1. Additional file 1 of Metallic phase enabling MoS2 nanosheets as an efficient sonosensitizer for photothermal-enhanced sonodynamic antibacterial therapy
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Chen, Huizhi, He, Xiaojun, Zhou, Zhan, Wu, Zhikang, Li, Hai, Peng, Xinsheng, Zhou, Yubin, Tan, Chaoliang, and Shen, Jianliang
- Abstract
Additional file 1: Fig. S1 (a) SEM images of 2H-phase MoS2 bulk crystals and (b) its XRD pattern with simulated reference. Fig. S2 (a) TEM image of S-MoS2 nanosheets and (b) the HRTEM image of a typical S-MoS2 nanosheet. (c) AFM height image of S-MoS2 nanosheets. (d) Atomic-resolution HAADF-STEM image of a typical S-MoS2 nanosheet. (e) The filtered of the marked squire regime in (d) and (f) the corresponding crystal structure of semiconducting 2H-phase MoS2. Fig. S3 (a) UV���vis-NIR absorption spectra of M-MoS2 nanosheets dispersed in water at different concentrations and (b) its corresponding normalized absorbance intensity divided by the characteristic length of the cell (A/L) at different concentrations for �� = 1064 nm. Fig. S4 (a) Thermal images of PVP-modified M-MoS2 and PVP-modified S-MoS2 nanosheets with different concentrations (0, 10, 20, and 50 ppm) under the irradiation by a laser at 1.0 W cm���2 for 6 min. Photothermal heating curves water solutions containing (b) PVP-modified M-MoS2 and (c) PVP-modified S-MoS2 nanosheets at different concentrations (0, 5, 10, 20 and 50 ppm). (d) Photothermal heating curves water solutions containing 50 ppm PVP-modified M-MoS2 irradiated with a laser at different power density. (e) Heating of solution of 50 ppm PVP-modified M-MoS2 and S-MoS2 nanosheets for five On/Off cycles. Fig. S5 (a) The molecular structure of the reaction between RB and active oxygen species. (b,c) UV���vis spectra of RB in absence of and in presence of 50 ppm (b) M-MoS2 and (c) S-MoS2 nanosheets after US treatments with different times. Fig. S6 Relative viabilities of cells (L929) after incubation in PVP-modified M-MoS2 and S-MoS2 nanosheets with different concentrations (0, 5, 10, 20, 40, 80, 100, 120, 150 and 200 ppm) for 24 h. Fig. S7 The bacterial survival from the bacterial colonies in Fig. 5b. Fig. S8 Gram, masson trichrome, and hematoxylin���eosin (H&E) and staining of wound tissues after exposure to different treatment (PBS, M-MoS2, M-MoS2 + Laser, M-MoS2 + US, and M-MoS2 + Laser + US) for 10 days. Fig. S9 H&E staining of main organs (heart, liver, spleen, lung, and kidney) in different treatment groups.
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- 2022
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