Search

Su Yuan,1,2 Biao Zuo,2,3 Si-Cong Zhou,1,2 Meng Wang,2,3 Kai-Yue Tan,2,3 Zhi-Wei Chen,2,3 Wen-Fu Cao1– 3 1Department of Combination of Chinese and Western Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, Chongqing, People’s Republic of China; 3College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Wen-Fu Cao, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400016, People’s Republic of China, Email caowenfu20220401@163.comPurpose: Our study aims to reveal the pharmacological mechanism of Astragaloside IV in the treatment of pulmonary fibrosis(PF) through network pharmacology and experimental validation.Methods: We first determined the in vivo anti-pulmonary fibrosis effect of Astragaloside IV by HE, MASSON staining, and lung coefficients, then used network pharmacology to predict the signaling pathways and molecularly docked key pathway proteins, and finally validated the results by in vivo and in vitro experiments.Results: In in vivo experiments, we found that Astragaloside IV improved body weight (P < 0.05), increased lung coefficients (P < 0.05), and reduced lung inflammation and collagen deposition in mice with pulmonary fibrosis. The network pharmacology results showed that Astragaloside IV had 104 cross-targets with idiopathic pulmonary fibrosis, and the results of KEGG enrichment analysis indicated that cellular senescence could be an important pathway for Astragaloside IV in the treatment of pulmonary fibrosis. Astragaloside IV also bound well to senescence-associated proteins, according to molecular docking results. The results of both in vivo and in vitro experiments showed that Astragaloside IV significantly inhibited senescence protein markers such as P53, P21, and P16 and delayed cellular senescence (P < 0.05). In in vivo experiments, we also found that Astragaloside IV reduced the production of SASPs (P < 0.05), and in in vitro experiments, Astragaloside IV also reduced the production of ROS. In addition, by detecting epithelial-mesenchymal transition(EMT)-related marker protein expression, we also found that Astragaloside IV significantly inhibited the development of EMT in both in vivo and in vitro experiments (P < 0.05).Conclusion: Our research found that Astragaloside IV could alleviate bleomycin-induced PF by preventing cellular senescence and EMT.Keywords: astragaloside IV, pulmonary fibrosis, network pharmacology, cellular senescence, epithelial-mesenchymal transition

Schisandra chinensisis a medicative and food plant in China, wealthy during a variety of functional components and wealthy during pharmacological activities. The specific aim of this study was to evaluate the anti-fatigue properties of Schisandra chinensis polysaccharides (SCP). It was first structurally characterized using FTIR and UV, followed by weight-loaded swimming test and determination of several fatigue-related biochemical indices in mice after exhaustion to evaluate the anti-fatigue ability of SCP. The results showed that SCP is a protein-bound polysaccharide, and it significantly prolonged swimming time, increased liver glycogen and muscle glycogen content, decreased lactate (LA), Blood urea nitrogen (BUN), malondialdehyde (MDA) levels, and increased glutathione peroxidase (GSH-PX), superoxide dismutase (SOD) and catalase (CAT) activities. Pearson correlation analysis showed that there was a good correlation between the in vivo anti-fatigue effect and antioxidant activity of SCP. Therefore, SCP can be applied as a potential anti-fatigue nutritional supplement in functional foods for the relief of exercise-related fatigue.

Additional file 1. Supplementary materials and methods. Additional Figures S1 to S10.

Motivated by a dynamical enhancement of the electromagnetic corrections by a power of $Λ_{\mathrm{QCD}}/m_b$ in $B_{d,s}\, \to\, μ^+\, μ^-$ at next-to-leading order (NLO), we extend the QED factorization effects on the leptonic $B$ meson decays with light muon leptons to tauonic final states, $B_{d,s} \, \to\, τ^+\, τ^-$, using soft-collinear effective theory (SCET). This extension is necessary owing to the appearance of the large $τ$ mass, which will lead to different power counting in SCET and also different results. We provide a complete NLO electromagnetic corrections to $B_{d,s} \, \to\, τ^+\, τ^-$, which include hard functions and hard-collinear functions below the bottom quark mass scale $μ_b$. The power enhanced electromagnetic effects from hard-collinear contributions on $B_{d,s}\, \to\, μ^+\, μ^-$ discussed before also exist in $B_{d,s} \, \to\, τ^+\, τ^-$. However the logarithm term arising from contributions of hard-collinear photon and lepton virtualities for $B_{d,s}\, \to\, τ^+\, τ^-$ is not large as it is in muon case due to the hard-collinear scale of $τ$ mass, which lead to only approximately $0.04\%$ QED corrections to the branching fraction of $B_{d,s} \, \to\, τ^+\, τ^-$ compared with overall reduction about $0.5\%$ in $B_{d,s}\, \to\, μ^+\, μ^-$., 29 pages, 3 figures

The role of Kupffer cell activation in immune liver damage induced by trichloroethylene associated with the IFN-γ/STAT1 signaling pathway by Si-fan Zhou, Qiong-ying Xu, Yi Yang, Hai-bo Xie, Jia-xiang Zhang, and Qi-xing Zhu in Toxicology and Industrial Health.

ObjectiveThe objective of this study was to compare the efficacy differences between Chinese patent medicines combined with hormone replacement therapy (HRT) in the treatment of premature ovarian failure (POF) by the Bayesian network meta-analysis (NMA) method.MethodsRandomized controlled trials (RCTs) reporting Chinese patent medicine combined with HRT for POF included Medline (via PubMed), Embase, Cochrane Library, China National Knowledge Infrastructure Database (CNKI), Wanfang Database (Wanfang), VIP Database (VIP), and China Biology Medicine Database (CBM) from the inception of the databases to July 2022. Two researchers independently screened the articles, extracted data, and evaluated the quality. The literature that met the inclusion criteria was screened out, the quality and risk of bias of the included studies were assessed according to the Cochrane 5.1 manual and RevMan 5.4, and NMA was performed using Stata 15.0 and R software.ResultsSixty-four RCTs involving 5,675 individuals containing 12 oral Chinese patent medicines combined with HRT were enrolled into the current NMA. The results showed that when compared with patients using only HRT, the total clinical response rate is greater in patients using HRT combined with one of these 12 oral Chinese patent medicines. Among them, Zuogui pills + HRT [odds ratio (OR) = 3.92; 95% credible interval (CrI) = 0.86, 23.84; SUCRA = 73.76%] is most likely to be the best intervention, and the suboptimal intervention is Guishen pills + HRT (OR = 3.22, 95% CrI = 1.16, 9.44, SUCRA = 70.60%).ConclusionChinese patent medicines combined with HRT were more effective than HRT alone in the treatment of POF. Zuogui pills are good at decreasing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and more effective in the improvement of total clinical response rate; Xuefu Zhuyu capsule is also good at decreasing FSH. Ziheche capsule is an expert in improving estradiol level; Kuntai capsule shows the lowest incidence of adverse reactions. However, the quality of the literature included in this study is relatively low, so it may affect the results of the study. Therefore, higher quality and multi-center trial would be necessary for supporting these results.Systematic review registration[www.crd.york.ac.uk/prospero], identifier [CRD42022350587].

Additional file 1. Mouse experimental methods.

Based on the capability of silyl ethers for efficient glycosylation, the new MTEAN glycosylation protocol utilizing 8-methyltosylaminoethynyl-1-naphthyl (MTEAN) glycosides as donors were extended to one-pot synthesis of nucleosides, late-stage modification of bioactive molecules, and stereoselective construction of 1,2-cis-glucosidic linkages using silyl ethers of the acceptors. Moreover, the reaction mechanism was systematically investigated by control reactions and side product characterizations, leading to the determination of a TfOH-catalyzed ynamide functionality-initiated process, which was further corroborated by identifications of the departure form of leaving group and the real catalyst.

Additional file2: Table S1. Primer sequences for PCR analysis. Table S2. Primary antibodies for Western blotting assays. Table S3. Primary antibodies for immunofluorescence staining. Fig. S1. Dual luciferase reporter assay were applied to detect the binding site and interaction between Risa or GSK3β and predicted miRNAs.

2.5-Dimensional SiO2 fiber-reinforced Al2O3-SiO2 (SiO2f/Al2O3-SiO2) composites were prepared by the sol-gel method, using diphasic SiO2 sol as the precursor into which Al2O3 powders were added. Their antioxidative behaviors and flexural strengths at high temperature were tested and compared. In an oxidation atmosphere, the composites showed high oxidation resistance, with a flexural strength retention ratio of over 90.00% at 1200 °C. After oxidation at 1500 °C, the mass retention ratio and flexural strength were 97.49% and 65.0 MPa respectively. The oxidation resistance of SiO2f/Al2O3-SiO2 composites was higher than that of SiO2f/SiO2 composites. After high-temperature test, the flexural strength retention ratios of SiO2f/SiO2 and SiO2f/Al2O3-SiO2 composites were 86.18% and 94.80% respectively, and the latter had a flexural strength of 134.9 MPa. SiO2 f/Al2O3-SiO2 composites worked better than SiO2f/SiO2 composites did in the flexural strength test at 1200 °C. The mechanical performance degradation and mass variations of the composites during tests were closely associated with their microstructural evolutions.

In this paper, a 3D model is created to investigate optical and thermodynamic performance of the spherical cavity receiver. Spiral copper pipes placed in the cavity absorb radiation energy and achieve solar-thermal conversion. The reflected rays loss and optical efficiency is calculated by using Monte-Carlo ray-tracing method. The optical efficiency of spherical cavity receiver is 88.9%, slightly higher than other shape cavity receivers. When the spherical cavity receiver moves away from the focal plane either in positive location or negative location, the radiation flux distribution is more uniform. The reflected rays loss decreases with D/d increasing from 1.0 to 2.5, while optical efficiency maintains approximately 86.3%. The radiation flux resulted from Monte-Carlo method is used as boundary condition of the CFD model. On this basis, the temperature distribution and heat loss of the spherical cavity receiver are investigated. Convection heat loss of the receiver with different D/d is estimated by varying the inclination from 0° to 90°. For a certain D/d, the maximum convection heat loss is θ = 0 ° and it decreases monotonously with inclination up to 90°. The temperature distribution with different D/d at θ = 0 ° is investigated. The temperature differences between the heat transfer pipe and heat transfer fluid decreases with D/d increasing. An increase in the inlet temperature of heat transfer fluid leads to the radiation loss remaining unchanged, but convection loss and total heat loss increasing slightly. Three kinds of heat losses decrease as inlet velocity of heat transfer fluid increases, including total heat loss, radiation loss and convection loss. Based on the simulation results, solar thermal conversion efficiency of a concentrator-receiver system varies from 81.9% to 84.4%, and optimal aperture size is about 1.0–1.5.

In this work, we evaluate the accuracy of the leading order results in Shifman-Vainshtein-Zakharov (SVZ) sum rules and the leading power results in the heavy quark limit for the mass of $��_{Q}$. Up to dim-5 condensate contributions are considered. By comparing with the experimental results, we find that the leading order results in SVZ sum rules can reach about 5\% accuracy both for $��_{b}$ and $��_{c}$, and it seems that better results can be obtained from the sum rules of the heavy quark limit both for $��_{b}$ and $��_{c}$. We re-check that the SVZ sum rules in the heavy quark limit coincide with the HQET sum rules. As a byproduct, we also have an exploratory discussion on the $ud$ diquark in $��_{Q}$., 10 pages, 3 figures

Direct conversion of carbon dioxide (CO2) to high-energy fuels and high-value chemicals is a fascinating sustainable strategy. For most of the current electrocatalysts for CO2 reduction, however, multi-carbon products are inhibited by large overpotentials and low selectivity. For practical applications, there remains a big gap of knowledge in proper manipulation of the C-C coupling process. Herein, we exploit dispersed 3d transition metal dimers as spatially confined dual reaction centers for selective reduction of CO2 to liquid fuels. Various nitrogenated holey carbon monolayers are shown to be promising templates to stabilize these metal dimers and dictate their electronic structures, allowing precise control of the catalytic activity and product selectivity. By comprehensive first-principles calculations, we screen the suitable transition metal dimers that universally have high activity for ethanol (C2H5OH). Furthermore, remarkable selectivity for C2H5OH against other C1 and C2 products is found for Fe2 dimer anchored on C2N monolayer. The correlation between the activity and d band center of the supported metal dimer as well as the role of electronic coupling between the metal dimer and the carbon substrates are thoroughly elucidated.

Additional file 1: Figure S1. Characterization of the functionalized CaP-MA nanoparticles. Synthetic route (A) and 1H NMR (B) and FTIR (C) spectrum of the conjugated mannitol-alendronate (MA-AL); Size distribution and polydispersity index (PDI) of CaP (D), CaP-MA-5 (E), CaP-MA-20 (F) and CaP-MA-40 (G); Morphology of CaP and different CaP-MA nanoparticles (H); Evaluation the abilities of different nanoparticles to protect DNA (I), (+) represented incubation with DNase I and (-) represented incubation without DNase I, mean ± SD, n=3. ★The intensity was too low to be determined. Figure S2. The biocompatibility of CaP and CaP-MA-5/20/40 nanoparticles. Cell viability of CaP nanoparticles, CaP-MA nanoparticles (A), and MA-AL (B) measured by the MTT assay. The mixture of fresh blood and nanoparticles after 1 hour incubation (C), Lip-2000 (a), CaP-MA-40 (b), CaP-MA-20 (c), CaP-MA-5 (d), CaP (e), saline (f), Triton-X (g). Hemolytic rates of Lip-2000, CaP and CaP-MA-5/20/40 nanoparticles (D). Data are shown as mean ± SD (n=3). * P

Heavy fermion (HF) states emerge in correlated quantum materials due to the interplay between localized magnetic moments and itinerant electrons, but rarely appear in 3d-electron systems due to high itinerancy of d-electrons. Here, an anomalous enhancement of Kondo screening is observed at the Kondo hole of local Fe vacancies in Fe3GeTe2 which is a recently discovered 3d-HF system featuring of Kondo lattice and two-dimensional itinerant ferromagnetism. An itinerant Kondo-Ising model is established to reproduce the experimental results which provides insight of the competition between Ising ferromagnetism and Kondo screening. This work explains the microscopic origin of the d-electron HF states and inspires study of the enriched quantum many-body phenomena with Kondo holes in Ising ferromagnets., Comment: 17 Pages, 4 Figures

Polymer infiltration pyrolysis (PIP) was used to prepare carbon fiber-reinforced silicon carbide (C/SiC) composites, and chemical vapor deposition (CVD) was employed to fabricate SiC coating. The oxidation behavior at 1700 °C and the flexural property at 1200 °C were tested. SiC coating exerted remarkable oxidation effects on PIP-C/SiC composites. In the absence of coating, PIP-C/SiC composites lost 29.2% of its mass, with merely 6.74% of the original flexural strength retained. In contrast, CVD-SiC coated PIP-C/SiC composites had the mass loss of 10.2% and the flexural strength retention ratio of 23.4%. In high-temperature tests, SiC coating played an important role in the flexural strength of PIP-C/SiC composites. The flexural strength of uncoated composites became 330.7 MPa, and that of coated ones reduced from 655.3 to 531.2 MPa.

Defect Detection is one of the most important parts of Automatic Identification and Data transmission. Quick Response code (QRcode) is one of the most popular types of two-dimensional barcodes. It isachallenge to detect defect of various QRcode images efficiently and accurately. In this paper, we propose the procedure byaserial of carefully designed preprocessing methods. The defect detection procedure consists of QRcode identification, QRcode reconstruction, perspective transformation, image binarization, morphological operation, image matching, and Blob analysis. By these steps, we can detect defect of different types of QRcode images. The experiment results show that our method has stronger robustness and higher efficiency. Moreover, experiment results on QRcode images show that the prediction accuracy of proposed method reaches 99.07%with an average execution time of 6.592 ms. This method can detect defect of these images in real time.

To investigate the relationship between various chronic mountain sickness (CMS) symptoms and cognitive performances and identify whether individual CMS symptom can be used as early warning signs of specific cognitive impairment in long-term high altitude migrators.A total of 287 workers living at an altitude of 3850 m for 1-5 years participated in the study. According to the International Qinghai CMS Diagnostic Criteria, a questionnaire survey was conducted to measure the existence and severity of 7 self-perceptible CMS symptoms in addition to hemoglobin (Hb) levels in the blood. Six neurobehavioral tests were then conducted to assess cognitive function, and physiological indices, including Pittsburgh Sleep Quality Index (PSQI) and arterial oxygen saturation were also measured.Compared with a score of 0 for each CMS symptom, scores of 1-3 universally corresponded to impairment in some aspects of cognition. Moreover, the correlation analysis revealed that subjects with different CMS symptoms exhibited specific aspects of cognitive impairment. Cyanosis was associated with slower auditory and visual reactions, reduced motion agility and poor visual memory ability (R = =0.236, 0.261, 0.155, 0.221, P 0.01). Sleep disturbance and excessive erythrocytosis were significantly correlated to poor memory ability (R = =0.206~0.251, P 0.01), and the symptoms of headache were mainly associated with impaired motion agility (R = =0.266, P0.01). The results also indicated that Hb ≥ 200 g/L, SpOThe characteristics of symptoms used in Qinghai CMS Score System were associated with specific cognitive impairments in long-term plateau migrators, which supported the usefulness of monitoring cognitive status using CMS-related symptoms for both CMS patients and non-CMS people at high altitude.

Additional file 1. Additional figures and table.

Utilizing all the experimental measured charmless $B \to PP$, $PV$ decay modes, where $P(V)$ denotes a light pseudoscalar (vector) meson, we extract the CKM angle $��$ by global fit. All the unknown hadronic parameters are fitted with $��$ together from experimental data, so as to make the approach least model dependent. The different contributions for various decay modes are classified by topological weak Feynman diagram amplitudes, which are to be determined by the global fit. To improve the precision of this approach, we consider flavor SU(3) breaking effects of topological diagram amplitudes among different decay modes by including the form factors and decay constants. The fitted result for CKM angle $��$ is $(69.8 \pm 2.1 \pm 0.9) ^{\degree}$. It is consistent with the current world average with a better precision., 15 pages, including 2 figures

We analyze charmless two-body non-leptonic $B$ decays under the framework of factorization assisted topological amplitude approach. Unlike the conventional flavor diagram approach, we consider flavor $SU(3)$ breaking effect assisted by factorization hypothesis for topological diagram amplitudes of different decay modes, by factorizing out the corresponding decay constants and form factors. The non-perturbative parameters of topology diagram magnitudes $\chi$ and strong phase $\phi$ are universal that can be extracted by $\chi^2$ fit from current abundant experimental data of charmless $B$ decays. The number of free parameters and the $\chi^2$ per degree of freedom are both reduced comparing with previous analysis. With these best fitted parameters, we predict branching fractions and $CP$ asymmetry parameters of nearly 100 $B_{u,d}$ and $B_s$ decay modes. The long-standing $\pi \pi$ and $\pi K$-$CP$ puzzles are solved simultaneously., Comment: 4 pages, no figures. talk given at 52nd Rencontres de Moriond QCD and High Energy Interactions, La Thuile, March 25 - April 1, 2017

We analyze the two-body charmed $B$ meson decays $B_{u,d,s} \to D^{(*)}P(V)$ in the factorization assisted topological amplitude approach, where $P(V)$ denoting a light pseudoscalar (vector) meson. Different from the conventional topological diagram approach, flavor $SU(3)$ symmetry breaking effects are taken into account. Therefore only four universal nonperturbative parameters are introduced to describe the contribution from non-factorization diagrams for all the decay channels. The number of free parameters and the $\chi^2$ per degree of freedom are both significantly reduced comparing with the conventional topological diagram approach. With the 4 fitted parameters, we predict the branching fractions of 120 decay modes induced by both $b\to c$ and $b\to u$ transitions, which are well consistent with the measured data or to be tested on the future experiments. We also investigated the relative size of different topological diagrams, isospin violation, flavor $SU(3)$ symmetry breaking effects, compared with previous approaches., Comment: 4 pages, 1 figure. Talk given at Moriond QCD conference. LA THUILE, MARCH 19-26, 2016

By applying tournament analysis to the UK Unit Trusts data, the results support significant risk shifting in the family tournament; i.e. interim winning managers tend to increase their level of risk exposure more than losing managers. It also shows that the risk-adjusted returns of the winners outperform those of the losers following the risk taking, which implies that risk altering can be regarded as an indication of managers’ superior ability. However, the tournament behaviour can still be a costly strategy for investors, since winners can be seen to beat losers in the observed returns due to the deterioration in the performance of their major portfolio holdings.

We find a new regularization scheme which is motivated by the Bose-Einstein condensation. The energy of the virtual particle is considered as discrete. Summing them and regulating the summation by the Riemann $\zeta$ function can give the result of loop integral. All the divergences vanish, we can get almost the same results as Dimensional Regularization. The prediction beyond Dimensional Regularization is also shown in the QED. The hierarchy problem of the radiative correction of scalar mass completely vanish., Comment: 9 pages, 1 figure, minor changes, add more comments

In the process of Web information extraction,Web pages on the target websites should be clustered in order to detect and generate templates that are used to extract required information.Traditional page clustering algorithm based on DOM tree edit distance is not suitable for the complex Document Object Model(DOM)tree structure pages created from dynamic templates.In this paper,an improved Web page clustering algorithm was proposed based on partial tag tree matching.In the proposed algorithm,the appropriate weights were assigned to the nodes according to their effects on the layout of Web pages and the level difference between template nodes and non-template nodes.After that,the structure similarity between Web pages was computed efficiently based on partial tree matching approach.Compared with the traditional algorithms,the experimental results show that the proposed algorithm is of higher accuracy in clustering dynamic Web pages and lower computing complexity.

The literature study indicates that the number of empirical studies on the relationship between work values and job performance of employees are very low, and the results are not complimentary. Although many scholars provide a considerable amount of research regarding the relationship between the work values of an employee and his job performance, few studies take the influence an enterprise environment has on the work values of employees into consideration. Based on social interaction theory, this research puts forward the work value's fulfilling level as a new variable to ascertain the relationship between it and job performance of employees, which takes into full account of the interaction between the enterprise environment and employees' work values. Moreover, the work value's fulfilling level is used to measure the degree of an employee's work value realized within the enterprise, This research surveyed 529 valid data from supervisor-subordinate dyads to examine the hypotheses proposed in this article, and the findings of the research finally indicate that the work value's fulfilling level of employees is significantly correlated with their job performance, including capacity & progress and status & independence dimensions of work value. However, comfort & security dimensions are uncorrelated with job performance.

Magnetic measurements have been carried out on partial melt (Tl0.5Pb0.5)(BaxSr0.8)2 Ca2 Cu3 Oy (x = 0.1, 0.2) (Tl-1223) samples, which indicate that higher melting temperature and longer melting time can be used to obtain Tl-1223 compound with better superconducting properties. On the contrary, introducing of Ba vacancy into Tl-1223 samples results in worse superconducting properties. At the end, the power law relationship between the critical current density and the applied field is explained by the flux creep model and the collective pinning theory.

Using the $B_s$ meson wave function extracted from non-leptonic $B_s$ decays, we reevaluate the rare decays $B_s\to \ell^+\ell^- ��, (\ell=e,��)$ in the standard model, including two kinds of contributions from magnetic-penguin operator with virtual and real photon. We find that the contributions from magnetic-penguin operator $b\to s��$ with real photon to the exclusive decays, which is regarded as to be negligible in previous literatures, are large, and the branchings of $B_s\to \ell^+\ell^-��$ are nearly enhanced by a factor 2. With the predicted branching ratios at order of $10^{-8}$, it is expected that the radiative dileptonic decays will be detected in the LHC-b and B factories in near future., 1 figures, 10 pages, minor changes, references and comments added

To investigate the role of Thl7 cells and the cytokine interleukin-17 (IL-17) in acute allograft rejection in mice.Mouse models of kidney transplantation were randomly divided into rejection group and isograft group. On the post-operative day (POD) 3 and 7, we tested the serum IL-17 level using enzyme-linked immunosorbent assay and measured the number of Th17 cells in the renal grafts by flow cytometry. The grafts were harvested and fixed in 10% formalin to prepare paraffin sections for routine pathological inspection.Compared to isograft group, the allograft group showed a significantly higher level of serum IL-17 on POD3 and POD7 (P0.05), and the level of IL-17 is significantly higher on POD7 than on POD3 (P0.05). The allograft group showed more infiltrating Th17 cells in the grafts on POD3 and POD7 (P0.05), and the cell number was significantly greater on POD7 (P0.05). Pathological examination also showed an increased severity of graft rejection with the post-transplantation time.Thl7 cells may play an important role in the development of renal graft rejection. IL-17 may serve as a potential specific indicator for predicting allograft rejection.

The logistics industry is the foundation and guarantee of the rapid development of manufacturing industry, and the manufacturing industry makes a huge demand for the development of logistics industry, therefore, it shows coordinated development trend between manufacturing industry and logistics. Using Logistic model, this paper gives quantitative research in the impact of Chinese manufacturing industry in driving the development of logistics industry and the impact of Chinese logistics in promoting the development of manufactory industry, which is an empirical of coordinated development between Chinese manufacturing industry and logistics. The paper also raises some suggestions to accelerate the development between Chinese manufacturing industry and logistics.

Foreign exchange reserve is a government's international reserve assets held in foreign currency, and is an important component of economic strength of a country. However, according to economic theory and experience of other countries, foreign exchange reserve of a country is not “the more, the better”. On the basis of classical theories and previous studies, we tried to study the main economic factors influencing the scale of foreign exchange reserve, and then established a model which related the scale of foreign exchange reserve to these economic factors. Based on the model and China's economic data, the simulation was done, and the moderate scale of China's foreign exchange reserve was given. Some suggestions on the policy of China's foreign exchange reverses were given at the end of this paper.

Interleukin 10 (IL-10), a Th2 type cytokine, modulates inflammatory responses by inhibiting the production of proinflammatory cytokines. This study was designed to investigate the protective effects of adenovirus-mediated human IL-10 (Ad-hIL-10) gene transfer on protecting grafts from cold ischemia-reperfusion injury following orthotopic liver transplantation in rats.Adenoviruses encoding hIL-10 or beta-galactosidase (Ad-lacZ) were injected via the superior mesenteric vein into prospective donor animals. The donor liver was harvested 48 hours after transduction, and stored for 12 hours at 4 degree centigrade in lactated Ringer's solution prior to transplantation. The rats were divided into saline, Ad-lacZ, and Ad-hIL-10 groups. Liver function test, histopathological examination, reverse transcriptase-polymerase chain reaction (RT-PCR), and Western blotting were performed at 24 hours after transplantation in the three groups.Liver function (ALT and AST) was significantly improved, and the Suzuki score was significantly decreased in the Ad-hIL-10 group. The levels of hepatic TNF-alpha, MIP-2, ICAM-1 mRNA, and NF-kappaB protein in the Ad-hIL-10 group were significantly decreased. The expression of hIL-10 mRNA was detected by RT-PCR in Ad-hIL-10-treated grafts but not in controls treated with saline or Ad-lacZ.Donor pretreatment with Ad-hIL-10 down-regulates the expression of proinflammatory cytokines TNF-alpha, MIP-2, and ICAM-1 mRNA. hIL-10 protects against hepatic cold ischemia-reperfusion injury, at least in part, by suppressing NF-kappaB activation and subsequent expression of proinflammatory mediators.

In this paper, the nanocomposites are synthesized by the non-equal precipitation method to study the effect of the metal ions doped in antiferromagnetic matrix on the exchange bias. XRD patterns and SEM images reveal that the as-synthesized CuO nanocomposites have uniform size (～80 nm), and the ferrimagnetic particles MFe2O4 (M=Cu, Ni) are embedded in the antiferromagnetic (AFM) CuO matrix by doping of magnetic metal ions Ni and Fe. And the ferrimagnetic phase MFe2O4 (M=Cu, Ni) is formed through the addition of a small amount of Fe that reacts with Cu and Ni ions. Effects of different doping amount of Ni on exchange bias are different. A small doping amount of Ni can induce magnetic disorder at the interface of both phases, then the spin-glass-like phase may be formed. The spin-glass-like phases enhance the pinning effect on the magnetic moments of ferrimagnetic phase. Meanwhile, during field cooling process the antiferromagnetic phase splits into domains, which are aligned either with cooling field or in the original antiferromagnetic configuration. The domain wall serves as pinning sites for the magnetic moments of ferromagnetic phase, and the exchange bias effect is increased. The AFM NiO grains with high anisotropic energy are generated, this also increases the exchange bias effect when continuous doping of Ni ions. In the process of field cooling (FC), upward shift occurs in all hysteresis loops, which is perpendicular to the exchange bias. As x=0.08 (x is the concentration of Ni) the perpendicular displacement is 3.6%, this behavior also proves that under FC measurements, the spin-glass-like phase can be formed between the antiferromagnetic nanopaticles. It is the magnetic exchange coupling at the interface between the ferrimagnetic phase and the spin-glass-like phase that result in an upward shift in the entire measurement range. The plot of M versus T under zero field cooling (ZFC) and field cooling (FC) indicates that the exchange bias effect in these composites is ascribed to the exchange coupling at the interface between the ferrimagnetic particles and the spin-glass-like phase. With continuous introduction of magnetic Ni ions, the exchange bias field first increases slowly, then at x=0.08 it increases sharply. The existence of AFM NiO with high anisotropic energy and the domain structure in AFM matrix are the causes of the result.

New composite systems consisting of Au nanoparticles (NPs) and CdTe quantum dots (QDs) are fabricated by spin coating chemically synthesizing CdTe QDs on silica substrates which have already been implanted by Ag ions through using a metal vapor vacuum arc (MEVVA) ion source implanter. By thermally annealing the Au ions implanted silica substrates, the growth and redistribution of Au NPs can be controlled, the influence of localized surface plasmon (LSP) of Au NPs on the photoluminescence (PL) of CdTe QDs is well studied. The optical properties, surface morphologies, microstructures, and light emission properties of the Au-ion implanted samples are investigated by using optical absorption spectroscopy, atomic force microscopy, transmission electron microscopy and PL spectra measurements. PL spectra show that the PL intensities from Au NPs and CdTe QDs composite systems can be enhanced or quenched compared with those of CdTe QDs directly spin coated on bare silica substrate. The underlying interaction processes between Au NPs and CdTe QDs are discussed in depth, and the new mechanisms for the PL enhancement and quenching in the Au-CdTe coupled systems are put forward. These results provide a good reference for the future designing of optoelectronic devices with improved luminescence efficiency by LSP of metal NPs.

Surgical repair of hypospadias was successfully performed by using free peritoneal graft in the model of rabbit hypospadias. The results showed that free peritoneal graft used as a substitute for urathra had a high survival rate, and the canal was formed well. Our study demonstrated that peritoneum could be used for the surgical repair of hypospadias and other urethral disorders such as urethral stricture.

To explore the protective effect of octreotide on liver warm ischemia-reperfusion injury and its possible mechanism.Pringle's maneuver liver ischemia-reperfusion models were established. Forty eight male Sprague Daweley rats were randomly divided into a sham operation group (S group, n=16), an ischemia-reperfusion group (I/R group, n=16) and an octreotide preconditioning group (OPC group, n=16). ALT and AST in the serum were measured at 30 min after the ischemia and 120 min after the reperfusion. The histomorphological changes and ultrastructure of hepatocellular were observed by optic and transmission electronic microscope. Hepatic adenine nucleotide levels and energy changes (EC) were determined by high performance liquid chromatography (HPLC).(1) At 30 min after the ischemia and 120 min after the reperfusion, the levels of ALT and AST in the serum of OPC group was lower than those in I/R group, whereas the levels of ATP and EC in the hepatic tissue were higher than those in the I/R group (P0.01 or P0.05). Compared with the I/R group, the injury of hepatocellular histomorphology and ultrastructure in the OPC group was abated. (2) At 30, 60, and 120 min after the reperfusion, the levels of ATP and EC in the OPC groups were higher than those in the I/R group. During the ischemia, the levels of ATP and EC in the OPC group dropped more slowly than those in the I/R group, but ATP and EC in the OPC groups rose more quickly than those in the I/R group during the reperfusion.Octreotide precondition can improve the hepatocellular energy reserve, and protect the liver from warm ischemia-reperfusion injury. The protective of octreotide on warm ischemia-reperfusion injury may be related to its influence on endocrine secretion.

In order to study the function of unknown genes in functional genome, traditional supervised classification algorithms were applied to gene classification with Microarray expression profiles. But the results show that the classification precision is poor and the accuracies achieved for different classes varies dramatically. Because the gene expression profiles are mixed with different biologically meaningful information and there is much noise in the genomic-scale dataset. Independent component analysis (ICA) is a method for multi-channel signal processing to separate mixed signals. Through linear transformation, ICA minimizes the statistical dependence of the components of the represented variables. So in this paper ICA based supervised gene classification in yeast functional genome is presented, which is a hybrid method of ICA with supervised classification approaches. This method recognizes the hidden patterns under the gene expression profiles and reduces the noise that is abundant in the gene expression profiles efficiently. Experimental results show that this method improves the performance of precision and recall

In our original contributions, we found that the time which a random walker spends in finding a given path is directly proportional to the continued product of the degrees of all the nodes which pass through the given path. In this paper, with our original contributions, we give a modified routing strategy to improve the capacity of the network when all nodes have the same packet-delivery rates. We define an average routing centrality degree of the node to analyze the traffic load on the node with different degrees, and then we analyze the transportation capacity by using the critical value of Rc, the average packet travel time, the average path length and the search information. Both theoretical and experimental results show that compared with the shortest path strategy and the efficient path strategy, the new strategy can enhance the network capability.

Hormonal abnormality in experimental varicocele induced by partial ligation of left renal vein and the effect of thymosin (fraction 5) on the secretion of the sexual Hormone were studied in rats. Serum testosterone level was lowered after varicocele formation, but could be reversed or increased by intraperitoneal administration of thymosin 5 mg/rat twice a week for 4 weeks with concomitant increase of testicular testosterone content. Changes in FSH and LH both in serum and testis, determined with immunoassay meihod as that of testosterone, were insignificant as compared with control or thymosin treated groups.

In this article,information traffic dynamics in scale-free networks with limited queue resource is investigated firstly. It is found that the network transits from a free flow state to full congestion state with the increase in the packet generation rate. Then,a queue resource allocation model based on node degree is proposed. The core of this model is to make the queue length of node i proportional to kβi (ki being the degree of node i and β being an allocation parameter). Simulations show that the capacity of the scale-free network is maximal when β is about 1.25 for the shortest path algorithm used to transfer information. Furthermore,the optimal value of allocation parameter β is irrelevant to the network size and the amount of queue resource.

Wireless sensor networks usually have limited energy and transmission capacity, and they can't match the transmission of a large number of data. So, it is necessary to perform in-network compression or aggregation of the raw data sampled by sensors. By designing a ring topology, this paper proposes an algorithm for wavelet based spatio-temporal data compression in wireless sensor networks. The algorithm is capable of supporting a broad scope of wavelets that can simultaneously explore the spatial and temporal correlations among the sensory data. In this algorithm, the data in sensor networks are abstracted as a matrix, and the temporal and spatial correlation is then captured by the column and row wavelet transform respectively. The performance of the algorithm is qualitatively analyzed from the viewpoints of energy and delay. Theoretically and experimentally, it is concluded that the proposed algorithm can effectively explore the spatial and temporal correlation in the sensory data and provide a

In Fe-doped Tl-1223 superconducting phase, Fe-dopants significantly destroy superconductivity . Hall coefficient, thermogravimetric measurements and M?ssbauer effect show that Fe-dopants not only directly destroy the integrity of Cu-O layers to low superconduction transition temperature, but also induce extra oxygen to enter lattice. These extra oxygen defects can strengtheningly bind carriers in Cu-O layers, Such binding effect gives rise to decreasing of the carrier density with Fe-doping level increasing. In addition. the extra oxygen results in a deviation of its neibouring Fe(Cu) from center of Cu-O network, and from a new Fe-O coordination. It is important for high-Tc superconducting mechanism to study the structural details and carrier-binding effect of extra oxygen defect on superconducticity.