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IntroductionIntegrated knowledge regarding pre-exposure prophylaxis (PrEP) awareness and willingness to use PrEP can be useful for HIV prevention in high incidence groups. This review summarizes the awareness of PrEP and willingness to use PrEP among men who have sex with men (MSM).MethodsOnline electronic databases were searched before 31 August 2021. A meta-analysis was conducted to pool studies analysing PrEP awareness and willingness to use PrEP. LOESS regression and linear regression were applied to fit the trends over time for the proportion of MSM aware of PrEP and willing to use PrEP. Dose-response meta-analysis (DRMA) was conducted by a restricted cubic spline model to explore the relationship between willingness to use PrEP and selected factors.Results and discussionA total of 156 articles involving 228,403 MSM were included. The pooled proportions of MSM aware of PrEP and willing to use PrEP were 50.0 (95% CI: 44.8-55.2) and 58.6% (95% CI: 54.8-62.4), respectively. PrEP awareness varied among countries with different economic status and different WHO regions, among different publication and research years, PrEP types and support policies. PrEP willingness differed among countries with different economic status and groups with different risks of HIV. The awareness of PrEP increased from 2007 to 2019 with a slope of 0.040260 (p

Background: The use of post-exposure prophylaxis (PEP) is effective in reducing HIV risk, but it is underused by men who have sex with men (MSM) due to certain psychological and sociostructural factors. This article assessed the awareness and use of PEP among MSM in an effort to increase the visibility and uptake of PEP among at-risk populations.Methods: We conducted a systematic literature search of the PubMed, Web of Science, PsycINFO, and Google Scholar electronic databases. Studies were screened for inclusion, and relevant data were abstracted, assessed for bias, and synthesized. Pooled effect estimates were calculated using random effects meta-analysis, meta-regression and subgroup analysis, and a qualitative review and risk of bias assessment were performed (PROSPERO, CRD42019123815).Results: Twenty eligible studies involving 12,579 MSM were included in the meta-analysis. The pooled estimate of the proportions of MSM who were aware of PEP was modest at 59.9% (95% CI: 50.5~68.7) and that of MSM who previously used PEP was very low at 4.9% (95% CI: 2.4~9.8). PEP awareness showed no clear change over time, while PEP use significantly changed over time. Multiple factors affected awareness, including educational attainment, race/ethnicity, levels of HIV stigma, access to condoms, and so on. Many factors could potentially impede or facilitate the use of PEP, such as income, lack of PEP information, and partnership.Conclusion: We observed that PEP is an underused HIV prevention strategy among MSM and that once MSM become aware of PEP, the majority are willing to use it if they are supported appropriately in terms of a range of individual, social, and structural barriers.Systematic Review Registration: http://www.cdr.york.ac.uk/prospero, PROSPERO [CRD42019123815].

Additional file 3. Standardized direct and indirect effects of knowledge, Those who have intention to take up HPV vaccine if the price is below NT$8000 vs. the referencea, Those who have intention to take up HPV vaccine no matter what the price is vs. the referencea and Vaccine uptake in the 6th month follow-up.

Additional file 2. Regression analysis to determine what percent of the variance of the outcome variable (vaccine uptake) is determined by the different independent variables.

Additional file 1.

Additional file 3. Standardized direct and indirect effects of knowledge, Those who have intention to take up HPV vaccine if the price is below NT$8000 vs. the referencea, Those who have intention to take up HPV vaccine no matter what the price is vs. the referencea and Vaccine uptake in the 6th month follow-up.

Additional file 2. Regression analysis to determine what percent of the variance of the outcome variable (vaccine uptake) is determined by the different independent variables.

Additional file 1. Additional Figures S1–S17 and Table S1.

Additional file 1: Table S1. Demographic characteristics of the 753 MSM with twice measurements of CD4 T-cell counts. Table S2. Demographic characteristics of the 216 MSM with twice measurements of HIV RNA viral load.

Additional file 1: Efficacy of HIV interventions among factory workers in low- and middle-income countries protocol of a systematic review.

Additional file 3: Quality assessment of 13 studies of HIV interventions among factory workers in LMICs.