13 results on '"Yuelin Yao"'
Search Results
2. A compendium of genetic regulatory effects across pig tissues
- Author
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Lingzhao Fang, Jinyan Teng, Yahui Gao, Hongwei Yin, Zhonghao Bai, Shuli Liu, Haonan Zeng, Lijing Bai, Zexi Cai, Bingru Zhao, Xiujin Li, Zhiting Xu, Qing Lin, Zhangyuan Pan, Wenjing Yang, Xiaoshan Yu, Dailu Guan, Yali Hou, Brittney Keel, Gary Rohrer, Amanda Lindholm-Perry, William Oliver, Maria Ballester, Daniel Crespo-Piazuelo, Raquel Quintanilla, Oriol Canela-Xandri, Konrad Rawlik, Charley Xia, Yuelin Yao, Qianyi Zhao, Wenye Yao, Liu Yang, Houcheng Li, Huicong Zhang, Wang Liao, Tianshuo Chen, Peter Karlskov-Mortensen, Merete Fredholm, Marcel Amills, Alex Clop, Elisabetta Giuffra, Jun Wu, Xiaodian Cai, Shuqi Diao, Xiangchun Pan, Chen Wei, Jinghui Li, Hao Cheng, Sheng Wang, Guosheng Su, Goutam Sahana, Mogens Lund, Jack Dekkers, Luke Kramer, Christopher Tuggle, Ryan Corbett, Martien A.M. Groenen, Ole Madsen, Marta Gòdia, Dominique Rocha, Mathieu Charles, Cong-jun Li, Hubert Pausch, Xiaoxiang Hu, Laurent Frantz, Yonglun Luo, Lin Lin, Zhong-Yin Zhou, Zhe Zhang, Zitao Chen, Leilei Cui, Ruidong Xiang, Xia Shen, Pinghua Li, Ruihua Huang, Guoqing Tang, Mingzhou Li, Yunxiang Zhao, Guoqiang Yi, Zhonglin Tang, Jicai Jiang, Fuping Zhao, Xiaolong Yuan, Xiaohong Liu, Yaosheng Chen, Xuewen Xu, Shuhong Zhao, Pengju Zhao, Chris Haley, Huaijun Zhou, Qishan Wang, Yuchun Pan, Xiangdong Ding, Li Ma, Jiaqi Li, Pau Navarro, Qin Zhang, Bingjie Li, Albert Tenesa, Kui Li, and George Liu
- Abstract
The Farm animal Genotype-Tissue Expression (FarmGTEx, https://www.farmgtex.org/) project has been established to develop a comprehensive public resource of genetic regulatory variants in domestic animal species, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biology discovery and exploitation in animal breeding and human biomedicine. Here we present results from the pilot phase of PigGTEx (http://piggtex.farmgtex.org/), where we processed 9,530 RNA-sequencing and 1,602 whole-genome sequencing samples from pigs. We build a pig genotype imputation panel, characterize the transcriptional landscape across over 100 tissues, and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We study interactions between genotype and breed/cell type, evaluate tissue specificity of regulatory effects, and elucidate the molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying about 80% of the genetic associations for 207 pig complex phenotypes, and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, corroborating the importance of pigs as a human biomedical model.
- Published
- 2022
3. Comparative transcriptome in large-scale human and cattle populations
- Author
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Yuelin Yao, Shuli Liu, Charley Xia, Yahui Gao, Zhangyuan Pan, Oriol Canela-Xandri, Ava Khamseh, Konrad Rawlik, Sheng Wang, Bingjie Li, Yi Zhang, Erola Pairo-Castineira, Kenton D’Mellow, Xiujin Li, Ze Yan, Cong-jun Li, Ying Yu, Shengli Zhang, Li Ma, John B. Cole, Pablo J. Ross, Huaijun Zhou, Chris Haley, George E. Liu, Lingzhao Fang, and Albert Tenesa
- Subjects
Multifactorial Inheritance ,Comparative transcriptome ,Bioinformatics ,Quantitative Trait Loci ,Heritability enrichment ,Human Genome ,Inter-individual variability ,Biological Sciences ,Phenotype ,Information and Computing Sciences ,Genetics ,Animals ,Humans ,Cattle ,Gene co-expression ,Generic health relevance ,RNA-seq ,Transcriptome ,Environmental Sciences ,Genome-Wide Association Study ,Biotechnology - Abstract
Background Cross-species comparison of transcriptomes is important for elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, yet to date it has been essentially limited to model organisms with relatively small sample sizes. Results Here, we systematically analyze and compare 10,830 and 4866 publicly available RNA-seq samples in humans and cattle, respectively, representing 20 common tissues. Focusing on 17,315 orthologous genes, we demonstrate that mean/median gene expression, inter-individual variation of expression, expression quantitative trait loci, and gene co-expression networks are generally conserved between humans and cattle. By examining large-scale genome-wide association studies for 46 human traits (average n = 327,973) and 45 cattle traits (average n = 24,635), we reveal that the heritability of complex traits in both species is significantly more enriched in transcriptionally conserved than diverged genes across tissues. Conclusions In summary, our study provides a comprehensive comparison of transcriptomes between humans and cattle, which might help decipher the genetic and evolutionary basis of complex traits in both species.
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- 2022
4. A multi-tissue atlas of regulatory variants in cattle: Cattle Genotype-Tissue Expression Atlas
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Shuli Liu, Yahui Gao, Oriol Canela-Xandri, Sheng Wang, Ying Yu, Wentao Cai, Bingjie Li, Erola Pairo-Castineira, Kenton D’Mellow, Konrad Rawlik, Charley Xia, Yuelin Yao, Xiujin Li, Ze Yan, Congjun Li, Benjamin D. Rosen, Curtis P. Van Tassell, Paul M. Vanraden, Shengli Zhang, Li Ma, John B. Cole, George E. Liu, Albert Tenesa, Lingzhao Fang
- Published
- 2022
- Full Text
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5. Pig genome functional annotation enhances biological interpretations of complex traits and comparative epigenomics
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Goutam Sahana, Pablo J. Ross, Merete Fredholm, Yuelin Yao, Zhangyuan Pan, Christopher K. Tuggle, Michelle M. Halstead, Peter Karlskov-Mortensen, Guosheng Su, Klaus Wimmers, Lingzhao Fang, Catherine W. Ernst, Mogens Sandø Lund, Nares Trakooljul, Lijing Bai, Ying Wang, Zexi Cai, Huaijun Zhou, Kelly Chanthavixay, Hongwei Ying, and Colin Kern
- Subjects
Functional annotation ,Computational biology ,Biology ,Genome ,Epigenomics - Abstract
The functional annotation of livestock genomes is crucial for understanding the molecular mechanisms that underpin complex traits of economic importance, adaptive evolution and comparative genomics. Here, we provide the most comprehensive catalogue to date of regulatory elements in the pig (Sus scrofa) by integrating 223 epigenomic and transcriptomic data sets, representing 14 biologically important tissues. We systematically describe the dynamic epigenetic landscape across tissues by functionally annotating 15 different chromatin states and defining their tissue-specific regulatory activities. We demonstrate that genomic variants associated with complex traits and adaptive evolution in pig are significantly enriched in active promoters and enhancers. Furthermore, we reveal distinct tissue-specific regulatory selection between Asian and European pig domestication processes. Compared with human and mouse epigenomes, we show that porcine regulatory elements are more conserved in DNA sequence, under both rapid and slow evolution, than those under neutral evolution across pig, mouse, and human. Finally, we provide novel biological insights on tissue-specific regulatory conservation and demonstrate that, depending on the traits, mouse or pig might be more appropriate biomedical models for different complex traits and diseases in humans through integrating comparative epigenomes with 47 human genome-wide association studies.
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- 2021
6. A comprehensive catalogue of regulatory variants in the cattle transcriptome
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Shuli Liu, Yahui Gao, Oriol Canela-Xandri, Sheng Wang, Ying Yu, Wentao Cai, Bingjie Li, Ruidong Xiang, Amanda J. Chamberlain, Erola Pairo-Castineira, Kenton D’Mellow, Konrad Rawlik, Charley Xia, Yuelin Yao, Pau Navarro, Dominique Rocha, Xiujin Li, Ze Yan, Congjun Li, Benjamin D. Rosen, Curtis P. Van Tassell, Paul M. Vanraden, Shengli Zhang, Li Ma, John B. Cole, George E. Liu, Albert Tenesa, and Lingzhao Fang
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Transcriptome ,Genetic gain ,Research community ,Gene expression ,Alternative splicing ,RNA ,Computational biology ,Biology - Abstract
Characterization of genetic regulatory variants acting on the transcriptome of livestock is essential for interpreting the molecular mechanisms underlying traits of economic value and for increasing the rate of genetic gain through artificial selection. Here, we build a cattle Genotype-Tissue Expression atlas (cattle GTEx, http://cgtex.roslin.ed.ac.uk/) as part of the pilot phase of Farm animal GTEx (FarmGTEx) project for the research community based on publicly available 11,642 RNA-Seq datasets. We describe the landscape of the transcriptome across over 100 tissues and report hundreds of thousands of genetic associations with gene expression and alternative splicing for 24 major tissues. We evaluate the tissue-sharing patterns of these genetic regulatory effects, and functionally annotate them using multi-omics data. Finally, we link gene expression in different tissues to 43 economically important traits using both transcriptome-wide association study (TWAS) and colocalization analyses to decipher the molecular regulatory mechanisms underpinning such agronomic traits in cattle.
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- 2020
7. A multi-tissue atlas of regulatory variants in cattle
- Author
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Shuli Liu, Yahui Gao, Oriol Canela-Xandri, Sheng Wang, Ying Yu, Wentao Cai, Bingjie Li, Ruidong Xiang, Amanda J. Chamberlain, Erola Pairo-Castineira, Kenton D’Mellow, Konrad Rawlik, Charley Xia, Yuelin Yao, Pau Navarro, Dominique Rocha, Xiujin Li, Ze Yan, Congjun Li, Benjamin D. Rosen, Curtis P. Van Tassell, Paul M. Vanraden, Shengli Zhang, Li Ma, John B. Cole, George E. Liu, Albert Tenesa, and Lingzhao Fang
- Subjects
Phenotype ,Gene Expression Regulation ,Sequence Analysis, RNA ,Quantitative Trait Loci ,Genetics ,Animals ,Cattle ,Cattle/genetics ,Transcriptome/genetics ,Quantitative Trait Loci/genetics ,Transcriptome - Abstract
Characterization of genetic regulatory variants acting on livestock gene expression is essential for interpreting the molecular mechanisms underlying traits of economic value and for increasing the rate of genetic gain through artificial selection. Here we build a Cattle Genotype-Tissue Expression atlas (CattleGTEx) as part of the pilot phase of the Farm animal GTEx (FarmGTEx) project for the research community based on 7,180 publicly available RNA-sequencing (RNA-seq) samples. We describe the transcriptomic landscape of more than 100 tissues/cell types and report hundreds of thousands of genetic associations with gene expression and alternative splicing for 23 distinct tissues. We evaluate the tissue-sharing patterns of these genetic regulatory effects, and functionally annotate them using multiomics data. Finally, we link gene expression in different tissues to 43 economically important traits using both transcriptome-wide association and colocalization analyses to decipher the molecular regulatory mechanisms underpinning such agronomic traits in cattle.
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- 2020
8. Evaluation of the Impacts of BRT Corridor
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Zhoongzhen Yang, Yuelin Yao, and Peng Jia
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Travel time ,Transport engineering ,Computer science ,Spatial model ,Microsimulation ,Traffic speed ,Load model ,Traffic flow ,Bus rapid transit ,Traffic simulator - Abstract
Taking BRT line in Dalian as study object, this paper evaluates the changes of traffic flow and its environmental load corresponding to several schemes of BRT lanes with micro traffic simulator. First, the capacity of BRT lane and the being removed bus routes and bus vehicles are calculated. Second, spatial model of the corresponding area is established in the Simulating Platform, and several BRT lane schemes are built in the model, then the attributes of the corresponding traffic flows are analyzed. Third, environmental load model is used to calculate the corresponding traffic environmental loads.
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- 2011
9. Research on the Method of BRT Network Planning
- Author
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Yan Chen, Yuelin Yao, Lianjie Jin, and Wenqian Zou
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Network planning and design ,Mathematical optimization ,Qualitative analysis ,Geographic information system ,Quantitative analysis (finance) ,Computer science ,business.industry ,Polygon ,Maximization ,Space (commercial competition) ,business ,Bus rapid transit - Abstract
Considering the fact that BRT (bus rapid transit) lines are generally constructed in built-up areas, this paper develops a method for BRT planning. The method can be used to design and optimize BRT lines in urban areas in terms of qualitative analysis and analytical calculation. Firstly, to calculate the density of bus lines on each road, Polygon Data is used to denote urban roads in GIS, and Polyline Data is used to denote bus lines. The number of overlapping bus lines could be computed with space calculation functions in GIS, and roads with a large number of bus lines can be found. Secondly, an optimization model based on the maximization of direct traveler density is developed to lay the lines one by one and form a network step by step. Finally, considering the actual situation, a BRT network of Dalian is built based on the result of qualitative analysis and analytical calculation.
- Published
- 2009
10. Tunable in-plane uniaxial anisotropy and the magnetization reversal mechanism of patterned high-frequency soft magnetic FeTa strips
- Author
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J H Ma, X M Han, Yuelin Yao, D.S. Xue, Li Xi, Yalu Zuo, and Zhong Lin Wang
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Materials science ,Kerr effect ,Acoustics and Ultrasonics ,Condensed matter physics ,Physics::Instrumentation and Detectors ,Isotropy ,STRIPS ,Coercivity ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,Magnetization ,Magnetic anisotropy ,Sputtering ,law ,Anisotropy - Abstract
FeTa films with thickness of 110 nm are fabricated on glass substrates by magnetron sputtering, and then a series of strips is designed on the FeTa films by conventional optical lithography and the ion beam etching method. Patterned FeTa strips show a tunable in-plane uniaxial magnetic anisotropy property in contrast with the magnetic isotropic property of as-deposited FeTa thin films. The magnetization reversal mechanism of the patterned FeTa strips is investigated via the in-plane angular dependences of magnetization and coercivity. The angular dependence of coercivity (ADC) is explained well in terms of the two-phase model, giving good quantitative agreement with the experimentally measured M-shaped ADC curve. The domain structure and spatial resolution magneto-optical Kerr effect measurement indicate that the smaller the strip width, the stronger will be the anisotropy field. Regarding the dynamic magnetic properties, a transformation from Debye dispersion spectrum for strips with weak anisotropy to natural resonance spectrum for strips with strong anisotropy is finally obtained. The tunable in-plane anisotropy fields of the FeTa strips result in tunable high-frequency soft magnetic properties by altering the strip width, indicating that patterned FeTa strips have great potential in high-frequency soft magnetic application fields.
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- 2013
11. Microwave absorption properties of amorphous iron nanostructures fabricated by a high-yield method
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Yalu Zuo, Yuelin Yao, Zhen Wang, Jihong Du, Jianbo Wang, Li Xi, and Desheng Xue
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Permittivity ,Materials science ,Acoustics and Ultrasonics ,Scanning electron microscope ,Analytical chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Amorphous solid ,Electron diffraction ,Transmission electron microscopy ,Paraffin wax ,Microwave ,Amorphism - Abstract
Amorphous Fe nanoparticles and a nanonecklace were synthesized at room temperature by an aqueous reduction procedure, which provided a simple and potential method for volume production of ferromagnetic materials. The morphology was examined by scanning electron microscopy and transmission electron microscopy. The amorphism of Fe nanoparticles and the nanonecklace was confirmed by x-ray diffraction and electron diffraction patterns in transmission electron microscopy. The complex permittivity and permeability behaviour of amorphous iron nanoparticles/paraffin wax (NPPW) and nanonecklace/paraffin wax (NCPW) composites was investigated in 0.1–18 GHz by a coaxial method. The strongest reflection loss values of NPPW and NCPW calculated from permittivity and permeability reached −53.2 dB and −47.8 dB at 6.4 GHz and 4.6 GHz with matching thicknesses of 2.4 mm and 2.3 mm, respectively. Moreover, the frequency ranges of microwave absorption exceeding 90% were around 4.9–8.8 GHz and 3.7–6.1 GHz for NPPW and NCPW, respectively. Comparing the microwave absorption property with crystallized Fe nanostructures, we may conclude that the relatively high resistivity and low permittivity of amorphous Fe nanostructures are favourable for impedance matching, and consequently result in the attracting microwave absorption property of amorphous Fe nanostructures. Thus, amorphous iron nanoparticles and the nanonecklace prepared by a high-yield method have great potential to be a highly efficient microwave absorber.
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- 2013
12. Voltage-Driven In-Plane Magnetization Easy Axis Switching in FeNi/Piezoelectric Actuator Hybrid Structure
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Zhen Wang, Li Xi, Yuelin Yao, Desheng Xue, Yue Li, Xiaobin Guo, and Yalu Zuo
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Condensed Matter::Materials Science ,Magnetization ,Magnetic anisotropy ,Kerr effect ,Materials science ,Condensed matter physics ,General Engineering ,General Physics and Astronomy ,Magnetostriction ,Thin film ,Rotation ,Anisotropy ,Magnetic field - Abstract
FeNi thin films with the in-plane uniaxial anisotropy were fabricated by direct current magnetron sputtering. An FeNi/piezoelectric actuator hybrid structure was used to investigate the voltage-controlled magnetization switching. A theoretical calculation was performed to provide a simplified vision of the magnetoelastic contribution to the magnetic anisotropy. Magneto-optical Kerr effect measurements were performed and the rotation of the magnetization easy axis in the FeNi film upon application of a voltage with or without the application of a magnetic field was demonstrated. A film-thickness dependent in-plane magnetization easy axis rotation angle was observed and explained by the variation of the magnetostriction.
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- 2013
13. Comparative transcriptome in large-scale human and cattle populations
- Author
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'Yuelin Yao
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