ,3)-beta-D-glucan ,Medical and Health Sciences ,Microbiology ,cerebrospinal fluid ,Fungal ,Infectious Diseases ,ROC Curve ,3)-β-d-glucan ,(1 ,Humans ,Proteoglycans ,Reagent Kits ,Diagnostic ,Infection ,Histoplasmosis ,Biomarkers - Abstract
The diagnosis of central nervous system (CNS) histoplasmosis is often difficult. Although cerebrospinal fluid (CSF) (1,3)-β-d-glucan (BDG) is available as a biological marker for the diagnosis of fungal meningitis, there are limited data on its use for the diagnosis of Histoplasma meningitis. We evaluated CSF BDG detection, using the Fungitell assay, in patients with CNS histoplasmosis and controls. A total of 47 cases and 153 controls were identified. The control group included 13 patients with a CNS fungal infection other than histoplasmosis. Forty-nine percent of patients with CNS histoplasmosis and 43.8% of controls were immunocompromised. The median CSF BDG level was 85 pg/ml for cases, compared to
- Published
- 2018