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In contemporary times, China has placed an elevated significance on the development and establishment of global communication initiatives, as they strive to effectively convey their narratives to a larger audience, ultimately resulting in the dissemination of a positive image of China. Consequently, the Chinese government has actively invested in the growth and expansion of digital networking technologies, recognizing the potential of online gaming as a nascent medium for communication. It is in this vein that online games have been tasked with the pivotal responsibility of leading the dissemination of Chinese culture overseas, serving as the vanguard of "Chinese excellent traditional culture to the sea" via the approach of "games to the sea". The Genshin Impact, a successful and exemplary case of Chinese "domestic games going abroad", serves as a benchmark for the study of innovative methods for foreign communication of Chinese traditional culture. This article endeavors to explore the novel pathways employed by Chinese traditional culture's foreign communication through the process of "domestic games going abroad", specifically through the lens of the game's space construction, character construction, and community construction in Genshin Impact. It is hoped that this research will serve as a reference point for the cross-cultural and international communication of Chinese games, offering invaluable insights to the field.

The excellent traditional Chinese culture is a profound and multifaceted domain that boasts an extensive and vibrant historical trajectory. This heritage is endowed with a unique appeal and holds an inexorable fascination for individuals worldwide. As such, the advancement of the "going out" policy in China to reinforce the dissemination of its traditional culture has become one of the paramount strategic pursuits of the country. The emergent technique of short video production presents a new and innovative modality to transform and amalgamate traditional culture into a compelling visual and auditory language, thereby presenting this rich legacy on the short video platform to resonate with audiences overseas. Yet, despite these promising prospects, the international communication of the excellent traditional Chinese culture faces several limitations and imperfections. To address these shortcomings, this paper undertakes a rigorous exploration of the innovative path of short video production, scrutinizing its potential to bolster the dissemination of Chinese traditional culture on a global scale. To this end, this study adopts a tripartite framework, scrutinizing the communication subject, content, and channel of short video production in order to provide a comprehensive and nuanced analysis of the challenges and opportunities that lie ahead. Drawing on theoretical perspectives, empirical evidence, and practical insights, this paper offers novel and instructive guidelines and recommendations to facilitate the international communication of excellent Chinese traditional culture. Ultimately, this research aims to advance the understanding of the potential of short video production in transcending cultural boundaries and promoting the intercultural dialogue that lies at the core of global communication.

ObjectivesThis study aimed to explore the predictive value of single and multiple risk factors for the clinical outcomes of critically ill patients receiving enteral nutrition and to establish an effective evaluation model.DesignRetrospective cohort study.SettingData from the 2020–2021 period were collected from the electronic records of the First Affiliated Hospital, Nanjing Medical University.Participants459 critically ill patients with enteral nutrition in the geriatric intensive care unit were included in the study.Primary and secondary outcome measuresThe primary outcome was 28-day mortality. The secondary outcomes were 28-day invasive mechanical ventilation time, intensive care unit stay, Nutrition Risk Screening 2002 (NRS2002) score and Acute Physiology and Chronic Health Evaluation II (APACHE II) score.ResultsIndependent prognostic factors, including prealbumin/procalcitonin (PCT) ratio and APACHE II score, were identified using a logistic regression model and used in the nomogram. The area under the receiver operating characteristic curve and concordance index indicated that the predictive capacity of the model was 0.753. Moreover, both the prealbumin/PCT ratio and the combination model of PCT, prealbumin and NRS2002 had a higher predictive value for clinical outcomes. Subgroup analysis also identified that a higher inflammatory state (PCT >0.5 ng/mL) and major nutritional risk (NRS2002 >3) led to worse clinical outcomes. In addition, patients on whole protein formulae bore less nutritional risk than those on short peptide formulae.ConclusionsThis nomogram had a good predictive value for 28-day mortality in critically ill patients receiving enteral nutrition. Both the prealbumin/PCT ratio and the combination model (PCT, prealbumin and NRS2002), as composite models of inflammation and nutrition, could better predict the prognosis of critically ill patients.

In order to study the effect of exogenous 5-aminolevulinic acid (ALA) on the expression of genes associated with anthocyanin biosynthesis in the transcriptome of ‘Crimson Seedless’ grape (Vitis vin...

The objective of this work was to explore how selection of feedstock affects nitrogen cycle genes during composting, which eventually determines the nitrogen loss. Four composting mixes (CM: chicken manure; SM: sheep manure; MM

With the promotion and popularization of machine cotton-picking, more and more attention has been paid to the selection of early-maturity varieties with compact plant architecture. The type of fruit branch is one of the most important factors affecting plant architecture and early maturity of cotton. Heredity analysis of the cotton fruit branch is beneficial to the breeding of machine-picked cotton. Phenotype analysis showed that the types of fruit branches in cotton are controlled by a single recessive gene. Using an F2 population crossed with Huaxin102 (normal branch) and 04N-11 (nulliplex branch), BSA (Bulked Segregant Analysis) resequencing analysis and GhNB gene cloning in 04N-11, and allelic testing, showed that fruit branch type was controlled by the GhNB gene, located on chromosome D07. Ghnb5, a new recessive genotype of GhNB, was found in 04N-11. Through candidate gene association analysis, SNP 20_15811516_SNV was found to be associated with plant architecture and early maturity in the Xinjiang natural population. The GhNB gene, which is related to early maturity and the plant architecture of cotton, is a branch-type gene of cotton. The 20_15811516_SNV marker, obtained from the Xinjiang natural population, was used for the assisted breeding of machine-picked cotton varieties.

The cross-sections of the 187Re(n,γ)188mRe and 187Re(n,γ)188gRe reactions were measured at the four neutron energies of 13.5, 14.1, 14.4 and 14.8 MeV through the activation method and using off-line γ-ray spectrometry. The previously developed formulas were used to subtract the effects of γ rays with close energies and the contribution from the excited state. A high-resolution γ-ray spectrometer with high-purity germanium detector was used to measure the induced γ activities. The simulation computations of the excitation functions concerning the above-mentioned two nuclear reactions were performed by adopting the nuclear theoretical model program system Talys-1.9. The theoretical excitation curves in the incident neutron energy range from 2.53 × 10−8 to 20 MeV were acquired. The fitting line of our results in the neutron energy range of 13.5–14.8 MeV, within experimental uncertainty, agrees very well with the theoretical excitation curve based on the computer code Talys-1.9.

Micro(nano)plastics (MNPs) are widely acknowledged as global environmental threat while determination methods for MNPs are still lacking and becoming a growing concern. This study provides a novel method for MNPs identification/quantification by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS). Factors affecting the measurement were optimized, including laser energy, matrix (M), analyte (A), cationization agent (C), and MAC volume ratio. Under the optimal conditions, the peaks representative of polystyrene (PS) and polyethylene terephthalate (PET) were identified, and the mass differences were consistent with the molecular weight of the corresponding oligomer. A quantitative correlation was built between normalized signal intensity and ln[polymer concentration] with a correlation coefficient above 0.96 for low-molecular-weight polymers and 0.98 for high-molecular-weight polymers. Furthermore, two types of environmental MNP samples were prepared, including aviation cup particles as fresh plastics and aged MNPs extracted from river sediment. By using MALDI-TOF MS, the PS-related MNPs (in both aviation cup and sediment) consisted of C8H8 and C16H16O oligomers, while the PET-related MNPs (only found in sediment) were identified with repeated units of C10H8O4 and C12H12O4. According to the quantitative correlation curve, the contents of PS and PET MNPs were quantified as 8.56 ± 0.04 and 28.71 ± 0.20 mg·kg-1, respectively, in the collected sediment. This study is the first attempt to propose a quantification method with the employment of MALDI-TOF MS for aged MNPs analysis in environmental samples, which can not only supply an effective method for MNP analysis but also inspire future studies on the in situ distribution and transformation of MNPs in environmental and biological samples.

As one of the most widely cultivated cotton species in China, upland cotton has moderate fiber quality and wide applicability, but its genetic basis is relatively narrow. To expand genetic diversity and improve fiber quality, in this study an introgression population (BC5S5) containing 107 lines was constructed by using G. hirsutum acc. 4105 as the recurrent parent and G. tomentosum as the donor parent. Using the specific-locus amplified fragment sequencing (SLAF-seq) strategy, 3157 high-throughput single nucleotide polymorphism (SNP) markers were obtained. Linkage analysis showed that a total of ninety-one QTLs related to fiber quality traits were detected in three environments, and the phenotypic variance explained (PVE) rates were 4.53–20.92%. Forty-six QTL (50.55%) synergistic genes were derived from G. tomentosum. Among them, qFS-A02-1 and qSCI-A02-1 were stably detected with a PVE of 9.8–16.71% and 14.78–20.92%, respectively. Within the candidate interval, Ghir_A02G012730, Ghir_A02G012790 and Ghir_A02G012830 were found to be possibly involved in cellulose and cell wall biosynthesis, with a relatively high expression during fiber development, 20 DPA and 25 DPA, which suggested that these three genes may be involved in the regulation of fiber strength traits, but their functions need further validation to determine the regulatory mechanism. Our research lays the foundation of fiber quality related to basic genetic research and breeding in cotton.

The most common type of diabetes among children and adolescents is type 1 diabetes mellitus (T1DM), which is associated with an increased risk of cardiovascular disease (CVD). Additionally, lower levels of cardiorespiratory fitness (CRF) are linked to an increased risk of CVD. Regular exercise is associated with a decreased risk of CVD and improved CRF. We conducted this scoping review to assess the effects of exercise on CRF in youth with T1DM. Three electronic databases (PubMed, Embase, and Cochrane Central Register of Controlled Trials) were used to search for the relevant literature. In this analysis, the PICOS method was used to select studies and was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines scoping review guidelines for the evaluation of the effects of physical activity and cardiac function; the criteria may include the type and intensity of physical activity, the duration of the intervention, peak oxygen consumption (VO2), peak minute ventilation (VE), and peak heart rate of cardiorespiratory fitness. Screening resulted in 434 records. Of these, nine articles were included in our study. These nine studies were experimental (noncontrolled trials or randomized controlled trials) (n = 7) and observational (cross-sectional) (n = 2), and could be used to evaluate the effectiveness of physical activity interventions on cardiac function. The effects of exercise on CRF in youth with T1DM vary according to the type, frequency, and intensity of the exercise. According to our review, the duration of exercise included in the studies did not meet the recommendations of the guidelines for youth with T1DM. Additionally, half of the studies revealed that exercise could optimize the lipid profile in youth with T1DM. Hence, this research is to provide an overview of the effects of physical activity and exercise on CRF, cardiovascular fitness, lipid profile, and blood pressure in youth with T1DM, as well as identified potential limitations of the existing studies. Nevertheless, the limited number of clinical studies employing exercise interventions for children and adolescents with T1DM emphasize the need for more studies in this area, and more specific modes of exercise should be developed in the future.

The increasing microplastic pollution together with the plastisphere-associated ecological threats in coastal areas have aroused global concern. Tropical cyclones have been increased in both frequency and intensity under global warming, causing intense impact on the microplastics distribution and the structure of coastal ecosystems. However, until most currently, the extent to which typhoon impacts the microplastics and plastisphere community remains poorly known. This study analyzed the effects of Typhoon Wipha (Code: 1907) on microplastics abundance and composition in surface water and sediment crossed coastal areas of Shenzhen. Here we found a significant typhoon-induced increase in microplastics abundance in surface water, whereas an opposite trend was observed in sediment. Despite the evident transportation of microplastics from sediment to surface water by agitation, a possible microplastics influx was introduced by typhoon as evidenced by the large attribution of unknown force in source tracking analysis. Furthermore, typhoon had adeptly uniformed the plastisphere community in the sediment along the 190 km costal line overnight. A significant increase of nitrogen fixer, Bradyrhizobiaceae, was observed ubiquitously after typhoon, which might alter the nitrogen cycling and increase eutrophic condition of the coastal ecological system. Together, this study expanded the knowledge about the impact of typhoon-induced influx of the microplastics on coastal biogeochemical cycling. Moreover, the microplastics and the plastisphere compositional pattern revealed here will underpin future studies on adsorption behavior, interfacial processes and ecotoxicity of the coastal microplastic pollution.

Two methods used to subtract the effect of the decay of different nuclear reaction products on the cross-section measurement of the studied nuclear reaction were given. Taking the cross-section measurement of the $^{91}\mathrm{Zr}(n,p)^{91\mathrm{m}}\mathrm{Y}$ reaction as an example, the accurate and reliable cross section of the $^{91}\mathrm{Zr}(n,p)^{91\mathrm{m}}\mathrm{Y}$ reaction in the neutron energy range of 13.5--14.8 MeV was measured by using the activation technique and the above two methods. Moreover, the excitation function in the neutron energies from the threshold to 21 MeV was calculated by using the nuclear theoretical model program system talys--1.9 with the adjusted relevant parameters. The measured cross-section values were discussed and compared with previous experiments by other researchers and with the theoretical values based on talys--1.9. The experimental values obtained by the above two methods were highly consistent within experimental error, and at some neutron energies they were consistent, within experimental error, with those of the fitting line of previous experiments at the corresponding energies, and were also consistent with those of theoretical excitation curve at the corresponding energies. The obtained theoretical excitation curve can match most of the experimental data.

The novel coronavirus SARS-CoV-2 has prompted a worldwide pandemic and poses a great threat to public safety and global economies. Most present personal protective equipment (PPE) used to intercept pathogenic microorganisms is deficient in biocidal properties. Herein, we present green nanofibers with effective antibacterial and antiviral activities that can provide sustainable bioprotection by continuously producing reactive oxygen species (ROS). The superiority of the design is that the nanofibers can absorb and store visible light energy and maintain the activity under light or dark environment. Moreover, the nanofibers can uninterruptedly release ROS in the absence of an external hydrogen donor, acting as a biocide under all weather conditions. A facile spraying method is proposed to rapidly deploy the functional nanofibers to existing PPE, such as protective suits and masks. The modified PPE exhibit stable ROS production, excellent capacity for storing activity potential, long-term durability, and high bactericidal (>99.9%) and viricidal (>99.999%) efficacies.

Aiming at the problems of the integration of ecotype supply chain platform, such as the uneven ability of suppliers, and the increasingly diversified market demand makes the platform cost difficult to reduce, etc., by positioning customer order decoupling point (CODP), considering the characteristics of ecotype supply chain with multiple orders, logistics services and manufacturing and production, a double objective and multiple decoupling point is constructed, which aims at the lowest total cost and the highest customer value positioning model, balancing cost and personalized demand, providing better customized rate decision-making scheme, and using the data provided by platform A, improving genetic algorithm, to verify the model solution. The customization rate and order quantity of platform operators under the decision-making of customer value preference and cost preference are solved. It is proved that the multi decoupling point positioning model can provide decision-making scheme for platform operators with different preferences, reduce the cost of ecological supply chain and improve customer satisfaction.

The cross sections of the

The objective of this study was to analyze the effects of additives (biochar (BC) and palygorskite (PG)) on predominant fungi succession throughout composting of corn stover/chicken manure mix to influence humic substances formation (HS). Results indicated that BC and PG promoted the polymerization of HS and formation of more humic acids (HA), and BC performed better than PG, 10% additive was better than 5%. ITS rRNA gene sequencing showed that predominant fungi succession was significantly affected by BC and PG in composting, correlation between HS formation and predominant fungi indicated that BC and PG boosted lignocellulose-degrading fungi which could break down fulvic acids (FA) and HM to form more HA. Fungi function analysis showed that 10% BC significantly increased saprotrophic fungi, and decreased pathogenic fungi. Therefore, addition of 10% BC was conductive to promote the formation of HA and improve compost quality.

The first experimental cross-section data for the 180Hf(n,γ)181Hf reaction have been measured within the neutron energies range of 13.5–14.8 MeV using the activation technique. The fast neutrons were produced by the T(d,n)4He reaction. Induced activities were measured by a high-resolution γ-ray spectrometer with high-purity germanium detector. The neutron fluence was determined by using the monitor reaction 93Nb(n,2n)92mNb. The neutron energies in the measurements were determined beforehand by the method of cross section ratios for the 90Zr(n,2n)89m+gZr and 93Nb(n,2n)92mNb reactions. The experimentally determined cross-section values were compared with the evaluation nuclear data in several major libraries of International Atomic Energy Agency and the theoretically calculated results by using the Talys1.8 code.

To observe and investigate the in vitro effect of ulipristal acetate (UPA) on human sperm parameters and function. The 20 patients with normal semen parameters and average age of (32.5±8.5) years old, who were treated in our hospital from January 2018 to August 2018, were selected as research objects. They were subjected to density gradient centrifugation, and then four groups were incubated for about an hour in a culture medium containing different concentrates of ulipristal acetate and the other two groups were set as blank control group and dimethylsulphoxide (DMSO) control group. Indicators including sperm motility, sperm hyperactivation and sperm concentration of free calcium ions of each group were tested. Under the ulipristal acetate concentration of 0.0.4 mol/L, the proportion of sperm damage was increased, the length of tail was increased, and the proportion of sperm hyperactivation was decreased, p0.05. In addition, the acrosome reaction was inhibited, which significantly reduced the calcium concentration in the sperm, p0.05. Ulipristal acetate can significantly inhibit acrosome reaction and hyperactivation of sperm in vitro, and can reduce the concentration of calcium ions in sperm, thus causing sperm damage.

Cross-section data of the 185Re(n,2n)184mRe, 185Re(n,2n)184gRe, 185Re(n,α)182m1+m2+gTa, 187Re(n, 2n)186g,(m)Re, 187Re(n,α)184Ta, and 187Re(n,p)187W reactions were measured at four neutron energies, namely 13.5, 14.1, 14.4, and 14.8 MeV, by means of the activation technique, relative to the reference cross-section values of the 93Nb(n,2n)92mNb reaction. The neutrons were generated from the T(d,n)4He reaction at the K-400 Neutron Generator at China Academy of Engineering Physics. The induced γ activities were measured using a high-resolution γ-ray spectrometer equipped with a coaxial high-purity germanium detector. The excitation functions of the six above-mentioned nuclear reactions at neutron energies from the threshold to 20 MeV were calculated by adopting the nuclear theoretical model program system Talys-1.9 with the relevant parameters properly adjusted. The measured cross sections were analyzed and compared with previous experiments conducted by other researchers, and with the evaluated data of BROND-3.1, ENDF/B-VIII.0, JEFF-3.3, and the theoretical values based on Talys-1.9. The new measured results agree with those of previous experiments and the theoretical excitation curve at the corresponding energies. The theoretical excitation curves based on Talys-1.9 generally match most of experimental data well.

The cross sections of the 180Hf(n,p)180Lu and 90Zr(n,2n)89mZr reactions were measured around the neutron energies of 13.5–14.8 MeV by using the activation technique. The excitation functions of the above reactions in the neutron energies from the threshold to 20 MeV were calculated by using the nuclear theoretical model program system Talys-1.9 with the adjusted relevant parameters. The measured results were discussed and compared with previous experiments by other researchers and with the evaluated data of ENDF/B-VIII.0, CENDL-3.1, JEFF-3.3, JENDL-4.0u2, BROND-3.1 as well as the theoretical values based on Talys-1.9. The obtained experimental values at some neutron energies, within experimental error, are consistent with those of the fitting line of the results of previous experiments and are also consistent with those of theoretical excitation curve at the corresponding energies. The obtained theoretical excitation curves match well with most of the experimental data.

The cross sections for the 94Zr(n,d*)93m+gY, 96Zr(n,γ)97Z, 96Zr(n,2n)95Zr, 90Zr(n,α)87mSr, 94Zr(n,α)91Sr,90Zr(n,p)90mY, 92Zr(n,p)92Y, and 94Zr(n,p)94Y reactions have been measured in the neutron energy range of 13.5-14.8 MeV by means of the activation technique. The neutrons were produced via the D-T reaction. A high-purity germanium detector with high energy resolution was used to measure the induced γ activities. In combination with the nuclear reaction theoretical models, the excitation curves of the above-mentioned eight nuclear reactions within the incident neutron energy range from the threshold to 20 MeV were obtained by adopting the nuclear theoretical model program system Talys-1.9. The resulting experimental cross sections were analyzed and compared with the experimental data from published studies. Calculations were performed using Talys-1.9 and are in agreement with our experimental results, previous experimental values, as well as results of the theoretical excitation curves at the corresponding energies. The theoretical excitation curves generally match the experimental data well.

In view of the fact that the fast-neutron experimental cross-section data of hafnium which is an important structural material of fusion reactor are few and there are the great differences in their evaluation values, several activation cross sections of (n, 2n), (n, p), (n, a) and (n, n′) reactions on hafnium isotopes have been investigated by neutrons generated from the T(d, n)4He reaction at the K-400 Neutron Generator at China Academy of Engineering Physics (CAEP). The gamma activities of the product nuclei were measured by a high-resolution gamma-ray spectrometer with a coaxial high-purity germanium detector. The 93Nb(n, 2n)92mNb reaction was used as neutron fluence standard, these experimental cross sections of the 174Hf(n, 2n)173Hf, 176Hf(n, 2n)175Hf, 178Hf(n, α)175m+gYb, 178Hf(n, p)178gLu, 178Hf(n, p)178mLu, 180Hf(n, 2n)179m2Hf, 180Hf(n, α)177m+gYb and 180Hf(n, n′)180mHf reactions were obtained in the neutron energy range of 13.5–14.8 MeV. These measured cross sections were discussed and compared with some previous experimental results from the literature and with the evaluation data from ENDF/B-VIII.0, CENDL-3.1, JEFF-3.3 and the theoretical results by using the computer code system Talys-1.9.

Recovering a decentralized low-rank matrix from an incomplete set of its entries is one of great research interests. Privacy makes our issue difficult. In this paper, we propose a novel scheme that allows analysts to perform great aggregate analysis while guaranteeing meaningful protection of each individuals privacy. Differential privacy aims to ensure means to maximize the accuracy of queries from statistical databases while minimizing the probabilities of identifying its records. With adding Gaussian noise, we are able to achieve this goal. First, we present an algorithm for private matrix completion. Secondly, we provide theoretical results for required Gaussian noise. Finally, we compare the performance of the proposed algorithm with the state-of-the-art, while both achieves the same level of differential privacy.

The objective of the present study was to evaluate the feasibility of using model drug metoprolol succinate (MS) as a pore former to modify the initial lag phase (i.e., a slow or non-release phase in the first 1-2 h) associated with the drug release from coated pellets. MS-layered cores with high drug-layering efficiency (97% w/w) were first prepared by spraying a highly concentrated drug aqueous solution (60% w/w, 70°C) on non-pareils without using other binders. The presence of MS in ethylcellulose (EC) coating solution significantly improved the coating process by reducing pellets sticking, which often occurs during organic coating. There may be a maximum physical compatibility of MS with EC, and the physical state of the drug in the functional coating layer of EC/MS (80:20) was simultaneously crystalline and non-crystalline (amorphous or solid molecule solution). The lag phase associated with hydroxypropylcellulose (HPC) as a pore former was not observed when MS was used as a pore former. The drug release from EC/MS-coated pellets was pH independent, inversely proportional to the coating levels, and directly related to the pore former levels. The functional coating layer with MS as a pore former was not completely stabilized without curing. Curing at 60°C for 1 day could substantially improve the stability of EC/MS-coated pellets. The physical state of the drug in the free film of EC/MS (85:15) changed partially from amorphous to crystal when cured at 60°C for 1 day, which should be attributed to the incompatibility of the drug with EC.

New experimental cross-section data for the 180W(n,2n)179mW, 186W(n,2n)185mW and 186W(n,p)186Ta reactions at the neutron energies of 13.5 and 14.4 MeV are obtained by the activation technique. The neutron beams are produced by means of the 3H(d,n)4He reaction. The gamma activities of the product nuclei are measured by a high-resolution gamma-ray spectrometer with a coaxial high-purity germanium detector. The neutron fluence is determined using the monitor reaction 93Nb(n,2n)92mNb. The results in the current work are discussed and compared with the measurement results found in the literature. It is shown that these higher accuracy experimental cross-section data around the neutron energy of 14 MeV agree with some previous experimental values from the literature within experimental uncertainties.

Delivering sparingly water-soluble drugs from ethylcellulose (EC) coated pellets with a controlled-release pattern remains challenging. In the present study, hydrophilic polyvinylpyrrolidone (PVP) was used both as a binder and a pore-former in EC coated pellets to deliver sparingly water-soluble topiramate, and the key factors that influenced drug release were identified. When the binder PVP content in drug layers below 20% w/w was decreased, the physical state of topiramate changed from amorphous to crystalline, making much difference to drug solubility and dissolution rates while modifying the drug release profile from first-order to zero-order. In addition, without PVP in drug layering solution, drug layered particles were less sticky during layering process, thus leading to a shorter process and higher loading efficiency. Furthermore, PVP level as a pore-former in EC coating layers mainly governed drug release from the coated pellets with the sensitivity ranging from 23% to 29%. PVP leaching rate and water permeability from EC/PVP film increased with the PVP level, which was perfectly correlated with drug release rate. Additionally, drug release from this formulation was independent of pH of release media or of the paddle mixing speed, but inversely proportional to the osmolality of release media above the physiological range.