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Additional file 7: Supplement Table 1. Summary of gene expression changes in tnFGFR1 expressing cells compared with cells expressing BCR-FGFR1m in the categories of ‘Oncogene’, transcription factor’ and involved in maintaining ‘stemness’. Gene expression (GE) is cited as the mean FPMK values (N-2) in both cases.

The PD-1/PD-L1 axis is characterized as an important checkpoint of immune activation, particularly through negatively regulating T cell function. Although accumulated evidence has demonstrated the patients with some types of tumor benefit from blockade of PD-1/PD-L1 signaling pathway, the possible synergistic effect of combination of radiotherapy and anti-PD-1/PD-L1 antibody still need to be explored. Here, we report a case of patient who was diagnosed with metastatic mediastinal leiomyosarcoma and treated by combination of local radiotherapy and anti-PD-1 antibody nivolumab. Remarkable tumor regression was observed at both the irradiated focus and distant metastatic sites 2 months later after combined treatment. The patient has tumor mutational burden (8.7 somatic mutations/Mb) and positive PD-L1 expression. The increased circulating lymphocytes suggest induced activation of immune response after combination treatment. Free disease progression has reached one and a half years as far.

In order to study the distribution of lateral floor abutment pressure at a working face, we first used elasticity theory to establish a distribution model of lateral floor abutment pressure and then analysed its distribution. Second, we established a three-dimensional numerical simulation model of the Haizi Coal Mine No. 86 mining area by using FLAC3D (ITASCA Consulting Group) software. We investigated the distribution of lateral floor abutment pressure of a stope, which indicated that the position of abutment pressure peak varies at different floor depths. We then determined the rational reinforcement range of a floor roadway, based on the conclusion reached earlier. Finally, we used our conclusions in support of the No. 86 mining area crossing-roadway. The supported crossing-roadway remained stable when mining the upper workface, which validates the accuracy of our numerical simulation and provides a future reference for the support of span-roadways under similar conditions.