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In this article, we propose a temperature-based proportional–integral–derivative (PID) controlling algorithm using highly dense fiber Bragg grating (FBG) arrays for laser ablation (LA) of ex vivo pancreatic tissues. Custom-made highly dense FBG arrays with a spatial resolution of 1.2 mm were fabricated with the femtosecond point-by-point writing technology and optimized for LA applications. In order to obtain proper PID gain values, finite element method-based iterative simulation of different PID gains was performed. Then, the proposed algorithm, with numerically derived PID gains, was experimentally validated. In the experiments, the point temperature was controlled at different distances from the laser fiber tip (6.0, 7.2, 8.4, and 10.8 mm). The obtained results report robust controlling and correlation between controlled distance and the resulting area of ablation. The results of the work encourage further investigation of FBG array application for LA control.

Laser ablation (LA) of cancer is a minimally invasive technique based on targeted heat release. Controlling tissue temperature during LA is crucial to achieve the desired therapeutic effect in the organs while preserving the healthy tissue around. Here, we report the design and implementation of a real-time monitoring system performing closed-loop temperature control, based on fiber Bragg grating (FBG) spatial measurements. Highly dense FBG arrays (1.19 mm length, 0.01 mm edge-to-edge distance) were inscribed in polyimide-coated fibers using the femtosecond point-by-point writing technology to obtain the spatial resolution needed for accurate reconstruction of high-gradient temperature profiles during LA. The zone control strategy was implemented such that the temperature in the laser-irradiated area was maintained at specific set values (43 and 55 &deg, C), in correspondence to specific radii (2 and 6 mm) of the targeted zone. The developed control system was assessed in terms of measured temperature maps during an ex vivo liver LA. Results suggest that the temperature-feedback system provides several advantages, including controlling the margins of the ablated zone and keeping the maximum temperature below the critical values. Our strategy and resulting analysis go beyond the state-of-the-art LA regulation techniques, encouraging further investigation in the identification of the optimal control-loop.