150 results on '"Yaopeng Zhang"'
Search Results
2. Intrinsically ionic conductive nanofibrils for ultra-thin bio-memristor with low operating voltage
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Yi Zhang, Suna Fan, Qianqian Niu, Fang Han, and Yaopeng Zhang
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General Materials Science - Published
- 2022
3. Inkjet printing of 2D polyaniline for fabricating flexible and patterned electrochromic devices
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Xiangyu Huang, Jie Chen, Hongjie Xie, Feixiang Zhao, Suna Fan, and Yaopeng Zhang
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General Materials Science - Published
- 2022
4. Enteral extended biliary stents versus conventional plastic biliary stents for the treatment of extrahepatic malignant biliary obstruction: a single-center prospective randomized controlled study
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Xiaofen Xu, Yaopeng Zhang, Wei Zheng, Yingchun Wang, Wei Yao, Ke Li, Xiue Yan, Hong Chang, and Yonghui Huang
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Treatment Outcome ,Cholestasis ,Neoplasms ,Palliative Care ,Humans ,Stents ,Surgery ,Prospective Studies ,Cholestasis, Extrahepatic ,Plastics - Abstract
The main limitation of plastic stents is the relatively short stent patency due to occlusion. We designed enteral extended biliary stents with lengths of 26 cm (EEBS-26 cm) and 30 cm (EEBS-30 cm) to prolong stent patency. This study aimed to compare patency among EEBS-26 cm, EEBS-30 cm, and conventional plastic biliary stent (CPBS).A single-center prospective randomized controlled study was conducted. Eligible patients were randomized into the EEBS-26 cm, EEBS-30 cm, and CPBS groups, respectively. All patients were followed up every 3 months until stent occlusion, patient death, or at 12-month follow-up. The primary outcome was stent patency. The secondary outcomes included stent occlusion rate, patient survival, mortality, the rate of technical success, and adverse events.Totally 117 patients were randomized into the three groups. There were no significant differences among the three groups in technical success rate, hospital stay, mortality, patient survival, and adverse events (P = 1.000, 0.553, 0.965, 0.302, and 0.427, respectively). Median stent patency durations in the EEBS-26 cm, EEBS-30 cm, and CPBS groups were 156.0 (95% CI 81.6-230.4) days, 81.0 (95% CI 67.9-94.1) days, and 68.0 (95% CI 20.0-116.0) days, respectively (P = 0.002). The EEBS-26 cm group had longer stent patency compared with the CPBS (P = 0.007) and EEBS-30 cm (P 0.001) groups. The EEBS-26 cm group had lower stent occlusion rates compared with the other groups at 6 months (48.1% vs. 90.5% vs. 82.8%, P = 0.001) and 9 months (75.0% vs. 100.0% vs. 92.9%, P = 0.022).EEBS-26 cm has prolonged stent patency and is safe and effective for the alleviation of unresectable extrahepatic malignant biliary obstruction.
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- 2022
5. Bioactive polymer-enabled conformal neural interface and its application strategies
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Zhanao Hu, Qianqian Niu, Benjamin S. Hsiao, Xiang Yao, and Yaopeng Zhang
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Mechanics of Materials ,Process Chemistry and Technology ,General Materials Science ,Electrical and Electronic Engineering - Abstract
Neural interface is a powerful tool to control the varying neuron activities in the brain, where the performance can directly affect the quality of recording neural signals and the reliability of
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- 2023
6. Fiber diameters and parallel patterns: proliferation and osteogenesis of stem cells
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Zhanghong Gu, Suna Fan, Subhas C Kundu, Xiang Yao, and Yaopeng Zhang
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Biomaterials - Abstract
Due to the innate extracellular matrix mimicking features, fibrous materials exhibited great application potential in biomedicine. In developing excellent fibrous biomaterial, it is essential to reveal the corresponding inherent fiber features’ effects on cell behaviors. Due to the inevitable ‘interference’ cell adhesions to the background or between adjacent fibers, it is difficult to precisely reveal the inherent fiber diameter effect on cell behaviors by using a traditional fiber mat. A single-layer and parallel-arranged polycaprolactone fiber pattern platform with an excellent non-fouling background is designed and constructed herein. In this unique material platform, the ‘interference’ cell adhesions through interspace between fibers to the environment could be effectively ruled out by the non-fouling background. The ‘interference’ cell adhesions between adjacent fibers could also be excluded from the sparsely arranged (SA) fiber patterns. The influence of fiber diameter on stem cell behaviors is precisely and comprehensively investigated based on eliminating the undesired ‘interference’ cell adhesions in a controllable way. On the SA fiber patterns, small diameter fiber (SA-D1, D1 means 1 μm in diameter) may seriously restrict cell proliferation and osteogenesis when compared to the middle (SA-D8) and large (SA-D56) ones and SA-D8 shows the optimal osteogenesis enhancement effect. At the same time, the cells present similar proliferation ability and even the highest osteogenic ability on the densely arranged (DA) fiber patterns with small diameter fiber (DA-D1) when compared to the middle (DA-D8) and large (DA-D56) ones. The ‘interference’ cell adhesion between adjacent fibers under dense fiber arrangement may be the main reason for inducing these different cell behavior trends along with fiber diameters. Related results and comparisons have illustrated the effects of fiber diameter on stem cell behaviors more precisely and objectively, thus providing valuable reference and guidance for developing effective fibrous biomaterials.
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- 2023
7. Durable Conducting Polymer Electrodes Pursue Low Impedance, Antifouling, and Electrochemical Stress Tolerance
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Yongjun Bian, Qichao Pan, Yicheng Zhu, Jia Liang, Yuhan Zhang, Yaqiong Zhang, Shouyan Zhang, Sihao Qian, Zhi Geng, Zhengwei You, Maciej Cieplak, Piyush S. Sharma, Yaopeng Zhang, Yong He, and Bo Zhu
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General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
8. One-Step Approach to Prepare Transparent Conductive Regenerated Silk Fibroin/PEDOT:PSS Films for Electroactive Cell Culture
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Ao Zhuang, Xiangyu Huang, Suna Fan, Xiang Yao, Bo Zhu, and Yaopeng Zhang
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Optical Phenomena ,Cell Survival ,Cell Culture Techniques ,Electric Conductivity ,Membranes, Artificial ,Electrochemical Techniques ,Thiophenes ,Bombyx ,PC12 Cells ,Culture Media ,Rats ,Animals ,Polystyrenes ,General Materials Science ,Fibroins - Abstract
Silk fibroin (SF)-based electroactive biomaterials with favorable electroconductive property and transparency have great potential applications for cell culture and tissue engineering. Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) is an excellent candidate as a conductive component, which has been widely used in the field of bioelectronics; however, it is hard to be directly coated onto the surface of regenerated SF (RSF) materials with good stability under a cell culture environment. In this study, a one-step facile PEDOT:PSS modification approach for RSF films based on a suitable post-treatment process of RSF was developed. PEDOT:PSS was successfully embedded and fixed into the shallow surface of an RSF film, forming a tightly conjunct conductive layer on the film surface based on the conformation transition of RSF during the post-treatment process. The conductive layer demonstrated a PSS-rich surface and a PEDOT-rich bulk structure and showed excellent stability under a cell culture environment. More specifically, the robust RSF/PEDOT:PSS film achieved in the post-treatment formula with 70% ethanol proportion possessed best comprehensive properties such as a sheet resistance of 3.833 × 10
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- 2021
9. Selective adsorption and fluorescence sensing of tetracycline by Zn-mediated chitosan non-woven fabric
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Chensi Shen, Yanbiao Liu, Chenye Xu, Mingyu Xiong, Man Wang, Huaping Wang, Fang Li, Chunyan Ma, and Yaopeng Zhang
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Nonwoven fabric ,Inorganic chemistry ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Fluorescence ,Water Purification ,Ion ,Biomaterials ,Chitosan ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Adsorption ,Aqueous solution ,Hydrogen-Ion Concentration ,Tetracycline ,021001 nanoscience & nanotechnology ,Anti-Bacterial Agents ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Kinetics ,Zinc ,chemistry ,Tetracyclines ,Selective adsorption ,0210 nano-technology ,Saturation (chemistry) ,Water Pollutants, Chemical - Abstract
Nowadays, numerous studies have focused on the newly developed technologies for the thorough removal of tetracyclines (TCs). The efficient removal of trace-amount pollutants requires the development of improved materials with higher adsorption capacity and increased adsorption selectivity. Zn(II)-mediated chitosan nonwoven fabric (Zn-CSNW) adsorbent with coordination capability was explored for the effective and selective removal of TC. The adsorption of TC to Zn-CSNW could reach equilibrium in about 30 min with a maximum adsorption capacity of 195.9 mg/g. It exhibited high anti-interference performance for TC adsorption at low concentrations, with good regeneration and effective reuse. Except for citrate, organic materials similar in structure to TC or common ions in aqueous solutions did not show obvious competition for the adsorption of low concentrations of TC. Additionally, the inherent fluorescence of chitosan and the fluorescence sensitization effect of Zn2+ for TC enabled function of Zn-CSNW as an indicator of the adsorption of TC by changes in fluorescence color and intensity under UV light (365 nm). It can indicate the saturation state of the Zn-CSNW, which will bring convenience to the use of the adsorbent. The Zn(II)-mediated coordination interaction plays a vital role in both the selective recognition of TC and the fluorescence sensing of adsorption amount, demonstrating an affordable and effective strategy for the treatment of water containing low amounts of antibiotics.
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- 2021
10. The Analyses of High Infectivity Mechanism of SARS-CoV-2 and Its Variants
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Tianfu Zhao, Xiang Yao, Fangyin Dai, Guangxian Zhang, Yaopeng Zhang, Yonghua Lu, Guoyi Wu, Ming Lu, and Fengxiu Zhang
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Infectivity ,Chemistry ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,fungi ,Spike Protein ,Charge density ,Charge (physics) ,respiratory tract diseases ,body regions ,Negative charge ,Coulomb ,Biophysics ,General Earth and Planetary Sciences ,skin and connective tissue diseases ,General Environmental Science - Abstract
SARS-CoV-2 has high infectivity and some of its variants have higher transmissibility. To explore the high infectivity mechanism, the charge distributions of SARS-CoV, SARS-CoV-2, and variants of concern were calculated through a series of net charge calculation formulas. The results showed that the SARS-CoV-2 spike protein had more positive charges than that of SARS-CoV. Further results showed that the variants had similar but higher positive charges than preexisting SARS-CoV-2. In particular, the Delta variant had the greatest increase in positive charges in S1 resulting in the highest infectivity. In particular, the S1 positive charge increased greatly in the Delta variant. The S1 positive charge increased, and due to the large negative charge of angiotensin-converting enzyme-2 (ACE2), this resulted in a large increase in Coulomb’s force between S1 and ACE2. This finding agrees with the expectation that the positive charges in the spike protein result in more negative charges on SARS-CoV-2 antibodies than that of SARS-CoV. Thus, the infectivity of a novel SARS-CoV-2 variant may be evaluated preliminarily by calculating the charge distribution.
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- 2021
11. Electrospun regenerated silk fibroin is a promising biomaterial for the maintenance of inner ear progenitors in vitro
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Yanbo Yin, Yaopeng Zhang, Guangfei Li, Jingfang Wu, and Shan Sun
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Tissue Engineering ,Biocompatibility ,Chemistry ,Silk ,Biomedical Engineering ,Fibroin ,Biomaterial ,Biocompatible Materials ,Tissue Adhesions ,Adhesion ,Cell biology ,Biomaterials ,Mice ,medicine.anatomical_structure ,Tissue engineering ,Ear, Inner ,medicine ,Animals ,Humans ,Inner ear ,sense organs ,Stem cell ,Progenitor cell ,Fibroins - Abstract
Objective We sought to determine the biocompatibility of electrospun regenerated silk fibroin (RSF) mats with inner ear progenitors, especially their effect on the differentiation of inner ear progenitors into hair cells. Methods Neonatal mouse cochleae (n = 20) were collected and digested and allowed to form spheres over several days. Cells digested from the spheres were then seeded onto aligned or random RSF mats, with laminin-coated coverslips serving as controls. The inner ear progenitor cell mortality was examined by TUNEL labeling, and the adhesion of cells to the RSF mats or coverslip was determined by scanning electron microscopy. Finally, the number of hair cells that differentiated from inner ear progenitors was determined by Myosin7a expression. Unpaired Student’s t-tests and one-way ANOVA followed by a Dunnett’s multiple comparisons test were used in this study ( p < 0.05). Results After 5 days of culture, the inner ear progenitors had good adhesion to both the aligned and random RSF mats and there was no significant difference in TUNEL+ cells between the mats compared to the coverslip ( p > 0.05). After 7 days of in vitro differentiation culture, the percentage of differentiated hair cells on the control, aligned, and random RSF mats was 2.5 ± 0.5%, 2.7 ± 0.4%, and 2.4 ± 0.2%, respectively, and there was no significant difference between Myosin7a+ cells on either RSF mat compared to controls ( p > 0.05). Conclusion The aligned and random RSF mats had excellent biocompatibility with inner ear progenitors and helped the inner ear progenitors maintain their stemness. Our results thus indicate that RSF mats represent a useful scaffold for the development of new strategies for inner ear tissue engineering research.
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- 2021
12. Root endophytic bacterial community composition of Aconitum carmichaelii debx. from three main producing areas in China
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Lan Zou, Qian Wang, Rongxing Wu, Yaopeng Zhang, Qingshan Wu, Wei Xiong, Kunhao Ye, Wei Dai, and Jing Huang
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General Medicine ,Applied Microbiology and Biotechnology - Abstract
Aconitum carmichaelii Debx. is famous for the bioactive aconitum alkaloids as traditional Chinese medicine. Endophytic bacteria play vital roles in plant growth, health, and the production of secondary metabolites such as alkaloids. In this study, we employed 16 S rRNA amplicon high-throughput sequencing to determine the root endophytic bacterial community of A. carmichaelii Debx. collected from three main producing areas including the geo-authentic area in China, high performance liquid chromatography to measure the contents of six bioactive alkaloids and correlation analysis to explore the relationship among environmental factors, alkaloids contents, and endophytic bacterial community. The results indicated that the root core microbiota of A. carmichaelii Debx. was dominated by Proteobacteria, Bacteroidetes, Firmicutes, and Actinobacteria. Root endophytic bacterial community in the geo-authentic area was distinct from the other two regions. Soil nitrogen contents, organic matter, and temperature were the main factors contributing to the endophytic bacterial community structure. Significant correlation was found between alkaloids contents and some bacterial genera. Particularly, the abundance of Lactobacillus was positively correlated with the contents of benzoyl-mesaconitine and benzoyl-aconine. This study provided the first insight into the root endophytic bacterial community composition of A. carmichaelii Debx., and can direct further isolation of functional bacterial strains.
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- 2022
13. Comparing the accuracy of full-arch implant impressions using the conventional technique and digital scans with and without prefabricated landmarks in the mandible: An in vitro study
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Yifang Ke, Yaopeng Zhang, Yong Wang, Hu Chen, and Yuchun Sun
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General Dentistry - Published
- 2023
14. Low-Power and Tunable-Performance Biomemristor Based on Silk Fibroin
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Yaopeng Zhang, Suna Fan, Yi Zhang, and Fang Han
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Bioelectronics ,Materials science ,business.industry ,0206 medical engineering ,Doping ,Biomedical Engineering ,Fibroin ,02 engineering and technology ,Memristor ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,Power (physics) ,law.invention ,Biomaterials ,Non-volatile memory ,law ,Heat generation ,Optoelectronics ,Fibroins ,0210 nano-technology ,business ,Voltage - Abstract
Biomemristors have attracted significant attention because of their potential applications in logic operations, nonvolatile memory, and synaptic emulators, thus leading to the urgent need to improve memristive performance. In this work, a silk fibroin (SF)-based memristor, integrated with both low power and low operating current simultaneously, has been reported. Doping the SF with Ag and an ethanol-based post-treatment promote microcrystal formation in the bulk of the SF. This induces carrier transport along fixed, short paths and results in a low set voltage, low operating current, and high memristive stability. Such performances can greatly reduce power consumption and heat generation, beneficial for the accuracy and durability of memristor devices. The memristive mechanism of SF-based memristors with different Ag contents is the space-charge-limited conduction (SCLC) mechanism. In addition, the nonlinear transmission property of SF-based memristors suggests useful applications in bioelectronics.
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- 2021
15. Nonmulberry silk fibroin-based biomaterials: Impact on cell behavior regulation and tissue regeneration
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Shengzhi Zou, Xiang Yao, Huili Shao, Rui L. Reis, Subhas C. Kundu, and Yaopeng Zhang
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Aspartic Acid ,Tissue Engineering ,Tissue Scaffolds ,Biomedical Engineering ,Silk ,Glycine ,Biocompatible Materials ,General Medicine ,Bombyx ,Arginine ,Biochemistry ,Biomaterials ,Animals ,Morus ,Fibroins ,Molecular Biology ,Biotechnology - Abstract
Silk fibroin (SF) is a promising biomaterial due to its good biocompatibility, easy availability, and high mechanical properties. Compared with mulberry silk fibroin (MSF), nonmulberry silk fibroin (NSF) isolated from typical nonmulberry silkworm silk exhibits unique arginine-glycine-aspartic acid (RGD) sequences with favorable cell adhesion enhancing effect. This inherent property probably makes the NSF more suitable for cell culture and tissue regeneration-related applications. Accordingly, various types of NSF-based biomaterials, such as particles, films, fiber mats, and 3D scaffolds, are constructed and their application potential in different biomedical fields is extensively investigated. Based on these promising NSF biomaterials, this review firstly makes a systematical comparison between the molecular structure and properties of MSF and typical NSF and highlights the unique properties of NSF. In addition, we summarize the effective fabrication strategies from degummed nonmulberry silk fibers to regenerated NSF-based biomaterials with controllable formats and their recent application progresses in cell behavior regulation and tissue regeneration. Finally, current challenges and future perspectives for the fabrication and application of NSF-based biomaterials are discussed. Related research and perspectives may provide valuable references for designing and modifying effective NSF-based and other natural biomaterials. STATEMENT OF SIGNIFICANCE: There exist many reviews about mulberry silk fibroin (MSF) biomaterials and their biomedical applications, while that about nonmulberry silk fibroin (NSF) biomaterials is scarce. Compared with MSF, NSF exhibits unique arginine-glycine-aspartic acid sequences with promising cell adhesion enhancing effect, which makes NSF more suitable for cell culture and tissue regeneration related applications. Focusing on these advanced NSF biomaterials, this review has systematically compared the structure and properties of MSF and NSF, and emphasized the unique properties of NSF. Following that, the effective construction strategies for NSF-based biomaterials are summarized, and their recent applications in cell behavior regulations and tissue regenerations are highlighted. Furthermore, current challenges and future perspectives for the fabrication and application of NSF-based biomaterials were discussed.
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- 2022
16. Efficacy of oral steroid gel in preventing esophageal stricture after extensive endoscopic submucosal dissection: a randomized controlled trial
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Yonghui Huang, Dan Nie, Yingchun Wang, Yaopeng Zhang, Ke Li, Wei Yao, Yiyang Zhang, Xiue Yan, and Hong Chang
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medicine.medical_specialty ,Endoscopic Mucosal Resection ,Esophageal Neoplasms ,Perforation (oil well) ,Triamcinolone ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Prednisone ,Internal medicine ,Clinical endpoint ,Humans ,Medicine ,business.industry ,Esophageal cancer ,medicine.disease ,Hypokalemia ,Balloon dilations ,030220 oncology & carcinogenesis ,Esophageal stricture ,Esophageal Stenosis ,Steroids ,030211 gastroenterology & hepatology ,Surgery ,medicine.symptom ,business ,Abdominal surgery ,medicine.drug - Abstract
Esophageal stricture is a distressing issue for patients with early esophageal cancer following extensive endoscopic submucosal dissection (ESD), and the current steroid-based approaches are unsatisfactory for stricture prophylaxis. We evaluated the efficacy of oral hydrocortisone sodium succinate and aluminum phosphate gel (OHA) for stricture prophylaxis after extensive ESD.Patients undergoing 3/4 circumferential ESD were randomized to either the endoscopic loco-regional triamcinolone acetonide injection (ETI) plus oral prednisone group or the OHA group. The primary endpoint was incidence of esophageal stricture, and the secondary endpoints included adverse events (AEs) and endoscopic balloon dilations (EBDs).The incidence of esophageal stricture in OHA group (per-protocol analysis, 9.4%, 3/32; intention-to-treat analysis, 12.1%, 4/33) was significantly less than that of control group (per-protocol analysis, 35.5%, 11/31, P = 0.013; intention-to-treat analysis, 39.4%, 13/33, P = 0.011). Two sessions of EBD were necessary to release all strictures in the OHA group, while the similar EBDs (median 2, range 1-4) for 11 of the control. Operation-related AEs included infection (control vs. OHA group = 9.7% vs. 31.3%, P = 0.034), operation-related hypokalemia (19.4% vs. 31.3%, P = 0.278), perforation (3.2% vs. 3.1%), post-ESD hemorrhage (6.5% vs. 0%), and cardiac arrhythmia (0% vs. 6.3%). Steroid-related AEs included steroid-related hypokalemia (16.1% vs. 25%) and bone fracture (3.2% vs. 0%). Multivariate logistic regression analysis demonstrated that OHA was an independent protective factor for stricture (OR 0.079; 95%CI 0.011, 0.544; P = 0.01) and mucosal defect 11/12 circumference was an independent risk factor (OR 49.91; 95%CI 6.7, 371.83; P 0.001).OHA showed significantly better efficacy in preventing esophageal stricture after 3/4 circumferential ESD compared to ETI plus oral prednisone.
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- 2021
17. Electrospun regenerated Antheraea pernyi silk fibroin scaffolds with improved pore size, mechanical properties and cytocompatibility using mesh collectors
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Xiang Yao, Shengzhi Zou, Huili Shao, Xinru Wang, Yaopeng Zhang, and Suna Fan
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Pore size ,Scaffold ,Materials science ,biology ,Biomedical Engineering ,Fibroin ,General Chemistry ,General Medicine ,Antheraea pernyi ,Permeation ,biology.organism_classification ,Electrospinning ,Chemical engineering ,General Materials Science ,Cell adhesion ,Porosity - Abstract
Generally, electrospun silk fibroin scaffolds collected by traditional plates present limited pore size and mechanical properties, which may restrict their biomedical applications. Herein, regenerated Antheraea pernyi silk fibroin (RASF) with excellent inherent cell adhesion property was chosen as a raw material and the conductive metal meshes were used as collectors to prepare modified RASF scaffolds by electrospinning from its aqueous solution. A traditional intact plate was used as a control. The morphology and mechanical properties of the obtained scaffolds were investigated. Schwann cells were further used to assess the cytocompatibility and cell migration ability of the typical scaffolds. Interestingly, compared with the traditional intact plate, the mesh collector with an appropriate gap size (circa 7 mm) could significantly improve the pore size, porosity and mechanical properties of the RASF scaffolds simultaneously. In addition, the scaffold collected under this condition (RASF-7mmG) showed higher cell viability, deeper cell permeation and faster cell migration of Schwann cells. Combined with the excellent inherent properties of ASF and the obviously enhanced scaffold cytocompatibility and mechanical properties, the RASF-7mmG scaffold is expected to be a candidate with great potential for biomedical applications.
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- 2021
18. A trade-off between antifouling and the electrochemical stabilities of PEDOTs
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Maciej Cieplak, Sihao Qian, Ya-Qiong Zhang, Bo Zhu, Ao Zhuang, Yaopeng Zhang, Haichao Zhao, Qi-Chao Pan, Piyush Sindhu Sharma, Shou-Yan Zhang, Hsing-An Lin, Shu-Hua Zhang, and Gao Qiu
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Materials science ,Biofouling ,Polymers ,Biomedical Engineering ,Electrochemistry ,Polymerization ,Mice ,chemistry.chemical_compound ,PEDOT:PSS ,Animals ,Molecule ,General Materials Science ,Cells, Cultured ,Conductive polymer ,Molecular Structure ,Optical Imaging ,Electrochemical Techniques ,General Chemistry ,General Medicine ,Adhesion ,Bridged Bicyclo Compounds, Heterocyclic ,Rats ,Chemical engineering ,chemistry ,Electrode ,NIH 3T3 Cells ,Microelectrodes ,Ethylene glycol - Abstract
Strong nonspecific protein/cell adhesion on conducting polymer (CP)-based bioelectronic devices can cause an increase in the impedance or the malfunction of the devices. Incorporating oligo(ethylene glycol) or zwitterionic functionalities with CPs has demonstrated superior performance in the reduction of nonspecific adhesion. However, there is no report on the evaluation of the antifouling stability of oligo(ethylene glycol) and zwitterion-functionalized CPs under electrical stimulation as a simulation of the real situation of device operation. Moreover, there is a lack of understanding of the correlation between the molecular structure of antifouling CPs and the antifouling and electrochemical stabilities of the CP-based electrodes. To address the aforementioned issue, we fabricated a platform with antifouling poly(3,4-ethylenedioxythiophene) (PEDOT) featuring tri(ethylene glycol), tetra(ethylene glycol), sulfobetaine, or phosphorylcholine (PEDOT-PC) to evaluate the stability of the antifouling/electrochemical properties of antifouling PEDOTs before and after electrical stimulation. The results reveal that the PEDOT-PC electrode not only exhibits good electrochemical stability, low impedance, and small voltage excursion, but also shows excellent resistance toward proteins and HAPI microglial cells, as a cell model of inflammation, after the electrical stimulation. The stable antifouling/electrochemical properties of zwitterionic PEDOT-PC may aid its diverse applications in bioelectronic devices in the future.
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- 2021
19. Bio-memristors based on silk fibroin
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Suna Fan, Yi Zhang, and Yaopeng Zhang
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Flexibility (engineering) ,Computer science ,Process Chemistry and Technology ,Fibroin ,Biocompatible Materials ,Nanotechnology ,Memristor ,law.invention ,Mechanics of Materials ,law ,General Materials Science ,Neural Networks, Computer ,Electrical and Electronic Engineering ,Fibroins - Abstract
Bio-memristors constitute candidates for the next generation of non-volatile storage and bionic synapses due to their biocompatibility, environmental benignity, sustainability, flexibility, degradability, and impressive memristive performance. Silk fibroin (SF), a natural and abundant biomaterial with excellent mechanical, optical, electrical, and structure-adjustable properties as well as being easy to process, has been utilized and shown to have potential in the construction of bio-memristors. Here, we first summarize the fundamental mechanisms of bio-memristors based on SF. Then, the latest achievements and developments of pristine and composited SF-based memristors are highlighted, followed by the integration of memristive devices. Finally, the challenges and insights associated with SF-based bio-memristors are presented. Advances in SF-based bio-memristors will open new avenues in the design and integration of high-performance bio-integrated systems and facilitate their application in logic operations, complex circuits, and neural networks.
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- 2021
20. C/MoS2@Ti3C2Tx composite flexible films for high performance supercapacitors
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Yi Ma, Linghong Lu, Yaopeng Zhang, and Tao Zhou
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General Chemical Engineering ,Electrochemistry - Published
- 2023
21. Gradient structure enabled robust silk origami with moisture responsiveness
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Jie Chen, Haoyang Xu, Chenjing Zhang, Rongliang Wu, Suna Fan, and Yaopeng Zhang
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
22. K+ alkalization promoted Ca2+ intercalation in V2CT MXene for enhanced Li storage
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Wei Zhang, Haibo Li, Yaopeng Zhang, Bingsen Zhang, Ming Lu, Xia Zhang, Wenjuan Han, and Junnan Chen
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Materials science ,Ion exchange ,Intercalation (chemistry) ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Ion ,Anode ,Fuel Technology ,chemistry ,Chemical engineering ,Electrochemistry ,Surface modification ,Lithium ,0210 nano-technology ,MXenes ,Ion transporter ,Energy (miscellaneous) - Abstract
Although MXenes is highly attractive as anode materials of lithium ion batteries, it sets a bottleneck for higher capacity of the V2CTx MXene due to the limited interlayer space and the derived surface terminations. Herein, the cation intercalation and ion-exchange were well employed to achieve a K+ and Ca2+ intercalated V2CTx MXene. A larger interlayer distance and low F surface terminations were thereof obtained, which accelerates the ion transport and promotes the delicate surface of V2CTx MXene. As a result, a package of enhanced capacity, rate performance and cyclability can be achieved. Furthermore, the ion exchange approach can be extended to other 2D layered materials, and both the interlayer control and the surface modification will be achieved.
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- 2020
23. Angiogenesis Potential of Bladder Acellular Matrix Hydrogel by Compounding Endothelial Cells
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Chengbo Cao, Huili Shao, Lujie Song, Yaopeng Zhang, Suna Fan, Nailong Cao, Jianwen Huang, Huihui Zhang, and Wenjing Liu
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Biomaterials ,Extracellular matrix ,Tissue engineering ,Angiogenesis ,Compounding ,Acellular matrix ,Chemistry ,Biochemistry (medical) ,Biomedical Engineering ,food and beverages ,Biomaterial ,General Chemistry ,Cell biology - Abstract
Rapid vascularization is very important in tissue engineering. Bladder acellular matrix (BAM) with inherent bioactive factors, a natural extracellular matrix (ECM) derived biomaterial, has been widely used as a scaffold to facilitate the repair and reconstruction of urinary tissues. However, the application of the traditional BAM scaffold has been limited due to the dense structure. To investigate the angiogenic potential of BAM, BAM hydrogels with tailored porous structures were prepared in this study by tuning BAM concentrations (4, 6, and 8 mg/mL). The 6 mg/mL BAM hydrogel was loaded with porcine iliac endothelial cells (PIECs), and their angiogenic potential was analyzed
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- 2022
24. Contributors
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Jafar Ai, Fatemeh Alipour, Moein Amoupour, Bahar Bahramimeimandi, Francesco Baino, Fatemeh Daneshimehr, Majid Darroudi, Durgalakshmi Dhinasekaran, Sergey V. Dorozhkin, Somayeh Ebrahimi-Barough, Alireza Ebrahimzadeh-Bideskan, Suna Fan, Gordon A. Ferns, Melina Ghasemian, Majid Ghayour-Mobarhan, Sara Ghodrat, Michael R Hamblin, Sung Soo Han, Ahmad Hivechi, Sara Hooshmand, Motaharesadat Hosseini, Seyede Atefe Hosseini, Hamid Jamialahmdi, Fatemeh Kabirian, Saeid Kargozar, Farzad Kermani, Hae-Won Kim, Anuj Kumar, Maziar Malekzadeh Kebria, Arezou Mehrabi, Peiman Brouki Milan, Marta Miola, Atieh Seyedian Moghaddam, Sahar Mollazadeh, Masoud Mozafari, Mojdeh Salehi Namini, Simin Nazarnezhad, Noshad Peyravian, Seeram Ramakrishna, Mohammad Rashidmayvan, Ehsan Saburi, Leila Sabouri, Yalda Samsami, Reyhaneh Shafieian, Lujie Song, Javad Verdi, Fabian Westhauser, Benedikt Widholz, Xiang Yao, and Yaopeng Zhang
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- 2022
25. Role of angiogenesis in bladder tissue engineering
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Xiang Yao, Suna Fan, Lujie Song, and Yaopeng Zhang
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- 2022
26. Enhanced Adsorption-Oxidation of Sb(Iii) Over Chitosan Bimetallic Beads: In-Situ Generated O2•– and Autocatalytic Effect of Sb(Iii)
- Author
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Yaopeng Zhang, Miaojia Du, Chensi Shen, Ran Zhang, Chenye Xu, Chunyan Ma, Manhong Huang, and Fang Li
- Subjects
History ,Polymers and Plastics ,General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Business and International Management ,Condensed Matter Physics ,Industrial and Manufacturing Engineering ,Surfaces, Coatings and Films - Published
- 2022
27. Observing the Ping-pong Modality of Isospin Degree of Freedom in Cluster Emission from Heavy Ion Reactions
- Author
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Yijie Wang, Fenhai Guan, Xinyue Diao, Mengting Wan, Yuhao Qin, Zhi Qin, Qianghua Wu, Dong Guo, Dawei Si, Sheng Xiao, Boyuan Zhang, Yaopeng Zhang, Baiting Tian, Xianglun Wei, Herun Yang, Peng Ma, Rongjiang Hu, Limin Duan, Fangfang Duan, Qiang Hu, Junbing Ma, Shiwei Xu, Zhen Bai, Yanyun Yang, Jiansong Wang, Wenbo Liu, Wanqing Su, Xiaobao Wei, Chun-Wang Ma, Xinxiang Li, Hongwei Wang, Fangyuan Wang, Yingxun Zhang, Michał Warda, Arthur Dobrowolski, Bożena Nerlo-Pomorska, Krzysztof Pomorski, Li Ou, and Zhigang Xiao
- Subjects
FOS: Physical sciences ,Nuclear Experiment (nucl-ex) ,Nuclear Experiment - Abstract
Two-body correlations of the isotope-resolved light and heavy clusters are measured in $^{86}$Kr+$^{\rm 208}$Pb reactions at 25 MeV/u. The yield and kinetic variables of the $A=3$ isobars, triton and $^3$He, are analyzed in coincidence with the heavy clusters of $7\le A \le 14$ emitted at the earlier chance. While the velocity spectra of both triton and $^3$He exhibit scaling behavior over the type of the heavy clusters, the yield ratios of ${\rm t/^3He}$ correlate reversely to the neutron-to-proton ratio $N/Z$ of the latter, showing the ping-pong modality of the $N/Z$ of emitted clusters. The commonality that the $N/Z$ of the residues keeps the initial system value is extended to the cluster emission in heavy ion reactions. The comparison of transport model calculations to the data is discussed.
- Published
- 2022
- Full Text
- View/download PDF
28. Highly safe and ionothermal synthesis of Ti3C2 MXene with expanded interlayer spacing for enhanced lithium storage
- Author
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Hao Meng, Yide Han, Yanfeng Dong, Yaopeng Zhang, Zhuopeng Wang, Yan Xu, Wang Yu, Junbiao Wu, and Xia Zhang
- Subjects
Materials science ,Vapor pressure ,Intercalation (chemistry) ,Oxalic acid ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Anode ,chemistry.chemical_compound ,Fuel Technology ,Chemical engineering ,chemistry ,Etching ,Electrochemistry ,Lithium ,0210 nano-technology ,Energy (miscellaneous) ,Eutectic system ,Choline chloride - Abstract
MXene is a rising star of two-dimensional (2D) materials for energy relative applications, however, the traditional synthesis of MXene etched by hazard HF acid or LiF+HCl mixed solution is highly dangerous with the risk of splashing or pouring liquid solutions. In this work, we developed a water-free ionothermal synthesis of 2D Ti3C2 MXene via etching pristine Ti3AlC2 MAX in low-cost choline chloride and oxalic acid based deep eutectic solvents (DES) with the presence of NH4F, thus it was highly safe and convenient to operate solid precursor and product materials at room temperature. Benefited from the low vapor pressure and solvating properties of DES, the prepared Ti3C2 (denoted as DES-Ti3C2) possessed a high purity up to 98% compared with 95% for HF etched Ti3C2 (denoted as HF-Ti3C2). Notably, an expanded interlayer spacing of 1.35 nm could be achieved due to the intercalation of choline cations in DES-Ti3C2, larger than that of HF-Ti3C2 (0.98 nm). As a result, the DES-Ti3C2 anodes exhibited enhanced lithium storage performance, such as high reversible capacity of 208 mAh g−1 at 0.5 A g−1, and long cycle life over 400 times, outperforming most reported pure MXene anodes. The ionothermal synthesis of MXene developed here may pave a new way to safely prepare other MXene for various energy relating applications.
- Published
- 2020
29. Dual-wavelength fluorescent anti-counterfeiting fibers with skin-core structure
- Author
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Yuanyuan Xu, Gesheng Yang, Huili Shao, Yonggui Li, Huihui Zhang, and Yaopeng Zhang
- Subjects
chemistry.chemical_classification ,010407 polymers ,Materials science ,integumentary system ,Polymers and Plastics ,General Chemical Engineering ,Industrial chemistry ,Nanotechnology ,02 engineering and technology ,Polymer ,021001 nanoscience & nanotechnology ,01 natural sciences ,Fluorescence ,Skin core ,0104 chemical sciences ,chemistry ,Materials Chemistry ,Dual wavelength ,0210 nano-technology - Abstract
In this work, a skin-core structure was designed, and three kinds of dual-wavelength fluorescent anti-counterfeiting (DWFA) fibers, including UV short-wavelength/UV long-wavelength, infrared/UV short-wavelength, and infrared/UV long-wavelength excitable DWFA fibers with skin-core structure, were spun using fluorescent powder/PP pellets as the skin material and pure PP as the core material. The results showed that these DWFA fibers emitted two different colors of light under excitation of two different wavelength lights, which exhibited higher anti-counterfeiting safety. Take UV short-wavelength/UV long-wavelength DWFA fibers, for example; the influence of skin-core ratio on the structure and properties of fibers were investigated, and then the luminous efficiency of DWFA fibers with skin-core structure and homogenous structure was compared. The microscope photos and 3D simulation of fluorescent powder in fibers by confocal laser scanning microscope showed that the fluorescent powders were basically distributed in the skin layer of fibers. The crystallinity degree and tensile strength of DWFA fibers with skin-core structure decreased first and then increased with the decrease in skin-core ratio, whereas elongation of fibers showed an increasing trend. Compared with homogenous DWFA fibers, the skin-core DWFA fibers exhibited higher luminous efficiency under the same fluorescent powder content.
- Published
- 2020
30. Natural polymer-based bioabsorbable conducting wires for implantable bioelectronic devices
- Author
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Suna Fan, Shasha Lv, Xiangyu Huang, Xiang Yao, Yaopeng Zhang, and Qianqian Niu
- Subjects
chemistry.chemical_classification ,Bioelectronics ,Materials science ,Biocompatibility ,Renewable Energy, Sustainability and the Environment ,business.industry ,Nanogenerator ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Substrate (electronics) ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry ,Microelectronics ,General Materials Science ,0210 nano-technology ,business ,Electrical impedance ,Triboelectric effect - Abstract
Biodegradable/bioabsorbable electrically conducting wires have an important role in the development of next-generation wearable microelectronics and implantable devices. The implantable devices, including conducting wires, must be biocompatible and biodegradable to avoid an inflammatory response and a second surgery. However, most conducting wires used in biomedicine are still conventional metallic wires. Herein, a new conducting wire with excellent conductivity, bioabsorbability, biocompatibility, and low weight was prepared from natural polymer and chromium/aurum (10/140 nm), providing the possibility to construct a fully bioabsorbable implantable device. The conducting wire substrate prepared from silk nanoribbons and konjac glucomannan has excellent mechanical properties. The wire resistance was approximately 8 Ω cm−1. The conducting wire exhibits an impedance of 140 Ω at 1000 Hz, which remains largely unchanged when the wire was immersed in buffer solution for ten days. Connection with a biodegradable triboelectric nanogenerator provides an integrated fully bioabsorbable energy generation device with a maximum output power density of 314.3 mW m−2. Compared with conventional metallic wires, this conducting wire has a higher transmission efficiency and biodegradability, better biocompatibility, and is more lightweight. This conducting wire and the integrated fully bioabsorbable energy generation device may be used in the fields of wearable electronics and implantable bioelectronics.
- Published
- 2020
31. Iron-catalyzed synthesis of phenanthrenes via intramolecular hydroarylation of arene-alkynes
- Author
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Xiao Hu, Guangxing Pan, Yang Li, Wangsheng Liu, Yaopeng Zhang, Yawei Li, and Hao Guo
- Subjects
010405 organic chemistry ,Iron catalyzed ,General Chemistry ,Phenanthrene ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,0104 chemical sciences ,Catalysis ,lcsh:Chemistry ,chemistry.chemical_compound ,lcsh:QD1-999 ,chemistry ,Intramolecular force ,Functional group ,Phenanthrenes - Abstract
An Fe(OTf)3-catalyzed intramolecular hydroarylation of arene-alkynes with high functional group tolerance has been reported, affording a series of phenanthrene derivatives efficiently. A low catalytic amount of Fe(OTf)3 is applied in this reaction. This transformation provides a convenient and practical method for the preparation of phenanthrenes. Keywords: Hydroarylation, Cyclization, Phenanthrene, Iron catalysis, Lewis acid
- Published
- 2019
32. A crosslinking-induced precipitation process for the simultaneous removal of poly(vinyl alcohol) and reactive dye: The importance of covalent bond forming and magnesium coagulation
- Author
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Chunyan Ma, Deli Wu, Yanbiao Liu, Chensi Shen, Yaopeng Zhang, Fang Li, Pan Yuting, and Ma Huijie
- Subjects
Vinyl alcohol ,integumentary system ,Precipitation (chemistry) ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,chemistry.chemical_compound ,Monomer ,chemistry ,Chemical engineering ,Covalent bond ,Environmental Chemistry ,Coagulation (water treatment) ,Reactive dye ,Dyeing ,0210 nano-technology ,Desizing - Abstract
High chemical oxygen demand (COD) and a strong color, which primarily originates from desizing and dyeing operations, are two major removal objectives in textile wastewater treatment. In this study, crosslinking-induced precipitation via the covalent bonding between –OH groups of PVA and vinyl sulfone groups of reactive dyes is proposed to simultaneously remove poly(vinyl alcohol) (PVA) and reactive dyes. Due to the nucleophilic addition reaction under an alkaline condition, PVA polymers can be efficiently crosslinked by dye molecules and destabilized in the presence of alkali and Na2SO4. Additionally, due to the high coagulation efficiency under the alkaline conditions, MgSO4 was used as a coagulant to facilitate the removal of the residual color after precipitation. After a two-step process, whereby coagulation was followed by crosslinking-induced precipitation, the maximum efficiencies of the removal of COD, PVA, and color attained 88.9%, 86.3%, and 99.2%, respectively, when the PVA monomer/RB5 mole ratio was 400. We hope that this technically feasible, highly efficient, and cost-effective process provides a basis for the practical application of the simultaneous treatment of desizing and dyeing wastewater.
- Published
- 2019
33. Recent progress on pure organic room temperature phosphorescence materials based on host-guest interactions
- Author
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Xiang Ma, Guojuan Qu, and Yaopeng Zhang
- Subjects
chemistry.chemical_classification ,Materials science ,Supramolecular chemistry ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Supramolecular polymers ,Molecular recognition ,Intersystem crossing ,chemistry ,Molecule ,0210 nano-technology ,Phosphorescence - Abstract
Pure organic room temperature phosphorescence (RTP) has been attracting a lot interest recently. So far, many strategies have succeeded in achieving efficient organic RTP materials by increasing the rate of intersystem crossing (ISC) and suppressing non-radiative transitions. In supramolecular chemistry, the control and regulation of molecular recognition based on the role of the host and guest in supramolecular polymers matrix, has attracted much attention. Recently, researchers have successfully achieved room temperature phosphorescence of pure organic complexes through host-guest interactions. The host molecule specifically includes the phosphorescent guest to reduce non-radiative transitions and enhance room temperature phosphorescence emission. This review aims to describe the developments and achievements of pure organic room temperature phosphorescence systems through the mechanism of host-guest interactions in recent years, and demonstrates the exploration and pursuit of phosphorescent materials of researchers in different fields.
- Published
- 2019
34. 3D-Printed Strong Dental Crown with Multi-Scale Ordered Architecture, High-Precision, and Bioactivity
- Author
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Menglu Zhao, Danlei Yang, Suna Fan, Xiang Yao, Jiexin Wang, Meifang Zhu, and Yaopeng Zhang
- Subjects
Compressive Strength ,Crowns ,Science ,General Chemical Engineering ,finite element method ,General Engineering ,hydroxyapatite ,General Physics and Astronomy ,Medicine (miscellaneous) ,hierarchical architecture ,3D printing ,mechanical properties ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Durapatite ,Flexural Strength ,Printing, Three-Dimensional ,General Materials Science - Abstract
Mimicking the multi‐scale highly ordered hydroxyapatite (HAp) nanocrystal structure of the natural tooth enamel remains a great challenge. Herein, a bottom‐up step‐by‐step strategy is developed using extrusion‐based 3D printing technology to achieve a high‐precision dental crown with multi‐scale highly ordered HAp structure. In this study, hybrid resin‐based composites (RBCs) with “supergravity +” HAp nanorods can be printed smoothly via direct ink writing (DIW) 3D printing, induced by shear force through a custom‐built nozzle with a gradually shrinking channel. The theoretical simulation results of finite element method are consistent with the experimental results. The HAp nanorods are first highly oriented along a programmable printing direction in a single printed fiber, then arranged in a layer by adjusting the printing path, and finally 3D printed into a highly ordered and complex crown structure. The printed samples with criss‐crossed layers by interrupting crack propagation exhibit a flexural strength of 134.1 ± 3.9 MPa and a compressive strength of 361.6 ± 8.9 MPa, which are superior to the corresponding values of traditional molding counterparts. The HAp‐monodispersed RBCs are successfully used to print strong and bioactive dental crowns with a printing accuracy of 95%. This new approach can help provide customized components for the clinical restoration of teeth.
- Published
- 2021
35. Biomolecule-friendly conducting PEDOT interface for long-term bioelectronic devices
- Author
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Qichao Pan, Qing Wu, Qingsong Sun, Xingyin Zhou, Lei Cheng, Shouyan Zhang, Yupeng Yuan, Zuwei Zhang, Jinyi Ma, Yaopeng Zhang, and Bo Zhu
- Subjects
Materials Chemistry ,Metals and Alloys ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Instrumentation ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2022
36. Effects of compound stimulation of fluid shear stress plus ultrasound on stem cell proliferation and osteogenesis
- Author
-
Suna Fan, Yaopeng Zhang, Xiang Yao, and Lingzhi Jing
- Subjects
Chemistry ,business.industry ,Ultrasound ,Fluid shear stress ,Stimulation ,microfluidic chip ,stem cell ,Biomaterials ,cell differentiation ,cell proliferation ,compound stimulation ,AcademicSubjects/SCI01410 ,Stem cell ,AcademicSubjects/MED00010 ,business ,Research Article ,Biomedical engineering - Abstract
Bone tissue with strong adaptability is often in a complex dynamical microenvironment in vivo, which is associated with the pathogenesis and treatment of orthopedic diseases. Therefore, it is of great significance to investigate the effects of corresponding compound stimulation on cell behaviors. Herein, a fluid shear stress (FSS) plus ultrasound stimulation platform suitable for cell studies based on a microfluidic chip was constructed and bone marrow mesenchymal stem cell (BMSC) was chosen as a model cell. The proliferation and osteogenesis of BMSCs under the compound stimulation of FSS plus ultrasound in growth medium without any soluble induction factors were firstly investigated. Single FSS stimulation and static culture conditions were also examined. Results illustrated that suitable single FSS stimulation (about 0.06 dyn/cm2) could significantly enhance cell proliferation and osteogenesis simultaneously when compared to the static control, while greater FSS mitigated or even restricted these enhancing effects. Interestingly, ultrasound stimulation combined with this suitable FSS stimulation further accelerated cell proliferation as the intensity of ultrasound increasing. As for the osteogenesis under compound stimulation, it was relatively restricted under lower ultrasound intensity (about 0.075 W/cm2), while promoted when the intensity became higher (about 1.75 W/cm2). This study suggests that both the cell proliferation and osteogenesis are very responsive to the magnitudes of FSS and ultrasound stimulations and can be both significantly enhanced by proper combination strategies. Moreover, these findings will provide valuable references for the construction of effective cell bioreactors and also the treatment of orthopedic diseases.
- Published
- 2021
37. Unconventional Spidroin Assemblies in Aqueous Dope for Spinning into Tough Synthetic Fibers
- Author
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Yaopeng Zhang, Zhi-Gang Qian, Qingfa Peng, Chun-Fei Hu, and Xiao-Xia Xia
- Subjects
Aqueous solution ,Tensile fracture ,Spidroin ,Chemistry ,Biomedical Engineering ,Silk ,Recombinant Proteins ,Biomaterials ,SILK ,Synthetic fiber ,Protein Domains ,Biophysics ,Spider silk ,Fiber ,Fibroins ,Spinning ,Micelles - Abstract
Spider dragline silk is a remarkable fiber made by spiders from an aqueous solution of spidroins, and this feat is largely attributed to the tripartite domain architecture of the silk proteins leading to the hierarchical assembly at the nano- and microscales. Although individual amino- and carboxy-terminal domains have been proposed to relate to silk protein assembly, their tentative synergizing roles in recombinant spidroin storage and spinning into synthetic fibers remain elusive. Here, we show biosynthesis and self-assembly of a mimic spidroin composed of amino- and carboxy-terminal domains bracketing 16 consensus repeats of the core region from spider Trichonephila clavipes. The presence of both termini was found essential for self-assembly of the mimic spidroin termed N16C into fibril-like (rather than canonical micellar) nanostructures in concentrated aqueous dope and ordered alignment of these nanofibrils upon extrusion into an acidic coagulation bath. This ultimately led to continuous, macroscopic fibers with a tensile fracture toughness of 100.9 ± 13.2 MJ m-3, which is comparable to that of their natural counterparts. We also found that the recombinant proteins lacking one or both termini were unable to similarly preassemble into fibrillar nanostructures in dopes and thus yielded inferior fiber properties. This work thereby highlights the synergizing role of terminal domains in the storage and processing of recombinant analogues into tough synthetic fibers.
- Published
- 2021
38. Benzoic Acid Metabolism and Lipopolysaccharide Synthesis of Intestinal Microbiome Affects the Health of Ruminants under Free-Range and Captive Mode
- Author
-
Xuan, Fu, Yaopeng, Zhang, Bin, Shi, Xiaokang, Wu, Hongwen, Zhao, Zhongbao, Xin, and Jinshui, Yang
- Subjects
Space and Planetary Science ,Paleontology ,gut microbes ,ruminant ,yak ,goat ,free-range ,captive ,General Biochemistry, Genetics and Molecular Biology ,Ecology, Evolution, Behavior and Systematics - Abstract
It is urgent to explore new ways to protect endangered wild animals and develop sustainable animal husbandry on the Qinghai–Tibet Plateau due to its fragile ecological environment. Ruminants, raised in captivity and free-range, have important niches in the Plateau and are the best models to analyze the effects of different feeding modes on their health. In this study, two ruminants, yaks and goats in free-range and captive modes, respectively, were selected to study the relationship between gut microbes and ruminant health. The results showed that the gut microbial diversity of free-range ruminants was higher than those of captive ruminants. Principal co-ordinates analysis (PCoA) showed that there were significant differences in the gut microbial communities in different breeding modes. Both the captive ruminants enriched the Succinivibrionaceae family, which had a strong potential to synthesize lipopolysaccharide, and the low exercise amount of the captive animals was significantly related to this function. Meanwhile, free-range ruminants enriched Oscillospiraceae, which had the potential to degrade benzoic acid, and this potential had a significant positive correlation with resistance to parasitic infections. We offer other possibilities, such as adding benzoic acid to feed or increasing the exercise time of captive ruminants to make them healthier.
- Published
- 2022
39. Electrospun regenerated
- Author
-
Shengzhi, Zou, Xinru, Wang, Suna, Fan, Xiang, Yao, Yaopeng, Zhang, and Huili, Shao
- Subjects
Tissue Engineering ,Tissue Scaffolds ,Cell Movement ,Cell Survival ,Surface Properties ,Silk ,Animals ,Particle Size ,Bombyx ,Fibroins ,Porosity ,Cells, Cultured ,Cell Proliferation - Abstract
Generally, electrospun silk fibroin scaffolds collected by traditional plates present limited pore size and mechanical properties, which may restrict their biomedical applications. Herein, regenerated Antheraea pernyi silk fibroin (RASF) with excellent inherent cell adhesion property was chosen as a raw material and the conductive metal meshes were used as collectors to prepare modified RASF scaffolds by electrospinning from its aqueous solution. A traditional intact plate was used as a control. The morphology and mechanical properties of the obtained scaffolds were investigated. Schwann cells were further used to assess the cytocompatibility and cell migration ability of the typical scaffolds. Interestingly, compared with the traditional intact plate, the mesh collector with an appropriate gap size (circa 7 mm) could significantly improve the pore size, porosity and mechanical properties of the RASF scaffolds simultaneously. In addition, the scaffold collected under this condition (RASF-7mmG) showed higher cell viability, deeper cell permeation and faster cell migration of Schwann cells. Combined with the excellent inherent properties of ASF and the obviously enhanced scaffold cytocompatibility and mechanical properties, the RASF-7mmG scaffold is expected to be a candidate with great potential for biomedical applications.
- Published
- 2021
40. Fabrication and characterization of regenerated Antheraea pernyi silk fibroin scaffolds for Schwann cell culturing
- Author
-
Shengzhi Zou, Jiaming Zhang, Huili Shao, Suna Fan, Yaopeng Zhang, and Xinru Wang
- Subjects
Scaffold ,Polymers and Plastics ,biology ,Chemistry ,fungi ,Organic Chemistry ,General Physics and Astronomy ,Fibroin ,02 engineering and technology ,Antheraea pernyi ,Confocal scanning microscopy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Crystallinity ,SILK ,Tissue engineering ,Bombyx mori ,Materials Chemistry ,Biophysics ,0210 nano-technology - Abstract
Antheraea pernyi silk, which is from a kind of non-mulberry silkworm produced in China, has better mechanical properties and cytocompatibility than the extensively studied silk from mulberry silkworm (Bombyx mori). In this work, the regenerated Antheraea pernyi silk fibroin (RASF) scaffolds were prepared from RASF aqueous solutions with different concentrations by a freeze-drying method. The morphologies, structures and properties of the obtained RASF scaffolds were investigated. It was found that with the decrease of RASF solution concentration and the increase of freezing temperature, the porosity of the scaffold increased while its apparent density decreased. The micro-morphology of the scaffold from the 1 wt% RASF solution was irregular. When the solution concentration was increased to the range of 4–13 wt%, the micro-morphologies of the obtained scaffolds mainly showed lamellar-like structure. And with the increase of solution concentration, the lamellar gap of the scaffold decreased while the lamellar thickness of the scaffold increased. However, with the further increase of solution concentration, the morphology of scaffold could gradually transfer into porous structure. In addition, the scaffold micro-morphology could be also affected by freezing temperature. Moreover, with the increase of RASF solution concentration or (and) the decrease of freezing temperature, the obtained scaffold had higher content of β-sheet conformation and higher crystallinity, which could improve its mechanical properties. It was further found that the swelling ratio and degradation rate of RASF scaffold prepared for tissue engineering increased with the decrease of solution concentration. The results of MTT indicated that the obtained RASF scaffold had no cytotoxicity. Moreover, the results of field emission scanning electron microscopy and laser confocal scanning microscopy revealed that the viability, cytocompatibility and migration ability of Schwann cells cultured on RASF scaffold were much better than those cultured on regenerated Bombyx mori silk fibroin (RBSF) scaffold. The RASF scaffold prepared in this work may have great potential applications in the area of nerve tissue engineering.
- Published
- 2019
41. Graphene trapped silk scaffolds integrate high conductivity and stability
- Author
-
Suna Fan, Xuechao Hu, Huili Shao, Chao Zhang, Yaopeng Zhang, and Bo Zhu
- Subjects
chemistry.chemical_classification ,Scaffold ,Materials science ,Graphene ,technology, industry, and agriculture ,Fibroin ,Nanotechnology ,02 engineering and technology ,General Chemistry ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biodegradable polymer ,0104 chemical sciences ,law.invention ,Neural tissue engineering ,SILK ,Tissue engineering ,chemistry ,law ,General Materials Science ,0210 nano-technology - Abstract
Incorporation of highly conducting graphene into electrospun biodegradable polymer mats is very promising for the fabrication of electroactive flexible scaffolds toward neural tissue engineering. However, the direct assembly of graphene onto electrospun polymer fibers for preparing stable conducting scaffolds remains a critical challenge due to the inertness of graphene. To overcome this issue, a one-pot assembly approach was developed to trap graphene inside electrospun mats of regenerated silk fibroin (RSF) by applying its ethanol-treatment driven supercontract. This approach is simple, direct, and controllable, loads only a small amount of graphene, and achieves high conductivity for scaffolds (a minimum resistance of (54.9 ± 20.3) Ω/sq). This ensures weak interference on the softness and biodegradability of graphene trapped RSF scaffolds. Thus, the prepared graphene functionalized RSF scaffold remains highly conductive and stable even with ultrasonic washing. It promotes cell spreading and differentiation, and significantly stimulates the neurite outgrowth by 74.5%, while applying an optimized constant electrical potential, thus indicating it as an ideal candidate as electroactive scaffold for tissue engineering. The application of graphene trapped electrospun polymer mats can be extended to electro-tuned tissue engineering, skin electronics, wearable sensors, and e-textiles due to its combination of flexibility, portability, and electrical conductivity.
- Published
- 2019
42. Synthesis of novel thioxanthone-containing macromolecular photosensitizer and its photocatalytic property
- Author
-
Yaopeng Zhang, Jianhua Hu, Aishun Ding, Yang Chen, Guowei Wang, and Hao Guo
- Subjects
Polymers and Plastics ,Chemistry ,Organic Chemistry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Thioxanthone ,Methacrylate ,01 natural sciences ,Small molecule ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Materials Chemistry ,Photocatalysis ,Photosensitizer ,0210 nano-technology ,Boronic acid ,Macromolecule - Abstract
Aiming to overcome the disadvantages of small molecule photosensitizers, a novel macromolecular photosensitizer was designed and synthesized in this work. Firstly, the functional small molecule photosensitizer 9-oxo-9H-thioxanthene-2-carboxylic acid (TX-COOH) and precursor poly(2-hydroxyethyl methacrylate) (PHEMA) was individually synthesized. Then, the macromolecular photosensitizer PHEMA-TX was realized by an optimized reaction procedure between PHEMA and TX-COCl, which was previously prepared by acyl chlorination of TX-COOH. The modification efficiency was calculated as 64%. Finally, the photocatalytic reaction using the as-synthesized PHEMA-TX was investigated based on three substrates of tris(4-methoxyphenyl)phosphane, methyl(phenyl)sulfane, (4-methoxyphenyl)boronic acid. The results showed that the photocatalyst PHEMA-TX can be easily separated, recovered by a simple precipitation, and reused 7 times without significant loss of the catalytic activity. The excellent photocatalytic property, easy separation, and recyclability of PHEMA-TX were comprehensively confirmed, which contributed great potential of this novel macromolecular photosensitizer in future application.
- Published
- 2019
43. Silk materials for medical, electronic and optical applications
- Author
-
Xiangyu Huang, Yi Zhang, Huili Shao, Yaopeng Zhang, Suna Fan, Lihong Geng, and Xuechao Hu
- Subjects
Materials science ,Biocompatibility ,biology ,General Engineering ,Fibroin ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,SILK ,Tissue engineering ,Bombyx mori ,Ultraviolet light ,General Materials Science ,0210 nano-technology - Abstract
Silk derived from the silkworm Bombyx mori is among the most important fibrous protein biomaterials due to large-scale production from natural sources, excellent biocompatibility, unique mechanical properties and controllable degradation. Silk fibroin can be processed into a variety of formats to match different applications, such as tissue engineering, drug delivery or as the passive substrate of a bio-device. Advances in fabrication technologies provide new possibilities for the combination of silk fibroin with other nanomaterials to functionalize silk fibroin for specialized purposes, including sensing, cell visualization, resistance to ultraviolet light and provision of antibacterial properties. As the requirement for wearable and intelligent devices has become increasingly important over recent years, silk fibroin has been utilized as the active element in electronic and optical instruments. This review summarizes these recent advances in the innovative applications of silk fibroin.
- Published
- 2019
44. Environmental factors influence yak milk composition by modulating short-chain fatty acid metabolism in intestinal microorganisms
- Author
-
Yaopeng Zhang, Hongwen Zhao, Qianqian Li, Dorji Tsechoe, Hongli Yuan, Guijin Su, and Jinshui Yang
- Subjects
Food Science - Published
- 2022
45. Biodegradable silk fibroin-based bio-piezoelectric/triboelectric nanogenerators as self-powered electronic devices
- Author
-
Qianqian Niu, Haifeng Wei, Benjamin S. Hsiao, and Yaopeng Zhang
- Subjects
Renewable Energy, Sustainability and the Environment ,General Materials Science ,Electrical and Electronic Engineering - Published
- 2022
46. Track recognition for the ΔE−E telescopes with silicon strip detectors
- Author
-
Fenhai Guan, Yijie Wang, Xinyue Diao, Yuhao Qin, Zhi Qin, Dong Guo, Qianghua Wu, Dawei Si, Sheng Xiao, Boyuan Zhang, Yaopeng Zhang, Xuan Zhao, and Zhigang Xiao
- Subjects
Nuclear and High Energy Physics ,Instrumentation - Published
- 2022
47. Effects of dynamic mechanical stimulations on the regeneration of in vitro and in vivo cartilage tissue based on silk fibroin scaffold
- Author
-
Minjing Gu, Suna Fan, Guangdong Zhou, Kai Ma, Xiang Yao, and Yaopeng Zhang
- Subjects
Mechanics of Materials ,Mechanical Engineering ,Ceramics and Composites ,Industrial and Manufacturing Engineering - Published
- 2022
48. Single Molecular Layer of Silk Nanoribbon as Potential Basic Building Block of Silk Materials
- Author
-
Li Lu, Yaopeng Zhang, Qianqian Niu, Huili Shao, Huihui Zhang, Suna Fan, Qingfa Peng, Rongliang Wu, and Benjamin S. Hsiao
- Subjects
Materials science ,General Engineering ,General Physics and Astronomy ,Fibroin ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Amorphous solid ,symbols.namesake ,Molecular dynamics ,SILK ,Chemical engineering ,symbols ,Molecule ,General Materials Science ,Potential of mean force ,van der Waals force ,0210 nano-technology ,Dissolution - Abstract
In this study, nascent silk nanoribbons (SNRs) with an average thickness of 0.4 nm were extracted from natural silkworm silk by partially dissolving degummed silk (DS) in sodium hydroxide (NaOH)/urea solution at -12 °C. In this gentle treatment, the solvent could not destroy the nanofibrillar structure completely, but the chosen conditions would influence the dimensions of resulting SNRs. Molecular dynamics simulations of silk models indicated that the potential of mean force required to break hydrogen bonds between silk fibroin chains was 40% larger than that of van der Waals interactions between β-sheet layers, allowing the exfoliating treatment. It was found that the resulting SNRs contained a single β-sheet layer and amorphous silk fibroin molecules, which could be considered as the basic building block of DS consisting of hierarchical structures. The demonstrated technique for extracting ultrathin SNRs having the height of a single β-sheet layer may provide a useful pathway for creating stronger and tougher silk-based materials and/or adding functionality and durability in materials for various applications. The hierarchical structure model based on SNRs may afford more insight into the structure and property relationship of fabricating silk-based materials.
- Published
- 2018
49. Intrinsically Fluorescent Silks from Silkworms Fed with Rare-Earth Upconverting Phosphors
- Author
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Xuechao Hu, Menglu Zhao, Huili Shao, Yaopeng Zhang, Huihui Zhang, Xiaoting Zheng, and Suna Fan
- Subjects
Materials science ,Rare earth ,Biomedical Engineering ,Fibroin ,Nanotechnology ,Phosphor ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Fluorescence ,Environmentally friendly ,0104 chemical sciences ,Biomaterials ,SILK ,Fluorescent materials ,0210 nano-technology - Abstract
Fluorescent silk fibroin (SF) fibers have great potential in biomedical application and special functions for marking and tracking. How to fabricate fluorescent SF fibers with good fluorescence stability by a simple and environmentally friendly method has yet to be explored. Here, we successfully produced fluorescent SF fibers by using silkworms as bioreactors to introduce rare-earth upconverting phosphors (UCPs) into silk fibroin. The modified silk exhibited bright green colors under 980 nm laser. This directly feeding method to produce fluorescent SF fibers is green and environmentally friendly and easy to use for mass production. Moreover, it provides an idea that SF fibers can be cooperated with more fluorescent materials which could exhibit different colors with a certain wavelength of light for broad application.
- Published
- 2018
50. Transparent Conductive Silk Film with a PEDOT-OH Nano Layer as an Electroactive Cell Interface
- Author
-
Xiang Yao, Bo Zhu, Lujie Song, Suna Fan, Ying Qian, Yaopeng Zhang, Qichao Pan, and Ao Zhuang
- Subjects
Materials science ,Polymers ,0206 medical engineering ,Biomedical Engineering ,Silk ,Fibroin ,02 engineering and technology ,engineering.material ,Biomaterials ,chemistry.chemical_compound ,PEDOT:PSS ,Coating ,Animals ,Sheet resistance ,Electric Conductivity ,Adhesion ,021001 nanoscience & nanotechnology ,Bridged Bicyclo Compounds, Heterocyclic ,020601 biomedical engineering ,Rats ,chemistry ,Chemical engineering ,engineering ,Ammonium persulfate ,0210 nano-technology ,Layer (electronics) ,Poly(3,4-ethylenedioxythiophene) - Abstract
Bioelectronics based on biomaterial substrates are advancing toward biomedical applications. As excellent conductors, poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives have been widely developed in this field. However, it is still a big challenge to obtain a functional layer with a good electroconductive property, transparency, and strong adhesion on the biosubstrate. In this work, poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PEDOT-OH) was chemically polymerized and deposited on the surface of a regenerated silk fibroin (RSF) film in an aqueous system. Sodium dodecyl sulfate (SDS) was used as the surfactant to form micelles which are beneficial to the polymer structure. To overcome the trade-off between transparency and the electroconductive property of the PEDOT-OH coating, a composite oxidant recipe of FeCl3 and ammonium persulfate (APS) was developed. Through electrostatic interaction of oppositely charged doping ions, a well-organized conductive nanoscale coating formed and a transparent conductive RSF/PEDOT-OH film was produced, which can hardly be achieved in a traditional single oxidant system. The produced film had a sheet resistance (Rs) of 5.12 × 104 Ω/square corresponding to a conductivity of 8.9 × 10-2 S/cm and a maximum transmittance above 73% in the visible range. In addition, strong adhesion between PEDOT-OH and RSF and favorable electrochemical stability of the film were demonstrated. Desirable transparency of the film allowed real-time observation of live cells. Furthermore, the PEDOT-OH layer provided an improved environment for adhesion and differentiation of PC12 cells compared to the RSF surface alone. Finally, the feasibility of using the RSF/PEDOT-OH film to electrically stimulate PC12 cells was demonstrated.
- Published
- 2021
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