1. Results of the 2nd part Scientific Workshop of the ECCO (II): measures and markers of prediction to achieve, detect, and monitor intestinal healing in Inflammatory Bowel Disease
- Author
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M. Daperno, L. d. Ridder, I. Dotan, M. Färkkilä, J. Florholmen, G. Fraser, W. Fries, X. Hebuterne, P. L. Lakatos, J. Panés, J. Rimola, E. Louis, S. C. of, C. Organization, CASTIGLIONE, FABIANA, Infection bactérienne, inflammation, et carcinogenèse digestive, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Service de Gastroentérologie (Pôle Digestif), Centre Hospitalier Universitaire de Nice (CHU Nice), Université Pierre et Marie Curie - Paris 6 (UPMC), Radiology, Hospital Clinic, Pediatrics, Université Nice Sophia Antipolis (1965 - 2019) (UNS), M., Daperno, Castiglione, Fabiana, L. d., Ridder, I., Dotan, M., Färkkilä, J., Florholmen, G., Fraser, W., Frie, X., Hebuterne, P. L., Lakato, J., Pané, J., Rimola, E., Loui, S. C., Of, and C., Organization
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medicine.medical_specialty ,Fecal markers ,Imaging techniques ,Routine practice ,Gastroenterology ,Inflammatory bowel disease ,Sensitivity and Specificity ,Endoscopy, Gastrointestinal ,analysis/metabolism, Endoscopy ,Transmural healing ,03 medical and health sciences ,0302 clinical medicine ,Intestinal mucosa ,Internal medicine ,medicine ,Terminal ileum ,Humans ,X-Ray Computed, Wound Healing ,Intestinal Mucosa ,Gastrointestinal, Humans, Inflammatory Bowel Disease ,Wound Healing ,medicine.diagnostic_test ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,business.industry ,Mucosal healing ,pathology/physiopathology, Intestinal Mucosa ,Inflammatory Bowel Diseases ,Mucous membrane ,Endoscopy ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,pathology/physiopathology, Magnetic Resonance Imaging, Sensitivity and Specificity, Tomography ,3. Good health ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Biological Marker ,Genetic markers ,030211 gastroenterology & hepatology ,Calprotectin ,business ,Tomography, X-Ray Computed ,Serologic markers ,Biomarkers - Abstract
International audience; The healing of the intestine is becoming an important objective in the management of inflammatory bowel diseases. It is associated with improved disease outcome. Therefore the assessment of this healing both in clinical studies and routine practice is a key issue. Endoscopy for the colon and terminal ileum and computerized tomography or magnetic resonance imaging for the small bowel are the most direct ways to evaluate intestinal healing. However, there are many unsolved questions about the definition and the precise assessment of intestinal healing using these endoscopic and imaging techniques. Furthermore, these are relatively invasive and expensive procedures that may be inadequate for regular patients' monitoring. Therefore, biomarkers such as C-reactive protein and fecal calprotectin have been proposed as surrogate markers for intestinal healing. Nevertheless, the sensitivity and specificity of these markers for the prediction of healing may be insufficient for routine practice. New stool, blood or intestinal biomarkers are currently studied and may improve our ability to monitor intestinal healing in the future.
- Published
- 2011
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