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Additional file 1: Fig. S1. Generation of the Mettl14 rod knockout mouse model. Fig. S2. RKO mice showed normal photopic ERG response at 5-month-old. Fig. S3. 2-month-old RKO mice presented normal retinal structure. Fig. S4. Retinal ONL was almost disappeared in aged RKO mice. Fig. S5. Heterozygous RKO mice showed retinal degeneration at 9-month-old. Fig. S6. Inflammatory response and apoptosis in RKO retinas. Fig. S7. Cre-mediated excision of METTL14 in HKO mice. Fig. S8. Visual function analysis of HKO mice.

Additional file 4: Tables S1. Information of selected differentially methylated RNA sites. Tables S2. Primers used in this study. Tables S3. Immunological antibodies used in this study.