926 results on '"Zhao, X"'
Search Results
2. Deformation incompatibility enables hetero-deformation induced strengthening in Ti/Nb laminates
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Jiang, S., Peng, R. Lin, Zhao, X., Zuo, L., and Jia, N.
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Inorganic Chemistry ,Oorganisk kemi ,Laminates ,hetero-deformation induced (HDI) hardening ,deformation incompatibility ,in-situ neutron diffraction ,General Materials Science - Abstract
IMPACT STATEMENT The phase-to-phase interaction is found to be an important indicator for evaluating the HDI strengthening and hardening in heterogeneous laminates, and the microstress analysis can guide the design of heterostructures. Deformation incompatibility in Ti/Nb laminates under uniaxial tension was revealed by in-situ neutron diffraction. During uniform deformation of the bulk laminates, the hard Nb constrained by the soft Ti showed moderate work hardening and only slightly decreased flow stress. The mechanical incompatibility accumulated in both elastic and elasto-plastic regimes between the metals lead to pronounced hetero-deformation induced (HDI) strengthening, and the HDI stress was comparable to the maximum phase-to-phase interaction. The HDI hardening and interphase stress showed consistent evolution trends, implying that the interaction between dissimilar metals can be used as an important indicator for evaluating HDI strengthening and hardening. Funding Agencies|National Key R&D Program of China [2021YFA1200203]; National Natural Science Foundation of China [51922026]; Fundamental Research Funds for the Central Universities [N2002005, N2007011]; 111 Project [B20029]
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- 2022
3. Validation of the Decipher genomic classifier in patients receiving salvage radiotherapy without hormone therapy after radical prostatectomy – an ancillary study of the SAKK 09/10 randomized clinical trial
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Dal Pra, A, Ghadjar, P, Hayoz, S, Liu, V Y T, Spratt, D E, Thompson, D J S, Davicioni, E, Huang, H-C, Zhao, X, Liu, Y, Schär, C, Gut, P, Plasswilm, L, Hölscher, T, Polat, B, Hildebrandt, G, Müller, A-C, Pollack, A, Thalmann, G N, Zwahlen, D, and Aebersold, D M
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Male ,Prostatectomy ,Salvage Therapy ,Prostatic Neoplasms ,610 Medicine & health ,Genomics ,Hematology ,Prostate-Specific Antigen ,Hormones ,Oncology ,Humans ,Neoplasm Recurrence, Local ,Retrospective Studies - Abstract
The Decipher genomic classifier (GC) has shown to independently prognosticate outcomes in prostate cancer. The objective of this study was to validate the GC in a randomized phase III trial of dose-escalated salvage radiotherapy (SRT) after radical prostatectomy.A clinical-grade whole-transcriptome assay was carried out on radical prostatectomy samples obtained from patients enrolled in Swiss Group for Clinical Cancer Research (SAKK) 09/10, a phase III trial of 350 men with biochemical recurrence after radical prostatectomy randomized to 64 Gy versus 70 Gy without concurrent hormonal therapy or pelvic nodal RT. A prespecified statistical plan was developed to assess the impact of the GC on clinical outcomes. The primary endpoint was biochemical progression; secondary endpoints were clinical progression and time to hormone therapy. Multivariable analyses adjusted for age, T-category, Gleason score, postradical prostatectomy persistent prostate-specific antigen (PSA), PSA at randomization, and randomization arm were conducted, accounting for competing risks.The analytic cohort of 226 patients was representative of the overall trial, with a median follow-up of 6.3 years (interquartile range 6.1-7.2 years). The GC (high versus low-intermediate) was independently associated with biochemical progression [subdistribution hazard ratio (sHR) 2.26, 95% confidence interval (CI) 1.42-3.60; P0.001], clinical progression (HR 2.29, 95% CI 1.32-3.98; P = 0.003), and use of hormone therapy (sHR 2.99, 95% CI 1.55-5.76; P = 0.001). GC high patients had a 5-year freedom from biochemical progression of 45% versus 71% for GC low-intermediate. Dose escalation did not benefit the overall cohort, nor patients with lower versus higher GC scores.This study represents the first contemporary randomized controlled trial in patients treated with early SRT without concurrent hormone therapy or pelvic nodal RT that has validated the prognostic utility of the GC. Independent of standard clinicopathologic variables and RT dose, high-GC patients were more than twice as likely than lower-GC patients to experience biochemical and clinical progression and receive of salvage hormone therapy. These data confirm the clinical value of Decipher GC to personalize the use of concurrent systemic therapy in the postoperative salvage setting.
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- 2022
4. EFFECT OF THE BAR DIAMETER ON THE LOAD RESPONSE OF GFRP-CONCRETE PULL-OUT TESTS
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Zhao, X., Rahman, M.M., D'Antino, T., Focacci, F., and Carloni, C.
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This study focuses on the effect of the bar diameter of glass fiber-reinforced polymer (GFRP) bars on their bond with concrete using pull-out tests. The investigation involves three nominal bar diameters: 6 mm, 12 mm, and 20 mm and several bonded lengths. Within this study, the pull-out test results for both the 6 mm and 20 mm bars are presented for the first time, whereas the findings for the 12 mm bars were previously reported in a paper by the authors where the effect of the bonded length on the experimental response was assessed. The influence of the bonded length on the bond strength for different diameters is discussed., Paper 308
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- 2023
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5. UHP-SWSSC FILLED GFRP TUBES UNDER COMBINED SUSTAINED LOAD AND SEAWATER EXPOSURE
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Saleh, S., Hamed, E., Mahmood, A.H., and Zhao, X-L.
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This experimental investigation evaluates the durability of GFRP tubular composites filled with marine resource-based ultra-high-performance concrete under combined sustained loading and seawater exposure at an elevated temperature. Material properties of the FRPs with different diameter to thickness ratio were determined in both longitudinal and hoop directions. Creep strains were monitored in both directions for 2000 hours, and a comprehensive analysis was conducted on the axial compressive stress-strain response, stiffness, and failure modes of unconditioned and conditioned composite specimens. GFRP composites exhibited larger creep strains in hoop direction, which were exacerbated due to swelling in long-term seawater exposure. The GFRP confining tube, with a lower diameter-to-thickness ratio and higher confining pressure, exhibited improved confinement, increased strength and stiffness, and comparable rupture strain after the combined conditioning process., Paper 30
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- 2023
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6. Going all the way in the search for WIMP dark matter at the muon collider through precision measurements
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Franceschini R., Zhao X., Franceschini, R., and Zhao, X.
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- 2023
7. Contraversive Ocular Tilt Reaction, Body Lateropulsion and Gaze-Evoked Nystagmus After Inferior Cerebellar Peduncle and Dentate Nucleus Stroke
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Yue X. Wu, Xia Ling, Tong T. Zhao, Yu F. Feng, Zhao X. Wang, Ji-Soo Kim, and Xu Yang
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Ophthalmology ,Neurology (clinical) - Published
- 2023
8. EVALUATION OF A COMPACT HELMET-BASED LASER SCANNING SYSTEM FOR ABOVEGROUND AND UNDERGROUND 3D MAPPING
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Li, J., Yang, B., Chen, Y., Wu, W., Yang, Y., Zhao, X., and Chen, R.
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As a strategic resource, urban underground space can be used for rail transportation, commercial streets, which has high economic and social benefits, and is of great significance to sustainable city development. Due to denied Global Navigation Satellite System (GNSS) signal, traditional mobile mapping systems have difficulty collecting accurate 3D point clouds in urban underground space. Thus, a helmet-based laser scanning system, named "WHU-Helmet", is integrated in this paper to make up for the shortcomings of the existing traditional mobile mapping systems. "WHU-Helmet" is mainly equipped with four types of sensors: a GNSS receiver (optional), an IMU, a laser scanner, and a global shutter camera. "WHU-Helmet" is not relying on GNSS signal and has the advantages of low cost, small volume and easy operation. Using "WHU-Helmet", a multi-scale Normal Distributions Transform (NDT) based LiDAR-IMU SLAM is implemented to collect underground 3D point cloud in real-time. To validate the performance of "WHU-Helmet" in aboveground and underground 3D mapping, experiments were conducted in a typical urban metro station. The experiments show that the average and RMSE of HLS point errors of "WHU-Helmet" are 0.44 meters and 0.23 meters, respectively, showing great potential of "WHU-Helmet" in the application of aboveground and underground 3D mapping.
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- 2022
9. Hydrogen Column Density Variability in a Sample of Local Compton-Thin AGN
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Torres-Albà, N., Marchesi, S., Zhao, X., Cox, I., Pizzetti, A., Ajello, M., and Silver, R.
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the analysis of multiepoch observations of a set of 12 variable, Compton-thin, local (z100$. This behavior, which suggests a physical disconnect between the absorber and the reflector, is more extreme in sources that present $N_{\rm H}$ variability. $N_{\rm H}$-variable AGN also tend to present larger obscuration and broader cloud distributions than their non-variable counterparts. We observe that large changes in obscuration only occur at long timescales, and use this to place tentative lower limits on torus cloud sizes., 16 pages, 6 figures, 3 tables, 3 Appendix (19 pages, 2 figures, 11 tables). Submitted to A&A
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- 2023
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10. On correlation between canopy vegetation and growth indexes of maize varieties with different nitrogen efficiencies
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Zhao, X., Wang, S., Wen, T., Xu, J., Huang, B., Yan, S., Gao, G., Zhao, Y., Li, H., Qiao, J., Yang, J., Wu, L., Wang, H., Liu, T., and Mu, X.
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Vegetation indices ,General Immunology and Microbiology ,Nitrogen efficiency ,General Neuroscience ,Dry matter content ,Leaf nitrogen content ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology ,Maize - Abstract
Studying the canopy spectral reflection characteristics of different N-efficient maize varieties and analyzing the relationship between their growth indicators and spectral vegetation indices can help the breeding and application of N-efficient maize varieties. To achieve the optimal management of N fertilizer resources, developing N-efficient maize varieties is necessary. In this research, maize varieties, i.e., the low-N-efficient (Zhengdan 958, ZD958), the high-N efficient (Xianyu 335, XY335), the double-high varieties (Qiule 368, QL368), and the double inefficient-type varieties (Yudan 606 YD606), were used as materials. Results indicate that nitrogen fertilization significantly increased the vegetation indices NDVI, GNDVI, GOSAVI, and RVI of maize varieties with different nitrogen efficiencies. These findings were consistent with the performance of yield, dry matter mass, and leaf nitrogen content and were also found highest under both medium and high nitrogen conditions in the double-high variety QL368. The correlations of dry matter quality, leaf nitrogen content, yield, and vegetation indices (NDVI, GNDVI, RVI, and GOSAVI) at the filling stage of different N-efficient maize varieties were all highly significant and positive. In this relationship, the best effect was found at the filling stages, with correlation coefficients reaching 0.772–0.942, 0.774–0.970, 0754–0.960, and 0.800–0.960. The results showed that the yield, dry matter weight, and leaf nitrogen content of maize varieties with different nitrogen efficiencies increased first and then stabilized with the increase in the nitrogen application level in different periods, and the highest nitrogen application level of maize yield should be between 270 and 360 kg/hm2. At the filling stage, canopy vegetation index of maize varieties with different nitrogen efficiencies was positively correlated with yield, dry matter weight, and leaf nitrogen content, especially GNDVI and GOSAVI on the leaf nitrogen content. It can be used as a means to predict its growth index.
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- 2023
11. Total ozone variability and trends over the South Pole during the wintertime
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Fioletov, V., Zhao, X., Abboud, I., Brohart, M., Ogyu, A., Sit, R., Lee, S., Petropavlovskikh, I., Johnson, B., Cullis, P., Booth, J., and McConville, G.
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The Antarctic polar vortex creates unique chemical and dynamic conditions when the stratospheric air over Antarctica is isolated from the rest of the stratosphere. As a result, stratospheric ozone within the vortex remains largely unchanged for a five-month period from April until late August when the sunrise and extremely cold temperatures create favorable conditions for rapid ozone loss. Such prolong stable conditions within the vortex make it possible to estimate the ozone levels there from sparse wintertime ozone observations at the South Pole. Total ozone measurements by Dobson and Brewer spectrophotometers that use the Moon as the light source, integrated ozonesonde profiles, and MERRA-2 reanalysis data were used to analyse ozone variability and trends over the South Pole. The wintertime ozone values over the South Pole during the last 20 years were 12%–15% below the pre-1980 level, i.e., the decline there was nearly twice larger than that over southern midlatitudes. It is probably the largest long-term ozone decline aside from the springtime Antarctic ozone depletion. While wintertime ozone decline over the pole hardly has any impact on the environment, it can be used as an indicator to diagnose the state of the ozone layer, particularly because it requires data only from one station. Data after 2004 show a small positive trend, although it is not statistically significant. Total ozone variability over the South Pole and observation uncertainties will be also discussed., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)
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- 2023
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12. The First GECAM Observation Results on Terrestrial Gamma-ray Flashes and Terrestrial Electron Beams
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Zhao, Y., Liu, J. C., Xiong, S. L., Xue, W. C., Yi, Q. B., Lu, G. P., Xu, W., Lyu, F. C., Sun, J. C., Peng, W. X., Zheng, C., Zhang, Y. Q., Cai, C., Xiao, S., Xie, S. L., Wang, C. W., Tan, W. J., An, Z. H., Chen, G., Du, Y. Q., Huang, Y., Gao, M., Gong, K., Guo, D. Y., He, J. J., Li, B., Li, G., Li, X. Q., Li, X. B., Liao, J. Y., Liang, J., Liang, X. H., Liu, Y. Q., Ma, X., Qiao, R., Song, L. M., Song, X. Y., Sun, X. L., Wang, J., Wang, J. Z., Wang, P., Wen, X. Y., Wu, H., Xu, Y. B., Yang, S., Zhang, B. X., Zhang, D. L., Zhang, F., Zhang, P., Zhang, H. M., Zhang, Z., Zhao, X. Y., Zheng, S. J., Zhang, K. K., Han, X. B., Wu, H. Y., Hu, T., Geng, H., Zhang, H. B., Lu, F. J., Zhang, S. N., and Yu, H.
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Earth and Planetary Astrophysics (astro-ph.EP) ,FOS: Physical sciences ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Gravitational-wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) is a space-borne instrument dedicated to monitoring high-energy transients, including Terrestrial Gamma-ray Flashes (TGFs) and Terrestrial Electron Beams (TEBs). We implemented a TGF/TEB search algorithm for GECAM, with which 147 bright TGFs, 2 typical TEBs and 2 special TEB-like events are identified during an effective observation time of $\sim$9 months. We show that, with gamma-ray and charged particle detectors, GECAM can effectively identify and distinguish TGFs and TEBs, and measure their temporal and spectral properties in detail. A very high TGF-lightning association rate of $\sim$80\% is obtained between GECAM and GLD360 in east Asia region., Comment: The paper was accepted by Geophysical Research Letters on June 16th, 2023
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- 2023
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13. Low-temperature specific heat and heat transport of Tb$_2$Ti$_{2-x}$Zr$_x$O$_7$ single crystals
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Che, H. L., Li, S. J., Wu, J. C., Li, N., Guang, S. K., Xia, K., Yue, X. Y., Wang, Y. Y., Zhao, X., Li, Q. J., and Sun, X. F.
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Condensed Matter - Strongly Correlated Electrons ,Strongly Correlated Electrons (cond-mat.str-el) ,FOS: Physical sciences - Abstract
We report a study on the specific heat and heat transport of Tb$_2$Ti$_{2-x}$Zr$_x$O$_7$ ($x =$ 0, 0.02, 0.1, 0.2, and 0.4) single crystals at low temperatures and in high magnetic fields. The magnetic specific heat can be described by the Schottky contribution from the crystal-electric-field (CEF) levels of Tb$^{3+}$, with introducing Gaussian distributions of the energy split of the ground-state doublet and the gap between the ground state and first excited level. These crystals has an extremely low phonon thermal conductivity in a broad temperature range that can be attributed to the scattering by the magnetic excitations, which are mainly associated with the CEF levels. There is strong magnetic field dependence of thermal conductivity, which is more likely related to the field-induced changes of phonon scattering by the CEF levels than magnetic transitions or spin excitations. For magnetic field along the [111] direction, there is large thermal Hall conductivity at low temperatures which displays a broad peak around 8 T. At high fields up to 14 T, the thermal Hall conductivity decreases to zero, which supports its origin from either the spinon transport or the phonon skew scattering by CEF levels. The thermal Hall effect is rather robust with Zr doping up to 0.2 but is strongly weakened in higher Zr-doped sample., Comment: 9 pages, 8 figures, accepted for publication in Phys. Rev. B
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- 2023
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14. Revisiting the ‘U-curve’ hypothesis: international students’ academic, sociocultural, and psychological adjustment trajectories at a British university
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Zhao X, Schartner A
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- 2023
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15. A decade of innovation to deepen the understanding of infectious diseases of poverty and foster their control and elimination
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Engels, D., Tang, S. L., Butler, C. D., Oduola, A. M. J., de Araujo-Jorge, T. C., Gao, G. F., Utzinger, J., and Zhao, X. N.
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Infectious Diseases ,Public Health, Environmental and Occupational Health ,General Medicine - Published
- 2022
16. Automatic Multi-source Data Fusion Technique of Powerline Corridor using UAV Lidar
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Su, C, Wu, X, Guo, Y, Lai, CS, Xu, L, and Zhao, X
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powerline system ,UAV Lidar ,three-dimensional model ,multi-source data fusion ,point cloud - Abstract
China Southern Power Grid Key Technology of High Performance Integrated Small Intelligent Transmission UAV (GDKJXM20198187).
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- 2022
17. Search for relativistic fractionally charged particles in space
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DAMPE Collaboration, Alemanno, F., Altomare, C., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cai, M. S., Casilli, E., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., De-Benedittis, A., De Mitri, I., de Palma, F., Deliyergiyev, M., Di Giovanni, A., Di Santo, M., Ding, Q., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Fang, K., Feng, C. Q., Feng, L., Alonso, M. F., Frieden, J. M., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, L. Y., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, W. L., Li, W. H., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Salinas, M. M., Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Qiao, R., Rao, J. N., Ruina, A., Shangguan, Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, H. R., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, J. Z., Wang, L. G., Wang, S., Wang, S. X., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xia, Z. Q., Xu, E. H., Xu, H. T., Xu, J., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, S. X., Zhang, W. Z., Zhang, Yan, Zhang, Yi., Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhu, Y., Alemanno, F., Altomare, C., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cai, M. S., Casilli, E., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., De Benedittis, A., De Mitri, I., de Palma, F., Deliyergiyev, M., Di Giovanni, A., Di Santo, M., Ding, Q., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., D’Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Fang, K., Feng, C. Q., Feng, L., Alonso, M. F., Frieden, J. M., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, L. Y., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, W. L., Li, W. H., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Salinas, M. M., Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Qiao, R., Rao, J. N., Ruina, A., Shangguan, Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, H. R., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, J. Z., Wang, L. G., Wang, S., Wang, S. X., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xia, Z. Q., Xu, E. H., Xu, H. T., Xu, J., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, S. X., Zhang, W. Z., Zhang, Yan, Zhang, Yi., Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.
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High Energy Astrophysical Phenomena (astro-ph.HE) ,monopoles ,High Energy Physics - Phenomenology ,High Energy Physics - Experiment (hep-ex) ,High Energy Physics - Phenomenology (hep-ph) ,Physics - Space Physics ,FOS: Physical sciences ,calibration ,Astrophysics - High Energy Astrophysical Phenomena ,electric charge ,Space Physics (physics.space-ph) ,plastic scintillator detector ,High Energy Physics - Experiment - Abstract
More than a century after the performance of the oil drop experiment, the possible existence of fractionally charged particles FCP still remains unsettled. The search for FCPs is crucial for some extensions of the Standard Model in particle physics. Most of the previously conducted searches for FCPs in cosmic rays were based on experiments underground or at high altitudes. However, there have been few searches for FCPs in cosmic rays carried out in orbit other than AMS-01 flown by a space shuttle and BESS by a balloon at the top of the atmosphere. In this study, we conduct an FCP search in space based on on-orbit data obtained using the DArk Matter Particle Explorer (DAMPE) satellite over a period of five years. Unlike underground experiments, which require an FCP energy of the order of hundreds of GeV, our FCP search starts at only a few GeV. An upper limit of $6.2\times 10^{-10}~~\mathrm{cm^{-2}sr^{-1} s^{-1}}$ is obtained for the flux. Our results demonstrate that DAMPE exhibits higher sensitivity than experiments of similar types by three orders of magnitude that more stringently restricts the conditions for the existence of FCP in primary cosmic rays., Comment: 19 pages, 6 figures, accepted by PRD
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- 2022
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18. Scintillator ageing of the T2K near detectors from 2010 to 2021
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Abe, K., Akhlaq, N., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Ban, S., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Bench, F., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Buizza Avanzini, M., Calabria, N. F., Cao, S., Carter, A. J., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Christodoulou, G., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Ershova, A., Fedotov, S., Fernandez, P., Finch, A. J., Fiorentini Aguirre, G. A., Fiorillo, G., Friend, M., Fujii, Y., Fukuda, Y., Fusshoeller, K., Giganti, C., Glagolev, V., Gonin, M., Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hatzikoutelis, A., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, J., Holin, A., Holvey, T. J., Hong Van, N. T., Honjo, T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Ives, S. J., Iwamoto, K., Izmaylov, A., Izumi, N., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesus-Valls, C., Jiang, J. J., Jonsson, P., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katayama, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kikutani, H., King, S., Kisiel, J., Knight, A., Kobata, T., Kobayashi, T., Koch, L., Kogan, G., Konaka, A., Kormos, L. L., Koshio, Y., Kostin, A., Kowalik, K., Kudenko, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lachner, K., Lagoda, J., Lakshmi, S. M., Lamers James, M., Lamont, I., Lamoureux, M., Last, D., Latham, N., Laveder, M., Lawe, M., Lee, Y., Lin, C., Lindner, T., Lin, S. -K., Litchfield, R. P., Liu, S. L., Longhin, A., Long, K. R., Ludovici, L., Lu, X., Lux, T., Machado, L. N., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., Mccauley, N., Mcelwee, J., Mcfarland, K. S., Mcgrew, C., Mefodiev, A., Megias, G. D., Mellet, L., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Molina Bueno, L., Moriyama, S., Mueller, T. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimura, Y., Nishizaki, K., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Ogawa, T., Okada, R., Okumura, K., Okusawa, T., Owen, R. A., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Parsa, S., Pasternak, J., Pavin, M., Payne, D., Penn, G. G., Perkin, J. D., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sanchez, F., Santucci, G., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Skwarczynski, K., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Spina, R., Su, H., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Takayasu, S., Takeda, A., Takeuchi, Y., Tanaka, H. K., Tanihara, Y., Tani, M., Tereshchenko, V. V., Teshima, N., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vacheret, A., Vagins, M., Vallari, Z., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., Vladisavljevic, T., Wachala, T., Waldron, A. V., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Y. -H., Xu, Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., Zsoldos, S., Medical Research Council (MRC), Abe, K., Akhlaq, N., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Ban, S., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Bench, F., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Buizza Avanzini, M., Calabria, N. F., Cao, S., Carter, A. J., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Christodoulou, G., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Ershova, A., Fedotov, S., Fernandez, P., Finch, A. J., Fiorentini Aguirre, G. A., Fiorillo, G., Friend, M., Fujii, Y., Fukuda, Y., Fusshoeller, K., Giganti, C., Glagolev, V., Gonin, M., Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hatzikoutelis, A., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, J., Holin, A., Holvey, T. J., Hong Van, N. T., Honjo, T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Ives, S. J., Iwamoto, K., Izmaylov, A., Izumi, N., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, J. J., Jonsson, P., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katayama, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kikutani, H., King, S., Kisiel, J., Knight, A., Kobata, T., Kobayashi, T., Koch, L., Kogan, G., Konaka, A., Kormos, L. L., Koshio, Y., Kostin, A., Kowalik, K., Kudenko, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lachner, K., Lagoda, J., Lakshmi, S. M., Lamers James, M., Lamont, I., Lamoureux, M., Last, D., Latham, N., Laveder, M., Lawe, M., Lee, Y., Lin, C., Lindner, T., Lin, S. -K., Litchfield, R. P., Liu, S. L., Longhin, A., Long, K. R., Ludovici, L., Lu, X., Lux, T., Nascimento Machado, L., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., Mccauley, N., Mcelwee, J., Mcfarland, K. S., Mcgrew, C., Mefodiev, A., Megias, G. D., Mellet, L., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Molina Bueno, L., Moriyama, S., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimura, Y., Nishizaki, K., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Ogawa, T., Okada, R., Okumura, K., Okusawa, T., Owen, R. A., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Parsa, S., Pasternak, J., Pavin, M., Payne, D., Penn, G. C., Perkin, J. D., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sánchez, F., Santucci, G., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Skwarczynski, K., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Spina, R., Su, H., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Takayasu, S., Takeda, A., Takeuchi, Y., Tanaka, H. K., Tanihara, Y., Tani, M., Tereshchenko, V. V., Teshima, N., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vacheret, A., Vagins, M., Vallari, Z., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., Vladisavljevic, T., Wachala, T., Waldron, A. V., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Xu, Y. -h., Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., Zsoldos, S., Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), T2K, and ANR-19-CE31-0001,SUNCORE,Incertitudes systématiques dans les combinaisons de résultats d'oscillations de neutrinos(2019)
- Subjects
Technology ,Physics - Instrumentation and Detectors ,gas and liquid scintillators) ,FOS: Physical sciences ,scintillation counter: plastics ,KAMIOKANDE ,Gamma detectors (scintillators, CZT, HPGe, HgI etc) ,Neutrino detectors ,Performance of High Energy Physics Detectors ,Scintillators ,scintillation and light emission processes (solid, gas and liquid scintillators) ,09 Engineering ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,near detector ,Hgl etc) ,performance: time dependence ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,AXIS ,Detectors and Experimental Techniques ,Instrumentation ,Instruments & Instrumentation ,physics.ins-det ,activity report ,Mathematical Physics ,radiation: damage ,HgI etc) ,wavelength shifter: fibre ,Science & Technology ,02 Physical Sciences ,hep-ex ,J-PARC Lab ,Instrumentation and Detectors (physics.ins-det) ,Gamma detectors Neutrino detectors Performance of High Energy Physics Detectors Scintillators Scintillation and light emission processes ,Nuclear & Particles Physics ,CZT ,scintillation and light emission processes (solid ,photon: yield ,HPGe ,Particle Physics - Experiment ,Gamma detectors (scintillators - Abstract
The T2K experiment widely uses plastic scintillator as a target for neutrino interactions and an active medium for the measurement of charged particles produced in neutrino interactions at its near detector complex. Over 10 years of operation the measured light yield recorded by the scintillator based subsystems has been observed to degrade by 0.9--2.2\% per year. Extrapolation of the degradation rate through to 2040 indicates the recorded light yield should remain above the lower threshold used by the current reconstruction algorithms for all subsystems. This will allow the near detectors to continue contributing to important physics measurements during the T2K-II and Hyper-Kamiokande eras. Additionally, work to disentangle the degradation of the plastic scintillator and wavelength shifting fibres shows that the reduction in light yield can be attributed to the ageing of the plastic scintillator., Comment: 29 pages, 18 figures. Prepared for submission to JINST
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- 2022
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19. Multi‐Centennial Variability of Yangtze Delta Growth Over the Last 2000 Years: Interplay of Climate and People
- Author
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Nian, X, Zhang, W, Wang, X, Hutchinson, SM, Zhao, X, and Liu, K
- Subjects
Earth and Planetary Sciences (miscellaneous) ,General Environmental Science - Abstract
Reconstruction of sediment accumulation in river deltas over the Holocene provides a basis for understanding the relationship between climate change, human activities and delta growth. However, variations in deposition rates on a centennial‐scale over the last 2000 years remain poorly studied for mega‐deltas. Based on optically stimulated luminescence and AMS 14C ages, we calculated deposited sediment volumes in the Yangtze River Delta (YRD) for 500‐year intervals over the last two millennia for the first time. Our results reveal that the 2.0–1.5 and 0.5–0 ka periods had higher sediment deposition rates than in 1.5–1.0 and 1.0–0.5 ka, with maximum value about two times that of the minimum. A comparison with historical records of flooding and drought events indicates that a wetter climate led to a higher sediment deposition, reflecting the role of fluvial discharge in delta growth. However, the highest sediment deposition (205 ± 29 × 106 m3/a) over the last 500 years is not only related to the wetter conditions of the Little Ice Age, but also linked to dramatic regional population growth. We suggest that human activities have predominated over natural forcing in determining the deltaic growth over the last five centuries. Taking the Medieval Climate Anomaly with the lowest deposition volume as an analog of current climate warming, and considering the decline in sediment loads due to recent damming and soil conservation, the YRD is likely to face an even more severe deficit in sediment supply and higher risk of delta destruction in the coming centuries.
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- 2022
20. Death in hospital following ICU discharge: insights from the LUNG SAFE study
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Madotto F., McNicholas B., Rezoagli E., Pham T., Laffey J. G., Bellani G., Pesenti A., Brochard L., Esteban A., Gattinoni L., van Haren F., Ranieri M., Rubenfeld G., Thompson B. T., Slutsky A. S., Rios F., Faruq M. O., Sottiaux T., Depuydt P., Lora F. S., Azevedo C. C., Fan E., Bugedo G., Qiu H., Gonzalez M., Silesky J., Cerny V., Nielsen J., Jibaja M., Wrigge H., Matamis D., Ranero J. L., Gomersall C., Amin P., Hashemian S. M., Clarkson K., Kurahashi K., Koh Y., Villagomez A., Zeggwagh A. A., Heunks L. M., Laake J. H., Kashif W., Synclair J., Palo J. E., do Vale Fernandes A., Sandesc D., Arabi Y., Bumbasierevic V., Nin N., Lorente J. A., Larsson A., Piquilloud L., Patjanasoontorn B., Abroug F., McAuley D. F., McNamee L., Hurtado J., Bajwa E., Dempaire G., Francois G. M., Rabboni F., Conti S., Sula H., Nunci L., Cani A., Zazu A., Dellera C., Insaurralde C. S., Alejandro R. V., Daldin J., Vinzio M., Fernandez R. O., Cardonnet L. P., Bettini L. R., Bisso M. C., Osman E. M., Setten M. G., Lovazzano P., Alvarez J., Villar V., Pozo N. C., Grubissich N., Plotnikow G. A., Vasquez D. N., Ilutovich S., Tiribelli N., Chena A., Pellegrini C. A., Saenz M. G., Estenssoro E., Brizuela M., Gianinetto H., Gomez P. E., Cerrato V. I., Bezzi M. G., Borello S. A., Loiacono F. A., Fernandez A. M., Knowles S., Reynolds C., Inskip D. M., Miller J. J., Kong J., Whitehead C., Bihari S., Seven A., Krstevski A., Rodgers H. J., Millar R. T., Mckenna T. E., Bailey I. M., Hanlon G. C., Aneman A., Lynch J. M., Azad R., Neal J., Woods P. W., Roberts B. L., Kol M. R., Wong H. S., Riss K. C., Staudinger T., Wittebole X., Berghe C., Bulpa P. A., Dive A. M., Verstraete R., Lebbinck H., Vermassen J., Meersseman P., Ceunen H., Rosa J. I., Beraldo D. O., Piras C., Rampinelli A. M., Nassar N. P., Mataloun S., Moock M., Thompson M. M., Goncalves C. H., Antonio A. C. P., Ascoli A., Biondi R. S., Fontenele D. C., Nobrega D., Sales V. M., Shindhe S., Aiman D. M., Ismail B. P. H., Laffey J., Beloncle F., Davies K. G., Cirone R., Manoharan V., Ismail M., Goligher E. C., Jassal M., Ferguson N. D., Nishikawa E., Javeed A., Curley G., Rittayamai N., Parotto M., Mehta S., Knoll J., Pronovost A., Canestrini S., Bruhn A. R., Garcia P. H., Aliaga F. A., Farias P. A., Yumha J. S., Ortiz C. A., Salas J. E., Saez A. A., Vega L. D., Labarca E. F., Martinez F. T., Carreno N. G., Lora P., Liu H., Liu L., Tang R., Luo X., An Y., Zhao H., Gao Y., Zhai Z., Ye Z. L., Wang W., Li W., Li Q., Zheng R., Yu W., Shen J., Li X., Yu T., Lu W., Wu Y. Q., Huang X. B., He Z., Lu Y., Han H., Zhang F., Sun R., Wang H. X., Qin S. H., Zhu B. H., Zhao J., Liu J., Li B., Liu J. L., Zhou F. C., Li Q. J., Zhang X. Y., Li-Xin Z., Xin-Hua Q., Jiang L., Gao Y. N., Zhao X. Y., Li Y. Y., Li X. L., Wang C., Yao Q., Yu R., Chen K., Shao H., Qin B., Huang Q. Q., Zhu W. H., Hang A. Y., Hua M. X., Li Y., Xu Y., Di Y. D., Ling L. L., Qin T. H., Wang S. H., Qin J., Han Y., Zhou S., Vargas M. P., Jimenez J. I. S., Rojas M. A. G., Solis-Quesada J. E., Ramirez-Alfaro C. M., Maca J., Sklienka P., Gjedsted J., Christiansen A., Villamagua B. G., Llano M., Burtin P., Buzancais G., Beuret P., Pelletier N., Mortaza S., Mercat A., Chelly J., Jochmans S., Terzi N., Daubin C., Carteaux G., de Prost N., Chiche J. -D., Daviaud F., Fartoukh M., Barberet G., Biehler J., Dellamonica J., Doyen D., Arnal J. -M., Briquet A., Klasen F., Papazian L., Follin A., Roux D., Messika J., Kalaitzis E., Dangers L., Combes A., Au S. -M., Beduneau G., Carpentier D., Zogheib E. H., Dupont H., Ricome S., Santoli F. L., Besset S. L., Michel P., Gelee B., Danin P. -E., Goubaux B., Crova P. J., Phan N. T., Berkelmans F., Badie J. C., Tapponnier R., Gally J., Khebbeb S., Herbrecht J. -E., Schneider F., Declercq P. -L. M., Rigaud J. -P., Duranteau J., Harrois A., Chabanne R., Marin J., Constantin J. -M., Thibault S., Ghazi M., Boukhazna M., Zein S. O., Richecoeur J. R., Combaux D. M., Grelon F., Le Moal C., Sauvadet E. P., Robine A., Lemiale V., Reuter D., Dres M., Demoule A., Goldgran-Toledano D., Baboi L., Guerin C., Lohner R., Krassler J., Schafer S., Zacharowski K. D., Meybohm P., Reske A. W., Simon P., Hopf H. -B. F., Schuetz M., Baltus T., Papanikolaou M. N., Papavasilopoulou T. G., Zacharas G. A., Ourailogloy V., Mouloudi E. K., Massa E. V., Nagy E. O., Stamou E. E., Kiourtzieva E. V., Oikonomou M. A., Avila L. E., Cortez C. A., Citalan J. E., Jog S. A., Sable S. D., Shah B., Gurjar M., Baronia A. K., Memon M., Muthuchellappan R., Ramesh V. J., Shenoy A., Unnikrishnan R., Dixit S. B., Rhayakar R. V., Ramakrishnan N., Bhardwaj V. K., Mahto H. L., Sagar S. V., Palaniswamy V., Ganesan D., Jamaati H., Heidari F., Meaney E. A., Nichol A., Knapman K. M., O'Croinin D., Dunne E. S., Breen D. M., Clarkson K. P., Jaafar R. F., Dwyer R., Amir F., Ajetunmobi O. O., O'Muircheartaigh A. C., Black C. S., Treanor N., Collins D. V., Altaf W., Zani G., Fusari M., Spadaro S., Volta C. A., Graziani R., Brunettini B., Palmese S., Formenti P., Umbrello M., Lombardo A., Pecci E., Botteri M., Savioli M., Protti A., Mattei A., Schiavoni L., Tinnirello A., Todeschini M., Giaccone P. P., Giarratano A., Cortegiani A., Sher S., Rossi A., Antonelli M. M., Montini L. M., Casalena P., Scafetti S., Panarello G., Occhipinti G., Patroniti N., Pozzi M., Biscione R. R., Poli M. M., Raimondi F., Albiero D., Crapelli G., Beck E., Pota V., Schiavone V., Molin A., Tarantino F., Monti G., Frati E., Mirabella L., Cinnella G., Fossali T., Colombo R., Pattarino P. T. I., Mojoli F., Braschi A., Borotto E. E., Cracchiolo A. N., Palma D. M., Raponi F., Foti G., Vascotto E. R., Coppadoro A., Brazzi L., Floris L., Iotti G. A., Venti A., Yamaguchi O., Takagi S., Maeyama H. 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S., Kennedy B., Parhar K., Srinivasa L., McAuley D., Hopkins P., Mellis C., Kakar V., Hadfield D., Vercueil A., Bhowmick K., Humphreys S. K., Ferguson A., Mckee R., Raj A. S., Fawkes D. A., Watt P., Twohey L., Thomas R. R. J. M., Morton A., Kadaba V., Smith M. J., Hormis A. P., Kannan S. G., Namih M., Reschreiter H., Camsooksai J., Kumar A., Rugonfalvi S., Nutt C., Oneill O., Seasman C., Dempsey G., Scott C. J., Ellis H. E., Mckechnie S., Hutton P. J., Di Tomasso N. N., Vitale M. N., Griffin R. O., Dean M. N., Cranshaw J. H., Willett E. L., Ioannou N., Gillis S., Csabi P., Macfadyen R., Dawson H., Preez P. D., Williams A. J., Boyd O., De Gordoa L. O. -R., Bramall J., Symmonds S., Chau S. K., Wenham T., Szakmany T., Toth-Tarsoly P., Mccalman K. H., Alexander P., Stephenson L., Collyer T., Chapman R., Cooper R., Allan R. M., Sim M., Wrathall D. W., Irvine D. A., Zantua K. S., Adams J. C., Burtenshaw A. J., Sellors G. P., Welters I. D., Williams K. E., Hessell R. J., Oldroyd M. G., Battle C. E., Pillai S., Kajtor I., Sivashanmugavel M., Okane S. C., Donnelly A., Frigyik A. D., Careless J. P., May M. M., Stewart R., Trinder T. J., Hagan S. J., Wise M. P., Cole J. M., MacFie C. C., Dowling A. T., Nunez E., Pittini G., Rodriguez R., Imperio M. C., Santos C., Deicas A., Serra C., Uppalapati A., Kamel G., Banner-Goodspeed V. M., Beitler J. R., Mukkera S. R., Kulkarni S., Lee J., Mesar T., Shinn Iii J. O., Gomaa D., Tainter C., Yeatts D. J., Warren J., Lanspa M. J., Miller R. R., Grissom C. K., Brown S. M., Bauer P. R., Gosselin R. J., Kitch B. T., Cohen J. E., Beegle S. H., Gueret R. M., Tulaimat A., Choudry S., Stigler W., Batra H., Huff N. G., Lamb K. D., Oetting T. W., Mohr N. M., Judy C., Saito S., Kheir F. M., Kheir F., Schlichting A. B., Delsing A., Crouch D. R., Elmasri M., Ismail D., Dreyer K. R., Blakeman T. C., Baron R. M., Grijalba C. Q., Hou P. C., Seethala R., Aisiku I., Henderson G., Frendl G., Hou S. -K., Owens R. L., Schomer A., Bumbasirevic V., Jovanovic B., Surbatovic M., Veljovic M., Madotto, F., Mcnicholas, B., Rezoagli, E., Pham, T., Laffey, J. G., Bellani, G., Pesenti, A., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Ranieri, M., Rubenfeld, G., Thompson, B. T., Slutsky, A. S., Rios, F., Faruq, M. O., Sottiaux, T., Depuydt, P., Lora, F. S., Azevedo, C. C., Fan, E., Bugedo, G., Qiu, H., Gonzalez, M., Silesky, J., Cerny, V., Nielsen, J., Jibaja, M., Wrigge, H., Matamis, D., Ranero, J. L., Gomersall, C., Amin, P., Hashemian, S. M., Clarkson, K., Kurahashi, K., Koh, Y., Villagomez, A., Zeggwagh, A. A., Heunks, L. M., Laake, J. H., Kashif, W., Synclair, J., Palo, J. E., do Vale Fernandes, A., Sandesc, D., Arabi, Y., Bumbasierevic, V., Nin, N., Lorente, J. A., Larsson, A., Piquilloud, L., Patjanasoontorn, B., Abroug, F., Mcauley, D. F., Mcnamee, L., Hurtado, J., Bajwa, E., Dempaire, G., Francois, G. 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M., Martinho, A. M., Tomescu, D. R., Marcu, A., Bedreag, O. H., Papurica, M., Corneci, D. E., Negoita, S. I., Grigoriev, E., Gritsan, A. I., Gazenkampf, A. A., Almekhlafi, G., Albarrak, M. M., Mustafa, G. M., Maghrabi, K. A., Salahuddin, N., Aisa, T. M., Al Jabbary, A. S., Tabhan, E., Arabi, Y. M., Trinidad, O. A., Al Dorzi, H. M., Tabhan, E. E., Bolon, S., Smith, O., Mancebo, J., Aguirre-Bermeo, H., Lopez-Delgado, J. C., Esteve, F., Rialp, G., Forteza, C., De Haro, C., Artigas, A., Albaiceta, G. M., De Cima-Iglesias, S., Seoane-Quiroga, L., Ceniceros-Barros, A., Ruiz-Aguilar, A. L., Claraco-Vega, L. M., Soler, J. A., del Carmen Lorente, M., Hermosa, C., Gordo, F., Prieto-Gonzalez, M., Lopez-Messa, J. B., Perez, M. P., Perez, C. P., Allue, R. M., Roche-Campo, F., Ibanez-Santacruz, M., Temprano, S., Pintado, M. C., De Pablo, R., Gomez, P. R. A., Ruiz, S. R., Moles, S. I., Jurado, M. ªT., Arizmendi, A., Piacentini, E. A., Franco, N., Honrubia, T., Cheng, M. P., Losada, E. P., Blanco, J., Yuste, L. J., Carbayo-Gorriz, C., Cazorla-Barranquero, F. G., Alonso, J. G., Alda, R. S., Algaba, A., Navarro, G., Cereijo, E., Diaz-Rodriguez, E., Marcos, D. P., Montero, L. A., Para, L. H., Sanchez, R. J., Navalpotro, M. A. B., Abad, R. D., Lez, R. M. G. A., Toribio, D. P., Castro, A. G., Artiga, M. J. D., Penuelas, O., Roser, T. P., Olga, M. F., Curto, E. G., Sanchez, R. M., Imma, V. P., Elisabet, G. M., Claverias, L., Magret, M., Pellicer, A. M., Rodriguez, L. L., Sanchez-Ballesteros, J., Gonzalez-Salamanca, A., Jimenez, A. G., Huerta, F. P., Diaz, J. C. J. S., Lopez, E. B., Moya, D. D. L., Alfonso, A. A. T., Luis, P. S. E., Cesar, P. S., Rafael, S. I., Virgilio, C. G., Recio, N. N., Adamsson, R. O., Rylander, C. C., Holzgraefe, B., Broman, L. M., Wessbergh, J., Persson, L., Schioler, F., Kedelv, H., Tibblin, A. O., Appelberg, H., Hedlund, L., Helleberg, J., Eriksson, K. E., Glietsch, R., Larsson, N., Nygren, I., Nunes, S. L., Morin, A. -K., Kander, T., Adolfsson, A., Zender, H. O., Leemann-Refondini, C., Elatrous, S., Bouchoucha, S., Chouchene, I., Ouanes, I., Marsa, L., Souissi, A. B., Kamoun, S., Demirkiran, O., Aker, M., Erbabacan, E., Ceylan, I., Girgin, N. K., Ozcelik, M., Unal, N., Meco, B. C., Akyol, O. O., Derman, S. S., Kennedy, B., Parhar, K., Srinivasa, L., Mcauley, D., Hopkins, P., Mellis, C., Kakar, V., Hadfield, D., Vercueil, A., Bhowmick, K., Humphreys, S. K., Ferguson, A., Mckee, R., Raj, A. S., Fawkes, D. A., Watt, P., Twohey, L., Thomas, R. R. J. M., Morton, A., Kadaba, V., Smith, M. J., Hormis, A. P., Kannan, S. G., Namih, M., Reschreiter, H., Camsooksai, J., Kumar, A., Rugonfalvi, S., Nutt, C., Oneill, O., Seasman, C., Dempsey, G., Scott, C. J., Ellis, H. E., Mckechnie, S., Hutton, P. J., Di Tomasso, N. N., Vitale, M. N., Griffin, R. O., Dean, M. N., Cranshaw, J. H., Willett, E. L., Ioannou, N., Gillis, S., Csabi, P., Macfadyen, R., Dawson, H., Preez, P. D., Williams, A. J., Boyd, O., De Gordoa, L. O. -R., Bramall, J., Symmonds, S., Chau, S. K., Wenham, T., Szakmany, T., Toth-Tarsoly, P., Mccalman, K. H., Alexander, P., Stephenson, L., Collyer, T., Chapman, R., Cooper, R., Allan, R. M., Sim, M., Wrathall, D. W., Irvine, D. A., Zantua, K. S., Adams, J. C., Burtenshaw, A. J., Sellors, G. P., Welters, I. D., Williams, K. E., Hessell, R. J., Oldroyd, M. G., Battle, C. E., Pillai, S., Kajtor, I., Sivashanmugavel, M., Okane, S. C., Donnelly, A., Frigyik, A. D., Careless, J. P., May, M. M., Stewart, R., Trinder, T. J., Hagan, S. J., Wise, M. P., Cole, J. M., Macfie, C. C., Dowling, A. T., Nunez, E., Pittini, G., Rodriguez, R., Imperio, M. C., Santos, C., Deicas, A., Serra, C., Uppalapati, A., Kamel, G., Banner-Goodspeed, V. M., Beitler, J. R., Mukkera, S. R., Kulkarni, S., Lee, J., Mesar, T., Shinn Iii, J. O., Gomaa, D., Tainter, C., Yeatts, D. J., Warren, J., Lanspa, M. J., Miller, R. R., Grissom, C. K., Brown, S. M., Bauer, P. R., Gosselin, R. J., Kitch, B. T., Cohen, J. E., Beegle, S. H., Gueret, R. M., Tulaimat, A., Choudry, S., Stigler, W., Batra, H., Huff, N. G., Lamb, K. D., Oetting, T. W., Mohr, N. M., Judy, C., Saito, S., Kheir, F. M., Kheir, F., Schlichting, A. B., Delsing, A., Crouch, D. R., Elmasri, M., Ismail, D., Dreyer, K. R., Blakeman, T. C., Baron, R. M., Grijalba, C. Q., Hou, P. C., Seethala, R., Aisiku, I., Henderson, G., Frendl, G., Hou, S. -K., Owens, R. L., Schomer, A., Bumbasirevic, V., Jovanovic, B., Surbatovic, M., Veljovic, M., UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, UCL - (SLuc) Service de soins intensifs, Investigators, LUNG SAFE, Group, ESICM Trials, Madotto, F, Mcnicholas, B, Rezoagli, E, Pham, T, Laffey, J, Bellani, G, Pesenti, A, Brochard, L, Esteban, A, Gattinoni, L, van Haren, F, Ranieri, M, Rubenfeld, G, Thompson, B, Slutsky, A, Rios, F, Faruq, M, Sottiaux, T, Depuydt, P, Lora, F, Azevedo, C, Fan, E, Bugedo, G, Qiu, H, Gonzalez, M, Silesky, J, Cerny, V, Nielsen, J, Jibaja, M, Wrigge, H, Matamis, D, Ranero, J, Gomersall, C, Amin, P, Hashemian, S, Clarkson, K, Kurahashi, K, Koh, Y, Villagomez, A, Zeggwagh, A, Heunks, L, Laake, J, Kashif, W, Synclair, J, Palo, J, do Vale Fernandes, A, Sandesc, D, Arabi, Y, Bumbasierevic, V, Nin, N, Lorente, J, Larsson, A, Piquilloud, L, Patjanasoontorn, B, Abroug, F, Mcauley, D, Mcnamee, L, Hurtado, J, Bajwa, E, Dempaire, G, Francois, G, 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Vladimir Cerny, Jonas Nielsen, Manuel Jibaja, Tài Pham, Hermann Wrigge, Dimitrios Matamis, Jorge Luis Ranero, Charles Gomersall, Pravin Amin, S M Hashemian, Kevin Clarkson, Giacomo Bellani, Kiyoyasu Kurahashi, Younsuck Koh, Asisclo Villagomez, Amine Ali Zeggwagh, Leo M Heunks, Jon Henrik Laake, Waqar Kashif, Jorge Synclair, Jose Emmanuel Palo, Antero do Vale Fernandes, Dorel Sandesc, Yaasen Arabi, Vesna Bumbasierevic, Nicolas Nin, Jose A Lorente, Anders Larsson, Lise Piquilloud, Boonsong Patjanasoontorn, Fekri Abroug, Daniel F McAuley, Lia McNamee, Javier Hurtado, Ed Bajwa, Gabriel Démpaire, Guy M Francois, Francesca Rabboni, Fabiana Madotto, Sara Conti, Hektor Sula, Lordian Nunci, Alma Cani, Alan Zazu, Christian Dellera, Carolina S Insaurralde, Risso V Alejandro, Julio Daldin, Mauricio Vinzio, Ruben O Fernandez, Luis P Cardonnet, Lisandro R Bettini, Mariano Carboni Bisso, Emilio M Osman, Mariano G Setten, Pablo Lovazzano, Javier Alvarez, Veronica Villar, Norberto C Pozo, Nicolas 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Gonçalves, Ana Carolina P Antônio, Aline Ascoli, Rodrigo S Biondi, Danielle C Fontenele, Danielle Nobrega, Vanessa M Sales, Suresh Shindhe, Dk Maizatul Aiman, BPg Hj Ismail, John Laffey, Francois Beloncle, Kyle G Davies, Rob Cirone, Venika Manoharan, Mehvish Ismail, Ewan C Goligher, Mandeep Jassal, Niall D Ferguson, Erin Nishikawa, Areej Javeed, Gerard Curley, Nuttapol Rittayamai, Matteo Parotto, Sangeeta Mehta, Jenny Knoll, Antoine Pronovost, Sergio Canestrini, Alejandro R Bruhn, Patricio H Garcia, Felipe A Aliaga, Pamela A Farías, Jacob S Yumha, Claudia A Ortiz, Javier E Salas, Alejandro A Saez, Luis D Vega, Eduardo F Labarca, Felipe T Martinez, Nicolás G Carreño, Pilar Lora, Haitao Liu, Haibo Qiu, Ling Liu, Rui Tang, Xiaoming Luo, Youzhong An, Huiying Zhao, Yan Gao, Zhe Zhai, Zheng L Ye, Wei Wang, Wenwen Li, Qingdong Li, Ruiqiang Zheng, Wenkui Yu, Juanhong Shen, Xinyu Li, Tao Yu, Weihua Lu, Ya Q Wu, Xiao B Huang, Zhenyang He, Yuanhua Lu, Hui Han, Fan Zhang, Renhua Sun, Hua X Wang, 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Anais Briquet, Fanny Klasen, Laurent Papazian, Arnaud Follin, Damien Roux, Jonathan Messika, Evangelos Kalaitzis, Laurence Dangers, Alain Combes, Siu-Ming Au, Gaetan Béduneau, Dorothée Carpentier, Elie H Zogheib, Herve Dupont, Sylvie Ricome, Francesco L Santoli, Sebastien L Besset, Philippe Michel, Bruno Gelée, Pierre-Eric Danin, Bernard Goubaux, Philippe J Crova, Nga T Phan, Frantz Berkelmans, Julio C Badie, Romain Tapponnier, Josette Gally, Samy Khebbeb, Jean-Etienne Herbrecht, Francis Schneider, Pierre-Louis M Declercq, Jean-Philippe Rigaud, Jacques Duranteau, Anatole Harrois, Russell Chabanne, Julien Marin, Jean-Michel Constantin, Sandrine Thibault, Mohammed Ghazi, Messabi Boukhazna, Salem Ould Zein, Jack R Richecoeur, Daniele M Combaux, Fabien Grelon, Charlene Le Moal, Elise P Sauvadet, Adrien Robine, Virginie Lemiale, Danielle Reuter, Martin Dres, Alexandre Demoule, Dany Goldgran-Toledano, Loredana Baboi, Claude Guérin, Ralph Lohner, Jens Kraßler, Susanne Schäfer, Kai D Zacharowski, Patrick Meybohm, Andreas W Reske, Philipp Simon, Hans-Bernd F Hopf, Michael Schuetz, Thomas Baltus, Metaxia N Papanikolaou, Theonymfi G Papavasilopoulou, Giannis A Zacharas, Vasilis Ourailogloy, Eleni K Mouloudi, Eleni V Massa, Eva O Nagy, Electra E Stamou, Ellada V Kiourtzieva, Marina A Oikonomou, Luis E Avila, Cesar A Cortez, Johanna E Citalán, Sameer A Jog, Safal D Sable, Bhagyesh Shah, Mohan Gurjar, Arvind K Baronia, Mohammedfaruk Memon, Radhakrishnan Muthuchellappan, Venkatapura J Ramesh, Anitha Shenoy, Ramesh Unnikrishnan, Subhal B Dixit, Rachana V Rhayakar, Nagarajan Ramakrishnan, Vallish K Bhardwaj, Heera L Mahto, Sudha V Sagar, Vijayanand Palaniswamy, Deeban Ganesan, Seyed Mohammadreza Hashemian, Hamidreza Jamaati, Farshad Heidari, Edel A Meaney, Alistair Nichol, Karl M Knapman, Donall O'Croinin, Eimhin S Dunne, Dorothy M Breen, Kevin P Clarkson, Rola F Jaafar, Rory Dwyer, Fahd Amir, Olaitan O Ajetunmobi, Aogan C O'Muircheartaigh, Colin S Black, Nuala Treanor, Daniel V Collins, Wahid Altaf, Gianluca Zani, Maurizio Fusari, Savino Spadaro, Carlo A Volta, Romano Graziani, Barbara Brunettini, Salvatore Palmese, Paolo Formenti, Michele Umbrello, Andrea Lombardo, Elisabetta Pecci, Marco Botteri, Monica Savioli, Alessandro Protti, Alessia Mattei, Lorenzo Schiavoni, Andrea Tinnirello, Manuel Todeschini, Antonino Giarratano, Andrea Cortegiani, Sara Sher, Anna Rossi, Massimo M Antonelli, Luca M Montini, Paolo Casalena, Sergio Scafetti, Giovanna Panarello, Giovanna Occhipinti, Nicolò Patroniti, Matteo Pozzi, Roberto R Biscione, Michela M Poli, Ferdinando Raimondi, Daniela Albiero, Giulia Crapelli, Eduardo Beck, Vincenzo Pota, Vincenzo Schiavone, Alexandre Molin, Fabio Tarantino, Giacomo Monti, Elena Frati, Lucia Mirabella, Gilda Cinnella, Tommaso Fossali, Riccardo Colombo, Pierpaolo Terragni Ilaria Pattarino, Francesco Mojoli, Antonio Braschi, Erika E Borotto, Andrea N Cracchiolo, Daniela M Palma, Francesco Raponi, Giuseppe Foti, Ettore R Vascotto, Andrea Coppadoro, Luca Brazzi, Leda Floris, Giorgio A Iotti, Aaron Venti, Osamu Yamaguchi, Shunsuke Takagi, Hiroki N Maeyama, Eizo Watanabe, Yoshihiro Yamaji, Kazuyoshi Shimizu, Kyoko Shiozaki, Satoru Futami, Sekine Ryosuke, Koji Saito, Yoshinobu Kameyama, Keiko Ueno, Masayo Izawa, Nao Okuda, Hiroyuki Suzuki, Tomofumi Harasawa, Michitaka Nasu, Tadaaki Takada, Fumihito Ito, Shin Nunomiya, Kansuke Koyama, Toshikazu Abe, Kohkichi Andoh, Kohei Kusumoto, Akira Hirata, Akihiro Takaba, Hiroyasu Kimura, Shuhei Matsumoto, Ushio Higashijima, Hiroyuki Honda, Nobumasa Aoki, Hiroshi Imai, Yasuaki Ogino, Ichiko Mizuguchi, Kazuya Ichikado, Kenichi Nitta, Katsunori Mochizuki, Tomoaki Hashida, Hiroyuki Tanaka, Tomoyuki Nakamura, Daisuke Niimi, Takeshi Ueda, Yozo Kashiwa, Akinori Uchiyama, Olegs Sabelnikovs, Peteris Oss, Youssef Haddad, Kong Y Liew, Silvio A Ñamendys-Silva, Yves D Jarquin-Badiola, Luis A Sanchez-Hurtado, Saira S Gomez-Flores, Maria C Marin, Asisclo J Villagomez, Jordana S Lemus, Jonathan M Fierro, Mavy Ramirez Cervantes, Francisco Javier Flores Mejia, Dulce Dector, Dulce M Dector, Daniel R Gonzalez, Claudia R Estrella, Jorge R Sanchez-Medina, Alvaro Ramirez-Gutierrez, Fernando G George, Janet S Aguirre, Juan A Buensuseso, Manuel Poblano, Mohammed V University, Tarek Dendane, Amine Ali Zeggwagh, Hicham Balkhi, Mina Elkhayari, Nacer Samkaoui, Hanane Ezzouine, Abdellatif Benslama, Mourad Amor, Wajdi Maazouzi, Nedim Cimic, Oliver Beck, Monique M Bruns, Jeroen A Schouten, Myra Rinia, Monique Raaijmakers, Leo M Heunks, Hellen M Van Wezel, Serge J Heines, Ulrich Strauch, Marc P Buise, Fabienne D Simonis, Marcus J Schultz, Jennifer C Goodson, Troy S Browne, Leanlove Navarra, Anna Hunt, Robyn A Hutchison, Mathew B Bailey, Lynette Newby, Colin Mcarthur, Michael Kalkoff, Alex Mcleod, Jonathan Casement, Danielle J Hacking, Finn H Andersen, Merete S Dolva, Jon H Laake, Andreas Barratt-Due, Kim Andre L Noremark, Eldar Søreide, Brit Å Sjøbø, Anne B Guttormsen, Hector H Leon Yoshido, Ronald Zumaran Aguilar, Fredy A Montes Oscanoa, Alain U Alisasis, Joanne B Robles, Rossini Abbie B Pasanting-Lim, Beatriz C Tan, Pawel Andruszkiewicz, Karina Jakubowska, Cristina M Coxo, António M Alvarez, Bruno S Oliveira, Gustavo M Montanha, Nelson C Barros, Carlos S Pereira, António M Messias, Jorge M Monteiro, Ana M Araujo, Nuno T Catorze, Susan M Marum, Maria J Bouw, Rui M Gomes, Vania A Brito, Silvia Castro, Joana M Estilita, Filipa M Barros, Isabel M Serra, Aurelia M Martinho, Dana R Tomescu, Alexandra Marcu, Ovidiu H Bedreag, Marius Papurica, Dan E Corneci, Silvius Ioan Negoita, Evgeny Grigoriev, Alexey I Gritsan, Andrey A Gazenkampf, Ghaleb Almekhlafi, Mohamad M Albarrak, Ghanem M Mustafa, Khalid A Maghrabi, Nawal Salahuddin, Tharwat M Aisa, Ahmed S Al Jabbary, Edgardo Tabhan, Yaseen M Arabi, Olivia A Trinidad, Hasan M Al Dorzi, Edgardo E Tabhan, Stefan Bolon, Oliver Smith, Jordi Mancebo, Hernan Aguirre-Bermeo, Juan C Lopez-Delgado, Francisco Esteve, Gemma Rialp, Catalina Forteza, Candelaria De Haro, Antonio Artigas, Guillermo M Albaiceta, Sara De Cima-Iglesias, Leticia Seoane-Quiroga, Alexandra Ceniceros-Barros, Antonio L Ruiz-Aguilar, Luis M Claraco-Vega, Juan Alfonso Soler, Maria Del Carmen Lorente, Cecilia Hermosa, Federico Gordo, Miryam Prieto-González, Juan B López-Messa, Manuel P Perez, Cesar P Perez, Raquel Montoiro Allue, Ferran Roche-Campo, Marcos Ibañez-Santacruz, Susana Temprano, Maria C Pintado, Raul De Pablo, Pilar Ricart Aroa Gómez, Silvia Rodriguez Ruiz, Silvia Iglesias Moles, Mª Teresa Jurado, Alfons Arizmendi, Enrique A Piacentini, Nieves Franco, Teresa Honrubia, Meisy Perez Cheng, Elena Perez Losada, Javier Blanco, Luis J Yuste, Cecilia Carbayo-Gorriz, Francisca G Cazorla-Barranquero, Javier G Alonso, Rosa S Alda, Ángela Algaba, Gonzalo Navarro, Enrique Cereijo, Esther Diaz-Rodriguez, Diego Pastor Marcos, Laura Alvarez Montero, Luis Herrera Para, Roberto Jimenez Sanchez, Miguel Angel Blasco Navalpotro, Ricardo Diaz Abad, Raquel Montiel Gonz Á Lez, Dácil Parrilla Toribio, Alejandro G Castro, Maria Jose D Artiga, Oscar Penuelas, Tomas P Roser, Moreno F Olga, Elena Gallego Curto, Rocío Manzano Sánchez, Vallverdu P Imma, Garcia M Elisabet, Laura Claverias, Monica Magret, Ana M Pellicer, Lucia L Rodriguez, Jesús Sánchez-Ballesteros, Ángela González-Salamanca, Antonio G Jimenez, Francisco P Huerta, Juan Carlos J Sotillo Diaz, Esther Bermejo Lopez, David D Llinares Moya, Alec A Tallet Alfonso, Palazon Sanchez Eugenio Luis, Palazon Sanchez Cesar, Sánchez I Rafael, Corcoles G Virgilio, Noelia N Recio, Richard O Adamsson, Christian C Rylander, Bernhard Holzgraefe, Lars M Broman, Joanna Wessbergh, Linnea Persson, Fredrik Schiöler, Hans Kedelv, Anna Oscarsson Tibblin, Henrik Appelberg, Lars Hedlund, Johan Helleberg, Karin E Eriksson, Rita Glietsch, Niklas Larsson, Ingela Nygren, Silvia L Nunes, Anna-Karin Morin, Thomas Kander, Anne Adolfsson, Lise Piquilloud, Hervé O Zender, Corinne Leemann-Refondini, Souheil Elatrous, Slaheddine Bouchoucha, Imed Chouchene, Islem Ouanes, La Marsa, Asma Ben Souissi, Salma Kamoun, Oktay Demirkiran, Mustafa Aker, Emre Erbabacan, Ilkay Ceylan, Nermin Kelebek Girgin, Menekse Ozcelik, Necmettin Ünal, Basak Ceyda Meco, Onat O Akyol, Suleyman S Derman, Barry Kennedy, Ken Parhar, Latha Srinivasa, Lia McNamee, Danny McAuley, Phil Hopkins, Clare Mellis, Vivek Kakar, Dan Hadfield, Andre Vercueil, Kaushik Bhowmick, Sally K Humphreys, Andrew Ferguson, Raymond Mckee, Ashok S Raj, Danielle A Fawkes, Philip Watt, Linda Twohey, Rajeev R JhaMatthew Thomas, Alex Morton, Varsha Kadaba, Mark J Smith, Anil P Hormis, Santhana G Kannan, Miriam Namih, Henrik Reschreiter, Julie Camsooksai, Alek Kumar, Szabolcs Rugonfalvi, Christopher Nutt, Orla Oneill, Colette Seasman, Ged Dempsey, Christopher J Scott, Helen E Ellis, Stuart Mckechnie, Paula J Hutton, Nora N Di Tomasso, Michela N Vitale, Ruth O Griffin, Michael N Dean, Julius H Cranshaw, Emma L Willett, Nicholas Ioannou, Sarah Gillis, Peter Csabi, Rosaleen Macfadyen, Heidi Dawson, Pieter D Preez, Alexandra J Williams, Owen Boyd, Laura Ortiz-Ruiz De Gordoa, Jon Bramall, Sophie Symmonds, Simon K Chau, Tim Wenham, Tamas Szakmany, Piroska Toth-Tarsoly, Katie H Mccalman, Peter Alexander, Lorraine Stephenson, Thomas Collyer, Rhiannon Chapman, Raphael Cooper, Russell M Allan, Malcolm Sim, David W Wrathall, Donald A Irvine, Kim S Zantua, John C Adams, Andrew J Burtenshaw, Gareth P Sellors, Ingeborg D Welters, Karen E Williams, Robert J Hessell, Matthew G Oldroyd, Ceri E Battle, Suresh Pillai, Istvan Kajtor, Mageswaran Sivashanmugavel, Sinead C Okane, Adrian Donnelly, Aniko D Frigyik, Jon P Careless, Martin M May, Richard Stewart, T John Trinder, Samantha J Hagan, Matt P Wise, Jade M Cole, Caroline C MacFie, Anna T Dowling, Javier Hurtado, Nicolás Nin, Javier Hurtado, Edgardo Nuñez, Gustavo Pittini, Ruben Rodriguez, María C Imperio, Cristina Santos, Alberto Deicas, Carolina Serra, Aditya Uppalapati, Ghassan Kamel, Valerie M Banner-Goodspeed, Jeremy R Beitler, Satyanarayana Reddy Mukkera, Shreedhar Kulkarni, Jarone Lee, Tomaz Mesar, John O Shinn Iii, Dina Gomaa, Christopher Tainter, Jarone Lee, Tomaz Mesar, Jarone Lee, Dale J Yeatts, Jessica Warren, Michael J Lanspa, Russel R Miller, Colin K Grissom, Samuel M Brown, Philippe R Bauer, Ryan J Gosselin, Barrett T Kitch, Jason E Cohen, Scott H Beegle, Renaud M Gueret, Aiman Tulaimat, Shazia Choudry, William Stigler, Hitesh Batra, Nidhi G Huff, Keith D Lamb, Trevor W Oetting, Nicholas M Mohr, Claine Judy, Shigeki Saito, Fayez M Kheir, Fayez Kheir, Adam B Schlichting, Angela Delsing, Daniel R Crouch, Mary Elmasri, Daniel R Crouch, Dina Ismail, Kyle R Dreyer, Thomas C Blakeman, Kyle R Dreyer, Dina Gomaa, Rebecca M Baron, Carolina Quintana Grijalba, Peter C Hou, Raghu Seethala, Imo Aisiku, Galen Henderson, Gyorgy Frendl, Sen-Kuang Hou, Robert L Owens, Ashley Schomer, Vesna Bumbasirevic, Bojan Jovanovic, Maja Surbatovic, Milic Veljovic, John G Laffey, Giacomo Bellani, Antonio Pesenti
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Male ,ARDS ,LUNG SAFE ,health care facilities, manpower, and services ,Acute hypoxemic respiratory failure ,Acute respiratory distress syndrome ,Hospital survival ,ICU discharge ,Kaplan-Meier Estimate ,Critical Care and Intensive Care Medicine ,0302 clinical medicine ,Risk Factors ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,COPD ,Medical emergencies. Critical care. Intensive care. First aid ,Middle Aged ,Patient Discharge ,Intensive Care Units ,medicine.anatomical_structure ,Lung safe ,SOFA score ,Female ,Respiratory Insufficiency ,Adult ,medicine.medical_specialty ,NO ,03 medical and health sciences ,Settore MED/41 - ANESTESIOLOGIA ,medicine ,Humans ,ddc:610 ,Risk factor ,Mortality ,Aged ,Lung ,RC86-88.9 ,business.industry ,Research ,030208 emergency & critical care medicine ,medicine.disease ,Logistic Models ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Respiratory failure ,Emergency medicine ,Observational study ,business - Abstract
Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073.
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- 2021
21. Learning an Effective Context-Response Matching Model with Self-Supervised Tasks for Retrieval-based Dialogues
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Xu, R., Tao, C., Daxin Jiang, Zhao, X., Zhao, D., and Yan, R.
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FOS: Computer and information sciences ,Computer Science - Computation and Language ,General Medicine ,Computation and Language (cs.CL) - Abstract
Building an intelligent dialogue system with the ability to select a proper response according to a multi-turn context is a great challenging task. Existing studies focus on building a context-response matching model with various neural architectures or PLMs and typically learning with a single response prediction task. These approaches overlook many potential training signals contained in dialogue data, which might be beneficial for context understanding and produce better features for response prediction. Besides, the response retrieved from existing dialogue systems supervised by the conventional way still faces some critical challenges, including incoherence and inconsistency. To address these issues, in this paper, we propose learning a context-response matching model with auxiliary self-supervised tasks designed for the dialogue data based on pre-trained language models. Specifically, we introduce four self-supervised tasks including next session prediction, utterance restoration, incoherence detection and consistency discrimination, and jointly train the PLM-based response selection model with these auxiliary tasks in a multi-task manner. By this means, the auxiliary tasks can guide the learning of the matching model to achieve a better local optimum and select a more proper response. Experiment results on two benchmarks indicate that the proposed auxiliary self-supervised tasks bring significant improvement for multi-turn response selection in retrieval-based dialogues, and our model achieves new state-of-the-art results on both datasets., Comment: 10 pages
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- 2021
22. Measurements of W+W−+ ≥ 1 jet production cross-sections in pp collisions at √s = 13 TeV with the ATLAS detector
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M, Weiser, C, Wells, PS, Wenaus, T, Wengler, T, Wenig, S, Wermes, N, Werner, MD, Werner, P, Wessels, M, Weston, TD, Whalen, K, Whallon, NL, Wharton, AM, White, AS, White, A, White, MJ, White, R, Whiteson, D, Whitmore, BW, Wickens, FJ, Wiedenmann, W, Wielers, M, Wiglesworth, C, Wiik-Fuchs, LAM, Wildauer, A, Wilk, F, Wilkens, HG, Wilkins, LJ, Williams, HH, Williams, S, Willis, C, Willocq, S, Wilson, JA, Wingerter-Seez, I, Winkels, E, Winklmeier, F, Winston, OJ, Winter, BT, Wittgen, M, Wobisch, M, Wolf, A, Wolf, TMH, Wolff, R, Wolter, MW, Wolters, H, Wong, VWS, Woods, NL, Worm, SD, Wosiek, BK, Wozniak, KW, Wraight, K, Wu, M, Wu, SL, Wu, X, Wu, Y, Wyatt, TR, Wynne, BM, Xella, S, Xi, Z, Xia, L, Xu, D, Xu, H, Xu, L, Xu, T, Xu, W, Yabsley, B, Yacoob, S, Yajima, K, Yallup, DP, Yamaguchi, D, Yamaguchi, Y, Yamamoto, A, Yamanaka, T, Yamane, F, Yamatani, M, Yamazaki, T, Yamazaki, Y, Yan, Z, Yang, HJ, Yang, HT, Yang, S, Yang, Y, Yang, Z, Yao, W-M, Yap, YC, Yasu, Y, Yatsenko, E, Ye, J, Ye, S, Yeletskikh, I, Yigitbasi, E, Yildirim, E, Yorita, K, Yoshihara, K, Young, CJS, Young, C, Yu, J, Yue, X, Yuen, SPY, Zabinski, B, Zacharis, G, Zaffaroni, E, Zaidan, R, Zaitsev, AM, Zakareishvili, T, Zakharchuk, N, Zalieckas, J, Zambito, S, Zanzi, D, Zaripovas, DR, Zeissner, SV, Zeitnitz, C, Zemaityte, G, Zeng, JC, Zeng, Q, Zenin, O, Zerwas, D, Zgubic, M, Zhang, DF, Zhang, D, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, L, Zhang, M, Zhang, P, Zhang, R, Zhang, X, Zhang, Y, Zhang, Z, Zhao, P, Zhao, X, Zhao, Y, Zhao, Z, Zhemchugov, A, Zhou, B, Zhou, C, Zhou, L, Zhou, MS, Zhou, M, Zhou, N, Zhou, Y, Zhu, CG, Zhu, HL, Zhu, H, Zhu, J, Zhu, Y, Zhuang, X, Zhukov, K, Zhulanov, V, Zibell, A, Zieminska, D, Zimine, NI, Zimmermann, S, Zinonos, Z, Zinser, M, Ziolkowski, M, Zobernig, G, Zoccoli, A, Zoch, K, Zorbas, TG, Zou, R, Nedden, MZ, Zwalinski, L, Collaboration, ATLAS, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2885, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), ATLAS (IHEF, IoP, FNWI), XENON (IHEF, IoP, FNWI), Other Research IHEF (IoP, FNWI), UAM. Departamento de Física Teórica, Aad, G. [0000-0002-6665-4934], Abbott, B. [0000-0002-5888-2734], Abbott, D. C. [0000-0002-7248-3203], Abed Abud, A. [0000-0002-2788-3822], Abeling, K. [0000-0002-1002-1652], Abhayasinghe, D. K. [0000-0002-2987-4006], Abidi, S. H. [0000-0002-8496-9294], AbouZeid, O. S. [0000-0002-8279-9324], Abramowicz, H. [0000-0001-5329-6640], Abreu, H. [0000-0002-1599-2896], Abulaiti, Y. [0000-0003-0403-3697], Abusleme Hoffman, A. C. [0000-0003-0762-7204], Acharya, B. S. [0000-0002-8588-9157], Achkar, B. [0000-0002-0288-2567], Adam, L. [0000-0001-6005-2812], Adam Bourdarios, C. [0000-0002-2634-4958], Adamczyk, L. [0000-0002-5859-2075], Adamek, L. [0000-0003-1562-3502], Adelman, J. [0000-0002-1041-3496], Adiguzel, A. [0000-0001-6644-0517], Adorni, S. [0000-0003-3620-1149], Adye, T. [0000-0003-0627-5059], Affolder, A. A. [0000-0002-9058-7217], Afik, Y. [0000-0001-8102-356X], Agapopoulou, C. [0000-0002-2368-0147], Agaras, M. N. [0000-0002-4355-5589], Aggarwal, A. [0000-0002-1922-2039], Agheorghiesei, C. [0000-0003-3695-1847], Aguilar-Saavedra, J. A. [0000-0002-5475-8920], Ahmad, A. [0000-0001-8638-0582], Ahmadov, F. [0000-0003-3644-540X], Ahmed, W. S. [0000-0003-0128-3279], Ai, X. [0000-0003-3856-2415], Aielli, G. [0000-0002-0573-8114], Akatsuka, S. [0000-0002-1681-6405], Akbiyik, M. [0000-0002-7342-3130], Åkesson, T. P. A. [0000-0003-4141-5408], Akilli, E. [0000-0003-1309-5937], Akimov, A. V. [0000-0002-2846-2958], Al Khoury, K. [0000-0002-0547-8199], Alberghi, G. L. [0000-0003-2388-987X], Albert, J. [0000-0003-0253-2505], Alconada Verzini, M. J. [0000-0003-2212-7830], Alderweireldt, S. [0000-0002-8224-7036], Aleksa, M. [0000-0002-1936-9217], Aleksandrov, I. N. [0000-0001-7381-6762], Alexa, C. [0000-0003-0922-7669], Alexopoulos, T. [0000-0002-8977-279X], Alfonsi, A. [0000-0001-7406-4531], Alfonsi, F. [0000-0002-0966-0211], Alhroob, M. [0000-0001-7569-7111], Ali, B. [0000-0001-8653-5556], Ali, S. [0000-0001-5216-3133], Aliev, M. [0000-0002-9012-3746], Alimonti, G. [0000-0002-7128-9046], Allaire, C. [0000-0003-4745-538X], Allbrooke, B. M. M. [0000-0002-5738-2471], Allport, P. P. [0000-0001-7303-2570], Aloisio, A. [0000-0002-3883-6693], Alonso, F. [0000-0001-9431-8156], Alpigiani, C. [0000-0002-7641-5814], Alvarez Estevez, M. [0000-0002-8181-6532], Alviggi, M. G. [0000-0003-0026-982X], Amaral Coutinho, Y. [0000-0002-1798-7230], Ambler, A. [0000-0003-2184-3480], Ambroz, L. [0000-0002-0987-6637], Amidei, D. [0000-0002-6814-0355], Amor Dos Santos, S. P. [0000-0001-7566-6067], Amoroso, S. [0000-0001-5450-0447], Anastopoulos, C. [0000-0003-1587-5830], Andari, N. [0000-0002-4935-4753], Andeen, T. [0000-0002-4413-871X], Anders, J. K. [0000-0002-1846-0262], Andrean, S. Y. [0000-0002-9766-2670], Andreazza, A. [0000-0001-5161-5759], Angelidakis, S. [0000-0002-8274-6118], Angerami, A. [0000-0001-7834-8750], Anisenkov, A. V. [0000-0002-7201-5936], Annovi, A. [0000-0002-4649-4398], Antel, C. 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R., Stroynowski, R., Strubig, A., Stucci, S. A., Stugu, B., Stupak, J., Styles, N. A., Su, D., Su, S., Su, W., Su, X., Suarez, N. B., Sugizaki, K., Sulin, V. V., Sullivan, M. J., Sultan, D. M. S., Sultansoy, S., Sumida, T., Sun, S., Sun, X., Suster, C. J. E., Sutton, M. R., Svatos, M., Swiatlowski, M., Swift, S. P., Swirski, T., Sydorenko, A., Sykora, I., Sykora, M., Sykora, T., Ta, D., Tackmann, K., Taffard, A., Tafirout, R., Tagiev, E., Taibah, R. H. M., Takashima, R., Takeda, K., Takeshita, T., Takeva, E. P., Takubo, Y., Talby, M., Talyshev, A. A., Tam, K. C., Tamir, N. M., Tanaka, J., Tanaka, R., Tapia Araya, S., Tapprogge, S., Tarek Abouelfadl Mohamed, A., Tarem, S., Tariq, K., Tarna, G., Tartarelli, G. F., Tas, P., Tasevsky, M., Tassi, E., Tateno, G., Tayalati, Y., Taylor, G. N., Taylor, W., Teagle, H., Tee, A. S., Teixeira De Lima, R., Teixeira-Dias, P., Ten Kate, H., Teoh, J. J., Terashi, K., Terron, J., Terzo, S., Testa, M., Teuscher, R. J., Themistokleous, N., Theveneaux-Pelzer, T., Thomas, D. W., Thomas, J. P., Thompson, E. A., Thompson, P. D., Thomson, E., Thorpe, E. J., Tian, Y., Tikhomirov, V. O., Tikhonov, Y. A., Timoshenko, S., Tipton, P., Tisserant, S., Tlou, S. H., Tnourji, A., Todome, K., Todorova-Nova, S., Todt, S., Togawa, M., Tojo, J., Tokar, S., Tokushuku, K., Tolley, E., Tombs, R., Tomoto, M., Tompkins, L., Tornambe, P., Torrence, E., Torres, H., Torro Pastor, E., Toscani, M., Tosciri, C., Toth, J., Tovey, D. R., Traeet, A., Treado, C. J., Trefzger, T., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Trischuk, D. A., Trischuk, W., Trocme, B., Trofymov, A., Troncon, C., Trovato, F., Truong, L., Trzebinski, M., Trzupek, A., Tsai, F., Tsiamis, A., Tsiareshka, P. V., Tsirigotis, A., Tsiskaridze, V., Tskhadadze, E. G., Tsopoulou, M., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Tsur, O., Tsybychev, D., Tu, Y., Tudorache, A., Tudorache, V., Tuna, A. N., Turchikhin, S., Turgeman, D., Turk Cakir, I., Turner, R. J., Turra, R., Tuts, P. M., Tzamarias, S., Tzanis, P., Tzovara, E., Uchida, K., Ukegawa, F., Unal, G., Unal, M., Undrus, A., Unel, G., Ungaro, F. C., Uno, K., Urban, J., Urquijo, P., Usai, G., Ushioda, R., Uysal, Z., Vacek, V., Vachon, B., Vadla, K. O. H., Vafeiadis, T., Valderanis, C., Valdes Santurio, E., Valente, M., Valentinetti, S., Valero, A., Valery, L., Vallance, R. A., Vallier, A., Valls Ferrer, J. A., Van Daalen, T. R., Van Gemmeren, P., Van Stroud, S., Van Vulpen, I., Vanadia, M., Vandelli, W., Vandenbroucke, M., Vandewall, E. R., Vannicola, D., Vannoli, L., Vari, R., Varnes, E. W., Varni, C., Varol, T., Varouchas, D., Varvell, K. E., Vasile, M. E., Vaslin, L., Vasquez, G. A., Vazeille, F., Vazquez Furelos, D., Vazquez Schroeder, T., Veatch, J., Vecchio, V., Veen, M. J., Veloce, L. M., Veloso, F., Veneziano, S., Ventura, A., Verbytskyi, A., Verducci, M., Vergis, C., Verissimo De Araujo, M., Verkerke, W., Vermeulen, A. T., Vermeulen, J. C., Vernieri, C., Verschuuren, P. J., Vesterbacka, M. L., Vetterli, M. C., Viaux Maira, N., Vickey, T., Vickey Boeriu, O. E., Viehhauser, G. H. A., Vigani, L., Villa, M., Villaplana Perez, M., Villhauer, E. M., Vilucchi, E., Vincter, M. G., Virdee, G. S., Vishwakarma, A., Vittori, C., Vivarelli, I., Vladimirov, V., Vogel, M., Vokac, P., Von Ahnen, J., von Buddenbrock, S. E., Von Toerne, E., Vorobel, V., Vorobev, K., Vos, M., Vossebeld, J. H., Vozak, M., Vranjes, N., Vranjes Milosavljevic, M., Vrba, V., Vreeswijk, M., Vu, N. K., Vuillermet, R., Vukotic, I., Wada, S., Wagner, C., Wagner, P., Wagner, W., Wahdan, S., Wahlberg, H., Wakasa, R., Wakida, M., Walbrecht, V. M., Walder, J., Walker, R., Walker, S. D., Walkowiak, W., Wallangen, V., Wang, A. M., Wang, A. Z., Wang, C., Wang, H., Wang, J., Wang, P., Wang, R. -J., Wang, R., Wang, S. M., Wang, S., Wang, T., Wang, W. T., Wang, W. X., Wang, X., Wang, Y., Wang, Z., Wanotayaroj, C., Warburton, A., Ward, C. P., Ward, R. J., Warrack, N., Watson, A. T., Watson, M. F., Watts, G., Waugh, B. M., Webb, A. F., Weber, C., Weber, M. S., Weber, S. A., Weber, S. M., Wei, C., Wei, Y., Weidberg, A. R., Weingarten, J., Weirich, M., Weiser, C., Wells, P. S., Wenaus, T., Wendland, B., Wengler, T., Wenig, S., Wermes, N., Wessels, M., Weston, T. D., Whalen, K., Wharton, A. M., White, A. S., White, A., White, M. J., Whiteson, D., Wiedenmann, W., Wiel, C., Wielers, M., Wieseotte, N., Wiglesworth, C., Wiik-Fuchs, L. A. M., Wilkens, H. G., Wilkins, L. J., Williams, D. M., Williams, H. H., Williams, S., Willocq, S., Windischhofer, P. J., Wingerter-Seez, I., Winklmeier, F., Winter, B. T., Wittgen, M., Wobisch, M., Wolf, A., Wolker, R., Wollrath, J., Wolter, M. W., Wolters, H., Wong, V. W. S., Wongel, A. F., Woods, N. L., Worm, S. D., Wosiek, B. K., Wozniak, K. W., Wraight, K., Wu, J., Wu, S. L., Wu, X., Wu, Y., Wu, Z., Wuerzinger, J., Wyatt, T. R., Wynne, B. M., Xella, S., Xiang, J., Xiao, X., Xie, X., Xiotidis, I., Xu, D., Xu, H., Xu, L., Xu, R., Xu, W., Xu, Y., Xu, Z., Yabsley, B., Yacoob, S., Yallup, D. P., Yamaguchi, N., Yamaguchi, Y., Yamatani, M., Yamauchi, H., Yamazaki, T., Yamazaki, Y., Yan, J., Yan, Z., Yang, H. J., Yang, H. T., Yang, S., Yang, T., Yang, X., Yang, Y., Yang, Z., Yao, W. -M., Yap, Y. C., Ye, H., Ye, J., Ye, S., Yeletskikh, I., Yexley, M. R., Yin, P., Yorita, K., Yoshihara, K., Young, C. J. S., Young, C., Yuan, R., Yue, X., Zaazoua, M., Zabinski, B., Zacharis, G., Zaffaroni, E., Zahreddine, J., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zambito, S., Zanzi, D., Zeissner, S. V., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zenin, O., Zenis, T., Zenz, S., Zerradi, S., Zerwas, D., Zgubic, M., Zhang, B., Zhang, D. F., Zhang, G., Zhang, J., Zhang, K., Zhang, L., Zhang, M., Zhang, R., Zhang, S., Zhang, X., Zhang, Z., Zhao, P., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Ziolkowski, M., Zivkovic, L., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zou, W., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Franchini , M., Romano , M., Valentinetti , S., Alberghi , G. L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., and ATLAS collaboration
- Subjects
Plus Plus ,13000 GeV-cms ,((n)jet dilepton) [final state] ,QC770-798 ,transverse momentum [jet] ,01 natural sciences ,Subatomär fysik ,Hadron-Hadron scattering (experiments) ,scattering [p p] ,Nuclear Experiment ,Settore FIS/01 ,Electroweak interaction ,hadronic [jet] ,mass dependence ,upper limit [coupling constant] ,CERN LHC Coll ,kinematics ,Distributions ,colliding beams [p p] ,p p: scattering ,Astrophysics::High Energy Astrophysical Phenomena ,coupling constant: upper limit ,jet: multiplicity ,Nuclear physics ,phase space ,Atlas (anatomy) ,quantum chromodynamics ,muon: pair ,coupling: (3gauge boson) ,TeV ,ddc:530 ,Rapidity ,High Energy Physics ,010306 general physics ,Particle Physics ,Particle Physics, LHC, ATLAS ,Parton Distributions ,final state: ((n)jet dilepton) ,010308 nuclear & particles physics ,jet: hadronic ,Hadron Colliders ,Automatic Keywords ,dependence [multiplicity] ,Experimental High Energy Physics ,p p: colliding beams ,electron ,Kjerne- og elementærpartikkelfysikk: 431 [VDP] ,Atlas detector ,(3gauge boson) [coupling] ,Hadron ,jet: transverse momentum ,GeV ,transverse momentum dependence ,High Energy Physics - Experiment ,gauge [coupling] ,W: pair production ,High Energy Physics - Experiment (hep-ex) ,Subatomic Physics ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Pair Production ,Quantum chromodynamics ,Physics ,Jet (fluid) ,mass: transverse ,multiplicity: dependence ,lepton: transverse momentum ,ATLAS ,Zz Production ,Nuclear and elementary particle physics: 431 [VDP] ,medicine.anatomical_structure ,jet: production ,pair production [W] ,Subtraction ,differential cross section ,LHC ,multiplicity [jet] ,anomaly [coupling] ,Particle Physics - Experiment ,perturbation theory [quantum chromodynamics] ,Nuclear and High Energy Physics ,topology ,Regular Article - Experimental Physics ,530 Physics ,coupling: gauge ,jet: associated production ,interference ,FOS: Physical sciences ,differential cross section: measured ,measured [differential cross section] ,Nuclear and particle physics. Atomic energy. Radioactivity ,electron muon ,0103 physical sciences ,medicine ,associated production [jet] ,quantum chromodynamics: perturbation theory ,coupling: anomaly ,electroweak interaction ,background ,High Energy Physics::Phenomenology ,Física ,W bosons ,production [jet] ,pair [muon] ,rapidity ,Pair production ,transverse [mass] ,High Energy Physics::Experiment ,Hadron-hadron collisions ,transverse momentum [lepton] ,experimental results - Abstract
We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Beijing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom., Fiducial and differential cross-section measurements of W+W− production in association with at least one hadronic jet are presented. These measurements are sensitive to the properties of electroweak-boson self-interactions and provide a test of perturbative quantum chromodynamics and the electroweak theory. The analysis is performed using proton-proton collision data collected at p s = 13TeV with the ATLAS experiment, corresponding to an integrated luminosity of 139 fb−1. Events are selected with exactly one oppositely charged electron-muon pair and at least one hadronic jet with a transverse momentum of pT > 30 GeV and a pseudorapidity of | | < 4.5. After subtracting the background contributions and correcting for detector effects, the jet-inclusive W+W−+ 1 jet fiducial cross-section and W+W−+ jets differential cross-sections with respect to several kinematic variables are measured. These measurements include leptonic quantities, such as the lepton transverse momenta and the transverse mass of the W+W− system, as well as jet-related observables such as the leading jet transverse momentum and the jet multiplicity. Limits on anomalous triple-gauge-boson couplings are obtained in a phase space where interference between the Standard Model amplitude and the anomalous amplitude is enhanced., ANPCyT, YerPhI, Armenia, Australian Research Council, BMWFW, Austria, Austrian Science Fund (FWF), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), NRC, Canada, Canada Foundation for Innovation, CERN, ANID, Chile, Chinese Academy of Sciences, Ministry of Science and Technology, China, National Natural Science Foundation of China (NSFC), Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government Czech Republic Government, DNRF, Denmark Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS) CEA-DRF/IRFU, France, SRNSFG, Georgia, Federal Ministry of Education & Research (BMBF), HGF, Germany Max Planck Society, Greek Ministry of Development-GSRT, RGC, China Hong Kong SAR, China, Israel Science Foundation Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland NCN, Poland, Portuguese Foundation for Science and Technology European Commission, MNE/IFA, Romania, JINR, Russian Federation NRC KI, Russian Federation, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia MIZS, Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden Wallenberg Foundation, Sweden, SERI, Switzerland Swiss National Science Foundation (SNSF), Canton of Bern, Switzerland Canton of Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC), United States Department of Energy (DOE) National Science Foundation (NSF), BCKDF, Canada CANARIE, Canada Compute Canada, Canada CRC, Canada IVADO, Canada, Beijing Municipal Science AMP; Technology Commission, China, COST, European Union European Research Council (ERC) ERDF, European Union Horizon 2020, European Union Marie Sklodowska-Curie Actions, European Union, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, Herakleitos programme - EU-ESF, Greece Thales Group Aristeia programme - EU-ESF, Greece Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain CERCA Programme Generalitat de Catalunya, Spain PROMETEO Programme Generalitat Valenciana, Spain GenT Programme Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust, Azerbaijan National Academy of Sciences (ANAS), SSTC, Belarus, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
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- 2021
- Full Text
- View/download PDF
23. The physics case of a 3 TeV muon collider stage
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De Blas, J., Buttazzo, D., Capdevilla, R., Curtin, D., Franceschini, R., Maltoni, F., Meade, P., Meloni, F., Su, S., Vryonidou, E., Wulzer, A., Aimè, C., Apyan, A., Asadi, P., Mahmoud, M., Azatov, A., Bartosik, N., Bertolin, A., Bottaro, S., Buonincontri, L., Casarsa, M., Castelli, L., Catanesi, M., Celiberto, F., Cerri, A., Cesarotti, C., Chachamis, G., Chen, S., Chien, Y., Chiesa, M., Costa, M., Da Molin, G., Dasu, S., Denisov, D., Denizli, H., Dermisek, R., Di Luzio, L., Di Micco, B., Dienes, K., Dorigo, T., Fabbrichesi, M., Fiorina, D., Forslund, M., Gabrielli, E., Garosi, F., Glioti, A., Greco, M., Greljo, A., Groeber, R., Grojean, C., Gu, J., Han, C., Han, T., Hermanek, K., Herndon, M., Holmes, T., Homiller, S., Huang, G., Jana, S., Jindariani, S., Kahn, Y., Kilian, W., Koppenburg, P., Kreher, N., Krizka, K., Krnjaic, G., Kumar, N., Lee, L., Li, Q., Liu, Z., Long, K., Low, I., Lu, Q., Lucchesi, D., Ma, L., Ma, Y., Mantani, L., Marzocca, D., McGinnis, N., Mele, B., Merlassino, C., Montella, A., Nardecchia, M., Nardi, F., Panci, P., Griso, S., Panico, G., Paradisi, P., Pastrone, N., Piccinini, F., Potamianos, K., Radicioni, E., Rattazzi, R., Redigolo, D., Reina, L., Reuter, J., Riccardi, C., Ricci, L., Ristori, L., Robens, T., Rodejohann, W., Ruiz, R., Queiroz, F., Sala, F., Salko, J., Salvini, P., Santiago, J., Sarra, I., Schulte, D., Selvaggi, M., Senol, A., Sestini, L., Sharma, V., Simoniello, R., Stark, G., Stolarski, D., Su, W., Sumensari, O., Sun, X., Tait, T., Tang, J., Tesi, A., Thomas, B., Thompson, E., Torre, R., Trifinopoulos, S., Vai, I., Valenti, A., Vittorio, L., Wang, L., Wu, Y., Xie, K., Zhao, X., and Zurita, J.
- Abstract
In the path towards a muon collider with center of mass energy of 10 TeV ormore, a stage at 3 TeV emerges as an appealing option. Reviewing the physicspotential of such muon collider is the main purpose of this document. In orderto outline the progression of the physics performances across the stages, a fewsensitivity projections for higher energy are also presented. There are manyopportunities for probing new physics at a 3 TeV muon collider. Some of themare in common with the extensively documented physics case of the CLIC 3 TeVenergy stage, and include measuring the Higgs trilinear coupling and testingthe possible composite nature of the Higgs boson and of the top quark at the 20TeV scale. Other opportunities are unique of a 3 TeV muon collider, and stemfrom the fact that muons are collided rather than electrons. This isexemplified by studying the potential to explore the microscopic origin of thecurrent $g$-2 and $B$-physics anomalies, which are both related with muons.
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- 2022
24. Muon Collider Physics Summary
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Aimè, C., Apyan, A., Mahmoud, M., Bartosik, N., Bertolin, A., Bonesini, M., Bottaro, S., Buttazzo, D., Capdevilla, R., Casarsa, M., Castelli, L., Catanesi, M., Celiberto, F., Cerri, A., Cesarotti, C., Chachamis, G., Chen, S., Chien, Y., Chiesa, M., Collazuol, G., Costa, M., Craig, N., Curtin, D., Dasu, S., De Blas, J., Denisov, D., Denizli, H., Dermisek, R., Di Luzio, L., Di Micco, B., Dienes, K., Dorigo, T., Ferrari, A., Fiorina, D., Franceschini, R., Garosi, F., Glioti, A., Greco, M., Greljo, A., Groeber, R., Grojean, C., Gu, J., Han, T., Henning, B., Hermanek, K., Holmes, T., Homiller, S., Jana, S., Jindariani, S., Kahn, Y., Karpov, I., Kilian, W., Kong, K., Koppenburg, P., Krizka, K., Lee, L., Li, Q., Lipton, R., Liu, Z., Long, K., Low, I., Lucchesi, D., Ma, Y., Ma, L., Maltoni, F., Mansoulie, B., Mantani, L., Marzocca, D., McGinnis, N., Mele, B., Meloni, F., Merlassino, C., Montella, A., Nardecchia, M., Nardi, F., Panci, P., Griso, S., Panico, G., Paparella, R., Paradisi, P., Pastrone, N., Piccinini, F., Potamianos, K., Radicioni, E., Rattazzi, R., Redigolo, D., Reina, L., Reuter, J., Riccardi, C., Ricci, L., van Rienen, U., Ristori, L., Robens, T., Ruiz, R., Sala, F., Salko, J., Salvini, P., Salvioni, E., Schulte, D., Selvaggi, M., Senol, A., Sestini, L., Sharma, V., Shu, J., Simoniello, R., Stark, G., Stolarski, D., Su, S., Su, W., Sumensari, O., Sun, X., Sundrum, R., Tang, J., Tesi, A., Thomas, B., Torre, R., Trifinopoulos, S., Vai, I., Valenti, A., Vittorio, L., Wang, L., Wu, Y., Wulzer, A., Zhao, X., and Zurita, J.
- Abstract
The perspective of designing muon colliders with high energy and luminosity,which is being investigated by the International Muon Collider Collaboration,has triggered a growing interest in their physics reach. We present a concisesummary of the muon colliders potential to explore new physics, leveraging onthe unique possibility of combining high available energy with very precisemeasurements.
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- 2022
25. Combination of stem cell therapy and acupuncture to treat ischemic stroke: a prospective review
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Jia, H, He, J, Zhao, L, Hsu, C-C, Zhao, X, Du, Y, Han, L, Cui, Z, Shi, X, and Ye, H
- Subjects
Stroke ,Treatment Outcome ,Acupuncture Therapy ,Stroke Rehabilitation ,Humans ,Molecular Medicine ,Medicine (miscellaneous) ,Prospective Studies ,Cell Biology ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Brain Ischemia ,Ischemic Stroke ,Stem Cell Transplantation - Abstract
Stroke is the second leading cause globally that leads to severe disability and death. Stem cell therapy has been developed over the recent years to treat stroke and diminish the mortality and disability rate of brain injuries. Acupuncture, which can activate endogenous recovery via physical stimuli, has been applied to enhance the recovery and rehabilitation of stroke patients. Attempts have been made to combine stem cell therapy and acupuncture to treat stroke patients and have shown the promising results. This prospective review will look into the possible mechanisms of stem cell therapy and acupuncture and intend to undercover the potential benefit of the combined therapy. It intends to bridge the modern emerging stem cell therapy and traditional acupuncture at cellular and molecular levels and to demonstrate the potential benefit to improve clinical outcomes.
- Published
- 2022
26. Measurement of photon?jet transverse momentum correlations in 5.02 TeV Pb + Pb and pp collisions with ATLAS
- Author
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Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Adachi, S., Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Akatsuka, S., Akesson, T. P. A., Akilli, E., Akimov, A., V, Alberghi, G. L., Albert, J., Albicocco, P., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alhroob, M., Ali, B., Alimonti, G., Alison, J., Alkire, S. P., Allaire, C., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alshehri, A. A., Alstaty, M., I, Gonzalez, B. Alvarez, Alvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amaral Coutinho, Y., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V, Anelli, C. R., Angelidakis, S., Angelozzi, I, Angerami, A., Anisenkov, A., Annovi, A., Antel, C., Anthony, M. T., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Bella, L. Aperio, Arabidze, G., Araque, J. P., Araujo Ferraz, V, Araujo Pereira, R., Arce, A. T. H., Ardell, R. E., Arduh, F. A., Arguin, J-F, Argyropoulos, S., Armbruster, A. J., Armitage, L. J., Armstrong, A., Arnaez, O., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Artz, S., Asai, S., Asbah, N., Ashkenazi, A., Asimakopoulou, E. M., Asquith, L., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Augsten, K., Avolio, G., Avramidou, R., Ayoub, M. K., Azuelos, G., Baas, A. E., Baca, M. J., Bachacou, H., Bachas, K., Backes, M., Bagnaia, P., Bahmani, M., Bahrasemani, H., Bailey, A. J., Baines, J. T., Bajic, M., Bakalis, C., Baker, O. K., Bakker, P. J., Gupta, D. Bakshi, Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandyopadhyay, A., Banerjee, S., Bannoura, A. A. E., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barillari, T., Barisits, M-S, Barkeloo, J., Barklow, T., Barlow, N., Barnea, R., Barnes, S. L., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., da Costa, J. Barreiro Guimaraes, Bartoldus, R., Barton, A. E., Bartos, P., Basalaev, A., Bassalat, A., Bates, R. L., Batista, S. J., Batlamous, S., Batley, J. R., Battaglia, M., Bauce, M., Bauer, F., Bauer, K. T., Bawa, H. S., Beacham, J. B., Beau, T., Beauchemin, P. H., Bechtle, P., Beck, H. C., Beck, H. P., Becker, K., Becker, M., Becot, C., Beddall, A., Beddall, A. J., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellomo, M., Bellos, P., Belotskiy, K., Belyaev, N. L., Benary, O., Benchekroun, D., Bender, M., Benekos, N., Benhammou, Y., Noccioli, E. Benhar, Benitez, J., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Kuutmann, E. Bergeaas, Berger, N., Bergsten, L. J., Beringer, J., Berlendis, S., Bernard, N. R., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Bertella, C., Bertoli, G., Bertram, I. A., Besjes, G. J., Bylund, O. Bessidskaia, Bessner, M., Besson, N., Bethani, A., Bethke, S., Betti, A., Bevan, A. J., Beyer, J., Bianchi, R. M. B., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N., Biglietti, M., Billoud, T. R., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birman, M., Bisanz, T., Biswal, J. P., Bittrich, C., Bjergaard, D. M., Black, J. E., Black, K. M., Blazek, T., Bloch, I, Blocker, C., Blue, A., Blumenschein, U., Blunier, Dr, Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bocci, A., Boerner, D., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V, Bokan, P., Bold, T., Boldyrev, A. S., Bolz, A. E., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Borisov, A., Borissov, G., Bortfeldt, J., Bortoletto, D., Bortolotto, V, Boscherini, D., Bosman, M., Bossio Sola, J. D., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E., Boumediene, D., Bourdarios, C., Boutle, S. K., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, A., Brandt, G., Brandt, O., Braren, F., Bratzler, U., Brau, B., Brau, J. E., Madden, W. D. Breaden, Brendlinger, K., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I, Brock, R., Brooijmans, G., Brooks, T., Brooks, W. K., Brost, E., Broughton, J. H., de Renstrom, P. A. Bruckman, Bruncko, D., Bruni, A., Bruni, G., Bruni, L. S., Bruno, S., Brunt, B. H., Bruschi, M., Bruscino, N., Bryant, P., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Buehrer, F., Bugge, M. K., Bulekov, O., Bullock, D., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burka, K., Burke, S., Burmeister, I, Burr, J. T. P., Buescher, D., Buescher, V, Buschmann, E., Bussey, P., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buzatu, A., Buzykaev, A. R., Cabras, G., Cabrera Urban, S., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calandri, A., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Toro, R. Camacho, Camarda, S., Camarri, P., Cameron, D., Armadans, R. Caminal, Camincher, C., Campana, S., Campanelli, M., Camplani, A., Campoverde, A., Canale, V, Bret, M. Cano, Cantero, J., Cao, T., Cao, Y., Garrido, M. D. M. Capeans, Caprini, I, Caprini, M., Capua, M., Carbone, R. M., Cardarelli, R., Cardillo, F. C., Carli, I, Carli, T., Carlino, G., Carlson, B. T., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carra, S., Carrillo-Montoya, G. D., Casadei, D., Casado, M. P., Casha, A. F., Casper, D. W., Castelijn, R., Castillo, F. L., Castillo Gimenez, V, Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Caudron, J., Cavaliere, V, Cavallaro, E., Cavalli, D., Cavalli-Sforza, M., Cavasinni, V, Celebi, E., Ceradini, F., Cerda Alberich, L., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chafaq, A., Chakraborty, D., Chan, S. K., Chan, W. S., Chan, Y. L., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Chau, C. C., Barajas, C. A. Chavez, Che, S., Chegwidden, A., Chekanov, S., Chekulaev, S., Chelkov, G. A., Chelstowska, M. A., Chen, C., Chen, C. H., Chen, H., Chen, J., Chen, S., Chen, S. J., Chen, X., Chen, Y., Chen, Y-H, Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., El Moursli, R. Cherkaoui, Cheu, E., Cheung, K., Chevalier, L., Chiarella, V, Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I, Chiu, Y. H., Chizhov, M., Choi, K., Chomont, A. R., Chouridou, S., Chow, Y. S., Christodoulou, V, Chu, M. C., Chudoba, J., Chuinard, A. J., Chwastowski, J. J., Chytka, L., Cinca, D., Cindro, V, Cioara, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Clark, A., Clark, M. R., Clark, P. J., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Cohen, H., Coimbra, A. E. C., Colasurdo, L., Cole, B., Colijn, A. P., Collot, J., Conde Muino, P., Coniavitis, E., Connell, S. H., Connelly, I. A., Constantinescu, S., Conventi, F., Cooper-Sarkar, A. M., Cormier, F., Cormier, K. J. R., Corradi, M., Corrigan, E. E., Corriveau, F., Cortes-Gonzalez, A., Costa, M. J., Costanzo, D., Cottin, G., Cowan, G., Cox, B. E., Crane, J., Cranmer, K., Crawley, S. J., Creager, R. A., Cree, G., Crepe-Renaudin, S., Crescioli, F., Cristinziani, M., Croft, V, Crosetti, G., Cueto, A., Donszelmann, T. Cuhadar, Cukierman, A. R., Cuth, J., Czekierda, S., Czodrowski, P., Da Cunha Sargedas De Sousa, M. J., Da Via, C., Dabrowski, W., Dado, T., Dahbi, S., Dai, T., Dallaire, F., Dallapiccola, C., Dam, M., D'Amen, G., Damp, J., Dandoy, J. R., Daneri, M. F., Dang, N. P., Dann, N. D., Danninger, M., Dao, V, Darbo, G., Darmora, S., Dartsi, O., Dattagupta, A., Daubney, T., D'Auria, S., Davey, W., David, C., Davidek, T., Davis, D. R., Dawe, E., Dawson, I, De, K., De Asmundis, R., De Benedetti, A., De Beurs, M., De Castro, S., De Cecco, S., De Groot, N., de Jong, P., De la Torre, H., De Lorenzi, F., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santis, M., De Santo, A., Corga, K. De Vasconcelos, De Regie, J. B. De Vivie, Debenedetti, C., Dedovich, D., Dehghanian, N., Del Gaudio, M., Del Peso, J., Diaz, Y. Delabat, Delgove, D., Deliot, F., Delitzsch, C. M., Della Pietra, M., Della Volpe, D., Dell'Acqua, A., Dell'Asta, L., Delmastro, M., Delporte, C., Delsart, P. A., Demarco, D. A., Demers, S., Demichev, M., Denisov, S. P., Denysiuk, D., D'Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Deterre, C., Dette, K., Devesa, M. R., Deviveiros, P. O., Dewhurst, A., Dhaliwal, S., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Clemente, W. K., Di Donato, C., Di Girolamo, A., Di Micco, B., Di Nardo, R., Di Petrillo, K. F., Di Sipio, R., Di Valentino, D., Diaconu, C., Diamond, M., Dias, F. A., Dias Do Vale, T., Diaz, M. A., Dickinson, J., Diehl, E. B., Dietrich, J., Cornell, S. Diez, Dimitrievska, A., Dingfelder, J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J., Do Vale, M. A. B., Dobre, M., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Donini, J., D'Onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dreyer, E., Dreyer, T., Du, Y., Duarte-Campderros, J., Dubinin, F., Dubovsky, M., Dubreuil, A., Duchovni, E., Duckeck, G., Ducourthial, A., Ducu, O. A., Duda, D., Dudarev, A., Dudder, A. C., Duffield, E. M., Duflot, L., Duhrssen, M., Duelsen, C., Dumancic, M., Dumitriu, A. E., Duncan, A. K., Dunford, M., Duperrin, A., Yildiz, H. Duran, Dueren, M., Durglishvili, A., Duschinger, D., Dutta, B., Duvnjak, D., Dyndal, M., Dysch, S., Dziedzic, B. S., Eckardt, C., Ecker, K. M., Edgar, R. C., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Kacimi, M., El Kosseifi, R., Ellajosyula, V, Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Enari, Y., Ennis, J. S., Epland, M. B., Erdmann, J., Ereditato, A., Errede, S., Escalier, M., Escobar, C., Estrada Pastor, O., Etienvre, A., Etzion, E., Evans, H., Ezhilov, A., Ezzi, M., Fabbri, F., Fabbri, L., Fabiani, V, Facini, G., Faisca Rodrigues Pereira, R. M., Fakhrutdinov, R. M., Falciano, S., Falke, P. J., Falke, S., Faltova, J., Fang, Y., Fanti, M., Farbin, A., Farilla, A., Farina, E. M., Farooque, T., Farrell, S., Farrington, S. M., Farthouat, P., Fassi, F., Fassnacht, P., Fassouliotis, D., Giannelli, M. Faucci, Favareto, A., Fawcett, W. J., Fayard, L., Fedin, O. L., Fedorko, W., Feickert, M., Feigl, S., Feligioni, L., Feng, C., Feng, E. J., Feng, M., Fenton, M. J., Fenyuk, A. B., Feremenga, L., Ferrando, J., Ferrari, A., Ferrari, P., Ferrari, R., de Lima, D. E. Ferreira, Ferrer, A., Ferrere, D., Ferretti, C., Fiedler, F., Filipcic, A., Filthaut, F., Finelli, K. D., Fiolhais, M. C. N., Fiorini, L., Fischer, C., Fisher, W. C., Flaschel, N., Fleck, I, Fleischmann, P., Fletcher, R. R. M., Flick, T., Flierl, B. M., Flores, L. M., Castillo, L. R. Flores, Follega, F. M., Fomin, N., Forcolin, G. T., Formica, A., Forster, F. A., Forti, A. C., Foster, A. G., Fournier, D., Fox, H., Fracchia, S., Francavilla, P., Franchini, M., Franchino, S., Francis, D., Franconi, L., Franklin, M., Frate, M., Fraternali, M., Fray, A. N., Freeborn, D., Fressard-Batraneanu, S. M., Freund, B., Freund, W. S., Frizzell, D. C., Froidevaux, D., Frost, J. A., Fukunaga, C., Fullana Torregrosa, E., Fusayasu, T., Fuster, J., Gabizon, O., Gabrielli, A., Gach, G. P., Gadatsch, S., Gadow, P., Gagliardi, G., Gagnon, L. G., Galea, C., Galhardo, B., Gallas, E. J., Gallop, B. J., Gallus, P., Galster, G., Goni, R. Gamboa, Gan, K. K., Ganguly, S., Gao, J., Gao, Y., Gao, Y. S., Garcia, C., Garcia Navarro, J. E., Pascual, J. A. Garcia, Garcia-Sciveres, M., Gardner, R. W., Garelli, N., Garonne, V, Gasnikova, K., Gaudiello, A., Gaudio, G., Gavrilenko, I. L., Gavrilyuk, A., Gay, C., Gaycken, G., Gazis, E. N., Gee, C. N. P., Geisen, J., Geisen, M., Geisler, M. P., Gellerstedt, K., Gemme, C., Genest, M. H., Geng, C., Gentile, S., George, S., Gerbaudo, D., Gessner, G., Ghasemi, S., Bostanabad, M. Ghasemi, Ghneimat, M., Giacobbe, B., Giagu, S., Giangiacomi, N., Giannetti, P., Giannini, A., Gibson, S. M., Gignac, M., Gillberg, D., Gilles, G., Gingrich, D. M., Giordani, M. P., Giorgi, F. M., Giraud, P. F., Giromini, P., Giugliarelli, G., Giugni, D., Giuli, F., Giulini, M., Gkaitatzis, S., Gkialas, I, Gkougkousis, E. L., Gkountoumis, P., Gladilin, L. K., Glasman, C., Glatzer, J., Glaysher, P. C. F., Glazov, A., Goblirsch-Kolb, M., Godlewski, J., Goldfarb, S., Golling, T., Golubkov, D., Gomes, A., Goncalves Gama, R., Goncalo, R., Gonella, G., Gonella, L., Gongadze, A., Gonnella, F., Gonski, J. L., Gonzalez de la Hoz, S., Gonzalez-Sevilla, S., Goossens, L., Gorbounov, P. A., Gordon, H. A., Gorini, B., Gorini, E., Gorisek, A., Goshaw, A. T., Goessling, C., Gostkin, M., Gottardo, C. A., Goudet, C. R., Goujdami, D., Goussiou, A. G., Govender, N., Goy, C., Gozani, E., Grabowska-Bold, I, Gradin, P. O. J., Graham, E. C., Gramling, J., Gramstad, E., Grancagnolo, S., Gratchev, V, Gravila, P. M., Gravili, F. G., Gray, C., Gray, H. M., Greenwood, Z. D., Grefe, C., Gregersen, K., Gregor, I. M., Grenier, P., Grevtsov, K., Grieser, N. A., Griffiths, J., Grillo, A. A., Grimm, K., Grinstein, S., Gris, Ph, Grivaz, J-F, Groh, S., Gross, E., Grosse-Knetter, J., Grossi, G. C., Grout, Z. J., Grud, C., Grummer, A., Guan, L., Guan, W., Guenther, J., Guerguichon, A., Guescini, F., Guest, D., Gugel, R., Gui, B., Guillemin, T., Guindon, S., Gul, U., Gumpert, C., Guo, J., Guo, W., Guo, Y., Guo, Z., Gupta, R., Gurbuz, S., Gustavino, G., Gutelman, B. J., Gutierrez, P., Gutschow, C., Guyot, C., Guzik, M. P., Gwenlan, C., Gwilliam, C. B., Haas, A., Haber, C., Hadavand, H. K., Haddad, N., Hadef, A., Hageboeck, S., Hagihara, M., Hakobyan, H., Haleem, M., Haley, J., Halladjian, G., Hallewell, G. D., Hamacher, K., Hamal, P., Hamano, K., Hamilton, A., Hamity, G. N., Han, K., Han, L., Han, S., Hanagaki, K., Hance, M., Handl, D. M., Haney, B., Hankache, R., Hanke, P., Hansen, E., Hansen, J. B., Hansen, J. D., Hansen, M. C., Hansen, P. H., Hara, K., Hard, A. S., Harenberg, T., Harkusha, S., Harrison, P. F., Hartmann, N. M., Hasegawa, Y., Hasib, A., Hassani, S., Haug, S., Hauser, R., Hauswald, L., Havener, L. B., Havranek, M., Hawkes, C. M., Hawkings, R. J., Hayden, D., Hayes, C., Hays, C. P., Hays, J. M., Hayward, H. S., Haywood, S. J., Heath, M. P., Hedberg, V, Heelan, L., Heer, S., Heidegger, K. K., Heilman, J., Heim, S., Heim, T., Heinemann, B., Heinrich, J. J., Heinrich, L., Heinz, C., Hejbal, J., Helary, L., Held, A., Hellesund, S., Hellman, S., Helsens, C., Henderson, R. C. W., Heng, Y., Henkelmann, S., Correia, A. M. Henriques, Herbert, G. H., Herde, H., Herget, V, Jimenez, Y. Hernandez, Herr, H., Herrmann, M. G., Herten, G., Hertenberger, R., Hervas, L., Herwig, T. 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A., Snyder, I. M., Snyder, S., Sobie, R., Soffa, A. M., Soffer, A., Sogaard, A., Soh, D. A., Sokhrannyi, G., Sanchez, C. A. Solans, Solar, M., Soldatov, E. Yu, Soldevila, U., Solodkov, A. A., Soloshenko, A., Solovyanov, O., Solovyev, V, Sommer, P., Son, H., Song, W., Song, W. Y., Sopczak, A., Sopkova, F., Sosa, D., Sotiropoulou, C. L., Sottocornola, S., Soualah, R., Soukharev, A. M., South, D., Sowden, B. C., Spagnolo, S., Spalla, M., Spangenberg, M., Spano, F., Sperlich, D., Spettel, F., Spieker, T. M., Spighi, R., Spigo, G., Spiller, L. A., Spiteri, D. P., Spousta, M., Stabile, A., Stamen, R., Stamm, S., Stanecka, E., Stanek, R. W., Stanescu, C., Stanislaus, B., Stanitzki, M. M., Stapf, B. S., Stapnes, S., Starchenko, E. A., Stark, G. H., Stark, J., Stark, S. H., Staroba, P., Starovoitov, P., Starz, S., Staszewski, R., Stegler, M., Steinberg, P., Stelzer, B., Stelzer, H. J., Stelzer-Chilton, O., Stenzel, H., Stevenson, T. J., Stewart, G. A., Stockton, M. 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E., Taylor, W., Tee, A. S., Teixeira-Dias, P., Ten Kate, H., Teng, P. K., Teoh, J. J., Tepel, F., Terada, S., Terashi, K., Terron, J., Terzo, S., Testa, M., Teuscher, R. J., Thais, S. J., Theveneaux-Pelzer, T., Thiele, F., Thomas, D. W., Thomas, J. P., Thompson, A. S., Thompson, P. D., Thomsen, L. A., Thomson, E., Tian, Y., Torres, R. E. Ticse, Tikhomirov, V. O., Tikhonov, Yu A., Timoshenko, S., Tipton, P., Tisserant, S., Todome, K., Todorova-Nova, S., Todt, S., Tojo, J., Tokar, S., Tokushuku, K., Tolley, E., Tomiwa, K. G., Tomoto, M., Tompkins, L., Toms, K., Tong, B., Tornambe, P., Torrence, E., Torres, H., Pastor, E. Torro, Tosciri, C., Toth, J., Touchard, F., Tovey, D. R., Treado, C. J., Trefzger, T., Tresoldi, F., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Tripiana, M. F., Trischuk, W., Trocme, B., Trofymov, A., Troncon, C., Trovatelli, M., Trovato, F., Truong, L., Trzebinski, M., Trzupek, A., Tsai, F., Tseng, J. 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T., Wittgen, M., Wobisch, M., Wolf, A., Wolf, T. M. H., Wolff, R., Wolter, M. W., Wolters, H., Wong, V. W. S., Woods, N. L., Worm, S. D., Wosiek, B. K., Wozniak, K. W., Wraight, K., Wu, M., S. L., Wu, Wu, X., Wu, Y., Wyatt, T. R., Wynne, B. M., Xella, S., Xi, Z., Xia, L., Xu, D., Xu, H., Xu, L., Xu, T., Xu, W., Yabsley, B., Yacoob, S., Yajima, K., Yallup, D. P., Yamaguchi, D., Yamaguchi, Y., Yamamoto, A., Yamanaka, T., Yamane, F., Yamatani, M., Yamazaki, T., Yamazaki, Y., Yan, Z., Yang, H. J., Yang, H. T., Yang, S., Yang, Y., Yang, Z., Yao, W-M, Yap, Y. C., Yasu, Y., Yatsenko, E., Ye, J., Ye, S., Yeletskikh, I, Yigitbasi, E., Yildirim, E., Yorita, K., Yoshihara, K., Young, C. J. S., Young, C., Yu, J., Yue, X., Yuen, S. P. Y., Zabinski, B., Zacharis, G., Zaffaroni, E., Zaidan, R., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zalieckas, J., Zambito, S., Zanzi, D., Zaripovas, D. R., Zeissner, S., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zeng, Q., Zenin, O., Zerwas, D., Zgubic, M., Zhang, D. F., Zhang, D., Zhang, F., Zhang, G., Zhang, H., Zhang, J., Zhang, L., Zhang, M., Zhang, P., Zhang, R., Zhang, X., Zhang, Y., Zhang, Z., Zhao, X., Zhao, Y., Zhao, Z., Zhemchugov, A., Zhou, B., Zhou, C., Zhou, L., Zhou, M. S., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V, Zibell, A., Zieminska, D., Zimine, N., Zimmermann, S., Zinonos, Z., Zinser, M., Ziolkowski, M., Zobernig, G., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zur Nedden, M., Zwalinski, L., Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), ATLAS, Ministerio de Economía y Competitividad (España), Aaboud, M., Aad, G., Abbott, B., Abdinov, O., Abeloos, B., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Adachi, S., Adamczyk, L., Adelman, J., Adersberger, M., Adiguzel, A., Adye, T., Affolder, A. A., Afik, Y., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmadov, F., Aielli, G., Akatsuka, S., Åkesson, T. P. A., Akilli, E., Akimov, A. V., Alberghi, G. L., Albert, J., Albicocco, P., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alhroob, M., Ali, B., Alimonti, G., Alison, J., Alkire, S. P., Allaire, C., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alshehri, A. A., Alstaty, M. I., Alvarez Gonzalez, B., Álvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amaral Coutinho, Y., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, J. K., Anderson, K. 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V., Tsirigotis, A., Tsirintanis, N., Tsiskaridze, V., Tskhadadze, E. G., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Tsybychev, D., Tu, Y., Tudorache, A., Tudorache, V., Tulbure, T. T., Tuna, A. N., Turchikhin, S., Turgeman, D., Turk Cakir, I., Turra, R., Tuts, P. M., Tzovara, E., Ucchielli, G., Ueda, I., Ughetto, M., Ukegawa, F., Unal, G., Undrus, A., Unel, G., Ungaro, F. C., Unno, Y., Uno, K., Urban, J., Urquijo, P., Urrejola, P., Usai, G., Usui, J., Vacavant, L., Vacek, V., Vachon, B., Vadla, K. O. H., Vaidya, A., Valderanis, C., Valdes Santurio, E., Valente, M., Valentinetti, S., Valero, A., Valéry, L., Vallance, R. A., Vallier, A., Valls Ferrer, J. A., Van Daalen, T. R., Van der Graaf, H., Van Gemmeren, P., Van Nieuwkoop, J., Van Vulpen, I., Vanadia, M., Vandelli, W., Vaniachine, A., Vankov, P., Vari, R., Varnes, E. W., Varni, C., Varol, T., Varouchas, D., Varvell, K. E., Vasquez, G. A., Vasquez, J. G., Vazeille, F., Vazquez Furelos, D., Vazquez Schroeder, T., Veatch, J., Vecchio, V., Veloce, L. M., Veloso, F., Veneziano, S., Ventura, A., Venturi, M., Venturi, N., Vercesi, V., Verducci, M., Vergel Infante, C. M., Vergis, C., Verkerke, W., Vermeulen, A. T., Vermeulen, J. C., Vetterli, M. C., Viaux Maira, N., Vicente Barreto Pinto, M., Vichou, I., Vickey, T., Vickey Boeriu, O. E., Viehhauser, G. H. A., Viel, S., Vigani, L., Villa, M., Villaplana Perez, M., Vilucchi, E., Vincter, M. G., Vinogradov, V. B., Vishwakarma, A., Vittori, C., Vivarelli, I., Vlachos, S., Vogel, M., Vokac, P., Volpi, G., Von Buddenbrock, S. E., Von Toerne, E., Vorobel, V., Vorobev, K., Vos, M., Vossebeld, J. H., Vranjes, N., Vranjes Milosavljevic, M., Vrba, V., Vreeswijk, M., Šfiligoj, T., Vuillermet, R., Vukotic, I., Ženiš, T., Živković, L., Wagner, P., Wagner, W., Wagner-Kuhr, J., Wahlberg, H., Wahrmund, S., Wakamiya, K., Walbrecht, V. M., Walder, J., Walker, R., Walker, S. D., Walkowiak, W., Wallangen, V., Wang, A. M., Wang, C., Wang, F., Wang, H., Wang, J., Wang, P., Wang, Q., Wang, R. -J., Wang, R., Wang, S. M., Wang, W. T., Wang, W., Wang, W. X., Wang, Y., Wang, Z., Wanotayaroj, C., Warburton, A., Ward, C. P., Wardrope, D. R., Washbrook, A., Watkins, P. M., Watson, A. T., Watson, M. F., Watts, G., Watts, S., Waugh, B. M., Webb, A. F., Webb, S., Weber, C., Weber, M. S., Weber, S. A., Weber, S. M., Weidberg, A. R., Weinert, B., Weingarten, J., Weirich, M., Weiser, C., Wells, P. S., Wenaus, T., Wengler, T., Wenig, S., Wermes, N., Werner, M. D., Werner, P., Wessels, M., Weston, T. D., Whalen, K., Whallon, N. L., Wharton, A. M., White, A. S., White, A., White, M. J., White, R., Whiteson, D., Whitmore, B. W., Wickens, F. J., Wiedenmann, W., Wielers, M., Wiglesworth, C., Wiik-Fuchs, L. A. M., Wildauer, A., Wilk, F., Wilkens, H. G., Wilkins, L. J., Williams, H. H., Williams, S., Willis, C., Willocq, S., Wilson, J. A., Wingerter-Seez, I., Winkels, E., Winklmeier, F., Winston, O. J., Winter, B. T., Wittgen, M., Wobisch, M., Wolf, A., Wolf, T. M. H., Wolff, R., Wolter, M. W., Wolters, H., Wong, V. W. S., Woods, N. L., Worm, S. D., Wosiek, B. K., Woźniak, K. W., Wraight, K., Wu, M., Wu, S. L., Wu, X., Wu, Y., Wyatt, T. R., Wynne, B. M., Xella, S., Xi, Z., Xia, L., Xu, D., Xu, H., Xu, L., Xu, T., Xu, W., Yabsley, B., Yacoob, S., Yajima, K., Yallup, D. P., Yamaguchi, D., Yamaguchi, Y., Yamamoto, A., Yamanaka, T., Yamane, F., Yamatani, M., Yamazaki, T., Yamazaki, Y., Yan, Z., Yang, H. J., Yang, H. T., Yang, S., Yang, Y., Yang, Z., Yao, W. -M., Yap, Y. C., Yasu, Y., Yatsenko, E., Ye, J., Ye, S., Yeletskikh, I., Yigitbasi, E., Yildirim, E., Yorita, K., Yoshihara, K., Young, C. J. S., Young, C., Yu, J., Yue, X., Yuen, S. P. Y., Zabinski, B., Zacharis, G., Zaffaroni, E., Zaidan, R., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zalieckas, J., Zambito, S., Zanzi, D., Zaripovas, D. R., Zeißner, S. V., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zeng, Q., Zenin, O., Zerwas, D., Zgubič, M., Zhang, D. F., Zhang, D., Zhang, F., Zhang, G., Zhang, H., Zhang, J., Zhang, L., Zhang, M., Zhang, P., Zhang, R., Zhang, X., Zhang, Y., Zhang, Z., Zhao, X., Zhao, Y., Zhao, Z., Zhemchugov, A., Zhou, B., Zhou, C., Zhou, L., Zhou, M. S., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zibell, A., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Zinser, M., Ziolkowski, M., Zobernig, G., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zur Nedden, M., Zwalinski, L., UAM. Departamento de Física Teórica, De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., D’Amen , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Spighi , R., Franchini , M., Mengarelli , A., Romano , M., Valentinetti , S., Alberghi , G. L., Biondi , S., Fabbri , F., Lasagni Manghi , F, Massa , L., Ucchielli , G., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Giangiacomi , N., Negrini , M., ATLAS collaboration, Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universidade do Minho, Aaboud, M, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Mirto, A, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, Ventura, Andrea, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Akilli, Ece, Amrouche, Cherifa Sabrina, Ancu, Lucian Stefan, Benoit, Mathieu, Calace, Noemi, Clark, Allan Geoffrey, Della Volpe, Domenico, Di Bello, Francesco Armando, Dubreuil, Arnaud, Ferrere, Didier, Gadatsch, Stefan, Golling, Tobias, Gonzalez Sevilla, Sergio, Iacobucci, Giuseppe, Iizawa, Tomoya, Jansky, Roland, Khoo, Teng Jian, Kiehn, Moritz, Lanfermann, Marie Christine, Lionti, Anthony Eric, March Ruiz, Luis, Mermod, Philippe, Paolozzi, Lorenzo, Poggi, Riccardo, Raine, Johnny, Salamani, Dalila, Schramm, Steven, Sfyrla, Anna, Sultan, D M S, Valente, Marco, Vicente Barreto Pinto, Mateus, Wu, Xin, Zaffaroni, Ettore, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2922, Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Ale, Ra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, Fakülteler, Fen - Edebiyat Fakültesi, Fizik Bölümü, TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Sultansoy, Saleh F., ATLAS (IHEF, IoP, FNWI), XENON (IHEF, IoP, FNWI), and IHEF (IoP, FNWI)
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Photon ,LEAD-LEAD COLLISIONS ,PP COLLISIONS ,ROOT-S(NN)=2.76 TEV ,DEPENDENCE ,heavy ion: scattering ,Physics::Instrumentation and Detectors ,Monte Carlo method ,Relativistic heavy ion collisions ,photon–jet transverse momentum correlations ,nucl-ex ,01 natural sciences ,High Energy Physics - Experiment ,Double Drell–Yan ,Subatomär fysik ,High Energy Physics - Experiment (hep-ex) ,Double parton-scattering ,Subatomic Physics ,scattering [p p] ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,luminosities ,Collisions ,Nuclear Experiment (nucl-ex) ,Nuclear Experiment ,dimension: 2 ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Monte Carlo ,ComputingMilieux_MISCELLANEOUS ,QC ,Computer Science::Databases ,Physics ,Jet (fluid) ,Large Hadron Collider ,Settore FIS/01 - Fisica Sperimentale ,photon ,yield [jet] ,transverse momentum: correlation ,ATLAS ,lcsh:QC1-999 ,Mathematics and natural scienses: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP] ,medicine.anatomical_structure ,CERN LHC Coll ,2 [dimension] ,nuclear matter ,LHC ,jet: yield ,Particle Physics - Experiment ,Nuclear and High Energy Physics ,p p: scattering ,energy loss [parton] ,530 Physics ,Ciências Naturais::Ciências Físicas ,Astrophysics::High Energy Astrophysical Phenomena ,Ciências Físicas [Ciências Naturais] ,FOS: Physical sciences ,ddc:500.2 ,LHC, ATLAS, High Energy Physics ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,jets ,Nuclear physics ,Atlas (anatomy) ,0103 physical sciences ,Calibration ,medicine ,ddc:530 ,Rapidity ,Nuclear Physics - Experiment ,5020 GeV-cms/nucleon ,High Energy Physics ,010306 general physics ,Ciencias Exactas ,Four-lepton production ,Higgs golden decay channel ,Science & Technology ,010308 nuclear & particles physics ,hep-ex ,High Energy Physics::Phenomenology ,nucleus ,Matematikk og naturvitenskap: 400::Fysikk: 430::Kjerne- og elementærpartikkelfysikk: 431 [VDP] ,Física ,Nuclear matter ,calibration ,jet quenching ,Automatic Keywords ,rapidity ,Experimental High Energy Physics ,High Energy Physics::Experiment ,parton: energy loss ,correlation [transverse momentum] ,lcsh:Physics ,experimental results - Abstract
Jets created in association with a photon can be used as a calibrated probe to study energy loss in the medium created in nuclear collisions. Measurements of the transverse momentum balance between isolated photons and inclusive jets are presented using integrated luminosities of 0.49 nb−1 of Pb + Pb collision data at TeV and 25 pb−1 of pp collision data at TeV recorded with the ATLAS detector at the LHC. Photons with transverse momentum GeV and are paired with all jets in the event that have GeV and pseudorapidity . The transverse momentum balance given by the jet-to-photon ratio, , is measured for pairs with azimuthal opening angle . Distributions of the per-photon jet yield as a function of , , are corrected for detector effects via a two-dimensional unfolding procedure and reported at the particle level. In pp collisions, the distributions are well described by Monte Carlo event generators. In Pb + Pb collisions, the distribution is modified from that observed in pp collisions with increasing centrality, consistent with the picture of parton energy loss in the hot nuclear medium. The data are compared with a suite of energy-loss models and calculations., We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS, CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF, and MPG, Germany; GSRT, Greece; RGC, Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; MES of Russia and NRC KI, Russian Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIA, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, Canarie, CRC and Compute Canada, Canada; COST, ERC, ERDF, Horizon 2020, and Marie Sklodowska-Curie Actions, European Union; Investissements d' Avenir Labex and Idex, ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya, Spain; The Royal Society and Leverhulme Trust, United Kingdom., info:eu-repo/semantics/publishedVersion
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- 2019
27. Peptide-functionalised magnetic silk nanoparticles produced by a swirl mixer for enhanced anticancer activity of ASC-J9
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Tomeh, M.A., Hadianamrei, R., Xu, D., Brown, S., and Zhao, X.
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Magnetic Phenomena ,Silk ,Reproducibility of Results ,Antineoplastic Agents ,Surfaces and Interfaces ,General Medicine ,Silicon Dioxide ,Colloid and Surface Chemistry ,Drug Delivery Systems ,Humans ,Nanoparticles ,Physical and Theoretical Chemistry ,Colorectal Neoplasms ,Peptides ,Biotechnology - Abstract
Silk fibroin is an FDA approved biopolymer for clinical applications with great potential in nanomedicine. However, silk-based nanoformulations are still facing several challenges in processing and drug delivery efficiency (such as reproducibility and targetability), especially in cancer therapy. To address these challenges, robust and controllable production methods are required for generating nanocarriers with desired properties. This study aimed to develop a novel method for the production of peptide-functionalized magnetic silk nanoparticles with higher selectivity for cancer cells for targeted delivery of the hydrophobic anticancer agent ASC-J9. A new microfluidic device with a swirl mixer was designed to fabricate magnetic silk nanoparticles (MSNP) with desired size and narrow size distribution. The surface of MSNPs was functionalized with a cationic amphiphilic anticancer peptide, G(IIKK)3I-NH2 (G3), to enhance their selectivity towards cancer cells. The G3-MSNPs increased the cellular uptake and anticancer activity of G3 in HCT 116 colorectal cancer cells compared to free G3. Moreover, the G3-MSNPs exhibited considerably higher cellular uptake and cytotoxicity in HCT 116 colorectal cancer cells compared to normal cells (HDFs). Encapsulating ASC-J9 in G3-MSNPs resulted in augmented anticancer activity compared to free ASC-J9 and non-functionalized ASC-J9 loaded MSNPs within its biological half-life. Hence, functionalizing MSNPs with G3 enabled targeted delivery of ASC-J9 to cancer cells and enhanced its anticancer effect. Functionalization of nanoparticles with anticancer peptides could be regarded as a new strategy for targeted delivery and enhanced efficiency of anticancer drugs. Furthermore, the microfluidic device introduced in this paper offers a robust and reproducible method for fabrication of small sized homogenous nanoparticles.
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- 2022
28. Palaeoclimate and palaeoenvironment evolution from the Last Glacial Maximum
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Zhao, X.
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- 2022
29. Application of Quantum Density Matrix in Classical Question Answering and Classical Image Classification
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Zhao, X. Q. and Wan, H.
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FOS: Computer and information sciences ,Computer Science - Machine Learning ,Quantum Physics ,Computer Science - Computation and Language ,FOS: Physical sciences ,Quantum Physics (quant-ph) ,Computation and Language (cs.CL) ,Machine Learning (cs.LG) - Abstract
Quantum density matrix represents all the information of the entire quantum system, and novel models of meaning employing density matrices naturally model linguistic phenomena such as hyponymy and linguistic ambiguity, among others in quantum question answering tasks. Naturally, we argue that applying the quantum density matrix into classical Question Answering (QA) tasks can show more effective performance. Specifically, we (i) design a new mechanism based on Long Short-Term Memory (LSTM) to accommodate the case when the inputs are matrixes; (ii) apply the new mechanism to QA problems with Convolutional Neural Network (CNN) and gain the LSTM-based QA model with the quantum density matrix. Experiments of our new model on TREC-QA and WIKI-QA data sets show encouraging results. Similarly, we argue that the quantum density matrix can also enhance the image feature information and the relationship between the features for the classical image classification. Thus, we (i) combine density matrices and CNN to design a new mechanism; (ii) apply the new mechanism to some representative classical image classification tasks. A series of experiments show that the application of quantum density matrix in image classification has the generalization and high efficiency on different datasets. The application of quantum density matrix both in classical question answering tasks and classical image classification tasks show more effective performance.
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- 2022
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30. Reliability and Failures in Solid State Lighting Systems
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van Driel, W.D., Jacobs, B.M.M., Onushkin, G., Watte, P., ZHAO, X., Davis, J. Lynn, van Driel, Willem Dirk, and Mehr, Maryam Yazdan Mehr
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Reliability is an essential scientific and technological domain intrinsically linked with system integration. Nowadays, semiconductor industries are confronted with ever-increasing design complexity, dramatically decreasing design margins, increasing chances for and consequences of failures, shortening of product development and qualification time, and increasing difficulties to meet quality, robustness, and reliability requirements. The scientific successes of many micro/nano-related technology developments cannot lead to business success without innovation and breakthroughs in the way that we address reliability through the whole value chain. The aim of reliability is to predict, optimize, and design upfront the reliability of micro/nanoelectronics and systems, an area denoted as “Design for Reliability (DfR)”. While virtual schemes based on numerical simulation are widely used for functional design, they lack a systematic approach when used for reliability assessments. Besides this, lifetime predictions are still based on old standards assuming a constant failure rate behavior. In this chapter, we will present the reliability and failures found in solid-state lighting systems. It includes both degradation and catastrophic failure modes from observation toward a full description of its mechanism obtained by extensive use of acceleration tests using knowledge-based qualification methods.
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- 2022
31. Genome-wide association study for reproduction-related traits in Chinese domestic goose
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Gao, G., Chen, P., Zhou, C., Zhao, X., Zhang, K., Wu, R., Zhang, C., Wang, Y., Xie, Y., and Wang, Q.
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1. This study measured six reproduction traits in a Sichuan white goose population (209 individuals), including fertility, qualified egg rate, plasma concentrations of progesterone (P), follicle-stimulating hormone (FSH), prolactin (PRL) and oestrogen (E2). 2. Whole-genome resequencing data from the same goose population (209 individuals) were used in a genome-wide association study (GWAS) utilising a mixed linear model to investigate the genes and genetic markers associated with reproduction traits. The frequency of the selected SNPs and haplotypes were determined using the Matrix-Assisted Laser Desorption Ionisation Time-Of-Flight Mass Spectrometry (MALDI-TOF MS) method. 3. In total, 42 SNPs significantly associated with these traits were identified. A haplotype block was constructed based on five SNPs that were significantly associated with qualified egg rate, with individuals having the haplotype CCTTAAGGAA having the lowest qualified egg rate. 4. In conclusion, these results provided potential markers for marker-assisted selection to improve goose reproductive performance and a basis for elucidating the genetics of goose reproduction.
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- 2022
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32. Thermal Transport of Fractionalized Antiferromagnetic and Field Induced States in the Kitaev Material Na$_2$Co$_2$TeO$_6$
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Guang, S. K., Li, N., Luo, R. L., Huang, Q., Wang, Y. Y., Yue, X. Y., Xia, K., Li, Q. J., Zhao, X., Chen, G., Zhou, H. D., and Sun, X. F.
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Condensed Matter - Strongly Correlated Electrons ,Strongly Correlated Electrons (cond-mat.str-el) ,FOS: Physical sciences - Abstract
We report an in-plane thermal transport study of the honeycomb Kitaev material Na$_2$Co$_2$TeO$_6$ at subKelvin temperatures. In zero field, the $\kappa(T)$ displays a rather weak $T$-dependence but has a non-zero residual term $\kappa_0/T$, indicating strong phonon scattering by magnetic excitation and the possibility of itinerant spinon-like excitations coexisting with an antiferromagnetic order below 27 K. We propose the zero-field ground state is a novel fractionalized antiferromagnetic (AF*) state with both magnetic order and fractionalized excitations. With both the heat current and external field along the $a*$ (Co-Co bond) direction, the $\kappa_{a*}$ exhibits two sharp minima at 7.5 T and 10 T, and its value at 8.5 T is almost the same as the pure phononic transport for the high-field polarized state. This confirms the phase boundaries of the reported field-induced intermediate state and suggest its gapless continuum excitations possibly transport heat. No such intermediate phase was found in the $\kappa_a$ for the current and field along the $a$ (zigzag chain) direction. Finally, Na$_2$Co$_2$TeO$_6$ displays a strongly anisotropic magneto-thermal conductivity since the in-plane (out-of-plane) field strongly enhances (suppresses) the $\kappa_{a*}$ and $\kappa_a$., Comment: 7 pages, 3 figures
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- 2022
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33. SuperFGD prototype time resolution studies
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Alekseev, I., Arihara, T., Baranov, V., Bartoszek, L., Bernardi, L., Blondel, A., Boikov, A. V., Buizza-Avanzini, M., Cadoux, F., Capó, J., Cayo, J., Chakrani, J., Chong, P. S., Chvirova, A., Danilov, M., Davydov, Yu. I., Dergacheva, A., Dokania, N., Douqa, D., Drapier, O., Eguchi, A., Favre, Y., Fedorova, D., Fedotov, S., Fujii, Y., Gastaldi, F., Gendotti, A., Glagolev, V., Guillaumat, R., Iwamoto, K., Jakkapu, M., Jesús-Valls, C., Jung, C. K., Kakuno, H., Kasetti, S. P., Khabibullin, M., Khotjantsev, A., Kikutani, H., Kobayashi, T., Kodama, S., Korzenev, A., Kose, U., Kudenko, Y., Kutter, T., Last, D., Li, B., Li, Z., Lin, L. S., Lin, S., Louzir, M., Lux, T., Maret, L., Martynenko, S., Matsubara, T., Mauger, C., McGrew, C., Mefodiev, A., Mineev, O., Nakadaira, T., Nakagiri, K., Nanni, J., Nicola, L., Noah, E., Paolone, V., Parsa, S., Pellegrino, R., Ramirez, M. A., Reh, M., Ricco, C., Rubbia, A., Sakashita, K., Sanchez, F., Sgalaberna, D., Shvartsman, A., Skrobova, N., Suslov, I. A., Suvorov, S., Svirida, D., Teklu, A., Tereshchenko, V. V., Tzanov, M., Vasilyev, I. I., Wood, K., Yang, G., Yershov, N., Yokoyama, M., Yoshimoto, Y., Zhao, X., Zilberman, P., and Zimmerman, E. D.
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Physics - Instrumentation and Detectors ,Physics::Instrumentation and Detectors ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,Instrumentation ,Mathematical Physics - Abstract
The SuperFGD will be a part of the ND280 near detector of the T2K and Hyper Kamiokande projects, that will help to reduce systematic uncertainties related with neutrino flux and cross-section modeling. The upgraded ND280 will be able to perform a full exclusive reconstruction of the final state from neutrino-nucleus interactions, including measurements of low momentum protons, pions and, for the first time, event-by event measurements of neutron kinematics. The time resolution defines the neutron energy resolution. We present the results of time resolution measurements made with the SuperFGD prototype that consists of 9216 plastic scintillator cubes (cube size is 1 cm$^3$) readout with 1728 wavelength-shifting fibers going along three orthogonal directions. We use data from the muon beam exposure at CERN. The time resolution of 0.97 ns was obtained for one readout channel after implementing the time calibration with a correction for the time-walk effect. The time resolution improves with energy deposited in a scintillator cube. Averaging two readout channels for one scintillator cube improves the time resolution to 0.68 ns which means that signals in different channels are not synchronous. Therefore the contribution from the time recording step of 2.5 ns is averaged as well. Averaging time values from N channels improves the time resolution by $\sim 1/\sqrt{N}$. Therefore a very good time resolution should be achievable for neutrons since neutron recoils hit typically several scintillator cubes and in addition produce larger amplitudes than muons. Measurements performed with a laser and a wide-bandwidth oscilloscope demonstrated that the time resolution obtained with the muon beam is not far from its expected limit. The intrinsic time resolution of one channel is 0.67 ns for signals of 56 photo-electron typical for minimum ionizing particles., Comment: 12 pages, 9 figures. Revised text, results unchanged
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- 2022
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34. Type 1 Diabetes Mellitus and Peripheral Nerve Injury Occurring After PD-1 Treatment: A Case Report and Analysis
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Tian Y, Li T, Ding H, Zhao X, Luo J, Chen K, Tang Z, Huang L, Li L, and Yang L
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Automotive Engineering - Abstract
Objective: To raise the clinicians’ awareness of the rare adverse event of Immune Checkpoint Inhibitor (ICPis)-associated diabetes mellitus and peripheral nerve injury. Methods: We report a case of ICPis-associated diabetes and peripheral nerve injury caused by treatment with pablizumab in a 60-year-old male with lung cancer. Results: We describe a 60-year-old male who presented with “three more and one less” diabetic symptoms and severe numbness in the extremities after treatment with pabrolizumab. Based on the patient’s clinical symptoms, ancillary tests and corresponding follow-up findings, the patient was finally diagnosed with ICPis-associated type 1 diabetes and ICPis-associated peripheral nerve injury. The patient had poor compliance and was not given insulin glucose-lowering therapy at the beginning of the disease, and now the pancreatic islet function was severely impaired, the glycemic control was poor, and the numbness of the extremities did not improve significantly, which seriously affected the quality of life of the patient. Conclusion: ICPis-related diabetes mellitus and peripheral nerve injury is a relatively rare immune-related adverse reaction, which progresses rapidly and is more harmful, and therefore, should be taken seriously by doctors and patients in clinical work.
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- 2022
35. Rechargeable Dual-Carbon Batteries: A Sustainable Battery Technology
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Tebyetekerwa, M, Duignan, TT, Xu, Z, Song Zhao, X, Tebyetekerwa, M [0000-0002-4243-6043], and Apollo - University of Cambridge Repository
- Subjects
dual-carbon batteries ,graphite ,carbon ,graphite intercalation compounds ,dual-ion batteries ,dual-ion intercalation ,sustainability - Abstract
Dual‐carbon batteries (DCBs) with both electrodes composed of carbon materials are currently at the forefront of industrial consideration. This is due to their low cost, safety, sustainability, fast charging, and simpler electrochemistry than lithium and other post‐lithium metal‐ion batteries. This article provides an overview of the past lessons on rechargeable DCBs and their future promises. In brief, it introduces the reader to DCBs as one of the most promising energy storage solutions for balancing sustainability, cost and performance, their history, electrochemistry and associated charge storage mechanisms. Then, the past lessons with respect to their ion intercalation are provided. These include DCB mechanisms during different anion/cation intercalation in layered carbons and their intercalation compounds and electrode structures versus electrochemical performance. This is followed by a description of the current issues affecting DCBs like capacity fading and self‐discharging, electrolyte instability, low energy densities and electrode exfoliation, together with their remedies. Finally, an insightful perspective proposing key areas requiring significant research efforts toward the success of DCBs is provided responsible for accelerating the commercialization and adoption of DCBs toward a sustainable and circular economy. This article is a simplified guide to understanding the current state and future research needed to develop sustainable DCBs.
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- 2022
36. Genome-wide association study for reproduction-related traits in Chinese domestic goose
- Author
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Gao, G., Chen, P., Zhou, C., Zhao, X., Zhang, K., Wu, R., Zhang, C., Wang, Y., Xie, Y., and Wang, Q.
- Abstract
1. This study measured six reproduction traits in a Sichuan white goose population (209 individuals), including fertility, qualified egg rate, plasma concentrations of progesterone (P), follicle-stimulating hormone (FSH), prolactin (PRL) and oestrogen (E2). 2. Whole-genome resequencing data from the same goose population (209 individuals) were used in a genome-wide association study (GWAS) utilising a mixed linear model to investigate the genes and genetic markers associated with reproduction traits. The frequency of the selected SNPs and haplotypes were determined using the Matrix-Assisted Laser Desorption Ionisation Time-Of-Flight Mass Spectrometry (MALDI-TOF MS) method. 3. In total, 42 SNPs significantly associated with these traits were identified. A haplotype block was constructed based on five SNPs that were significantly associated with qualified egg rate, with individuals having the haplotype CCTTAAGGAA having the lowest qualified egg rate. 4. In conclusion, these results provided potential markers for marker-assisted selection to improve goose reproductive performance and a basis for elucidating the genetics of goose reproduction.
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- 2022
- Full Text
- View/download PDF
37. Magnon-Polaron Driven Thermal Hall Effect in a Heisenberg-Kitaev Antiferromagnet
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Li, N., Neumann, R. R., Guang, S. K., Huang, Q., Liu, J., Xia, K., Yue, X. Y., Sun, Y., Wang, Y. Y., Li, Q. J., Jiang, Y., Fang, J., Jiang, Z., Zhao, X., Mook, A., Henk, J., Mertig, I., Zhou, H. D., and Sun, X. F.
- Subjects
Condensed Matter - Strongly Correlated Electrons ,Strongly Correlated Electrons (cond-mat.str-el) ,FOS: Physical sciences ,Condensed Matter::Strongly Correlated Electrons ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect - Abstract
The thermal Hall effect, defined as a heat current response transversal to an applied temperature gradient, is a central experimental probe of exotic electrically insulating phases of matter. A key question is how the interplay between magnetic and structural degrees of freedom gives rise to a nonzero thermal Hall conductivity (THC). Here, we present evidence for an intrinsic thermal Hall effect in the Heisenberg-Kitaev antiferromagnet and spin-liquid candidate Na$_2$Co$_2$TeO$_6$ brought about by the quantum-geometric Berry curvature of so-called magnon polarons, resulting from magnon-phonon hybridization. At low temperatures, our field- and temperature-dependent measurements show a negative THC for magnetic fields below 10 T and a sign change to positive THC above. Theoretically, the sign and the order of magnitude of the THC cannot be solely explained with magnetic excitations. We demonstrate that, by incorporating spin-lattice coupling into our theoretical calculations, the Berry curvature of magnon polarons counteracts the purely magnonic contribution, reverses the overall sign of the THC, and increases its magnitude, which significantly improves agreement with experimental data. Our work highlights the crucial role of spin-lattice coupling in the thermal Hall effect., Comment: 19 pages, 4 figures
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- 2022
- Full Text
- View/download PDF
38. Carbothermal reduction of mill scales formed on steel billets during continuous casting
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Suarez, SME, Borja-Castro, LE, Valerio-Cuadros, MI, Domínguez, AB, Cabrera-Tinoco, HA, Huaman, E, Valencia-Bedregal, RA, Zhao, X, Zhang, Y, Zhang, D, Barnes, Crispin, De Los Santos Valladares, Luis, Barnes, Crispin [0000-0001-7337-7245], De Los Santos Valladares, Luis [0000-0001-5930-9916], and Apollo - University of Cambridge Repository
- Subjects
Proceedings of the International Conference on the Applications of the M��ssbauer Effect (ICAME 2021), 5-10 September 2021, Brasov, Romania ,Steel industry ,Mill scales ,Mossbauer spectroscopy ,Proceedings of the International Conference on the Applications of the Mössbauer Effect (ICAME 2021), 5-10 September 2021, Brasov, Romania ,Steel billets ,Continuous casting process ,Carbothermal reduction ,Article ,X-ray diffraction - Abstract
A billet is a bar made from crude steel which surface contains scales which are rich in iron oxides. This study presents the carbothermal reduction of the scales formed in steel billets. The process included the reaction of the iron oxides contents with carbon (in ratio 5:1) and annealing in a tubular furnace under argon atmosphere. The occurred reactions are discussed using thermodynamic calculations and thermal analysis which indicate a three-stage reduction process Fe3O4 ➔ FeO ➔ Fe3C ➔α-Fe with intermediate reactions at the interval temperature 960 and 1300 °C. The X-ray diffraction confirms the reduction to α-Fe with minor presence of unreacted C, magnetite and wustite. Mössbauer spectroscopy analysis was performed at room temperature where a typical sextet corresponding to the dominant α-Fe is shown as well as wustite, magnetite and cementite to a lesser extent. The magnetization measurements confirm the ferromagnetic state corresponding to the α-Fe.
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- 2021
39. Enzyme-catalyzed Synthesis of Novel Solid–liquid Phase Change Energy Storage Materials Based on Levulinic Acid and 1,4 butanediol
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Zhang L, Zhao X, Wang Q, Yan Y, Xu Z, Li C, and Zhai S
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Phase change ,chemistry.chemical_compound ,Enzyme catalyzed ,chemistry ,Levulinic acid ,Organic chemistry ,1,4-Butanediol ,Solid liquid ,Energy storage - Abstract
With the rapid development of society, all kinds of non-renewable energy resources are constantly developed and utilized, energy storage is one of the best ways to solve the energy shortage. In this study , levulinic acid (LA) and 1,4 butanediol (BDO) were used to synthesize a novel polyol ester (LABDO) by biological and chemical methods. The biological method exhibited excellent performance in the synthesis process, where 87.5% of LABDO yield under optimal conditions, while the chemical method had more byproducts and higher energy consumption. Finally, the thermal properties of the obtained phase change materials (PCMs) were evaluated. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the melting temperature of LABDO was 50.51°C, the latent heat of melting was 156.1J/g, and the pyrolysis temperature was 150-160°C. Compared with traditional paraffin wax, the prepared PCMs have suitable phase transition temperature, higher latent heat of melting and better thermal stability. The thermal conductivity can be increased to 0.34W·m-1· k-1 by adding expanded graphite. In summary, LABDO can be used as low temperature phase change energy storage materials.
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- 2021
40. Three channels of monetary policy international transmission: Identifying spillover effects from the US to China
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Zhang, M., Şensoy, Ahmet, Cheng, F., Zhao, X., and Şensoy, Ahmet
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China ,US monetary policy ,Business, Management and Accounting (miscellaneous) ,Spillovers ,Proxy VAR model ,Financial transmission channel ,Finance - Abstract
We identify and compare three channels through which the adjustment of US monetary policy spills over into China, including trade, exchange rate, and financial channels. A proxy vector autoregression model, with a high-frequency identification strategy, is applied to measure the causal effect of monetary policy shocks to the fundamentals of China’s economy. The analysis reveals that tightness in US monetary policy increases inflation in China by 0.2% and drives down output by 1%. We also find that the spillover effect from the US to China is immediate and significant through each of the three channels. Furthermore, the financial channel is significant in terms of its effect on interest rate expectations and long-term financing premia for Chinese companies. Our results support the notion of the financial channel as a key transmission mechanism for cross-country spillovers of monetary policy, which should be of much interest to participants in financial markets.
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- 2022
41. The clinical relevance of oliguria in the critically ill patient: analysis of a large observational database
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Vincent J. -L., Ferguson A., Pickkers P., Jakob S. M., Jaschinski U., Almekhlafi G. A., Leone M., Mokhtari M., Fontes L. E., Bauer P. R., Sakr Y., Tomas E., Bibonge E. A., Charra B., Faroudy M., Doedens L., Farina Z., Adler D., Balkema C., Kok A., Alaya S., Gharsallah H., Muzha D., Temelkov A., Georgiev G., Simeonov G., Tsaryanski G., Georgiev S., Seliman A., Vrankovic S., Vucicevic Z., Gornik I., Barsic B., Husedzinovic I., Pavlik P., Manak J., Kieslichova E., Turek R., Fischer M., Valkova R., Dadak L., Dostal P., Malaska J., Hajek R., Zidkova A., Lavicka P., Starkopf J., Kheladze Z., Chkhaidze M., Kaloiani V., Medve L., Sarkany A., Kremer I., Marjanek Z., Tamasi P., Krupnova I., Vanags I., Liguts V., Pilvinis V., Vosylius S., Kekstas G., Balciunas M., Kolbusz J., Kubler A., Mielczarek B., Mikaszewska-Sokolewicz M., Kotfis K., Tamowicz B., Sulkowski W., Smuszkiewicz P., Pihowicz A., Trejnowska E., Hagau N., Filipescu D., Droc G., Lupu M. N., Nica A., Stoica R., Tomescu D. R., Constantinescu D. L., Valcoreanu Zbaganu G. M., Slavcovici A., Bagin V., Belsky D., Palyutin S., Shlyapnikov S., Bikkulova D., Gritsan A., Natalia G., Makarenko E., Kokhno V., Tolkach A., Kokarev E., Belotserkovskiy B., Zolotukhin K., Kulabukhov V., Soskic L., Palibrk I., Jankovic R., Jovanovic B., Pandurovic M., Bumbasirevic V., Uljarevic B., Surbatovic M., Ladjevic N., Slobodianiuk G., Sobona V., Cikova A., Gebhardtova A., Jun C., Yunbo S., Dong J., Feng S., Duan M., Xu Y., Xue X., Gao T., Xing X. Z., Zhao X., Li C. H., Gengxihua G., Tan H., Xu J., Jiang L., Tiehe Q., Bingyu Q., Shi Q., Lv Z., Zhang L., Jingtao L., Zhen Z., Wang Z., Wang T. H., Yuhong L., Zhai Q., Chen Y., Wang C., Jiang W., Ruilan W., Xiaobo H., Ge H., Yan T., Yuhui C., Zhang J., Jian-Hong F., Zhu H., Huo F., Wang Y., Li C., Zhuang M., Ma Z., Sun J., Liuqingyue L., Yang M., Meng J., Ma S., Kang Y., Yu L., Peng Q., Wei Y., Zhang W., Sun R., Yeung A., Wan W. L., Sin K. K. C., Lee K. L., Wijanti M., Widodo U., Samsirun H., Sugiman T., Wisudarti C., Maskoen T. T., Hata N., Kobe Y., Nishida O., Miyazaki D., Nunomiya S., Uchino S., Kitamura N., Yamashita K., Hashimoto S., Fukushima H., Adib N. A. N., Tai L. L., Tony B., Bigornia R. R., Palo J. E., Chatterjee S., Tan B. H., Kong A., Goh S., Lee C. -C., Pothirat C., Khwannimit B., Theerawit P., Pornsuriyasak P., Piriyapatsom A., Mukhtar A., Hamdy A. N., Hosny H., Ashraf A., Nowruzinia S., Lotfi A. H., Zand F., Nikandish R., Moghaddam O. M., Cohen J., Sold O., Sfeir T., Hasan A. Y., Abugaber D., Ahmad H., Tantawy T., Baharoom S., Algethamy H., Amr A., Almekhlafi G., Coskun R., Sungur M., Cosar A., Gucyetmez B., Demirkiran O., Senturk E., Ulusoy H., Atalan H. K., Serin S., Kati I., Alnassrawi Z., Almemari A., Krishnareddy K., Kashef S., Alsabbah A., Poirier G., Marshall J. C., Herridge M., Fernandez-Medero R., Fulda G., Banschbach S., Quintero J., Schroeder E., Sicoutris C., Gueret R., Kashyap R., Bauer P., Nanchal R., Wunderink R. G., Jimenez E., Ryan A., Prince D., Edington J., Van Haren F., Bersten A., Hawkins D. J., Kilminster M., Sturgess D., Ziegenfuss M., O' Connor S., Lipman J., Campbell L., McAllister R., Roberts B., Williams P., Parke R., Seigne P., Freebairn R., Nistor D., Oxley C., Young P., Valentini R., Wainsztein N., Comignani P., Casaretto M., Sutton G., Villegas P., Galletti C., Neira J., Rovira D., Hidalgo J., Sandi F., Caser E., Thompson M. M., D'Agostino Dias M., Lunardi M. C., Youssef N. C., Lobo S., Silva R., Sales J. A., Melo L. M. C., Oliveira M., Fonte M., Grion C., Feijo C., Rezende V., Assuncao M., Neves A. P., Gusman P., Dalcomune D., Teixeira C., Kaefer K., Maia I., Dantas V. S., Filho R. C., Amorim F., Assef M., Schiavetto P., Houly J., Bianchi F., Dias F., Avila C., Rego L., Castro P., Passos J., Mendes C., Mecatti G. C., Ferrreira M., Irineu V., Guerreiro M., Ugarte S., Tomicic V., Godoy C., Samaniego W., Escamilla I., Castro Castro L. F., Duque G. L., Diaz-Guio D., Benitez F., Urrego A. G., Buitrago R., Ortiz G., Villalba Gaviria M. C., Salas D., Ramirez-Arce J., Salgado E., Morocho D., Vergara J., Sang M. C., Orellana-Jimenez C., Garrido L., Diaz O., Resiere D., Osorio C., De La Vega A., Carrillo R., Sanchez V., Villagomez A., Zubieta R. M., Sandia M., Zalatiel M., Poblano M., Gonzalez D. R., Arrazola F., Juan Francisco L. L., Namendys-Silva S. A., Moya R. G., Hernandez M., Rodriguez Cadena D. M., Islas I. L., Ballesteros Zarzavilla C. M., Matos A., Oyanguren I., Cerna J., Sierra R. Q., Jimenez R., Castillo L., Ocal R., Sencan A., Mareque Gianoni S. M., Deicas A., Hurtado J., Burghi G., Martinelli A., Von Der Osten I., Du Maine C., Bhattacharyya M., Bandyopadhyay S., Yanamala S., Gopal P., Sahu S., Ibrahim M., Rathod D., Mukundan N., Dewan A., Amin P., Samavedam S., Shah B., Gurupal G., Lahkar B., Mandal A. K., Sircar M., Ghosh S., Balasubramani V., Kapadia F., Vadi S., Nair K., Tripathy S., Nandakumar S., Sharma J., Kar A., Jha S., Zirpe K., Patel M., Bhavsar A., Samaddar D. P., Kulkarni A., Hashmi M., Ali W., Nadeem S., Indraratna K., Margarit A., Urbanek P., Schlieber J., Reisinger J., Auer J., Hartjes A., Lerche A., Janous T., Kink E., Krahulec W., Smolle K. -H., Van Der Schueren M., Thibo P., Vanhoof M., Ahmet I., Gadisseux P., Dufaye P., Jacobs O., Fraipont V., Biston P., Dive A., Bouckaert Y., Gilbert E., Gressens B., Pinck E., Collin V., De Waele J. J., Rimachi R., Gusu D., De Decker K., Mandianga K., Heytens L., Wittebole X., Spapen H., Van Collie O., Vandenheede W., Rogiers P., Kolodzeike P., Kruse M., Andersen T., Harjola V. -P., Saarinen K., Durocher A., Moulront S., Lepape A., Losser M. -R., Cabaret P., Kalaitzis E., Zogheib E., Charve P., Francois B., Lefrant J. -Y., Beilouny B., Forceville X., Misset B., Jacobs F., Floccard B., Payen D., Wynckel A., Castelain V., Faure A., Lavagne P., Lepoivre T., Moussa M. D., Vieillard-Baron A., Durand M., Gainnier M., Ichai C., Arens S., Hoffmann C., Kaffarnik M., Scharnofske C. -J., Voigt I., Peckelsen C., Weber M., Gille J., Lange A., Schoser G., Sablotzki A., Bluethgen A., Vogel F., Tscheu A., Fuchs T., Wattenberg M., Helmes T., Scieszka S., Heintz M., Sakka S., Kohler J., Fiedler F., Danz M., Riessen R., Kerz T., Kersten A., Tacke F., Marx G., Volkert T., Schmutz A., Nierhaus A., Kluge S., Abel P., Janosi R. A., Utzolino S., Bracht H., Toussaint S., Peftoulidou M. G., Myrianthefs P., Armaganidis A., Routsi C., Xini A., Mouloudi E., Kokoris I., Kyriazopoulos G., Vlachos S., Lavrentieva A., Partala P., Nakos G., Moller A., Stefansson S. O., Barry J., O'Leary R. A., Motherway C., Faheem M., Dunne E., Donnelly M., Konrad T., Bonora E., Achilli C., Rossi S., Castiglione G., Peris A., Albanese D., Stocchetti N., Citerio G., Mozzoni L., Sisillo E., De Negri P., Savioli M., Vecchiarelli P., Puflea F., Stankovic V., Minoja G., Montibeller S., Calligaro P., Sorrentino R., Feri M., Zambon M., Colombaroli E., Giarratano A., Pellis T., Capra C., Antonelli M., Gullo A., Chelazzi C., De Capraris A., Patroniti N., Girardis M., Franchi F., Berlot G., Buttigieg M., Ponssen H., Ten Cate J., Bormans L., Husada S., Buise M., Van Der Hoven B., Reidinga A., Kuiper M., Kluge G., Den Boer S., Kesecioglu J., Van Leeuwen H., Flaatten H., Mo S., Branco V., Rua F., Lafuente E., Sousa M., Catorze N., Barros M., Pereira L., De Oliveira A. V., Gomes J., Gaspar I., Pereira M. F., Cymbron M., Dias A., Almeida E., Beirao S., Serra I., Ribeiro R., Povoa P., Faria F., Costa-E-Silva Z., Nobrega J. J., Fernandes F., Gabriel J., Voga G., Rupnik E., Kosec L., Povsic M. K., Osojnik I., Tomic V., Sinkovic A., Gonzalez J., Zavala E., Valenzuela J. P., Marina L., Vidal-Cortes P., Posada P., Martin-Loeches I., Guillen N. M., Palomar M., Sole-Violan J., Torres A., Gonzalez Gallego M. A., Aguilar G., Allue R. M., Argueso M., Parejo M., Navarro M. P., Jose A., Nin N., Lerma F. A., Martinez O., Lozano E. T., Lopez S. A., Perez Granda M. J., Moreno S., Llubia C., Martos C. D. L. F., Gonzalez-Arenas P., Fernandez N. L., Rueda B. G., Pons I. E., Cruza N., Maroto F., Estella A., Ferrer A., Fraile L. I., Quindos B., Quintano A., Tebar M. T., Cardinal P., Reyes A., Rodriguez A., Abella A., Del Valle S. G., Yus S., Maseda E., Berezo J. A., Pedregosa A. T., Laplaza C., Ferrer R., Rico-Feijoo J., Rodriguez M., Monedero P., Eriksson K., Lind D., Chabanel D., Zender H., Heer K., Frankenberger B., Jakob S., Haller A., Matthew S., Downes R., Groba C. B., Johnston A., Meacher R., Keays R., Haji-Michael P., Tyler C., Jones S., Tyl D., Ball A., Vogel J., Booth M., Downie P., Watters M., Brett S., Garfield M., Everett L., Heenen S., Dhir S., Beardow Z., Mostert M., Brosnan S., Pinto N., Harris S., Summors A., Norton A., Rose A., Appelboam R., Davies O., Vickers E., Agarwal B., Szakmany T., Wimbush S., Welters I., Pearse R., Hollands R., Kirk-Bayley J., Fletcher N., Bray B., Brealey D., Alexander P., Henderson S., Hargreaves C., Black H., Gowda K, Citerio G, Université libre de Bruxelles (ULB), Belfast City Hospital, Department Intensive Care Medicine, Center of Infectious Diseases, Radboudumc, Nijmegen, The Netherlands., University of Bern [Bern, Switzerland] (University Hospital Bern ), Universität Augsburg [Augsburg], Prince Sultan university (saudi Arabia), Riyadh, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Assistance Publique - Hôpitaux de Marseille (APHM), Mayo Clinic, Jena University Hospital [Jena], Supporting clinical sciences, Intensive Care, Internal Medicine Specializations, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Services des soins intensifs, UCL - (SLuc) Service de soins intensifs, Vincent, J. -L., Ferguson, A., Pickkers, P., Jakob, S. M., Jaschinski, U., Almekhlafi, G. A., Leone, M., Mokhtari, M., Fontes, L. E., Bauer, P. R., Sakr, Y., Tomas, E., Bibonge, E. A., Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, J., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Kotfis, K., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M. N., Nica, A., Stoica, R., Tomescu, D. R., Constantinescu, D. L., Valcoreanu Zbaganu, G. M., Slavcovici, A., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, J., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X. Z., Zhao, X., Li, C. H., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T. H., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Li, C., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W. L., Sin, K. K. C., Lee, K. L., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T. T., Hata, N., Kobe, Y., Nishida, O., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, N. A. N., Tai, L. L., Tony, B., Bigornia, R. R., Palo, J. E., Chatterjee, S., Tan, B. H., Kong, A., Goh, S., Lee, C. -C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Hamdy, A. N., Hosny, H., Ashraf, A., Nowruzinia, S., Lotfi, A. H., Zand, F., Nikandish, R., Moghaddam, O. M., Cohen, J., Sold, O., Sfeir, T., Hasan, A. Y., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H. K., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J. C., Herridge, M., Fernandez-Medero, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Kashyap, R., Bauer, P., Nanchal, R., Wunderink, R. G., Jimenez, E., Ryan, A., Prince, D., Edington, J., Van Haren, F., Bersten, A., Hawkins, D. J., Kilminster, M., Sturgess, D., Ziegenfuss, M., O' Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M. M., D'Agostino Dias, M., Lunardi, M. C., Youssef, N. C., Lobo, S., Silva, R., Sales, J. A., Melo, L. M. C., Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A. P., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, V. S., Filho, R. C., Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, G. C., Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro Castro, L. F., Duque, G. L., Diaz-Guio, D., Benitez, F., Urrego, A. G., Buitrago, R., Ortiz, G., Villalba Gaviria, M. C., Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, M. C., Orellana-Jimenez, C., Garrido, L., Diaz, O., Resiere, D., Osorio, C., De La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, R. M., Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, D. R., Arrazola, F., Juan Francisco, L. L., Namendys-Silva, S. A., Moya, R. G., Hernandez, M., Rodriguez Cadena, D. M., Islas, I. L., Ballesteros Zarzavilla, C. M., Matos, A., Oyanguren, I., Cerna, J., Sierra, R. Q., Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Mareque Gianoni, S. M., Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Von Der Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, G., Lahkar, B., Mandal, A. K., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Zirpe, K., Patel, M., Bhavsar, A., Samaddar, D. P., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, J., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K. -H., Van Der Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Gadisseux, P., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., De Waele, J. J., Rimachi, R., Gusu, D., De Decker, K., Mandianga, K., Heytens, L., Wittebole, X., Spapen, H., Van Collie, O., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V. -P., Saarinen, K., Durocher, A., Moulront, S., Lepape, A., Losser, M. -R., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, J. -Y., Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Floccard, B., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Lepoivre, T., Moussa, M. D., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C. -J., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R. A., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, M. G., Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S. O., Barry, J., O'Leary, R. A., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Peris, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., De Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., De Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Ten Cate, J., Bormans, L., Husada, S., Buise, M., Van Der Hoven, B., Reidinga, A., Kuiper, M., Kluge, G., Den Boer, S., Kesecioglu, J., Van Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., De Oliveira, A. V., Gomes, J., Gaspar, I., Pereira, M. F., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, J. J., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, M. K., Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, J. P., Marina, L., Vidal-Cortes, P., Posada, P., Martin-Loeches, I., Guillen, N. M., Palomar, M., Sole-Violan, J., Torres, A., Gonzalez Gallego, M. A., Aguilar, G., Allue, R. M., Argueso, M., Parejo, M., Navarro, M. P., Jose, A., Nin, N., Lerma, F. A., Martinez, O., Lozano, E. T., Lopez, S. A., Perez Granda, M. J., Moreno, S., Llubia, C., Martos, C. D. L. F., Gonzalez-Arenas, P., Fernandez, N. L., Rueda, B. G., Pons, I. E., Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, L. I., Quindos, B., Quintano, A., Tebar, M. T., Cardinal, P., Reyes, A., Rodriguez, A., Abella, A., Del Valle, S. G., Yus, S., Maseda, E., Berezo, J. A., Pedregosa, A. T., Laplaza, C., Ferrer, R., Rico-Feijoo, J., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Haller, A., Matthew, S., Downes, R., Groba, C. B., Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Jones, S., Tyl, D., Ball, A., Vogel, J., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Norton, A., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, J., Fletcher, N., Bray, B., Brealey, D., Alexander, P., Henderson, S., Hargreaves, C., Black, H., Gowda, K., Vincent, J, Ferguson, A, Pickkers, P, Jakob, S, Jaschinski, U, Almekhlafi, G, Leone, M, Mokhtari, M, Fontes, L, Bauer, P, Sakr, Y, Tomas, E, Bibonge, E, Charra, B, Faroudy, M, Doedens, L, Farina, Z, Adler, D, Balkema, C, Kok, A, Alaya, S, Gharsallah, H, Muzha, D, Temelkov, A, Georgiev, G, Simeonov, G, Tsaryanski, G, Georgiev, S, Seliman, A, Vrankovic, S, Vucicevic, Z, Gornik, I, Barsic, B, Husedzinovic, I, Pavlik, P, Manak, J, Kieslichova, E, Turek, R, Fischer, M, Valkova, R, Dadak, L, Dostal, P, Malaska, J, Hajek, R, Zidkova, A, Lavicka, P, Starkopf, J, Kheladze, Z, Chkhaidze, M, Kaloiani, V, Medve, L, Sarkany, A, Kremer, I, Marjanek, Z, Tamasi, P, Krupnova, I, Vanags, I, Liguts, V, Pilvinis, V, Vosylius, S, Kekstas, G, Balciunas, M, Kolbusz, J, Kubler, A, Mielczarek, B, Mikaszewska-Sokolewicz, M, Kotfis, K, Tamowicz, B, Sulkowski, W, Smuszkiewicz, P, Pihowicz, A, Trejnowska, E, Hagau, N, Filipescu, D, Droc, G, Lupu, M, Nica, A, Stoica, R, Tomescu, D, Constantinescu, D, Valcoreanu Zbaganu, G, Slavcovici, A, Bagin, V, Belsky, D, Palyutin, S, Shlyapnikov, S, Bikkulova, D, Gritsan, A, Natalia, G, Makarenko, E, Kokhno, V, Tolkach, A, Kokarev, E, Belotserkovskiy, B, Zolotukhin, K, Kulabukhov, V, Soskic, L, Palibrk, I, Jankovic, R, Jovanovic, B, Pandurovic, M, Bumbasirevic, V, Uljarevic, B, Surbatovic, M, Ladjevic, N, Slobodianiuk, G, Sobona, V, Cikova, A, Gebhardtova, A, Jun, C, Yunbo, S, Dong, J, Feng, S, Duan, M, Xu, Y, Xue, X, Gao, T, Xing, X, Zhao, X, Li, C, Gengxihua, G, Tan, H, Xu, J, Jiang, L, Tiehe, Q, Bingyu, Q, Shi, Q, Lv, Z, Zhang, L, Jingtao, L, Zhen, Z, Wang, Z, Wang, T, Yuhong, L, Zhai, Q, Chen, Y, Wang, C, Jiang, W, Ruilan, W, Xiaobo, H, Ge, H, Yan, T, Yuhui, C, Zhang, J, Jian-Hong, F, Zhu, H, Huo, F, Wang, Y, Zhuang, M, Ma, Z, Sun, J, Liuqingyue, L, Yang, M, Meng, J, Ma, S, Kang, Y, Yu, L, Peng, Q, Wei, Y, Zhang, W, Sun, R, Yeung, A, Wan, W, Sin, K, Lee, K, Wijanti, M, Widodo, U, Samsirun, H, Sugiman, T, Wisudarti, C, Maskoen, T, Hata, N, Kobe, Y, Nishida, O, Miyazaki, D, Nunomiya, S, Uchino, S, Kitamura, N, Yamashita, K, Hashimoto, S, Fukushima, H, Adib, N, Tai, L, Tony, B, Bigornia, R, Palo, J, Chatterjee, S, Tan, B, Kong, A, Goh, S, Lee, C, Pothirat, C, Khwannimit, B, Theerawit, P, Pornsuriyasak, P, Piriyapatsom, A, Mukhtar, A, Hamdy, A, Hosny, H, Ashraf, A, Nowruzinia, S, Lotfi, A, Zand, F, Nikandish, R, Moghaddam, O, Cohen, J, Sold, O, Sfeir, T, Hasan, A, Abugaber, D, Ahmad, H, Tantawy, T, Baharoom, S, Algethamy, H, Amr, A, Coskun, R, Sungur, M, Cosar, A, Gucyetmez, B, Demirkiran, O, Senturk, E, Ulusoy, H, Atalan, H, Serin, S, Kati, I, Alnassrawi, Z, Almemari, A, Krishnareddy, K, Kashef, S, Alsabbah, A, Poirier, G, Marshall, J, Herridge, M, Fernandez-Medero, R, Fulda, G, Banschbach, S, Quintero, J, Schroeder, E, Sicoutris, C, Gueret, R, Kashyap, R, Nanchal, R, Wunderink, R, Jimenez, E, Ryan, A, Prince, D, Edington, J, Van Haren, F, Bersten, A, Hawkins, D, Kilminster, M, Sturgess, D, Ziegenfuss, M, O' Connor, S, Lipman, J, Campbell, L, Mcallister, R, Roberts, B, Williams, P, Parke, R, Seigne, P, Freebairn, R, Nistor, D, Oxley, C, Young, P, Valentini, R, Wainsztein, N, Comignani, P, Casaretto, M, Sutton, G, Villegas, P, Galletti, C, Neira, J, Rovira, D, Hidalgo, J, Sandi, F, Caser, E, Thompson, M, D'Agostino Dias, M, Lunardi, M, Youssef, N, Lobo, S, Silva, R, Sales, J, Melo, L, Oliveira, M, Fonte, M, Grion, C, Feijo, C, Rezende, V, Assuncao, M, Neves, A, Gusman, P, Dalcomune, D, Teixeira, C, Kaefer, K, Maia, I, Dantas, V, Filho, R, Amorim, F, Assef, M, Schiavetto, P, Houly, J, Bianchi, F, Dias, F, Avila, C, Rego, L, Castro, P, Passos, J, Mendes, C, Mecatti, G, Ferrreira, M, Irineu, V, Guerreiro, M, Ugarte, S, Tomicic, V, Godoy, C, Samaniego, W, Escamilla, I, Castro Castro, L, Duque, G, Diaz-Guio, D, Benitez, F, Urrego, A, Buitrago, R, Ortiz, G, Villalba Gaviria, M, Salas, D, Ramirez-Arce, J, Salgado, E, Morocho, D, Vergara, J, Sang, M, Orellana-Jimenez, C, Garrido, L, Diaz, O, Resiere, D, Osorio, C, De La Vega, A, Carrillo, R, Sanchez, V, Villagomez, A, Zubieta, R, Sandia, M, Zalatiel, M, Poblano, M, Gonzalez, D, Arrazola, F, Juan Francisco, L, Namendys-Silva, S, Moya, R, Hernandez, M, Rodriguez Cadena, D, Islas, I, Ballesteros Zarzavilla, C, Matos, A, Oyanguren, I, Cerna, J, Sierra, R, Jimenez, R, Castillo, L, Ocal, R, Sencan, A, Mareque Gianoni, S, Deicas, A, Hurtado, J, Burghi, G, Martinelli, A, Von Der Osten, I, Du Maine, C, Bhattacharyya, M, Bandyopadhyay, S, Yanamala, S, Gopal, P, Sahu, S, Ibrahim, M, Rathod, D, Mukundan, N, Dewan, A, Amin, P, Samavedam, S, Shah, B, Gurupal, G, Lahkar, B, Mandal, A, Sircar, M, Ghosh, S, Balasubramani, V, Kapadia, F, Vadi, S, Nair, K, Tripathy, S, Nandakumar, S, Sharma, J, Kar, A, Jha, S, Zirpe, K, Patel, M, Bhavsar, A, Samaddar, D, Kulkarni, A, Hashmi, M, Ali, W, Nadeem, S, Indraratna, K, Margarit, A, Urbanek, P, Schlieber, J, Reisinger, J, Auer, J, Hartjes, A, Lerche, A, Janous, T, Kink, E, Krahulec, W, Smolle, K, Van Der Schueren, M, Thibo, P, Vanhoof, M, Ahmet, I, Gadisseux, P, Dufaye, P, Jacobs, O, Fraipont, V, Biston, P, Dive, A, Bouckaert, Y, Gilbert, E, Gressens, B, Pinck, E, Collin, V, De Waele, J, Rimachi, R, Gusu, D, De Decker, K, Mandianga, K, Heytens, L, Wittebole, X, Spapen, H, Van Collie, O, Vandenheede, W, Rogiers, P, Kolodzeike, P, Kruse, M, Andersen, T, Harjola, V, Saarinen, K, Durocher, A, Moulront, S, Lepape, A, Losser, M, Cabaret, P, Kalaitzis, E, Zogheib, E, Charve, P, Francois, B, Lefrant, J, Beilouny, B, Forceville, X, Misset, B, Jacobs, F, Floccard, B, Payen, D, Wynckel, A, Castelain, V, Faure, A, Lavagne, P, Lepoivre, T, Moussa, M, Vieillard-Baron, A, Durand, M, Gainnier, M, Ichai, C, Arens, S, Hoffmann, C, Kaffarnik, M, Scharnofske, C, Voigt, I, Peckelsen, C, Weber, M, Gille, J, Lange, A, Schoser, G, Sablotzki, A, Bluethgen, A, Vogel, F, Tscheu, A, Fuchs, T, Wattenberg, M, Helmes, T, Scieszka, S, Heintz, M, Sakka, S, Kohler, J, Fiedler, F, Danz, M, Riessen, R, Kerz, T, Kersten, A, Tacke, F, Marx, G, Volkert, T, Schmutz, A, Nierhaus, A, Kluge, S, Abel, P, Janosi, R, Utzolino, S, Bracht, H, Toussaint, S, Peftoulidou, M, Myrianthefs, P, Armaganidis, A, Routsi, C, Xini, A, Mouloudi, E, Kokoris, I, Kyriazopoulos, G, Vlachos, S, Lavrentieva, A, Partala, P, Nakos, G, Moller, A, Stefansson, S, Barry, J, O'Leary, R, Motherway, C, Faheem, M, Dunne, E, Donnelly, M, Konrad, T, Bonora, E, Achilli, C, Rossi, S, Castiglione, G, Peris, A, Albanese, D, Stocchetti, N, Citerio, G, Mozzoni, L, Sisillo, E, De Negri, P, Savioli, M, Vecchiarelli, P, Puflea, F, Stankovic, V, Minoja, G, Montibeller, S, Calligaro, P, Sorrentino, R, Feri, M, Zambon, M, Colombaroli, E, Giarratano, A, Pellis, T, Capra, C, Antonelli, M, Gullo, A, Chelazzi, C, De Capraris, A, Patroniti, N, Girardis, M, Franchi, F, Berlot, G, Buttigieg, M, Ponssen, H, Ten Cate, J, Bormans, L, Husada, S, Buise, M, Van Der Hoven, B, Reidinga, A, Kuiper, M, Kluge, G, Den Boer, S, Kesecioglu, J, Van Leeuwen, H, Flaatten, H, Mo, S, Branco, V, Rua, F, Lafuente, E, Sousa, M, Catorze, N, Barros, M, Pereira, L, De Oliveira, A, Gomes, J, Gaspar, I, Pereira, M, Cymbron, M, Dias, A, Almeida, E, Beirao, S, Serra, I, Ribeiro, R, Povoa, P, Faria, F, Costa-E-Silva, Z, Nobrega, J, Fernandes, F, Gabriel, J, Voga, G, Rupnik, E, Kosec, L, Povsic, M, Osojnik, I, Tomic, V, Sinkovic, A, Gonzalez, J, Zavala, E, Valenzuela, J, Marina, L, Vidal-Cortes, P, Posada, P, Martin-Loeches, I, Guillen, N, Palomar, M, Sole-Violan, J, Torres, A, Gonzalez Gallego, M, Aguilar, G, Allue, R, Argueso, M, Parejo, M, Navarro, M, Jose, A, Nin, N, Lerma, F, Martinez, O, Lozano, E, Lopez, S, Perez Granda, M, Moreno, S, Llubia, C, Martos, C, Gonzalez-Arenas, P, Fernandez, N, Rueda, B, Pons, I, Cruza, N, Maroto, F, Estella, A, Ferrer, A, Fraile, L, Quindos, B, Quintano, A, Tebar, M, Cardinal, P, Reyes, A, Rodriguez, A, Abella, A, Del Valle, S, Yus, S, Maseda, E, Berezo, J, Pedregosa, A, Laplaza, C, Ferrer, R, Rico-Feijoo, J, Rodriguez, M, Monedero, P, Eriksson, K, Lind, D, Chabanel, D, Zender, H, Heer, K, Frankenberger, B, Haller, A, Matthew, S, Downes, R, Groba, C, Johnston, A, Meacher, R, Keays, R, Haji-Michael, P, Tyler, C, Jones, S, Tyl, D, Ball, A, Vogel, J, Booth, M, Downie, P, Watters, M, Brett, S, Garfield, M, Everett, L, Heenen, S, Dhir, S, Beardow, Z, Mostert, M, Brosnan, S, Pinto, N, Harris, S, Summors, A, Norton, A, Rose, A, Appelboam, R, Davies, O, Vickers, E, Agarwal, B, Szakmany, T, Wimbush, S, Welters, I, Pearse, R, Hollands, R, Kirk-Bayley, J, Fletcher, N, Bray, B, Brealey, D, Alexander, P, Henderson, S, Hargreaves, C, Black, H, and Gowda, K
- Subjects
Male ,umrljivost ,medicine.medical_treatment ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,udc:616.1/.4 ,Critical Care and Intensive Care Medicine ,urologic and male genital diseases ,akutna ledvična odpoved ,renal insufficiency ,law.invention ,0302 clinical medicine ,law ,Oliguria ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,030212 general & internal medicine ,Prospective Studies ,ComputingMilieux_MISCELLANEOUS ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,oligurija ,nadomestno zdravljenje ledvične odpovedi ,Acute Kidney Injury ,Middle Aged ,kidney diseases ,Intensive care unit ,urine ,3. Good health ,urine output ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Mortality, Renal replacement therapy, Urine output ,Female ,oliguria ,medicine.symptom ,renal replacement therapy ,Adult ,kidney ,medicine.medical_specialty ,oskrba kritično bolnih ,urin ,Critical Illness ,610 Medicine & health ,Statistics, Nonparametric ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,acute kidney failure ,medicine ,critical illness ,Humans ,Clinical significance ,In patient ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,ddc:610 ,Renal replacement therapy ,izločanje urina ,Mortality ,Urine output ,Aged ,Observational database ,Analysis of Variance ,Critically ill ,business.industry ,Research ,renalna insuficienca ,Médecine pathologie humaine ,030208 emergency & critical care medicine ,lcsh:RC86-88.9 ,mortality ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,critical care ,bolezni ledvic ,Emergency medicine ,kritično stanje ,ledvica ,business - Abstract
BackgroundUrine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis.ResultsOf the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient—oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged—oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent—oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19–1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97–1.34], p = 0.103).ConclusionsOliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome., 0, info:eu-repo/semantics/published
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- 2019
42. An Automatic Model Selection-Based Machine Learning Framework to Estimate FORC Distributions
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Heslop, D, Roberts, AP, Oda, H, Zhao, X, Harrison, RJ, Muxworthy, AR, Hu, PX, Sato, T, Heslop, D [0000-0001-8245-0555], Roberts, AP [0000-0003-0566-8117], Oda, H [0000-0001-7142-9208], Zhao, X [0000-0002-1168-3439], Harrison, RJ [0000-0003-3469-762X], Hu, PX [0000-0003-2066-6355], Sato, T [0000-0003-3998-3844], and Apollo - University of Cambridge Repository
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37 Earth Sciences ,3705 Geology ,3706 Geophysics - Published
- 2020
43. ultraID: a compact and efficient enzyme for proximity-dependent biotinylation in living cells
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Cappio Barazzone E, Kerstin Schmitt, Sebastian Bitsch, Lukas Deweid, Julien Béthune, Oliver Valerius, Zhao X, Harald Kolmar, Roehrig A, and Kubitz L
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chemistry.chemical_classification ,0303 health sciences ,DNA ligase ,Protein Data Bank (RCSB PDB) ,COPI ,Interactome ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Enzyme ,Biotin ,chemistry ,Biochemistry ,Coatomer ,Biotinylation ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Proximity-dependent biotinylation (PDB) combined with mass spectrometry analysis has established itself as a key technology to study protein-protein interactions in living cells. A widespread approach, BioID, uses an abortive variant of the E. coli BirA biotin protein ligase, a quite bulky enzyme with slow labeling kinetics. To improve PDB versatility and speed, various enzymes have been developed by different approaches. Here we present a novel small-size engineered enzyme: ultraID. We show its practical use to probe the interactome of Argonaute-2 after a 10 min labeling pulse and expression at physiological levels. Moreover, using ultraID, we provide a membrane-associated interactome of coatomer, the coat protein complex of COPI vesicles. To date, ultraID is the smallest and most efficient biotin ligase available for PDB and offers the possibility of investigating interactomes at a high temporal resolution.
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- 2021
44. Mutation of SLC7A14 Causes Auditory Neuropathy and Retinitis Pigmentosa Mediated by Lysosomal Dysfunction
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Wang T, Baofu Chen, Gong S, Giffen Kp, Janesick A, Yongzhe Li, Zhao X, Shen R, Bechara Kachar, Liu H, Jin Z, David Z.Z. He, and Chao Zhang
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Mutation ,Auditory neuropathy ,Autophagy ,Cellular homeostasis ,Nutrient sensing ,Biology ,medicine.disease ,medicine.disease_cause ,Cell biology ,Transport protein ,Retinitis pigmentosa ,medicine ,Secretion ,sense organs - Abstract
Lysosomes contribute to cellular homeostasis via processes including phagocytosis, macromolecule catabolism, secretion, and nutrient sensing mechanisms. Defective proteins related to lysosomal macromolecule catabolism are known to cause a broad range of lysosomal storage diseases. It is unclear, however, if mutations in genes in the autophagy-lysosomal pathway can cause syndromic disease. Here we show that SLC7A14, a transporter protein mediating lysosomal uptake of cationic amino acids, is evolutionarily conserved in vertebrate mechanosensitive hair cells and highly expressed in lysosomes of mammalian cochlear inner hair cells (IHCs) and retinal photoreceptors. Autosomal recessive mutation of SLC7A14 caused loss of IHCs and photoreceptors, leading to pre-synaptic auditory neuropathy and retinitis pigmentosa in mice and humans. Loss of function mutation altered protein trafficking and disrupted lysosomal homeostasis, resulting in dysregulation of basal autophagy and progressive cell degeneration. This study is the first to implicate autophagy-lysosomal dysfunction in syndromic hearing and vision loss in mice and humans.
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- 2021
45. A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit
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Kotfis, K., Wittebole, X., Jaschinski, U., Sole-Violan, J., Kashyap, R., Leone, M., Nanchal, R., Fontes, Le, Sakr, Y., Vincent, Jl, Tomas, E., Bibonge, Ea, Charra, B., Faroudy, M., Doedens, L., Farina, Z., Adler, D., Balkema, C., Kok, A., Alaya, S., Gharsallah, H., Muzha, D., Temelkov, A., Georgiev, G., Simeonov, G., Tsaryanski, G., Georgiev, S., Seliman, A., Vrankovic, S., Vucicevic, Z., Gornik, I., Barsic, B., Husedzinovic, I., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., Zidkova, A., Lavicka, P., Starkopf, J., Kheladze, Z., Chkhaidze, M., Kaloiani, V., Medve, L., Sarkany, A., Kremer, I., Marjanek, Z., Tamasi, P., Krupnova, I., Vanags, I., Liguts, V., Pilvinis, V., Vosylius, S., Kekstas, G., Balciunas, M., Kolbusz, A., Kubler, A., Mielczarek, B., Mikaszewska-Sokolewicz, M., Tamowicz, B., Sulkowski, W., Smuszkiewicz, P., Pihowicz, A., Trejnowska, E., Hagau, N., Filipescu, D., Droc, G., Lupu, M., Nica, A., Stoica, R., Tomescu, D., Constantinescu, D., Zbaganu, Gv, Slavcovici, A., Bagin, V., Belsky, D., Palyutin, S., Shlyapnikov, S., Bikkulova, D., Gritsan, A., Natalia, G., Makarenko, E., Kokhno, V., Tolkach, A., Kokarev, E., Belotserkovskiy, B., Zolotukhin, K., Kulabukhov, V., Soskic, L., Palibrk, I., Jankovic, R., Jovanovic, B., Pandurovic, M., Bumbasirevic, V., Uljarevic, B., Surbatovic, M., Ladjevic, N., Slobodianiuk, G., Sobona, V., Cikova, A., Gebhardtova, A., Jun, C., Yunbo, S., Dong, U., Feng, S., Duan, M., Xu, Y., Xue, X., Gao, T., Xing, X., Zhao, X., Li, C., Gengxihua, G., Tan, H., Xu, J., Jiang, L., Tiehe, Q., Bingyu, Q., Shi, Q., Lv, Z., Zhang, L., Jingtao, L., Zhen, Z., Wang, Z., Wang, T., Yuhong, L., Zhai, Q., Chen, Y., Wang, C., Jiang, W., Ruilan, W., Xiaobo, H., Ge, H., Yan, T., Yuhui, C., Zhang, J., Jian-Hong, F., Zhu, H., Huo, F., Wang, Y., Zhuang, M., Ma, Z., Sun, J., Liuqingyue, L., Yang, M., Meng, J., Ma, S., Kang, Y., Yu, L., Peng, Q., Wei, Y., Zhang, W., Sun, R., Yeung, A., Wan, W., Sin, K., Lee, K., Wijanti, M., Widodo, U., Samsirun, H., Sugiman, T., Wisudarti, C., Maskoen, T., Hata, N., Kobe, Y., Nishida, O., Miyazaki, D., Nunomiya, S., Uchino, S., Kitamura, N., Yamashita, K., Hashimoto, S., Fukushima, H., Adib, Nn, Tai, L., Tony, B., Bigornia, R., Palo, J., Chatterjee, S., Tan, B., Kong, A., Goh, S., Lee, C., Pothirat, C., Khwannimit, B., Theerawit, P., Pornsuriyasak, P., Piriyapatsom, A., Mukhtar, A., Dsicu, Hamdy, An, Hosny, H., Ashraf, A., Mokhtari, M., Nowruzinia, S., Lotfi, A., Zand, F., Nikandish, R., Moghaddam, Om, Cohen, J., Sold, O., Sfeir, T., Hasan, A., Abugaber, D., Ahmad, H., Tantawy, T., Baharoom, S., Algethamy, H., Amr, A., Almekhlafi, G., Coskun, R., Sungur, M., Cosar, A., Gucyetmez, B., Demirkiran, O., Senturk, E., Ulusoy, H., Atalan, H., Serin, S., Kati, I., Alnassrawi, Z., Almemari, A., Krishnareddy, K., Kashef, S., Alsabbah, A., Poirier, G., Marshall, J., Herridge, M., Fernandez-Medero, R., Fulda, G., Banschbach, S., Quintero, J., Schroeder, E., Sicoutris, C., Gueret, R., Bauer, P., Wunderink, R., Jimenez, E., Ryan, A., Prince, D., Edington, J., Haren, F., Bersten, A., Hawkins, Dj, Kilminster, M., Sturgess, D., Ziegenfuss, M., O Connor, S., Lipman, J., Campbell, L., Mcallister, R., Roberts, B., Williams, P., Parke, R., Seigne, P., Freebairn, R., Nistor, D., Oxley, C., Young, P., Valentini, R., Wainsztein, N., Comignani, P., Casaretto, M., Sutton, G., Villegas, P., Galletti, C., Neira, J., Rovira, D., Hidalgo, J., Sandi, F., Caser, E., Thompson, M., Dias, Md, Fontes, L., Lunardi, M., Youssef, N., Lobo, S., Silva, R., Sales, J., Melo, Lmc, Oliveira, M., Fonte, M., Grion, C., Feijo, C., Rezende, V., Assuncao, M., Neves, A., Gusman, P., Dalcomune, D., Teixeira, C., Kaefer, K., Maia, I., Dantas, Vs, Filho, Rc, Amorim, F., Assef, M., Schiavetto, P., Houly, J., Bianchi, F., Dias, F., Avila, C., Gomez, J., Rego, L., Castro, P., Passos, J., Mendes, C., Mecatti, Gc, Ferrreira, M., Irineu, V., Guerreiro, M., Ugarte, S., Tomicic, V., Godoy, C., Samaniego, W., Escamilla, I., Castro, Lc, Duque, Gl, Diaz-Guio, D., Benitez, F., Urrego, Ag, Buitrago, R., Ortiz, G., Gaviria, Mv, Salas, D., Ramirez-Arce, J., Salgado, E., Morocho, D., Vergara, J., Sang, Mc, Carlos E. Orellana-Jimenez, Garrido, L., Diaz, O., Resiere, D., Osorio, C., La Vega, A., Carrillo, R., Sanchez, V., Villagomez, A., Zubieta, Rm, Sandia, M., Zalatiel, M., Poblano, M., Gonzalez, Dr, Arrazola, F., Francisco, Lj, Liamendys-Silva, Sa, Hernandez, M., Cadena, Dr, Islas, Il, Zarzavilla, Cb, Matos, A., Oyanguren, I., Cerna, J., Sierra, Rq, Jimenez, R., Castillo, L., Ocal, R., Sencan, A., Gianoni, Sm, Deicas, A., Hurtado, J., Burghi, G., Martinelli, A., Osten, I., Du Maine, C., Bhattacharyya, M., Bandyopadhyay, S., Yanamala, S., Gopal, P., Sahu, S., Ibrahim, M., Rathod, D., Mukundan, N., Dewan, A., Amin, P., Samavedam, S., Shah, B., Gurupal, D., Lahkar, B., Mandal, A., Sircar, M., Ghosh, S., Balasubramani, V., Kapadia, F., Vadi, S., Nair, K., Tripathy, S., Nandakumar, S., Sharma, J., Kar, A., Jha, S., Gurav, Kz, Patel, M., Bhaysar, A., Samaddar, D., Kulkarni, A., Hashmi, M., Ali, W., Nadeem, S., Indraratna, K., Margarit, A., Urbanek, P., Schlieber, J., Reisinger, J., Auer, U., Hartjes, A., Lerche, A., Janous, T., Kink, E., Krahulec, W., Smolle, K., Schueren, M., Thibo, P., Vanhoof, M., Ahmet, I., Gadisseux, P., Dufaye, P., Jacobs, O., Fraipont, V., Biston, P., Dive, A., Bouckaert, Y., Gilbert, E., Gressens, B., Pinck, E., Collin, V., Waele, J., Rimachi, R., Gusu, D., Decker, K., Mandianga, K., Heytens, L., Spapen, H., Olivier, V., Vandenheede, W., Rogiers, P., Kolodzeike, P., Kruse, M., Andersen, T., Harjola, V., Saarinen, K., Durocher, A., Moulront, S., Lepape, A., Losser, M., Cabaret, P., Kalaitzis, E., Zogheib, E., Charve, P., Francois, B., Lefrant, Jy, Beilouny, B., Forceville, X., Misset, B., Jacobs, F., Floccard, B., Payen, D., Wynckel, A., Castelain, V., Faure, A., Lavagne, P., Thierry, I., Moussa, M., Vieillard-Baron, A., Durand, M., Gainnier, M., Ichai, C., Arens, S., Hoffmann, C., Kaffarnik, M., Scharnofske, C., Voigt, I., Peckelsen, C., Weber, M., Gille, J., Lange, A., Schoser, G., Sablotzki, A., Bluethgen, A., Vogel, F., Tscheu, A., Fuchs, T., Wattenberg, M., Helmes, T., Scieszka, S., Heintz, M., Sakka, S., Kohler, J., Fiedler, F., Danz, M., Riessen, R., Kerz, T., Kersten, A., Tacke, F., Marx, G., Volkert, T., Schmutz, A., Nierhaus, A., Kluge, S., Abel, P., Janosi, R., Utzolino, S., Bracht, H., Toussaint, S., Peftoulidou, Mg, Myrianthefs, P., Armaganidis, A., Routsi, C., Xini, A., Mouloudi, E., Kokoris, I., Kyriazopoulos, G., Vlachos, S., Lavrentieva, A., Partala, P., Nakos, G., Moller, A., Stefansson, S., Barry, J., O Leary, R., Motherway, C., Faheem, M., Dunne, E., Donnelly, M., Konrad, T., Bonora, E., Achilli, C., Rossi, S., Castiglione, G., Penis, A., Albanese, D., Stocchetti, N., Citerio, G., Mozzoni, L., Sisillo, E., Negri, P., Savioli, M., Vecchiarelli, P., Puflea, F., Stankovic, V., Minoja, G., Montibeller, S., Calligaro, P., Sorrentino, R., Feri, M., Zambon, M., Colombaroli, E., Giarratano, A., Pellis, T., Capra, C., Antonelli, M., Gullo, A., Chelazzi, C., Capraris, A., Patroniti, N., Girardis, M., Franchi, F., Berlot, G., Buttigieg, M., Ponssen, H., Cate, Jt, Bormans, L., Husada, S., Buise, M., Hoven, B., Reidinga, A., Kuiper, M., Pickkers, P., Kluge, G., Den Boer, S., Kesecioglu, J., Leeuwen, H., Flaatten, H., Mo, S., Branco, V., Rua, F., Lafuente, E., Sousa, M., Catorze, N., Barros, M., Pereira, L., Oliveira, Av, Gomes, J., Gaspar, I., Pereira, M., Cymbron, M., Dias, A., Almeida, E., Beirao, S., Serra, I., Ribeiro, R., Povoa, P., Faria, F., Costa-E-Silva, Z., Nobrega, A., Fernandes, F., Gabriel, J., Voga, G., Rupnik, E., Kosec, L., Povsic, Mk, Osojnik, I., Tomic, V., Sinkovic, A., Gonzalez, J., Zavala, E., Valenzuela, Ap, Marina, L., Vidal-Cortes, P., Posada, I., Martin-Loeches, Ai, Guillen, Nm, Palomar, M., Sole-Violan, U., Torres, A., Gallego, Mg, Aguilar, G., Allue, Rm, Argueso, M., Parejo, M., Navarro, Mp, Jose, A., Nin, N., Lerma, Fa, Martinez, O., Lozano, Et, Lopez, Sa, Granda, Mp, Moreno, S., Llubia, C., Martos, Cd, Gonzalez-Arenas, P., Fernandez, Nl, Rueda, Bg, Pons, Ie, Cruza, N., Maroto, F., Estella, A., Ferrer, A., Fraile, Li, Quindos, B., Quintano, A., Tebar, M., Cardinal, I., Reyes, A., Rodriguez, A., Abella, A., Del Valle, Sg, Yus, S., Maseda, E., Berezo, U., Pedregosa, At, Laplaza, C., Ferrer, R., Rico-Feijoo, U., Rodriguez, M., Monedero, P., Eriksson, K., Lind, D., Chabanel, D., Zender, H., Heer, K., Frankenberger, B., Jakob, S., Mathew, S., Downes, R., Groba, Cb, Johnston, A., Meacher, R., Keays, R., Haji-Michael, P., Tyler, C., Ferguson, A., Jones, S., Tyl, D., Ball, A., Vogel, U., Booth, M., Downie, P., Watters, M., Brett, S., Garfield, M., Everett, L., Heenen, S., Dhir, S., Beardow, Z., Mostert, M., Brosnan, S., Pinto, N., Harris, S., Summors, A., Andrew, N., Rose, A., Appelboam, R., Davies, O., Vickers, E., Agarwal, B., Szakmany, T., Wimbush, S., Welters, I., Pearse, R., Hollands, R., Kirk-Bayley, U., Fletcher, N., Bray, B., Brealey, D., Intensive Care, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs, UCL - (MGD) Services des soins intensifs, Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], and University of Wisconsin School of Medicine and Public Health
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Adult ,Male ,medicine.medical_specialty ,Critical Illness ,Medizin ,Audit ,Critical Care and Intensive Care Medicine ,Sepsis ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Internal medicine ,Epidemiology ,medicine ,Humans ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,In patient ,Hospital Mortality ,Prospective Studies ,Mortality ,ComputingMilieux_MISCELLANEOUS ,Outcome ,Aged ,computer.programming_language ,Aged, 80 and over ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,business.industry ,Critically ill ,ICU ,030208 emergency & critical care medicine ,Middle Aged ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Hospitalization ,Intensive Care Units ,Increased risk ,030228 respiratory system ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Female ,Observational study ,Icon ,business ,computer - Abstract
Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world., Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ( >16 years ) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - 80 years. Sepsis was defined as infection plus at least one organ failure., Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients 70 years was independently associated with increased risk of dying., Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years. (C) 2019 Elsevier Inc. All rights reserved., C1 [Kotfis, Katarzyna] Pomeranian Med Univ, Dept Anaesthesiol Intens Therapy & Acute Intoxica, Szczecin, Poland., [Wittebole, Xavier] UCL, Clin Univ St Luc, Dept Crit Care, Brussels, Belgium., [Jaschinski, Ulrich] Klinikum Augsburg, Klin Anasthesiol & Operat Intens Med, Augsburg, Germany., [Sole-Violan, Jordi] Hosp Univ Gran Canaria Dr Negrin, Dept Intens Care, Las Palmas Gran Canaria, Spain., [Kashyap, Rahul] Mayo Clin, Dept Anesthesia Ei Perioperat Med, Rochester, MN USA., [Leone, Marc] Aix Marseille Univ, Hop Nord, AP HM, Serv Anesthesie & Reanimat, Marseille, France., [Nanchal, Rahul] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA., [Fontes, Luis E.] Hosp Alcides Carneiro, Petropolis Med Sch, Dept Intens Care & Evidence Based Med, Petropolis, Brazil., [Sakr, Yasser] Uniklinikum Jena, Dept Anesthesiol & Intens Care, Jena, Germany., [Vincent, Jean-Louis] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Route Lenn 808, B-1070 Brussels, Belgium., [Tomas, E.] Clin Sagrada Esperanca, Luanda, Angola., [Bibonge, E. 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J.] Joondalup Hlth Campus, Joondalup, WA, Australia., [Kilminster, M.] Lismore Base Hosp, Lismore, NSW, Australia., [Sturgess, D.] Mater Adult Hosp, South Brisbane, Qld, Australia., [Ziegenfuss, M.] Prince Charles Hosp, Brisbane, Qld, Australia., [O'Connor, S.] Royal Adelaide Hosp, Adelaide, SA, Australia., [Lipman, J.] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia., [Campbell, L.] Royal Darwin Hosp, Tiwi, NT, Australia., [Mcallister, R.] Royal Hobart Hosp, Hobart, Tas, Australia., [Roberts, B.] Sir Charles Gairdner Hosp, Nedlands, WA, Australia., [Williams, P.] Queen Elizabeth Hosp, Woodville, SA, Australia., [Parke, R.] Auckland Dist Hlth Board, Auckland, New Zealand., [Seigne, P.] Christchurch Hosp, Christchurch, New Zealand., [Freebairn, R.] Hawkes Bay Hosp, Hastings, New Zealand., [Nistor, D.] Palmerston North Hosp, Midcent Hlth, Palmerston North, New Zealand., [Oxley, C.] Middlemore Hosp, Auckland, New Zealand., [Young, P.] Wellington Hosp, Wellington, New Zealand., [Valentini, R.] Cemic, Buenos Aires, DF, Argentina., [Wainsztein, N.] Fleni, Buenos Aires, DF, Argentina., [Comignani, P.] Hosp Aleman, Buenos Aires, DF, Argentina., [Casaretto, M.] Hosp Cent San Isidro, Buenos Aires, DF, Argentina., [Sutton, G.] Hosp Fernandez, Buenos Aires, DF, Argentina., [Villegas, P.] Hosp Francisco Lopez Lima Area Programa Gen Roca, Gen Roca, Argentina., [Galletti, C.] Sanatorio Allende, Cordoba, Argentina., [Neira, J.] Sanatorio Trinidad Palermo, Buenos Aires, DF, Argentina., [Rovira, D.] Sanatorio Julio Corzo Rosario, Rosario, Santa Fe, Argentina., [Hidalgo, J.] Karl Heusner Mem Hosp, Belize City, Belize., [Hidalgo, J.] Belize Healthcare Partner, Belize City, Belize., [Sandi, F.] Hosp Obrero 1, La Paz, Bolivia., [Caser, E.] Cias Unimed Vitoria, Vitoria, ES, Brazil., [Thompson, M.] Evangelical Hosp Cachoeiro De Itapemirim, Cachoeiro De Itapemirim, Brazil., [D'agostino Dias, M.] Hosp 9 Julho, Sao Paulo, Brazil., [Fontes, L.] Hosp Alcides Carneiro, Petropolis, Brazil., [Lunardi, M.] Hosp Clin Luzia De Pinho Melo, Mogi Das Cruzes, Brazil., [Youssef, N.] Hosp Nacoes Curitiba, Curitiba, Parana, Brazil., [Lobo, S.] Hosp Base Famerp, Sao Jose Do Rio Preto, Brazil., [Silva, R.] Hosp Clin Niteroi, Niteroi, RJ, Brazil., [Sales Jr, J.] Hosp Clin Padre Miguel, Rio De Janeiro, Brazil., [Madeira Campos Melo, L.] Hosp Terapia Intens, Sao Paulo, Brazil., [Oliveira, M.] Hosp Trabalhador, Curitiba, Parana, Brazil., [Fonte, M.] Hosp Esperanza, Olinda, PE, Brazil., [Grion, C.] Hosp Evangel Londrina, Londrina, Brazil., [Feijo, C.] Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil., [Rezende, V] Hosp Geral Roraima, Boa Vista, Brazil., [Assuncao, M.] Hosp Israelita Albert Einstein, Sao Paulo, Brazil., [Neves, A.] Hosp Mater Dei, Belo Horizonte, MG, Brazil., [Gusman, P.; Dalcomune, D.] Hosp Meridional, Cariacica, ES, Brazil., [Teixeira, C.] Hosp Moinhos Vento, Porto Alegre, RS, Brazil., [Kaefer, K.] Hosp Municipal Ruth Cardoso, Balneario, Brazil., [Maia, I] Hosp Nereu Ramos, Florianopolis, SC, Brazil., [Souza Dantas, V] Hosp Pasteur, Rio De Janeiro, Brazil., [Costa Filho, R.] Hosp Pro Cardiaco, Rio De Janeiro, Brazil., [Amorim, F.] Hosp Reg Samambaia, Brasilia, DF, Brazil., [Assef, M.] Hosp Reg Hans Dieter Schmidt, Joinville, Brazil., [Schiavetto, P.] Hosp Santa Casa Campo Mourao, Campo Mourao, PR, Brazil., [Houly, J.] Hosp Santa Paula, Sao Paulo, SP, Brazil., [Houly, J.] Hosp Santapaula, Sao Paulo, Brazil., [Bianchi, F.] Hosp Sao Jose Avai, Itaperuna, RJ, Brazil., [Dias, F.] Hosp Sao Lucas Pucrs, Porto Alegre, RS, Brazil., [Avila, C.] Hosp Sao Vicente Paula, Rio De Janeiro, RJ, Brazil., [Gomez, J.] Hosp Sao Vicente Paulo, Rio De Janeiro, Brazil., [Rego, L.] Hosp Saude Mulher, Belem, Para, Brazil., [Castro, P.] Hosp Tacchini, Bento Goncalves, RS, Brazil., [Passos, J.] Hosp Unimed Costa Do Sol Macae Rj, Macae, RJ, Brazil., [Mendes, C.] Hosp Univ Ufpb Joao Pessoa, Joao Pessoa, Paraiba, Brazil., [Grion, C.] Hosp Univ Londrina, Londrina, Brazil., [Colozza Mecatti, G.] Hosp Univ Sao Francisco, Braganca Paulista, SP, Brazil., [Ferrreira, M.] Santa Casa Caridade Diamantina, Diamantina, MG, Brazil., [Irineu, V] Santa Casa Misericordia Tatui, Tatui, Brazil., [Guerreiro, M.] Sao Francisco de Paula Hosp, Sao Francisco De Paula, RS, Brazil., [Ugarte, S.] Clin Indisa, Providencia, Chile., [Tomicic, V] Clin Las Lilas, Providencia, Chile., [Godoy, C.] Hosp Carlos Van Buren, Valparaiso, Chile., [Samaniego, W.] Hosp Trabajador Santiago, Santiago, Chile., [Escamilla, I] Hosp El Pino, San Bernardo, Chile., [Escamilla, I] Hosp Mutual De Seguridad, Santiago, Chile., [Castro Castro, L.] Ctr Med Imbanaco, Valle Del Cauca, Colombia., [Libreros Duque, G.] Clin Colombia Cali, Cali, Colombia., [Diaz-Guio, D.] Clin Del Cafe, Armenia, Colombia., [Benitez, F.] Clin La Estancia SA, Popayan, Colombia., [Guerra Urrego, A.] Clin Medellin, Medellin, Colombia., [Buitrago, R.] Fdn Clin Shaio, Bogota, Colombia., [Ortiz, G.] Hosp Santa Clara, Bogota, Colombia., [Villalba Gaviria, M.] Hosp Univ Fdn Santa Fe De Bogota, Bogota, Colombia., [Salas, D.] Calderon Guardia Hosp, San Jose, Costa Rica., [Ramirez-Arce, J.] Hosp Dr Rafael Angel Varlderon Guardia Ccss, San Jose, Costa Rica., [Salgado, E.] Clin La Merced, Quito, Ecuador., [Morocho, D.] Hosp Eugenio Espejo, Quito, Ecuador., [Vergara, J.] Hosp Luis Vernaza, Quito, Ecuador., [Chung Sang, M.] Shdug Sistema Hosp Docente De La Univ Guayaquil, Quito, Ecuador., [Orellana-Jimenez, C.] Gen Hosp, San Salvador, El Salvador., [Garrido, L.] Hosp Ctr Med, Guatemala City, Guatemala., [Diaz, O.] Inst Hondureno Seguro Social, La Ceiba, Honduras., [Resiere, D.] Ctr Hosp Univ Ft De France, Fort De France, Martinique, France., [Osorio, C.] Ctr Estatal Cuidados Crit, Salamanca, Mexico., [De La Vega, A.] Ctr Med Nacl 20 Noviembre Issste, Mexico City, DF, Mexico., [Carrillo, R.] Fdn Clin Med Sur, Mexico City, DF, Mexico., [Sanchez, V] Hosp San Jose TEC Monterrey, Monterrey, Mexico., [Villagomez, A.] Hosp 1 Octubre, Issste, Mexico., [Martinez Zubieta, R.] Hosp Espanol Mexico, Mexico City, DF, Mexico., [Sandia, M.] Hosp Gen Ajusco Medio, Mexico City, DF, Mexico., [Zalatiel, M.] Hosp Gen Guadalupe Victoria, Texcoco, Mexico., [Poblano, M.] Hosp Juarez Mexico, Mexico City, DF, Mexico., [Rodriguez Gonzalez, D.] Hosp Civil Guadalajara, Hspitaljuan I Menchaca, Guadalajara, Jalisco, Mexico., [Arrazola, F.; Juan Francisco, L.] Inst Mexicano Seguro Social, Mexico City, DF, Mexico., [Liamendys-Silva, S. A.] Inst Nacl Cancerol, Mexico City, DF, Mexico., [Hernandez, M.] ISSSTE Guerra Moya, Mexico City, DF, Mexico., [Hernandez, M.] Med Ctr ISSEMYM Toluca, Mexico City, DF, Mexico., [Rodriguez Cadena, D.] Mixta, Mexico City, DF, Mexico., [Lopez Islas, I.] Secretaria Salud Dist Fed, Mexico City, DF, Mexico., [Ballesteros Zarzavilla, C.] Hosp Santo Comas, Panama City, Panama., [Matos, A.] Social Secur Hosp, La Chorrera, Panama., [Oyanguren, I] Clin Anglo Amer, Lima, Peru., [Cerna, J.] Essalud, Lima, Peru., [Quispe Sierra, R.] Hosp Nacl Dos De Mayo, Lima, Peru., [Jimenez, R.] Hosp Rebagliati, Lince Dist, Peru., [Castillo, L.] Inst Nacl Enfermedades Neoplas, Surquillo, Peru., [Ocal, R.] Gulhane Med Fac, Istanbul, Turkey., [Sencan, A.] Izmir Ataturk Educ & Res Hosp, Izmir, Turkey., [Gianoni, S. Mareque] CAMS, Montevideo, Uruguay., [Deicas, A.] CASMU, Montevideo, Uruguay., [Hurtado, J.] Hosp Espanol Asse, Montevideo, Uruguay., [Burghi, G.] Hosp Maciel, Montevideo, Uruguay., [Martinelli, A.] Ctr Med Caracas, Caracas, Venezuela., [Von der Osten, I] Hosp Miguel Perez Carreno, Caracas, Venezuela., [Du Maine, C.] MSF Trauma Hosp Kunduz, Kunduz, Afghanistan., [Bhattacharyya, M.] Amri Hosp, Kolkata, India., [Bandyopadhyay, S.] Amri Hosp Salt Lake, Kolkata, W Bengal, India., [Yanamala, S.] Apollo Hosp, Hyderabad, India., [Gopal, P.] Apollo Hosp, Bangalore, Karnataka, India., [Sahu, S.] Apollo Hosp, Bhubaneswar, India., [Ibrahim, M.] Apollo Special Hosp, Chennai, Tamil Nadu, India., [Rathod, D.] Asian Heart Inst, Mumbai, Maharashtra, India., [Mukundan, N.] Baby Mem Hosp Ltd, Calicut, Kerala, India., [Dewan, A.] Batra Hosp & Mrc, New Delhi 110062, India., [Amin, P.] Bombay Hosp Inst Med Sci, Mumbai, Maharashtra, India., [Samavedam, S.] Care Hosp, Hyderabad, India., [Shah, B.] Cims Hosp, Ahmadabad, Gujarat, India., [Gurupal, D.] Columbiaasia Hosp, Mysore, Karnataka, India., [Lahkar, B.] Dispur Hosp, Gauhati, India., [Mandal, A.] Fortis Hosp, Bangalore, Karnataka, India., [Sircar, M.] Fortis Hosp, Noida, India., [Ghosh, S.] Fortis Escorts Hosp, Faridabad, India., [Balasubramani, V] Ganga Med Ctr & Hosp P Ltd, Coimbatore, Tamil Nadu, India., [Kapadia, F.] Hinduja Hosp, Mumbai, Maharashtra, India., [Vadi, S.] KDAH, Mumbai, Maharashtra, India., [Nair, K.] Kerala Inst Med Sci, RMCC, Thiruvananthapuram, Kerala, India., [Tripathy, S.] Kalinga Inst Med Sci, DTEM, Bhubaneswar, Odisha, India., [Nandakumar, S.] Kovai Med Ctr & Hosp, Coimbatore, Tamil Nadu, India., [Sharma, J.] Medanta Medic, Gurgaon, India., [Kar, A.] Med Superspecialty Hosp, Kolkata, W Bengal, India., [Jha, S.] Metro Heart Inst Multispecial, Faridabad, India., [Gurav, K. Zirpe] Ruby Hall Pune, Pune, Maharashtra, India., [Patel, M.] Saifee Hosp, Mumbai, Maharashtra, India., [Bhaysar, A.] Spandan Multispecial Hosp, Vadodara, India., [Samaddar, D.] Tata Main Hosp, Jamshedpur, Jharkhand, India., [Kulkarni, A.] Tata Mem Hosp, Mumbai, Maharashtra, India., [Hashmi, M.] Aga Khan Univ, Karachi, Pakistan., [Ali, W.] Hearts Int Hosp, Rawalpindi, Pakistan., [Nadeem, S.] Liaquat Natl Hosp, Karachi, Pakistan., [Indraratna, K.] Sri Jayewardenepura Gen Hosp, Sri Jayawardenepura Kott, Sri Lanka., [Margarit, A.] Hosp Nostra Senyora Meritxell, Les Escaldes, Andorra., [Urbanek, P.] Akh Wien, Vienna, Austria., [Schlieber, J.] Allgemeines & Orthopad Landeskrankenhaus Stolzalp, Stolzalpe, Austria., [Reisinger, J.] Barmherzige Schwestern Linz, Linz, Austria., [Auer, U.] Gen Hosp Braunau, Braunau, Austria., [Hartjes, A.] Krankenhaus D Barmherzigen Schwestern Ried II, Ried Im Innkreis, Austria., [Lerche, A.] Krankenhaus Floridsdorf, Vienna, Austria., [Janous, T.] LK Gmund Waidhofen Thaya Zwettl, Standort Zwettl, Austria., [Kink, E.] LKH Horgas Enzenbach, Gratwein, Austria., [Krahulec, W.] LKH West, Graz, Austria., [Smolle, K.] Univ Hosp, Graz, Austria., [Van der Schueren, M.] AZ Groeninge Kortrijk, Kortrijk, Belgium., [Thibo, P.] AZ Jan Palfijn Gent, Ghent, Belgium., [Vanhoof, M.] AZ Turnhout, Turnhout, Belgium., [Ahmet, I] Bracops Anderlecht, Anderlecht, Belgium., [Gadisseux, P.] Ctr Hosp Mouscron, Mouscron, Belgium., [Dufaye, P.] CH Peltzer La Tourelle, Verviers, Belgium., [Jacobs, O.] Chirec Edith Cavell, Auderghem, Belgium., [Fraipont, V] CHR Citadelle, Liege, Belgium., [Biston, P.] CHU Charleroi, Charleroi, Belgium., [Dive, A.] CHU Mt Godinne, Yvoir, Belgium., [Bouckaert, Y.] CHU Tivoli, La Louviere, Belgium., [Gilbert, E.] CHwapi, Tournai, Belgium., [Gressens, B.] Clin St Pierre Ottignies, Ottignies, Belgium., [Pinck, E.] Clin Maternite St Elisabeth, Namur, Belgium., [Collin, V] Clin Europe St Michel, Etterbeek, Belgium., [Vincent, J. L.] Erasme Univ Hosp, Anderlecht, Belgium., [De Waele, J.] Ghent Univ Hosp, Ghent, Belgium., [Rimachi, R.] Moliere Hosp, Forest, Belgium., [Gusu, D.] Notre Dame, Brussels, Belgium., [De Decker, K.] Onze Lieve Vrouw Hosp, Aalst, Belgium., [Mandianga, K.] Ixelles Hosp, Ixelles, Belgium., [Heytens, L.] Sint Augustinus, Antwerp, Belgium., [Wittebole, X.] St Luc Univ Hosp UCL, Brussels, Belgium., [Spapen, H.] UZ Brussel, Brussels, Belgium., [Olivier, V] Vivalia Site Libramt, Libramont, Belgium., [Vandenheede, W.] VZW Gezondheidszorg Oostkust Knokke Heist, Knokke Heist, Belgium., [Rogiers, P.] ZNA Middelheim, Antwerp, Belgium., [Kolodzeike, P.] Herning Hosp, Herning, Denmark., [Kruse, M.] Hjoerring Hosp, Hjorring, Denmark., [Andersen, T.] Vejle Hosp, Vejle, Denmark., [Harjola, V] Helsinki Univ Cent Hosp, Helsinki, Finland., [Saarinen, K.] Seinajoki Cent Hosp, Seinajoki, Finland., [Leone, M.] Aix Marseille Univ, Hop Nord, Marseille, France., [Durocher, A.] Calmette Hosp, Lille, France., [Moulront, S.] Ctr Hosp Dunkerque, Dunkerque, France., [Lepape, A.] Ctr Hosp Lyon Sud, Lyon, France., [Losser, M.] CHU Nancy Brabois, Nancy, France., [Cabaret, P.] CH St Philibert, GHICL, Lille, France., [Kalaitzis, E.] CHR Dax, Dax, France., [Zogheib, E.] CHU Amiens, Amiens, France., [Charve, P.] CHU Dijon, Dijon, France., [Francois, B.] CHU Dupuytren, Limoges, France., [Lefrant, J. Y.] CHU Nimes, Nimes, France., [Beilouny, B.] Ctr Hosp Troyes, Troyes, France., [Forceville, X.] Ctr Hosp Meaux, Grp Hosp Est Francilien, Meaux, France., [Misset, B.] Grp Hosp Paris St Joseph, Paris, France., [Jacobs, F.] Hop Antoine Beclere, Clamart, France., [Floccard, B.] Hop Edouard Herriot, Lyon, France., [Payen, D.] Hop Lariboisere, AP HP, Paris, France., [Wynckel, A.] Hop Maison Blanche, Reims, France., [Castelain, V] Hop Univ Strasbourg, Strasbourg, France., [Faure, A.] Hosp Civils Lyon, Lyon, France., [Lavagne, P.] CHU Grenoble, Grenoble, France., [Thierry, I] CHU Nantes, Nantes, France., [Moussa, M.] CHRU Lille, Reanimat Chirurg Cardiovasc, Lille, France., [Vieillard-Baron, A.] Univ Hosp Ambroise Pare, Boulogne, France., [Durand, M.] Univ Hosp Grenoble, La Tronche, France., [Gainnier, M.] Univ Hosp Marseille, Marseille, France., [Ichai, C.] Univ Nice, Nice, France., [Arens, S.] Alexianer Krefeld Gmbh, Krefeld, Germany., [Hoffmann, C.] Charite Hochschulmed Berlin, Berlin, Germany., [Kaffarnik, M.] Charite, Berlin, Germany., [Scharnofske, C.] Diakoniekrankenhaus Henriettenstiftung Gmbh, Hannover, Germany., [Voigt, I] Elisabeth Krankenhaus Essen, Essen, Germany., [Peckelsen, C.] Munich Municipal Hosp Grp, Harlaching Hosp, Munich, Germany., [Weber, M.] Helios St Johannes Klin, Duisburg, Germany., [Gille, J.] Hosp St Georg Leipzig, Leipzig, Germany., [Lange, A.] Klin Hennigsdorf Oberhavel Kliniken Gmbh, Hennigsdorf, Germany., [Schoser, G.] Klin Tettnang, Tettnang, Germany., [Sablotzki, A.] Klinikum St Georg Leipzig, Leipzig, Germany., [Jaschinski, U.; Bluethgen, A.] Klinikum Augsburg, Augsburg, Germany., [Vogel, F.] Klinikum Bremen Mitte, Bremen, Germany., [Tscheu, A.] Klinikum Bremen Ost, Bremen, Germany., [Fuchs, T.] Klinikum Heidenheim, Heidenheim, Germany., [Wattenberg, M.] Klinikum Links Weser Gmbh, Bremen, Germany., [Helmes, T.] Klinikum Luedenscheid, Luedenscheid, Germany., [Scieszka, S.] Krankenhaus Neuwerk, Monchengladbach, Germany., [Heintz, M.] Marienkrankenhaus Schwerte, Schwerte, Germany., [Sakka, S.] Med Ctr Cologne Merheim, Cologne, Germany., [Kohler, J.] Schwarzwald Baar Klinikum Villingen Schwenningen, Villingen Schwenningen, Germany., [Fiedler, F.] St Elisabeth Krankenhaus Koln Hohenlind, Cologne, Germany., [Danz, M.] St Martinus Hosp Olpe, Olpe, Germany., [Sakr, Y.] Uniklinikum Jena, Jena, Germany., [Riessen, R.] Univ Klinikum Tubingen, Tubingen, Germany., [Kerz, T.] Univ Med Mainz, Mainz, Germany., [Kersten, A.] Univ Hosp Aachen, CPACC, Aachen, Germany., [Tacke, F.] Univ Hosp Aachen, DMIII, Aachen, Germany., [Marx, G.] Univ Hosp Aachen, OIC, Aachen, Germany., [Volkert, T.] Univ Hosp Muenster, Munster, Germany., [Schmutz, A.] Univ Med Ctr Freiburg, Fr
- Published
- 2019
46. Correction to: Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via A β ligation to β1-integrin conformers
- Author
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Woo, J. A., Zhao, X., Khan, H., Penn, C., Wang, X., Joly-Amado, A., Weeber, E., Morgan, D., and Kang, D. E.
- Subjects
Amyloid beta-Peptides ,Integrin beta1 ,Immunoblotting ,Correction ,Apoptosis ,CHO Cells ,Cell Biology ,Hippocampus ,Cell Line ,Mitochondria ,Electrophysiology ,Mice ,Cricetulus ,Actin Depolymerizing Factors ,Synapses ,Phosphoprotein Phosphatases ,Animals ,Humans ,Reactive Oxygen Species ,Molecular Biology ,Protein Binding - Abstract
The accumulation of amyloid-β protein (Aβ) is an early event associated with synaptic and mitochondrial damage in Alzheimer's disease (AD). Recent studies have implicated the filamentous actin (F-actin) severing protein, Cofilin, in synaptic remodeling, mitochondrial dysfunction, and AD pathogenesis. However, whether Cofilin is an essential component of the AD pathogenic process and how Aβ impinges its signals to Cofilin from the neuronal surface are unknown. In this study, we found that Aβ42 oligomers (Aβ42O, amyloid-β protein 1-42 oligomers) bind with high affinity to low or intermediate activation conformers of β1-integrin, resulting in the loss of surface β1-integrin and activation of Cofilin via Slingshot homology-1 (SSH1) activation. Specifically, conditional loss of β1-integrin prevented Aβ42O-induced Cofilin activation, and allosteric modulation or activation of β1-integrin significantly reduced Aβ42O binding to neurons while blocking Aβ42O-induced reactive oxygen species (ROS) production, mitochondrial dysfunction, depletion of F-actin/focal Vinculin, and apoptosis. Cofilin, in turn, was required for Aβ42O-induced loss of cell surface β1-integrin, disruption of F-actin/focal Talin-Vinculin, and depletion of F-actin-associated postsynaptic proteins. SSH1 reduction, which mitigated Cofilin activation, prevented Aβ42O-induced mitochondrial Cofilin translocation and apoptosis, while AD brain mitochondria contained significantly increased activated/oxidized Cofilin. In mechanistic support in vivo, AD mouse model (APP (amyloid precursor protein)/PS1) brains contained increased SSH1/Cofilin and decreased SSH1/14-3-3 complexes, indicative of SSH1-Cofilin activation via release of SSH1 from 14-3-3. Finally, genetic reduction in Cofilin rescued APP/Aβ-induced synaptic protein loss and gliosis in vivo as well as deficits in long-term potentiation (LTP) and contextual memory in APP/PS1 mice. These novel findings therefore implicate the essential involvement of the β1-integrin-SSH1-Cofilin pathway in mitochondrial and synaptic dysfunction in AD.
- Published
- 2022
47. BRIT1 Inhibits Invasion and Metastasis by Regulating SERPINA5 in Hepatocellular Carcinoma
- Author
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Xin M, Zhang X, Li N, Liang Y, Fang J, Wang J, and Zhao X
- Subjects
Text mining ,business.industry ,Hepatocellular carcinoma ,medicine ,Cancer research ,medicine.disease ,business ,Metastasis - Abstract
Purpose: BRIT1 (also known as MCPH1) is a DNA repair and tumor suppressor gene, whose alterations might be potentially associated with tumor progression and metastasis in HCC. SERPINA5, also known as Protein C inhibitor, has been reported to be decreased in a variety of human cancers and its decrease is associated with cellular invasion and tumor metastasis. However, little is known about the underlying mechanism of SERPINA5 downregulation and whether BRIT1 deficiency contributed to regulation control of SEPINA5 and invasion and metastasis in HCC.Methods: The expression of BRIT1 and SERPINs in HCC cells or human tumor tissue microarrays were determined by using quantitative real-time PCR, Western blot analysis, or immunohistochemistry. Migratory and invasive capacity of HCC cells were assessed by using in vitro wound-healing and Transwell-based assays or in vivo mouse xenograft tumor model. Dual luciferase reporter assay was performed to measure promoter activity of the SERPINA5 gene. HCC datasets analyzed in this study was performed by using Oncomine and cBioPortal Cancer Genomics with default parameters.Results: In this study we showed that BRIT1 protein was low expressed in HCC cells and tumor tissues. BRIT1 deficiency increased the capacity of migration, invasion and metastasis of HCC in vitro and in vivo; its expression level was positively correlated with that of SERPINA5 in HCC cells and tissue microarray. With the transcription factor E2F1, BRIT1 can upregulated the promoter activity of the SERPINA5 gene in HCC. Conclusion: These findings suggest that BRIT1 deficiency might induce tumor invasion and metastasis of HCC through regulatory control of SERPINA5 with the help of E2F1, and provide convincing evidence that BRIT1/SERPINA5 might be a novel biomarker for HCC metastasis.
- Published
- 2021
48. Global Well-posedness and Asymptotics of Full Compressible Non-resistive MHD System with Large External Potential Forces
- Author
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Yang W and Zhao X
- Subjects
Physics ,Resistive touchscreen ,Mathematical analysis ,Compressibility ,Magnetohydrodynamics ,Well posedness - Abstract
We consider the global well-posedness and asymptotic behavior of compressible viscous, heat-conductive, and non-resistive magnetohydrodynamics (MHD) fluid in a field of external forces over three-dimensional periodic thin domain $\Omega=\mathbb{T}^2\times(0,\delta)$. The unique existence of the stationary solution is shown under the adhesion and the adiabatic boundary conditions. Then, it is shown that a solution to the initial boundary value problem with the same boundary and periodic conditions uniquely exists globally in time and converges to the stationary solution as time tends to infinity. Moreover, if the external forces are small or disappeared in an appropriate Sobolev space, then $\delta$ can be a general constant. Our proof relies on the two-tier energy method for the reformulated system in Lagrangian coordinates and the background magnetic field which is perpendicular to the flat layer. Compared to the work of Tan and Wang (SIAM J. Math. Anal. 50:1432–1470, 2018), we not only overcome the difficulties caused by temperature, but also consider the big external forces.
- Published
- 2021
49. Knockdown of ANGPTL4 May Reduce the Expression of LPL during Differentiation of 3T3-L1 Preadipocyte
- Author
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Liu H, Zhang F, Wang C, Zhao X, Liu Y, Xing K, and Ao H
- Subjects
Gene knockdown ,Expression (architecture) ,ANGPTL4 ,General Earth and Planetary Sciences ,3T3-L1 ,Biology ,General Environmental Science ,Cell biology - Abstract
Adipose tissue is a complex, highly metabolically active tissue. The expansion of adipose tissue is mainly affected by two processes: the number of adipocytes and the change of adipocyte size. Adipocyte differentiation is regulated by multiple factors. 3T3-L1 preadipocyte line has become the most widely studied cell line for adipocyte proliferation, differentiation and regulation of related genes. In our previous study, we found that ANGPTL4 was related to preadipocyte differentiation through PPAR signaling pathway. Recent studies have shown that ANGPTL4 has functions of regulating oncogenesis, vascular permeability, glucose homeostasis, lipid metabolism, energy homeostasis. In this study, we observed the changes of key genes expression before and after inhibiting ANGPTL4 to explore how ANGPTL4 influence on lipid metabolism. Results shows that, ANGPTL4 and LPL have similar expression pattern. We suspect that, ANGPTL4 and LPL may form a pathway, when ANGPTL4 is suppressed it may block the pathway and inhibit LPL.
- Published
- 2021
50. Nomogram-Based Prediction of the Risk of Macrosomia: A Prospective Cohort Study in a Chinese Population
- Author
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Yu X, Zhang X, Yuan N, Chai S, Sun J, Du J, Zhao X, and Zhang Q
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Chinese population ,business.industry ,Medicine ,Nomogram ,business ,Prospective cohort study ,Demography - Abstract
Objective: This study aimed to establish a nomogram for predicting the risk of macrosomia in early pregnancy.Methods: We performed a prospective cohort study involving 1,549 pregnant women. According to the birth weight of newborn, the subjects were divided into two groups: macrosomia group and non-macrosomia group. Multivariate logistic regression was used to analyze the risk factors for macrosomia.Results: The prevalence of macrosomia was 6.13% (95/1549) in our hospital. Multivariate logistic regression analysis showed the risk factors of macrosomia were prepregnancy overweight (OR: 2.126, 95% CI: 1.181-3.826)/obesity (OR: 3.536, 95% CI: 1.555-8.036), multiparity (OR:1.877, 95% CI: 1.160-3.039), the history of macrosomia (OR: 36.971, 95% CI: 19.903-68.674), the history of GDM/DM (OR: 2.285, 95% CI: 1.314-3.976), the higher levels of HbA1c (OR: 1.763, 95% CI: 1.004-3.097) and TC (OR: 1.360, 95% CI: 1.004-1.842). A nomogram was developed for predicting macrosomia based on maternal factors related to the risk of macrosomia in early pregnancy. The area under the receiver operating characteristic (ROC) curve of the nomogram was 0.807 (95% CI: 0.755–0.859), the sensitivity and specificity of the model were 0.716 and 0.777, respectively.Conclusion: The nomogram model provides an accurate mothed for clinicians to early predict macrosomia.
- Published
- 2021
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