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Additional file 5: Figure S1. Venn diagram showing the overlap among differentially expressed metabolic pathways among ME of different etiologies. AMD-ME, age-related macular degeneration; BRVO-ME, branch retinal vein occlusion; DME, diabetic macular edema; ME, macular edema.

Additional file 5: Table S1. Lists of differentially expressed RNAs between COVID-19 patients and healthy donors.

Additional file 3: Figure S3. Functional characterization of key regulators in circulating platelets during SARS-CoV-2 infection. (A) Tissue and cell-specific enrichment analysis. (B) Disease enrichment analysis. (C) Enrichment analysis of differentially expressed RNAs in viral perturbations datasets from the Gene Expression Omnibus database. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Additional file 2: Figure S2. Hierarchical clustering of transcriptome-wide RNA expression. Hierarchical clustering of samples according to global gene expression segregates SARS-CoV-2-infected patients (red numbers) from healthy donors (gray numbers). SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Additional file 4: Figure S4. Boxplots showing expression levels of four key regulators using RT-qPCR.

Additional file 1: Fig. S1. Precision-Recall curve for the performance of the miR2PE-score in the WMU cohort-1 (A) and WMU cohort-2 (B). Fig. S2. Precision-Recall curve for the performance of the miR2PE-score in the Canada cohort (A) and USA cohort (B). Fig. S3. Precision-Recall curve for the performance of the miR2PE-score in the WMU cohort-3 (A) and WMU cohort-4 (B). Fig. S4. Forest plots of adjusted regression coefficients by gestational ages. Fig. S5. Performance comparison of the miR2PE-score with other parallel methods to detect PE.

Additional file 1: Figure S1. The imaging of all patients.

Edible coating preservation with the advantages of low cost and operable, and good preservation effects, has broad prospects. Using edible materials to coated foods can not only keep fresh food quality, extend shelf life, enhance food safety and sensory characteristics, edible coatings can also be used as the carrier of active ingredients. The principle of edible coating preservation, the types of coating membranes and their advantages and disadvantages, the factors affecting the coating effect of aspects are summarized in this paper. Finally, out-look the future trends of edible coating preservation.