1. Bovine Serum Albumin Nanoparticle-Mediated Delivery of Sorafenib for Improving Hepatocellular Carcinoma Therapy
- Author
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Xu Jing, Li Li, Ruoqiu Fu, Xiang Mingfeng, Yao Liu, Ziwei Li, Haiyan Xing, Bin Li, Jianhong Chen, Dongyu Duan, Rui Ni, Song Hongyu, Yue Ming, and Chen Li
- Subjects
Drug ,Sorafenib ,Carcinoma, Hepatocellular ,Materials science ,media_common.quotation_subject ,Biomedical Engineering ,Serum albumin ,Antineoplastic Agents ,Bioengineering ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,Carcinoma ,medicine ,Humans ,Distribution (pharmacology) ,General Materials Science ,Bovine serum albumin ,Cytotoxicity ,neoplasms ,030304 developmental biology ,media_common ,0303 health sciences ,biology ,Liver Neoplasms ,Serum Albumin, Bovine ,General Chemistry ,Condensed Matter Physics ,medicine.disease ,digestive system diseases ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,biology.protein ,Cancer research ,Nanoparticles ,medicine.drug - Abstract
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. The majority of patients with HCC are diagnosed with advanced-stage disease. Sorafenib is a frontline therapy drug approved by the Food and Drug Administration for advanced HCC. However, the poor aqueous solubility of sorafenib limits its applications. The present study aimed to overcome this limitation of sorafenib. Thus, bovine serum albumin (BSA)-based nanoparticles were developed to encapsulate hydrophobic sorafenib. The resultant sorafenib-loaded BSA nanoparticles (Sf-BSA-NPs) were thoroughly characterized for size distribution, encapsulation efficiency and morphology. Previous studies on HepG2 cells in vitro have demonstrated that Sf-BSA-NPs exhibit remarkable superiority to free sorafenib in cytocompatibility, cytotoxicity and proapoptotic effect. The results of the present study demonstrated that Sf-BSA-NPs were effective in improving aqueous solubility, and enhanced drug cytotoxicity, suggesting its therapeutic potential for HCC.
- Published
- 2021