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While the eco-environmental effects of rural settlement expansion are of great significance to rural sustainable land use, the relationship between rural settlement expansion and eco-environment under different expansion patterns is still unclear. To fill this gap, the current study used Baota district of the loess hilly and gully region as a case study area. We first investigated the spatiotemporal expansion patterns of rural settlements from 1990 to 2015 and then estimated their impacts on ecosystem services by implementing the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model and the global agro-ecological zones (GAEZ) model. Results showed the following: 1) edge expansion was the primary pattern of rural settlement expansion in Baota district from 1990 to 2015, and the area of edge expansion was 757.40 h m2, accounting for 71.76% of the total expansion area of rural settlements. 2) Rural settlement expansion caused 1744.60 t loss of crop yield, 40,155.78 Mg C loss of carbon storage, and a significant decline in habitat quality of water areas during 1990–2015. 3) According to the unit expansion area, the edge expansion and leapfrog expansion patterns contributed more to ecosystem services loss than the infilling expansion pattern. 4) There were gradient differences in the impacts of three expansion patterns on ecosystem services, and the impacts were gradually weakened by the increased distance. Accordingly, we concluded that the expansion of rural settlements reduced surrounding ecosystem services, especially food production service, and that the edge expansion and leapfrog expansion patterns had higher levels of stress on ecosystem services.

With global climate change, the agricultural light-temperature potential productivity in the agro-pastoral ecotone has increased. This offers a good opportunity to develop agriculture in the agro-pastoral ecotone. However, the agro-pastoral ecotone is also an ecologically fragile area in which land degradation challenges agricultural development. As population grows and the need for food increases, the land carrying capacity of the agro-pastoral ecotone becomes insufficient, and the human–land relationship is not harmonious. Such conditions have limited the agricultural and rural development in the ecotone. The paper demonstrates how land engineering may improve land quality and support agricultural development in the ecotone based on studies at a research station established in 2015 in Yulin, Shaanxi Province, China. The studies target three factors: soil improvement, crop selection, and field management. The results show that: (1) The highest yield of crops planted on improved land is close to or even higher than that achieved under previous crop growth conditions. For instance, the corn yields can exceed 25%. (2) The potatoes grown on the improved land yield the highest gross income, reaching 67,200 yuan/ha. By way of land engineering, input costs can be balanced in 3–5 years. (3) As a result of land engineering, some villages in Yulin City have realized sustainable agricultural and even rural development, and promotion of this model will support the sustainable development of agriculture in the agro-pastoral ecotone.

Climate warming and its corresponding impacts on agriculture system increasingly attach great attentions. Earlier studies more concerned the impacts of the cultivated area expansion under climate change. Yet limited knowledge is about the impacts of climate warming on the cropping index change with the shifts of cropping system border. In this study, we used climatic data (1961-2015) to firstly investigate impacts of warming temperature on potential cropping system border expansion of China, and further used agricultural statistical data and satellite-based land use data to analyze the response of current land system to potential cropping system border expansion. Results of this study indicated that obviously advanced SDT10 and prolonged EDT10 contributed to the 88.4% regions of increased AAT10 at the past half century. Moreover, the northward expansion of the suitable cultivated areas in different cropping systems provided advantages for potential multiple cropping index (PMCI) improvement. Unfortunately, this study found that a significantly declined multiple cropping index (MCI) was observed in the peri-urban regions and the provinces with large out-migration of agriculture labor. The evidently increased MCI was only greatly observed in Xinjiang province. Besides, the potential increment of multiple cropping index (PIMCI) for different cropping system border expansion regions presented a rising trend and reached 53.6% in 2015 due to warming climate. Particularly, the significantly increased PIMCI was observed in the Loess Plateau, the Inner Mongolia, the Middle-lower Yangtze Plain, Northeast China Plain, Southern China and Beijing-Tianjin-Hebei Metropolitan Region. However, the response of current land system to the changes of PMCI and PIMCI was not timely. Based on the findings of our study, some potential agriculture development strategies were suggested by comprehensively considering regional natural conditions, agricultural production conditions and socioeconomic conditions. We hope these findings of this study could provide some valuable information for agricultural development policy decision-making.

Background Microglia are innate immune effector cells in the central nervous system and play an extremely important role in the physiological processes of the central nervous system. When microglia are activated, there are two polarization states, M1 and M2 phenotype. Dexamethasone is a glucocorticoid widely used in clinical practice, which pharmacological effects are mainly anti-inflammatory, anti-toxic. However, whether Dexamethasone affects polarization state of microglia is unknown. In this study, we investigate the effect of Dexamethasone on IL-4-induced alternative activation in murine BV-2 microglial cells. Methods BV-2 cells were incubated with Dexamethasone alone, IL-4 alone, or the combination of Dexamethasone and IL-4. Western blot and immunofluorescence were performed to detect protein levels of alternative activation markers arginase 1 (Arg1), found in inflammatory zone 1 (FIZZ1). Moreover, we investigated the effects of Dexamethasone on IL-4 induced activation of signal transducer and activators of transcription 6 (STAT6) and peroxisome proliferator-activated receptor-gamma (PPARγ). Results Dexamethasone promoted IL-4 induced microglia alternative activation by increasing the expression of Arg1 and FIZZ1. Dexamethasone also enhanced the expression of PPARγ. These effects were reversed by RU486 (a Dexamethasone antagonist). Further, the effects of Dexamethasone and IL-4 on Arg1 and FIZZ1 were blocked by the application of GW9662 (a PPARγ antagonist). Conclusions Our studies confirm that Dexamethasone promotes IL-4 induced alternative activation via STAT6/PPARγ signaling pathways in microglia. At the same time, it was confirmed that Dexamethasone acts on PPARγ instead of STAT6. These findings support that Dexamethasone has a therapeutic potential for neuroinflammatory diseases via alternative activation.

Land use change and its impacts on eco-environment attract great attentions. Earlier studies shed light on the impacts of urban build-up land and agriculture land. Yet, knowledge about the impacts of rural residential land on eco-environment, especially from different expansion patterns perspective, is relatively limited. Taking Baota District, a typical city in loess hilly and gully region during the period of 1990–2015 as a case study, this paper analyzed rural residential land and habitat quality changes based on land-use data (30-m spatial resolution), and further used direct/indirect measurement model to explore the impacts of different expansion patterns of rural residential land on eco-environment. Results showed that the growth rate of rural residential land decreased first and then increased during study period, and the pattern of edge expansion has the largest scale among the newly added residential land. Moreover, the eco-environment in northern area of Baota District had been significantly improved, especially the habitat quality of shrubs and grasslands. Unfortunately, this study found that the eco-environment around cities and townships deteriorated dramatically. Environment policy, land engineering projects and residential land changes were important driving factors on eco-environment changes. Furthermore, this study verified the difference in indirect impacts of rural residential land expansion patterns on eco-environment (infilling pattern

Accurate implantation of pedicle screw in spinal deformity correction surgeries is always challenging. We have developed a method of pedicle screw placement in severe and rigid scoliosis with a multi-level 3D printing drill guide template. From November 2011 to March 2015, ten patients (4 males and 6 females) with severe and rigid scoliosis (Cobb angle >70° and flexibility

Soil water overconsumption is threatening the sustainability of regional vegetation rehabilitation in the Loess Plateau of China. In this study, two typical natural and artificial grasslands under different precipitation regimes were selected and the spatial variations in and the factors that impact the soil water content were investigated to provide support for vegetation restoration and sustainability management in the Loess Plateau. Soil samples were collected in May and September. Medicago sativa L. and Stipa bungeana Trin. were selected as representatives of natural and artificial grasslands, respectively. Soil measurements were conducted at the beginning and end of the rainy seasons at soil depths of 0 to 3 m in 0.2-m increments, and 147 undisturbed and 2205 disturbed soil samples were collected at 27 sampling sites with different precipitation gradients across the Loess Plateau. The plant height, the field capacity, the saturated hydraulic conductivity, the bulk density, and the slope gradient were considered as impact factors. Statistic methods included one-way ANOVA, correlation tests, significance tests, and redundancy analyses. Spatial variation trends indicated that the mean soil water content increased as the multi-year mean precipitation increased, and the soil water content was higher in the natural grassland of Stipa bungeana Trin. than in the artificial grassland of Medicago sativa L. in the same precipitation gradient zone. Vertical spatial variation trends indicated that the soil water content was higher in most surface layers than in the deep layer and lower at the end of the rainy season than at the beginning of the rainy season, when the mean annual precipitation was less than 510 mm. The soil water content of the Stipa bungeana Trin. grassland was significantly correlated with precipitation and plant height, whereas the soil water content of the Medicago sativa L. grassland only exhibited a significant correlation with precipitation. Thus, grasses with fine palatability, good adaptability, and low water consumption should be cultivated in the Loess Plateau. The decreased soil water content is more obvious in the soil layers with active vegetation roots. In the areas with multi-year precipitation at 370–440 mm, natural grasslands are more suitable for restoration and these areas should be treated as key areas for vegetation restoration. With regard to the spatial distribution of vegetation restoration, the economic and ecological benefits must be balanced so that the ratio of artificial vegetation and natural restoration can be optimized to realize the continued sustainability of vegetation restorations.

With the rapid development of urbanization and industrialization, China&rsquo, s metropolitan areas have experienced dramatic transitions of land use, which has had a profound impact on the eco-environment. Accordingly, the contradictions of regional production, living, and ecological spaces have intensified. In this context, analysis of the dynamics of regional production&ndash, living&ndash, ecological (PLE) spaces has become an important entry point for studying land use transition and its eco-environmental effects, by constructing a classification system of PLE land functions. Using remote sensing data from four periods from 1985 to 2018, this paper explores the spatiotemporal evolution characteristics of PLE spaces and their eco-environmental effects in the Beijing&ndash, Tianjin&ndash, Hebei (BTH) urban agglomeration, based on GIS and the InVEST model. The results revealed that from 1985 to 2018, the living space of the BTH region expanded rapidly, the production space gradually shrank, and the ecological land remained relatively stable. The eco-environmental quality index within the study area shows obvious regional differences, demonstrating the spatial distribution of &ldquo, high in the northwest and low in the southeast&rdquo, and an overall deteriorating trend in the past 33 years. Moreover, the carbon density decreased gradually from northwest to southeast, and the transformations from production land into living land and from ecological land into production land were the major types of eco-environment deterioration. Our findings will provide guidelines for land use management, and offer references for the functional division of PLE spaces and ecological civilization construction, especially in terms of the coordinated development of the BTH region.

High-mobility group box 1 (HMGB1) facilitates neural stem cells (NSCs) proliferation and differentiation into neuronal linage. However, the effect of HMGB1 on NSCs migration is still elusive. The present study is to investigate the corelation between HMGB1 and NSCs migration and the potential mechanism. The results indicated that 1 ng/ml HMGB1 promoted NSCs proliferation using CCK8 assays. Moreover, data showed that 1 ng/ml HMGB1 facilitated NSCs migration via filopodia formation using phase-contrast and transwell assays. Furthermore, 1 ng/ml HMGB1 upregulated the expression of RAGE, one of the HMGB1 receptor, using western blotting assays and immunofluorescence staining. In addition, 1 ng/ml HMGB1 increased the percentage of filopodia formation using phalloidin staining. Meanwhile, the enhanced migration effect could be abrogated by 50 nM FPS-ZM1, one of the RAGE antagonist, and RAGE-specific siRNA through immunofluorescence and phalloidin staining. Together, our data demonstrate that HMGB1/RAGE axis facilitates NSCs migration via promoting filopodia formation, which might serve as a candidate for central nervous system (CNS) injury treatment and/or a preconditioning method for NSCs implantation.