1. Additional file 1 of IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis
- Author
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Wang, Chang, Zhou, Mingxia, Zhu, Peiyu, Ju, Chenxi, Sheng, Jinxiu, Du, Dan, Wan, Junhu, Yin, Huiqing, Xing, Yurong, Li, Hongle, He, Jing, and He, Fucheng
- Abstract
Additional file 1: Figure S1. High expression of circRUNX1 is related to advanced TNM stage and differentiation grade. Figure S2. CircRUNX1 overexpression promotes ESCC progression. Figure S3. FOXP3 is a downstream target of circRUNX1. Figure S4. FOXP3 knocking down inhibites ESCC cell proliferation and metastasis. Figure S5. CircRUNX1 facilitates ESCC cell progression by regulating FOXP3 in vitro. Figure S6. CircRUNX1 functions as a miR-449b-5p sponge in ESCC cells. Figure S7. The cancer-inhibiting effect of miR-449b-5p in ESCC cells can be reversed by FOXP3. Figure S8. Relative expression of seven candidate circRUNX1 binding proteins in ESCC tissues was predicted from GEPIA. Figure S9. Depletion of circRUNX1 rescues the promotive effect of IGF2BP2 overexpression on malignant behaviors in ESCC cells. Table S1. Sequences of siRNA and shRNA used in this study. Table S2. Primers used in this study. Table S3. Information of top 8 circRNAs in ESCC tissues. Table S4. The correlation between circRUNX1 and ESCC clinicopathological features. Table S5. The correlation between IGF2BP2 and ESCC clinicopathological features.
- Published
- 2023
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