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Background: Lung adenocarcinoma with the classical EGFR 19 deletion and exon 21 L858R point mutations has exhibited good responses to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) treatment. However, the sensitivity of uncommon EGFR exon 20 insertion mutation to third-generation EGFR-TKIs has not been determined. Although emerging targeted therapies for EGFR exon 20 insertion mutation have been reported in recent years, such patients still have a poorer prognosis than those with typical or wild-type EGFR mutations.Case summary: Here, we report the case of a 57-year-old man with advanced non-small cell lung cancer (NSCLC) with a rare EGFR exon 20 N771_P772insH mutation. The patient was treated with furmonertinib as second-line therapy. Although his pleural effusion was more than before that during treatment, various examination results showed that the pleural effusion was closely related to hypoproteinemia; thus, local progression was not considered. His cough was significantly alleviated, and the dose was well tolerated. The patient was evaluated for a remarkable progression-free survival (PFS) of 10.0 months, a duration of response (DOR) of 8.0 months, and an overall survival (OS) of 22.0 months, which had not previously been achieved.Conclusion: The present study indicated that furmonertinib might be a good treatment option for first-line progressive NSCLC patients with EGFR exon 20 insertion mutation.

The dendrite morphology is determined by the interaction between the capillarity effect and the transports of heat and solute,and is significantly altered by the presence of fluid flow during solidification.A lot of numerical models have been developed to investigate the effect of fluid flow on the dendritic growth of pure materials.But up to date,only a few researches were carried out on the effect of fluid flow on the dendritic growth of alloys.The effect of fluid flow on three dimensional (3D) dendrite tip selection parameter of alloys remains an unsolved scientific problem.A 3D cellular automaton(CA) model for dendritic growth of alloys was developed in this paper.3D CA is solved in coupling with a momentum transport model in order to predict the evolution of dendritic morphology during solidification of alloys in the presence of flow.The dendrite growth with a forced flow in an undercooled melt of an Al-4%Cu(mass fraction) alloy was simulated.The effect of forced flow on dendritic growth was investigated.The results show that a forced flow affect the three dimensional dendritic growth of an alloy significantly.The growth of the primary and secondary arm in the upstream direction is much greater than that in the downstream direction.The growth direction of the primary arm perpendicular to the flow direction tilted into the upstream direction.The dendrite tip of the primary arm perpendicular to the flow direction shows an asymmetric morphology.The degree of the tilt and the asymmetry of the tip become stronger with the increase of the forced flow velocity. With the increase of the flow velocity the growth velocity of the upstream dendrite tip increases,the radius and the selection parameter of the upstream dendrite tip decrease.For a given undercooling, the effect of forced flow on the selection parameter of the upstream dendrite tip becomes stronger with the increase of the anisotropy of the interfacial energy.For a given alloy,the effect of forced flow on the selection parameter of the upstream dendrite tip also becomes stronger with the increase of undercooling.

The microstructure evolution during the liquid-liquid phase transformation of Al-Pb alloy was calculated. The numerical results indicate that the interaction between the minority phase droplets has effect on the nucleation process of the droplets, and the effect increases with the cooling rate and the content of Pb.

Continuous solidification experiments were carried out with Cu-Bi-Sn alloys under the effects of Electric Current Pulses (ECPs). A model describing the microstructure evolution was developed. The formation of the microstructure in the continuously solidified alloys was calculated. The calculations demonstrated that ECPs mainly affect the solidification process through changing the energy barrier for the nucleation of the minority phase droplets (MPDs). When the matrix liquid has a lower electric conductivity compared to the MPD, the ECPs lead to a decrease in the energy barrier for the nucleation of the MPDs which then promote the formation of a finely dispersed microstructure. When the matrix liquid has a higher electric conductivity compared to the MPD, the ECPs cause an increase in the energy barrier for the nucleation and lead to the formation of a phase segregated microstructure.

A numerical model reflecting the real physical processes well is developed to predict the coarsening mode of the second phase droplets and the microstructural evolution under the common action of nucleation, diffusional growth, collision coagulation during rapid cooling Al–In hypermonotectic alloys.

The main idea was to find out the common principle of Bipedalism among all kinds of researches on human bipedalism to explain the mechanism deeply, which will be a significant guidance to robot walking. Energetic optimum was found to be a key principle to human bipedalism, inspired by that, a natural gait generation methods was proposed to test the feasibility that using the similar method on robot. The result shows that by using the method the robot could walk simply and efficiently, close to human, which is of huge significance for the future work in this area.

Monotectic alloys have great potentials to be used in industry due to their special physical and mechanical properties.But these alloys have an essential drawback that just the miscibility gap in the liquid state poses problem during solidification.When a homogeneous,single-phase liquid is cooled into the miscibility gap,the components are no longer miscible and two liquid phases develop.Generally,the liquid-liquid decomposition causes the formation of the microstructure with serious phase segregation.Recent researches demonstrate that the only effective method to prevent the formation of the phase segregated microstructure in the immiscible alloys is using the rapid or sub-rapid solidification processing techniques.Laser surface treatment is a well known rapid solidification technique. It is widely applied in the industry to improve the surface properties of different type of alloys. But up to date,the solidification behaviors of the monotectic alloys under the laser surface treatment conditions have not been investigated.In this work,laser surface treatment experiments with Al-Pb alloys were carried out.A numerical model was developed to describe the microstructure evolution in the surface layer of Al-Pb alloys under the conditions of laser surface treatment.The model was applied to calculate the microstructure formation in the surface layer.The numerical results have a good agreement with the experimental ones.Both of the numerical and experimental results indicate that the microstructure of the laser treated surface layer is determined by the re-melting,composition homogenization and solidification of the alloy.Laser surface treatment can lead to the formation of an Al-Pb surface layer with well dispersed microstructure.

Molecular dynamics simulation has been used to investigate the effect of pressure on the formation of glassy Cu. The results indicate that a higher pressure leads to a strong crystallization tendency during cooling. The glassy Cu formed under high pressures contains more crystal cluster and has a higher degree of order.