1. Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway
- Author
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Chen Feiteng, Chen Lei, Li Deng, Xu Chaoliang, Xu Zijie, Shao Yi, and Sha Minglei
- Subjects
Disease Models, Animal ,Mice ,Epithelial-Mesenchymal Transition ,Nephrology ,Relaxin ,Animals ,Humans ,General Medicine ,Renal Insufficiency, Chronic ,Critical Care and Intensive Care Medicine ,Fibrosis ,Wnt Signaling Pathway - Abstract
Renal fibrosis is a common characteristic and the final pathological mechanism of chronic kidney disease (CKD). Although CKD remains incurable, inhibition of renal fibrosis is beneficial to inhibit the CKD process. Relaxin alleviates renal fibrosis in some experimental models, but its mechanism remains unclear. In the following, we studied the regulatory effect of relaxin on epithelial-mesenchymal transition (EMT) after unilateral ureteral obstruction (UUO). Our results demonstrate that relaxin could downregulate Wnt/β-catenin signaling and decrease EMT, thus protecting against loss of transporters in tubular epithelial cells (TECs) and abrogate renal interstitial fibrosis following UUO. We confirmed that relaxin can downregulate Wnt/β-catenin signaling and decrease EMT in NRK52E, thus abrogating G2 cell cycle arrest
- Published
- 2022